{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:23:20Z","timestamp":1772252600401,"version":"3.50.1"},"reference-count":84,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>The purpose of this study is to evaluate and compare, retrospectively, the outcome of two different periodontal regeneration procedures in patients suffering from aggressive periodontitis (AgP). Twenty-eight patients were diagnosed with AgP, suffering from several intra-bony defects (IBD); that were treated by one of two periodontal regeneration techniques randomly assigned to each patient: a. guided tissue regeneration (GTR) or b. an application of extracted enamel matrix derivatives (EMD) combined with demineralized bone xenograft particles (DBX). Probing pocket depth (PPD), clinical attachment level (CAL), and gingival recession were recorded. Pre-treatment and follow-up (up to 10 years from the surgery) recordings were analyzed statistically within and between groups. A significant reduction was shown at time on PPD and CAL values, however, not between subject groups. CAL values decreased in all sites. At the EMD group (44 sites), CAL gain was 1.92 mm (\u00b11.68) from pre-treatment to follow-up (p &lt; 0.001) and at the GTR group (12 sites) CAL gain of 2.27 (\u00b11.82) mm. In conclusion, 1\u201310 years observations have shown that surgical treatment of AgP patients by either GTR or by application of EMD\/DBX results in similar successful clinical results.<\/jats:p>","DOI":"10.3390\/dj7010029","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T11:21:59Z","timestamp":1552044119000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regeneration of the Periodontal Apparatus in Aggressive Periodontitis Patients"],"prefix":"10.3390","volume":"7","author":[{"given":"Zvi","family":"Artzi","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Tel Aviv University, Tel Aviv-Yafo 69979, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiran","family":"Sudri","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Tel Aviv University, Tel Aviv-Yafo 69979, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ori","family":"Platner","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Tel Aviv University, Tel Aviv-Yafo 69979, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avital","family":"Kozlovsky","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Implantology, Tel Aviv University, Tel Aviv-Yafo 69979, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/prd.12014","article-title":"Aggressive periodontitis: Case definition and diagnostic criteria","volume":"65","author":"Albandar","year":"2000","journal-title":"Periodontology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann. Periodontol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1902\/jop.1971.42.8.516","article-title":"The case for periodontosis as a clinical entity","volume":"42","author":"Baer","year":"1971","journal-title":"J. Periodontol."},{"key":"ref_4","first-page":"1","article-title":"Periodontosis: Case report with long-term follow-up","volume":"1","author":"Baer","year":"1979","journal-title":"Periodontal Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1600-051X.1979.tb01939.x","article-title":"Juvenile periodontitis. Localization of bone loss in relation to age, sex, and teeth","volume":"6","author":"Frandsen","year":"1979","journal-title":"J. Clin. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S149","DOI":"10.1111\/jcpe.12945","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition","volume":"45","author":"Tonetti","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/prd.12015","article-title":"Aggressive forms of periodontitis secondary to systemic disorders","volume":"65","author":"Khocht","year":"2000","journal-title":"Periodontology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/prd.12021","article-title":"Role of genetic factors in the pathogenesis of aggressive periodontitis","volume":"65","author":"Vieira","year":"2000","journal-title":"Periodontology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/prd.12019","article-title":"Epidemiology and demographics of aggressive periodontitis","volume":"65","author":"Susin","year":"2000","journal-title":"Periodontology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1600-0757.2009.00334.x","article-title":"Response of chronic and aggressive periodontitis to treatment","volume":"53","author":"Deas","year":"2000","journal-title":"Periodontology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/0022034513501878","article-title":"Tooth loss in aggressive periodontitis: A systematic review","volume":"92","author":"Nibali","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1600-051X.1986.tb00854.x","article-title":"New attachment formation in the human periodontium by guided tissue regeneration. Case reports","volume":"13","author":"Gottlow","year":"1986","journal-title":"J. Clin. Periodontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1600-051X.1997.tb00247.x","article-title":"Enamel matrix, cementum development and regeneration","volume":"24","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1600-051X.1997.tb00253.x","article-title":"Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects","volume":"24","author":"Heijl","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1902\/jop.2000.71.7.1110","article-title":"A comparison between enamel matrix proteins used alone or in combination with bovine porousbone mineral in the treatment of intrabony periodontal defects in humans","volume":"71","author":"Lekovic","year":"2000","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1902\/jop.2001.72.5.583","article-title":"Combination use of bovine porous bone mineral, enamel matrix proteins, and a bioabsorbable membrane in intrabony periodontal defects in humans","volume":"72","author":"Lekovic","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1600-051X.2001.281105.x","article-title":"The effectiveness of enamel matrix proteins used in combination with bovine porous bone mineral in the treatment of intrabony defects in humans","volume":"28","author":"Camargo","year":"2001","journal-title":"J. Clin. Periodontol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1902\/jop.2002.73.4.423","article-title":"A clinical comparison of a bovine-derived xenograft used alone and in combination with enamel matrix derivative for the treatment of periodontal osseous defects in humans","volume":"73","author":"Scheyer","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1902\/jop.2002.73.4.423","article-title":"Clinical comparison of an enamel matrix derivative used alone or in combination with a bovine-derived xenograft for the treatment of periodontal osseous defects in humans","volume":"73","author":"Scheyer","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_20","first-page":"259","article-title":"Clinical evaluation of an enamel matrix protein derivative (Emdogain) combined with a bovine-derived xenograft (Bio-Oss) for the treatment of intrabony periodontal defects in humans","volume":"22","author":"Sculean","year":"2002","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_21","first-page":"47","article-title":"Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative combined with a bovine-derived xenograft","volume":"23","author":"Sculean","year":"2003","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-051X.2004.00635.x","article-title":"Healing of human intrabony defects following regenerative periodontal therapy with an enamel matrix protein derivative alone or combined with a bioactive glass. A controlled clinical study","volume":"32","author":"Sculean","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_23","first-page":"153","article-title":"Five-year clinical and histologic results following treatment of human intrabony defects with an enamel matrix derivative combined with a natural bone mineral","volume":"28","author":"Sculean","year":"2008","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1902\/jop.2003.74.12.1725","article-title":"Enamel matrix proteins and bovine porous bone mineral in the treatment of intrabony defects: A comparative controlled clinical trial","volume":"74","author":"Zucchelli","year":"2003","journal-title":"J. Periodontol."},{"key":"ref_25","first-page":"471","article-title":"Combination of bovine-derived xenografts and enamel matrix derivative in the treatment of intrabony periodontal defects in dogs","volume":"27","author":"Yamamoto","year":"2007","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1902\/jop.2014.130420","article-title":"Clinical Outcomes Following Regenerative Therapy of Non-Contained Intrabony Defects Using a Deproteinized Bovine Bone Mineral Combined with Either Enamel Matrix Derivative or Collagen Membrane","volume":"85","author":"Andreuccetti","year":"2014","journal-title":"J. Periodontol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.11607\/prd.2050","article-title":"Single-flap approach in combination with enamel matrix derivative in the treatment of periodontal intraosseous defects","volume":"34","author":"Farina","year":"2014","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0501.2004.00986.x","article-title":"Effect of GBR in combination with deproteinized bovine bone mineral and\/or enamel matrix proteins on the healing of critical-size defects","volume":"15","author":"Donos","year":"2004","journal-title":"Clin. Oral Implants Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1600-0501.2004.01088.x","article-title":"Bone formation by enamel matrix proteins and xenografts: An experimental study in the rat ramus","volume":"16","author":"Donos","year":"2005","journal-title":"Clin. Oral Implants Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1600-0501.2006.01260.x","article-title":"The effect of enamel matrix proteins and deproteinized bovine bone mineral on heterotopicbone formation","volume":"17","author":"Donos","year":"2006","journal-title":"Clin. Oral Implants Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-051X.2009.01499.x","article-title":"Do bone grafts or barrier membranes provide additional treatment effects for infrabony lesions treated with enamel matrix derivatives? A network meta-analysis of randomized-controlled trials","volume":"37","author":"Tu","year":"2010","journal-title":"J. Clin. Periodontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1532-3382(12)70024-6","article-title":"The use of a membrane and\/or a bone graft may not improve the effects of enamel matrix derivatives in infrabony defects","volume":"12","author":"Verardi","year":"2012","journal-title":"J. Evid. Based Dent. Pract."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1902\/jop.2011.110480","article-title":"Adsorption of enamel matrix proteins to a bovine-derived bone grafting material and its regulation of cell adhesion, proliferation, and differentiation","volume":"83","author":"Miron","year":"2012","journal-title":"J. Periodontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00784-013-0992-5","article-title":"Effects of enamel matrix proteins in combination with a bovine-derived natural bone mineral for the repair of bone defects","volume":"18","author":"Miron","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1902\/jop.1996.67.6.603","article-title":"Comparison between 2 surgical techniques for the treatment of early-onset periodontitis","volume":"67","author":"Sirirat","year":"1996","journal-title":"J. Periodontol."},{"key":"ref_36","first-page":"323","article-title":"GTR treatment of intrabony defects in patients with early-onset and chronic adult periodontitis","volume":"22","author":"Zucchelli","year":"2002","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1902\/jop.2002.73.6.675","article-title":"Aggressive periodontitis: 5-year follow-up of treatment","volume":"73","author":"Buchmann","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_38","first-page":"397","article-title":"Use of Emdogain enamel matrix proteins in the surgical treatment of aggressive periodontitis","volume":"58","author":"Kiernicka","year":"2003","journal-title":"Ann. Univ. Mar. Curie Sklodowska Med."},{"key":"ref_39","first-page":"247","article-title":"The use of enamel matrix protein in the treatment of localized aggressive periodontitis: A case report","volume":"34","author":"Bonta","year":"2003","journal-title":"Quintessence Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1902\/jop.2007.060492","article-title":"Successful management of aggressive periodontitis by regenerative therapy (EMD): A 3-year follow-up case report","volume":"78","author":"Miliauskaite","year":"2007","journal-title":"J. Periodontol."},{"key":"ref_41","first-page":"89","article-title":"Minimally invasive flap surgery and enamel matrix derivative in the treatment of localized aggressive periodontitis: Case report","volume":"29","author":"Kaner","year":"2009","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1902\/jop.1985.56.4.204","article-title":"Flap technique for periodontal bone implants. Papilla preservation technique","volume":"56","author":"Takei","year":"1985","journal-title":"J. Periodontol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0011-8532(22)01190-9","article-title":"Maxillary anterior esthetics. Preservation of the interdental papilla","volume":"33","author":"Takei","year":"1989","journal-title":"Dent. Clin. N. Am."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1902\/jop.1995.66.4.261","article-title":"The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures","volume":"66","author":"Cortellini","year":"1995","journal-title":"J. Periodontol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1902\/jop.2001.72.12.1702","article-title":"The simplified papilla preservation flap in the regenerative treatment of deep intrabony defects: Clinical outcomes and postoperative morbidity","volume":"12","author":"Cortellini","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jcpe.12413","article-title":"Deproteinized bovine bone in association with guided tissue regeneration or enamel matrix derivatives procedures in aggressive periodontitis patients: A 1-year retrospective study","volume":"42","author":"Artzi","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-051X.1975.tb01734.x","article-title":"Periodontal treatment of multirooted teeth. Results after 5 years","volume":"2","author":"Hamp","year":"1975","journal-title":"J. Clin. Periodontol."},{"key":"ref_48","first-page":"41","article-title":"Reduced plaque formation by the chloromethyl analogue of victamine, C","volume":"41","author":"Turesky","year":"1970","journal-title":"J. Periodontol."},{"key":"ref_49","first-page":"905","article-title":"Motivation and education","volume":"85","author":"Saxer","year":"1975","journal-title":"SSO Schweiz. Mon. Zahnheilkd."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1600-051X.1989.tb01626.x","article-title":"Metronidazole plus amoxicillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis","volume":"16","author":"Rodenburg","year":"1989","journal-title":"J. Clin. Periodontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1600-051X.2005.00814.x","article-title":"Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: A randomized placebo-controlled clinical trial","volume":"32","author":"Guerrero","year":"2005","journal-title":"J. Clin. Periodontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","article-title":"A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients","volume":"29","author":"Herrera","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1902\/jop.2002.73.1.3","article-title":"Enamel matrix proteins and guided tissue regeneration with titanium-reinforced expanded polytetrafluoroethylene membranes in the treatment of infrabony defects: A comparative controlled clinical trial","volume":"73","author":"Zucchelli","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0765.1999.tb02259.x","article-title":"Healing of human intrabony defects following treatment with enamel matrix proteins or guided tissue regeneration","volume":"34","author":"Sculean","year":"1999","journal-title":"J. Periodontal Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1902\/jop.1999.70.3.255","article-title":"Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study","volume":"70","author":"Sculean","year":"1999","journal-title":"J. Periodontol."},{"key":"ref_56","first-page":"157","article-title":"Treatment of intrabony periodontal defects with an enamel matrix protein derivative (Emdogain): A report of 32 cases","volume":"19","author":"Sculean","year":"1999","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1034\/j.1600-051x.2000.027007466.x","article-title":"Treatment of intrabony defects with guided tissue regeneration and enamel-matrix-proteins. An experimental study in monkeys","volume":"27","author":"Sculean","year":"2000","journal-title":"J. Clin. Periodontol."},{"key":"ref_58","first-page":"374","article-title":"Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain)","volume":"20","author":"Sculean","year":"2000","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1034\/j.1600-051x.2001.028005397.x","article-title":"Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study","volume":"28","author":"Sculean","year":"2001","journal-title":"J. Clin. Periodontol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1902\/jop.2001.72.12.1695","article-title":"Treatment of intrabony defects with enamel matrix proteins or bioabsorbable membranes. A 4-year follow-up split-mouth study","volume":"72","author":"Sculean","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_61","first-page":"345","article-title":"Four-year results following treatment of intrabony periodontal defects with an enamel matrix protein derivative: A report of 46 cases","volume":"23","author":"Sculean","year":"2003","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_62","first-page":"326","article-title":"Human histologic evaluation of an intrabony defect treated with enamel matrix derivative, xenograft, and GTR","volume":"24","author":"Sculean","year":"2004","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1600-051X.2004.00518.x","article-title":"Five-year results following treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration","volume":"31","author":"Sculean","year":"2004","journal-title":"J. Clin. Periodontol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1902\/jop.2006.060002","article-title":"Treatment of intrabony defects with an enamel matrix protein derivative or bioabsorbable membrane: An 8-year follow-up split-mouth study","volume":"77","author":"Sculean","year":"2006","journal-title":"J. Periodontol."},{"key":"ref_65","first-page":"221","article-title":"Nine-year results following treatment of intrabony periodontal defects with an enamel matrix derivative: Report of 26 cases","volume":"27","author":"Sculean","year":"2007","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1600-051X.2008.01295.x","article-title":"Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration","volume":"35","author":"Sculean","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_67","first-page":"117","article-title":"A systematic review of graft materials and biological agents for periodontal intraosseous defects","volume":"3","author":"Tonetti","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1902\/jop.2002.73.4.409","article-title":"Comparison of clinical, radiographic, and histometric measurements following treatment with guided tissue regeneration or enamel matrix proteins in human periodontal defects","volume":"73","author":"Windisch","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1902\/jop.2004.75.5.726","article-title":"Treatment of intrabony defects with enamel matrix proteins or barrier membranes: Results from a multicenter practice-based clinical trial","volume":"75","author":"Sanz","year":"2004","journal-title":"J. Periodontol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1902\/jop.2005.76.3.341","article-title":"Clinical performance of a regenerative strategy for intrabony defects: Scientific evidence and clinical experience","volume":"76","author":"Cortellini","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_71","first-page":"247","article-title":"Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. A Cochrane systematic review","volume":"2","author":"Esposito","year":"2009","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1902\/jop.2011.110266","article-title":"Periodontal regeneration with enamel matrix derivative in reconstructive periodontal therapy: A systematic review","volume":"83","author":"Koop","year":"2012","journal-title":"J. Periodontol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1902\/jop.2012.120238","article-title":"Ten-year results following treatment of intrabony defects with an enamel matrix protein derivative combined with either a natural bone mineral or a \u03b2-tricalcium phosphate","volume":"84","author":"Arweiler","year":"2013","journal-title":"J. Periodontol."},{"key":"ref_74","first-page":"185","article-title":"Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients","volume":"24","author":"Vandana","year":"2004","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1902\/jop.1995.66.8.673","article-title":"Comparative effectiveness of various regenerative modalities for the treatment of localized juvenile periodontitis","volume":"66","author":"DiBattista","year":"1995","journal-title":"J. Periodontol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1600-051X.2008.01262.x","article-title":"Group B of European Workshop on Periodontology Periodontal tissue engineering and regeneration: Consensus Report of the Sixth European Workshop on Periodontology","volume":"35","author":"Palmer","year":"2008","journal-title":"J. Clin. Periodontol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1902\/jop.2010.090643","article-title":"Immunologic and microbiologic profiles ofchronic and aggressive periodontitis subjects","volume":"81","author":"Rescala","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1902\/jop.2011.100579","article-title":"Effect of non-surgical treatment on chronic and aggressive periodontitis: Clinical, immunologic, and microbiologic findings","volume":"82","author":"Rosalem","year":"2011","journal-title":"J. Periodontol."},{"key":"ref_79","first-page":"69","article-title":"A combined regenerative approach for the treatment of aggressive periodontitis: Long-term follow-up of a familial case","volume":"29","author":"Passanezi","year":"2009","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_80","first-page":"61","article-title":"Treatment of generalized aggressive periodontitis: A 4-year follow-up case report","volume":"15","author":"Lu","year":"2012","journal-title":"Chinese J. Dent. Res."},{"key":"ref_81","first-page":"44","article-title":"Periodontal regeneration with enamel matrix derivative\u2014Case reports","volume":"2","author":"Manor","year":"2000","journal-title":"J. Int. Acad. Periodontol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00784-005-0002-7","article-title":"Five-year results of guided tissue regeneration in combination with deproteinized bovine bone (Bio-Oss) in the treatment of intrabony periodontal defects: A case series report","volume":"9","author":"Stavropoulos","year":"2005","journal-title":"Clin. Oral Investig."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1902\/jop.2000.72.9.1157","article-title":"The use of bovine porous bone mineral in combination with enamel matrix proteins or with an autologous fibrinogen\/fibronectin system in the treatment of intrabony periodontal defects in humans","volume":"72","author":"Lekovic","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/clr.12170","article-title":"Ridge preservation with the use of deproteinized bovine bone mineral","volume":"25","author":"Lindhe","year":"2014","journal-title":"Clin. 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