{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:49:14Z","timestamp":1785548954919,"version":"3.56.0"},"reference-count":17,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>It is known that cortisol level increases in stress situations. The aim of the study was to measure the levels of salivary cortisol in patients with oral lichen planus (OLP) and healthy controls. This was a case-control pilot study which included seven patients with reticular (non-symptomatic) OLP, eight patients with atrophic\/erosive (symptomatic) OLP, and nine healthy controls. We hypothesized that patients with an atrophic\/erosive type of OLP have higher levels of cortisol compared to patients with the reticular type of OLP and healthy controls. In each participant, unstimulated saliva was collected in order to determine cortisol levels by using commercially available ELISA kit. Our results have shown no differences between levels of salivary cortisol in OLP patients and healthy controls. We can conclude that further research with a larger number of OLP patients is needed to determine the correlation between OLP and stress.<\/jats:p>","DOI":"10.3390\/dj7020059","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T02:08:40Z","timestamp":1559527720000},"page":"59","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Salivary Cortisol Levels in Patients with Oral Lichen Planus\u2014A Pilot Case-Control Study"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-7591","authenticated-orcid":false,"given":"Ivana","family":"Skrinjar","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, University Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Vidranski","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Oncology, University Clinical Hospital Sisters of Mercy, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-6796","authenticated-orcid":false,"given":"Bozana Loncar","family":"Brzak","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Dental Medicine University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Vidovic Juras","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia"},{"name":"Department of Oral Medicine, School of Dental Medicine University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Andabak Rogulj","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Dental Medicine University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlaho","family":"Brailo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia"},{"name":"Department of Oral Medicine, School of Dental Medicine University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanja","family":"Vucicevic Boras","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University Clinical Hospital Center Zagreb, 10000 Zagreb, Croatia"},{"name":"Department of Oral Medicine, School of Dental Medicine University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"ref_1","first-page":"19","article-title":"Salivary Cortisol and Salivary Flow Rate in Clinical Types of Oral Lichen Planus","volume":"16","author":"Mansourian","year":"2018","journal-title":"Skinmed"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.otc.2010.09.004","article-title":"Oral lichen planus","volume":"44","author":"Parashar","year":"2011","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e12363","DOI":"10.1111\/jicd.12363","article-title":"Psychological disorders and oral lichen planus: A systematic review","volume":"9","author":"Cerqueira","year":"2018","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_4","first-page":"1","article-title":"Association between psychological disorders and the presence of Oral lichen planus, Burning mouth syndrome and Recurrent aphthous stomatitis","volume":"9","author":"Soto","year":"2004","journal-title":"Med. Oral."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00403-016-1667-2","article-title":"Oral lichen planus: A literature review and update","volume":"308","author":"Alrashdan","year":"2016","journal-title":"Arch. Dermatol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/2230-8210.77573","article-title":"Stress and Hormones","volume":"15","author":"Ranabir","year":"2011","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/MED.0000000000000328","article-title":"Salivary cortisol and cortisone in the clinical setting","volume":"24","author":"Blair","year":"2017","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1590\/1807-3107bor-2018.vol32.0082","article-title":"Cytokines, cortisol, and nitric oxide as salivary biomarkers in oral lichen planus: A systematic review","volume":"32","author":"Humberto","year":"2018","journal-title":"Braz. Oral Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1034\/j.1601-0825.2003.00960.x","article-title":"The evaluation of anxiety and salivary cortisol levels in patients with oral lichen planus","volume":"9","author":"Koray","year":"2003","journal-title":"Oral Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jop.12345","article-title":"Oral lichen planus: Salival biomarkers cortisol, immunoglobulin A, adiponectin","volume":"45","author":"Cayuela","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/0970-9290.57361","article-title":"Evaluation of salivary cortisol and psychological factors in patients with oral lichen planus","volume":"20","author":"Shah","year":"2009","journal-title":"Indian J. Dent. Res."},{"key":"ref_12","first-page":"ZC01","article-title":"Association of salivary cortisol and anxiety levels in lichen planus patients","volume":"8","author":"Nadendla","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2334\/josnusd.15-0610","article-title":"Stress as an etiologic co-factor in recurrent aphthous ulcers and oral lichen planus","volume":"58","author":"Karthikeyan","year":"2016","journal-title":"J. Oral Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1034\/j.1600-0714.2001.300501.x","article-title":"Erosive oral lichen planus and salivary cortisol","volume":"30","author":"Jontell","year":"2001","journal-title":"J. Oral Pathol. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.archoralbio.2011.02.003","article-title":"Salivary cortisol and dehydroepiandrosterone (DHEA) levels, psychological factors in patients with oral lichen planus","volume":"56","author":"Girardi","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"ref_16","first-page":"31","article-title":"The evaluation of psychological factor and salivary cortisol and IgA levels in patients with oral lichen planus","volume":"16","author":"Nosratzehi","year":"2014","journal-title":"Zahedan J. Res. Med. 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