{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:56:54Z","timestamp":1774115814591,"version":"3.50.1"},"reference-count":9,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:00:00Z","timestamp":1571788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Pulmonary nodules are frequently considered to be a metastatic disease or primary lung tumors in oral cancer patients. We present a case of pulmonary cryptococcosis in a 68-year-old man with oral and lung cancer. This lung cancer was treated with thoracoscopic resection of the right inferior lobe and mediastinal lymph node dissection. Lower gingival cancer was treated with a mandibulectomy, neck dissection, and reconstruction after chemoradiotherapy. A 20 mm cavitary nodule appeared at the left lung S6 one-month after surgery, during post-operative computed tomography. Thoracoscopic partial resection of the left inferior lobe was performed under the suspicion of lung metastasis. Pathology results revealed a pseudo-epithelial granuloma with necrosis and many yeast-shaped fungi with capsules. A pathological diagnosis of Cryptococcus infection was made. The patient was prescribed the antifungal agent fosfluconazole, which was administered intravenously for 1 week and intraoral fluconazole for 12 months. No recurrence of the Cryptococcus infection has been noted after 1.5 years.<\/jats:p>","DOI":"10.3390\/dj7040102","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T03:20:36Z","timestamp":1571973636000},"page":"102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary Nodule in a Patient with Oral and Lung Cancer: Cryptococcus Infection"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-7478","authenticated-orcid":false,"given":"Kenji","family":"Yamagata","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikako","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-2563","authenticated-orcid":false,"given":"Toru","family":"Yanagawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Bukawa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000485627","article-title":"Risk factors for distant metastasis in patients with oral cavity squamous cell carcinoma undergoing surgical treatment","volume":"79","author":"Aires","year":"2017","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.joms.2012.12.023","article-title":"Risk factors for distant metastasis in squamous cell carcinoma of the oral cavity","volume":"71","author":"Sumioka","year":"2014","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lungcan.2014.07.020","article-title":"Metastatic sites and survival in lung cancer","volume":"86","author":"Hemminki","year":"2014","journal-title":"Lung Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/myc.12496","article-title":"Cryptococcus neoformans infection in malignancy","volume":"59","author":"Schmalzle","year":"2016","journal-title":"Mycoses"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1016\/j.ijid.2009.03.007","article-title":"Asymptomatic pulmonary nodules in a patient with early-stage breast cancer: Cryptococcus infection","volume":"14","author":"Ou","year":"2010","journal-title":"Int. J. Infect. Dieases"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1259\/bjr.75.891.750275","article-title":"Cryptococcus infection in a patient with nasopharyngeal carcinoma: Imaging findings mimicking pulmonary metastases","volume":"75","author":"Sun","year":"2002","journal-title":"Br. J. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.idc.2006.07.001","article-title":"Cryptococcosis","volume":"20","author":"Chayakulkeeree","year":"2006","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E145","DOI":"10.1086\/320524","article-title":"Cryptococcosis in patients with cancer","volume":"32","author":"Kontoyiannis","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1378\/chest.129.2.333","article-title":"Pulmonary Cryptococcosis: comparison of clinical and radiographic characteristics in immunocompetent and immunocompromised patients","volume":"129","author":"Chang","year":"2006","journal-title":"Chest"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/7\/4\/102\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:28:44Z","timestamp":1760189324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/7\/4\/102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,23]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["dj7040102"],"URL":"https:\/\/doi.org\/10.3390\/dj7040102","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,23]]}}}