{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T17:41:19Z","timestamp":1765993279159,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Periodontal disease can be treated in several ways. This paper reviewed whether antimicrobial photodynamic therapy (aPDT) in addition to scaling and root planing (SRP) produces improved clinical results over systemic antibiotics (ABs) in conjunction with SRP in adults with periodontitis. Studies were searched using the following electronic databases: MEDLINE, the Cochrane Database of Systematic Reviews, and the Web of Science Core Collection up to and including November 2018. Four randomized controlled trials (RCTs) were reviewed to maximise the reliability of the evidence. All participants suffered from either chronic or aggressive periodontitis and each study contained SRP as an adjunct to ABs or aPDT. To determine whether groups showed improvement after treatment, the outcome parameters chosen were probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Despite finding significant improvements in all groups, the differences among groups were not consistently statistically significant. The lack of homogeneity in the results among these studies indicates that it was not possible to determine a conclusion about whether aPDT or AB as an adjunct to SRP provides better improvements in periodontitis as measured by PD, CAL, and BOP. Further studies with more similar study designs are required before firm conclusions can be deduced.<\/jats:p>","DOI":"10.3390\/dj7040108","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T04:31:10Z","timestamp":1574051470000},"page":"108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Is the Use of Antimicrobial Photodynamic Therapy or Systemic Antibiotics More Effective in Improving Periodontal Health When Used in Conjunction with Localised Non-Surgical Periodontal Therapy? A Systematic Review"],"prefix":"10.3390","volume":"7","author":[{"given":"Animesh","family":"Pal","sequence":"first","affiliation":[{"name":"Bristol Dental School, Lower Maudlin Street, Bristol BS1 2LY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Paul","sequence":"additional","affiliation":[{"name":"Bristol Dental School, Lower Maudlin Street, Bristol BS1 2LY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5874-3016","authenticated-orcid":false,"given":"Rachel","family":"Perry","sequence":"additional","affiliation":[{"name":"University Hospitals Bristol Research and Education Centre, Upper Maudlin Street, Bristol BS2 8AE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-0215","authenticated-orcid":false,"given":"James","family":"Puryer","sequence":"additional","affiliation":[{"name":"Bristol Dental School, Lower Maudlin Street, Bristol BS1 2LY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2147\/CCIDE.S7712","article-title":"Treating chronic periodontitis: Current status, challenges, and future directions","volume":"2","author":"Shaddox","year":"2010","journal-title":"Clin. Cosmet. Investig. Dent."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4103\/1305-7456.195162","article-title":"Comparing the effects of manual and ultrasonic instrumentation on root surface mechanical properties","volume":"10","author":"Zafar","year":"2016","journal-title":"Eur. J. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1902\/jop.1990.61.1.3","article-title":"The effectiveness of subgingival scaling and root planning 1. Clinical detection of residual calculus","volume":"61","author":"Sherman","year":"1990","journal-title":"J. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1600-051X.1985.tb00928.x","article-title":"Scaling and granulation tissue removal in periodontal therapy","volume":"12","author":"Lindhe","year":"1985","journal-title":"J. Clin. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4103\/0975-7406.100226","article-title":"Antibiotics in the management of aggressive periodontitis","volume":"4","author":"Prakasam","year":"2012","journal-title":"J. Pharm. Bioall. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cden.2015.06.011","article-title":"Should Antibiotics Be Prescribed to Treat Chronic Periodontitis?","volume":"59","author":"Walters","year":"2015","journal-title":"Dent. Clin. N. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jpp.328","article-title":"Basic principles of photodynamic therapy","volume":"5","author":"Macdonald","year":"2001","journal-title":"J. Porphyr. Phthalocyanines"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1177\/154405910708600803","article-title":"Photodynamic Therapy in Dentistry","volume":"86","author":"Konopka","year":"2007","journal-title":"J. Dent. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pdpdt.2016.09.004","article-title":"Effect of photodynamic therapy and laser alone as adjunct to scaling and root planing on gingival crevicular fluid inflammatory proteins in periodontal disease: A systematic review","volume":"16","author":"Akram","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4103\/ccd.ccd_623_17","article-title":"Differential diagnosis between Chronic versus Aggressive Periodontitis and Staging of Aggressive periodontitis: A Cross-sectional Study","volume":"8","author":"Ramachandra","year":"2017","journal-title":"Contemp. Clin. Dent."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.pdpdt.2018.09.002","article-title":"Evaluation of the local effect of nonsurgical periodontal treatment with and without systemic antibiotic and photodynamic therapy in generalized aggressive periodontitis. A randomized clinical trial","volume":"24","author":"Andere","year":"2018","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_13","first-page":"532","article-title":"Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics. Three-month results of a randomized, prospective, controlled clinical study","volume":"123","author":"Arweiler","year":"2013","journal-title":"Schweiz Mon."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00784-014-1193-6","article-title":"Six-month results following treatment of aggressive periodontitis with antimicrobial photodynamic therapy or amoxicillin and metronidazole","volume":"18","author":"Arweiler","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1007\/s00784-016-2018-6","article-title":"Antimicrobial photodynamic therapy vs. local minocycline in addition to non-surgical therapy of deep periodontal pockets: A controlled randomized clinical trial","volume":"21","author":"Tabenski","year":"2016","journal-title":"Clin. Oral Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jphotobiol.2017.08.012","article-title":"Comparison of repeated applications of aPDT with amoxicillin and metronidazole in the treatment of chronic periodontitis: A short-term study","volume":"174","author":"Theodoro","year":"2017","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.pdpdt.2018.04.003","article-title":"Treatment of Periodontitis in Smokers with Multiple Sessions of Antimicrobial Photodynamic Therapy or Systemic Antibiotics: A Randomized Clinical Trial","volume":"22","author":"Theodoro","year":"2018","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/jcpe.12498","article-title":"Antimicrobial Photodynamic Therapy as an Alternative to Systemic Antibiotics: Results from a Double-Blind, Randomized, Placebo-Controlled, Clinical Study on Type 2 Diabetics","volume":"43","author":"Ramos","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1902\/jop.2009.090206","article-title":"Short-term effects of photodynamic therapy on periodontal status and glycemic control of patients with diabetes","volume":"80","author":"Bamshmous","year":"2009","journal-title":"J. Periodontol."},{"key":"ref_20","first-page":"7","article-title":"Loss to Follow-Up","volume":"2","author":"Dettori","year":"2011","journal-title":"Evid. Based Spine Care J."},{"key":"ref_21","first-page":"1339","article-title":"Intention-to-Treat Principle","volume":"165","author":"Montori","year":"2001","journal-title":"CMAJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1600-051X.2009.01432.x","article-title":"One-year outcomes of repeated adjunctive photodynamic therapy during periodontal maintenance: A proof-of-principle randomized-controlled clinical trial","volume":"36","author":"Lulic","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.12968\/denu.2017.44.5.402","article-title":"Diagnosis and management of chronic and aggressive periodontitis part 2: Periodontal management","volume":"44","author":"Chatzistavrianou","year":"2017","journal-title":"Dent. Update"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.17219\/acem\/70413","article-title":"Comparison of the Clinical and Microbiological Effects Therapy in Periodontal Pockets Following Laser Treatment: An in Vivo Study","volume":"27","author":"Matys","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s10103-013-1285-6","article-title":"Additional Effects of APDT on Nonsurgical Periodontal Treatment with Doxycycline in Type II Diabetes: A Randomized, Controlled Clinical Trial","volume":"29","author":"Macedo","year":"2013","journal-title":"Lasers Med. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Skurska, A., Dolinska, E., Pietruska, M., Peitruski, J.K., Dymicka, V., Kemona, H., Arweiler, N.B., Milewski, R., and Sculean, A. (2015). Effect of Nonsurgical Periodontal Treatment in Conjunction with Either Systemic Administration of Amoxicillin and Metronidazole or Additional Photodynamic Therapy on the Concentration of Matrix Metalloproteinases 8 and 9 in Gingival Crevicular Fluid in Patients with Aggressive Periodontitis. BMC Oral. Health, 15.","DOI":"10.1186\/s12903-015-0048-0"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/7\/4\/108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:35:19Z","timestamp":1760189719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/7\/4\/108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,18]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["dj7040108"],"URL":"https:\/\/doi.org\/10.3390\/dj7040108","relation":{},"ISSN":["2304-6767"],"issn-type":[{"type":"electronic","value":"2304-6767"}],"subject":[],"published":{"date-parts":[[2019,11,18]]}}}