{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:09:25Z","timestamp":1789063765791,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>The aim of this study was to evaluate the accuracy, invasiveness and impact on clinical results of a digital oral impression protocol in the pre-surgical orthopedic treatment (PSOT) of newborn cleft lip and palate (CLP) patients undergoing primary alveolar surgical repair. Six patients were divided, according to impression technique used, into a digital (intraoral scanner (IOS)) and a non-digital (tray and putty (T&amp;P)) group. Parents considered IOS impressions to be less invasive, compared to T&amp;P impressions. The clinician that took all the impressions considered the IOS to be less stressful compared to the T&amp;P method. In two T&amp;P patients, the impression was repeated because some important anatomical details were missing, in one case due to patient regurgitation during the first attempt. No impression was repeated, and any adverse event was reported in the IOS group. There were no significant differences between these two protocols in pre-surgical alveolar gap reduction and surgical challenge. The study results indicate that this digital protocol can accelerate the production process of the passive molding plate with an instantaneous transmission of the digital impression to the dental lab, maintaining the same accuracy level and clinical outcomes of classical techniques and reducing the invasiveness of impression taking, avoiding any risk of impression material ingestion or inhalation.<\/jats:p>","DOI":"10.3390\/dj7040111","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T10:52:41Z","timestamp":1575975161000},"page":"111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of a Digital Protocol for Pre-Surgical Orthopedic Treatment of Cleft Lip and Palate in Newborn Patients: A Pilot Study"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-7843","authenticated-orcid":false,"given":"Domenico","family":"Dalessandri","sequence":"first","affiliation":[{"name":"School of Dentistry, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Tonni","sequence":"additional","affiliation":[{"name":"School of Dentistry, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Laffranchi","sequence":"additional","affiliation":[{"name":"School of Dentistry, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Migliorati","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School of Dentistry, University of Genova, Largo Rossana Benzi 10, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"additional","affiliation":[{"name":"School of Dentistry, Department of General Surgery and Medical and Surgical Specialties, University of Catania, Via S. Sofia 78, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonetti","sequence":"additional","affiliation":[{"name":"School of Dentistry, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Visconti","sequence":"additional","affiliation":[{"name":"School of Dentistry, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-3587","authenticated-orcid":false,"given":"Corrado","family":"Paganelli","sequence":"additional","affiliation":[{"name":"School of Dentistry, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Piazzale Spedali Civili 1, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/0165-5876(94)01141-J","article-title":"The nose in children with unilateral cleft lip and palate","volume":"32","author":"Verwoerd","year":"1995","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1097\/01.prs.0000287322.79619.de","article-title":"Primary repair in adult patients with untreated cleft lip-cleft palate","volume":"120","author":"Morioka","year":"2007","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1597\/11-043","article-title":"Fifteen-Year Follow-Up Results of Presurgical Orthopedics Followed by Primary Correction for Unilateral Cleft Lip Nose in Program SEHATI in Indonesia","volume":"50","author":"Sulaiman","year":"2013","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/01.PRS.0000133027.04252.7A","article-title":"The progressive changes of nasal symmetry and growth after nasoalveolar molding: A three-year follow-up study","volume":"114","author":"Liou","year":"2004","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/00001665-200309000-00018","article-title":"Modified nasal alveolar molding appliance for management of cleft lip defect","volume":"14","author":"Oliveira","year":"2003","journal-title":"J. Craniofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1597\/1545-1569_1999_036_0391_lteonm_2.3.co_2","article-title":"Long-term effects of nasoalveolar molding on three-dimensional nasal shape in unilateral clefts","volume":"36","author":"Maull","year":"1999","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/PRS.0b013e318184590c","article-title":"Nasoalveolar molding improves appearance of children with bilateral cleft lip\u2013cleft palate","volume":"122","author":"Lee","year":"2008","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1597\/1545-1569_1998_035_0077_rnfabg_2.3.co_2","article-title":"Reduced need for alveolar bone grafting by pre-surgical orthopedics and primary gingivoperiosteoplasty","volume":"35","author":"Santiago","year":"1998","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1597\/1545-1569_1999_036_0486_pnmiiw_2.3.co_2","article-title":"Presurgical nasoalveolar molding in infants with cleft lip and palate","volume":"36","author":"Grayson","year":"1999","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/01.sap.0000259001.98869.d8","article-title":"Correction of the alveolar gap and nostril deformity by presurgical passive orthodontia in the unilateral cleft lip","volume":"59","author":"Jaeger","year":"2007","journal-title":"Ann. Plast. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/MOO.0b013e3283079c7b","article-title":"Recent advances in presurgical molding in cleft lip and palate","volume":"16","author":"Aminpour","year":"2008","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.fsc.2016.03.004","article-title":"Controversies in the Management of Patients with Cleft Lip and Palate","volume":"24","author":"Rodman","year":"2016","journal-title":"Facial. Plast. Surg. Clin. N. Am."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1177\/1055665619837132","article-title":"The Nasoalveolar Molding (NAM) Treatment Protocol","volume":"56","author":"Flores","year":"2019","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.17796\/jcpd.34.3.7r7615h422235773","article-title":"Presurgical nasoalveolar molding assisted primary reconstruction in complete unilateral cleft lip palate infants","volume":"34","author":"Radhakrishnan","year":"2010","journal-title":"J. Clin. Pediatr. Dent."},{"key":"ref_15","first-page":"570","article-title":"Nasoalveolar molding and gingivoperiosteoplasty verses alveolar bone graft: An outcome analysis of costs in the treatment of unilateral cleft alveolus","volume":"39","author":"Sachs","year":"2002","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1097\/PRS.0b013e31829b69fe","article-title":"A Comparative Cost Analysis of Cleft Lip Adhesion and Nasoalveolar Molding before Formal Cleft Lip Repair","volume":"136","author":"Shay","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_17","first-page":"11","article-title":"Full arch scans: Conventional versus digital impressions--an In-Vitro study","volume":"14","author":"Ender","year":"2001","journal-title":"Int. J. Comput. Dent."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Scotti, R., Cardelli, P., Baldissara, P., and Monaco, C. (2011). Clinical fitting of CAD\/CAM zirconia single crowns generated from digital intraoral impressions based on active wavefront sampling. J. Dent.","DOI":"10.1016\/j.jdent.2011.10.005"},{"key":"ref_19","first-page":"1","article-title":"Cadent iTero\u2019s digital system for dental impressions: The end of trays and putty?","volume":"19","author":"Garg","year":"2008","journal-title":"Dent. Implantol. Update"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"van der Meer, W.J., Andriessen, F.S., Wismeijer, D., and Ren, Y. (2012). Application of intra-oral dental scanners in the digital workflow of implantology. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043312"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1097\/SCS.0b013e31826b8043","article-title":"Optical impression systems for CAD-CAM restorations","volume":"23","author":"Galhano","year":"2012","journal-title":"J. Craniofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.11607\/ijp.3014","article-title":"Accuracy of dies captured by an intraoral digital impression system using parallel confocal imaging","volume":"26","author":"Kim","year":"2013","journal-title":"Int. J. Prosthodont."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/205016841800700207","article-title":"Powder and Powder-Free Intra-Oral Scanners: Digital Impression Accuracy","volume":"7","author":"Hategan","year":"2018","journal-title":"Prim. Dent. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/clr.12994","article-title":"Digital vs. conventional full-arch implant impressions: A comparative study","volume":"28","author":"Amin","year":"2017","journal-title":"Clin. Oral Implants Res."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ajioka, H., Kihara, H., Odaira, C., Kobayashi, T., and Kondo, H. (2016). Examination of the Position Accuracy of Implant Abutments Reproduced by Intra-Oral Optical Impression. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164048"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00784-013-1132-y","article-title":"Accuracy of full-arch scans using intraoral scanners","volume":"18","author":"Patzelt","year":"2014","journal-title":"Clin. Oral Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jdent.2017.12.006","article-title":"Accuracy and precision of 3 intraoral scanners and accuracy of conventional impressions: A novel in vivo analysis method","volume":"69","author":"Nedelcu","year":"2018","journal-title":"J. Dent."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yuzbasioglu, E., Kurt, H., Turunc, R., and Bilir, H. (2014). Comparison of digital and conventional impression techniques: Evaluation of patients\u2019 perception, treatment comfort, effectiveness and clinical outcomes. BMC Oral Health, 14.","DOI":"10.1186\/1472-6831-14-10"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kamimura, E., Tanaka, S., Takaba, M., Tachi, K., and Baba, K. (2017). In Vivo evaluation of inter-operator reproducibility of digital dental and conventional impression techniques. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0179188"},{"key":"ref_30","first-page":"51","article-title":"Clinical factors influence the trueness of intra-oral scanning","volume":"27","author":"Jivanescu","year":"2019","journal-title":"Eur. J. Prosthodont. Restor. Dent."},{"key":"ref_31","first-page":"40","article-title":"The Influence of Nitrile Gloves on the Setting Behavior of Polyvinyl Siloxane Putty Impression Materials","volume":"26","author":"Delgado","year":"2018","journal-title":"Eur. J. Prosthodont. Restor. Dent."},{"key":"ref_32","first-page":"ZE05","article-title":"Information and consent in dentistry","volume":"12","author":"Niola","year":"2018","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/109442819800100106","article-title":"A brief tutorial on the development of measures for use in survey questionnaires","volume":"2","author":"Hinkin","year":"1998","journal-title":"Organ. Res. Methods"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jpor.2017.05.005","article-title":"Development of complete dentures based on digital intraoral impressions-Case report","volume":"62","author":"Fang","year":"2018","journal-title":"J. Prosthodont. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11845","DOI":"10.1038\/s41598-018-29959-6","article-title":"A semi-automated virtual workflow solution for the design and production of intraoral molding plates using additive manufacturing: The first clinical results of a pilot-study","volume":"8","author":"Grill","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1472","DOI":"10.1097\/GOX.0000000000001472","article-title":"Validation of a unilateral cleft lip surgical outcomes evaluation scale for surgeons and laypersons","volume":"5","author":"Campbell","year":"2017","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1597\/1545-1569_1991_028_0385_doamfr_2.3.co_2","article-title":"Development of a method for rating nasolabial appearance in patients with clefts of the lip and palate","volume":"28","author":"Roberts","year":"1991","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_38","unstructured":"Kuijpers-Jagtman, A.M., and Prahl, C. (1996). A study into the effects of presurgical orthopaedic treatment in complete unilateral cleft lip and palate patients. Interim Analysis, Nijmegen University Press."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00006534-199803000-00009","article-title":"Presurgical columellar elongation and primary retrograde nasal reconstruction in one stage bilateral cleft lip and nose repair","volume":"101","author":"Cutting","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.dental.2019.02.026","article-title":"Additive manufacturing of ceramics for dental applications: A review","volume":"35","author":"Galante","year":"2019","journal-title":"Dent. Mater."},{"key":"ref_41","first-page":"1579","article-title":"Additive manufacturing and biomimetic materials in oral and maxillofacial surgery: A topical overview","volume":"32","author":"Pacifici","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jpor.2018.10.005","article-title":"The potential of three-dimensional printing technologies to unlock the development of new \u2018bio-inspired\u2019 dental materials: An overview and research roadmap","volume":"63","author":"Saratti","year":"2019","journal-title":"J. Prosthodont. Res."},{"key":"ref_43","first-page":"1","article-title":"The effect of a functional appliance in the management of temporomandibular joint disorders in patients with juvenile idiopathic arthritis","volume":"66","author":"Isola","year":"2017","journal-title":"Minerva Stomatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jbspin.2015.04.014","article-title":"Occlusal and MRI characterizations in systemic sclerosis patients: A prospective study from Southern Italian cohort","volume":"83","author":"Matarese","year":"2016","journal-title":"Joint Bone Spine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/ejo\/cjy034","article-title":"The impact of temporomandibular joint arthritis on functional disability and global health in patients with juvenile idiopathic arthritis","volume":"41","author":"Isola","year":"2019","journal-title":"Eur. J. Orthod."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1597\/15-036","article-title":"Intraoral 3D Scanning or Dental Impressions for the Assessment of Dental Arch Relationships in Cleft Care: Which is Superior?","volume":"53","author":"Chalmers","year":"2016","journal-title":"Cleft Palate Craniofac. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ajodo.2018.04.031","article-title":"Presurgical nasoalveolar molding with 3D printing for a patient with unilateral cleft lip, alveolus, and palate","volume":"156","author":"Zheng","year":"2019","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jcms.2016.01.008","article-title":"Pitfalls and solutions in virtual design of nasoalveolar molding plates by using CAD\/CAM technology\u2014A preliminary clinical study","volume":"44","author":"Ritschl","year":"2016","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1097\/SCS.0000000000003812","article-title":"A Digital Assessment of the Maxillary Deformity Correction in Infants with Bilateral Cleft Lip and Palate Using Computer-Aided Nasoalveolar Molding","volume":"28","author":"Gong","year":"2017","journal-title":"J. Craniofac. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.tripleo.2011.08.031","article-title":"Correction of maxillary deformity in infants with bilateral cleft lip and palate using computer-assisted design","volume":"114","author":"Gong","year":"2012","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bjoms.2015.03.002","article-title":"Analysis of computer-aided techniques for virtual planning in nasoalveolar moulding","volume":"53","author":"Loeffelbein","year":"2015","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_52","first-page":"343","article-title":"Patients\u2019 expectations assessment in orthodontic treatment: Findings from a questionnaire survey","volume":"65","author":"Papakostopoulou","year":"2016","journal-title":"Minerva Stomatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1007e","DOI":"10.1097\/PRS.0000000000001286","article-title":"Presurgical nasoalveolar molding for cleft lip and palate: The application of digitally designed molds","volume":"135","author":"Shen","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Rau, A., Ritschl, L.M., M\u00fccke, T., Wolff, K.D., and Loeffelbein, D.J. (2015). Nasoalveolar molding in cleft care--experience in 40 patients from a single centre in Germany. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118103"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cps.2018.11.002","article-title":"Orthognathic Surgery for Patients with Cleft Lip and Palate","volume":"46","author":"Roy","year":"2019","journal-title":"Clin. Plast. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.archoralbio.2016.03.013","article-title":"Effects of therapy on masseter activity and chewing kinematics in patients with unilateral posterior crossbite","volume":"67","author":"Piancino","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.oooo.2012.04.025","article-title":"Reverse cycle chewing before and after orthodontic-surgical correction in class III patients","volume":"115","author":"Piancino","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_58","first-page":"296","article-title":"Evaluation of magnification systems in restorative dentistry. An In-Vitro study","volume":"83","author":"Matarese","year":"2015","journal-title":"Dent. Cadmos."},{"key":"ref_59","first-page":"97","article-title":"Rapid palatal expander vs. quad-helix in the orthodontic treatment of cleft lip and palate patients","volume":"65","author":"Dalessandri","year":"2016","journal-title":"Minerva Stomatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/1465312518823010","article-title":"Orthodontic burden of care for patients with a cleft lip and\/or palate","volume":"46","author":"Hameed","year":"2019","journal-title":"J. Orthod."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/7\/4\/111\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:40:51Z","timestamp":1760190051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/7\/4\/111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,9]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["dj7040111"],"URL":"https:\/\/doi.org\/10.3390\/dj7040111","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,9]]}}}