{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T04:28:00Z","timestamp":1776918480281,"version":"3.51.2"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Research Unit in Oral Diseases, Chulalongkorn University, Thailand.","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Subjective patient\u2019s symptoms and Oral Health-Related Quality of Life (OHRQoL) are recommended to be involved in oral lichen planus (OLP) studies. This study aims to assess the OHRQoL of OLP patients, and their associations with pain and OLP in Thai patients. Sixty-nine patients were interviewed using the Numeric Rating Scale (NRS) for pain perception and Oral Impacts on Daily Performance (OIDP) index. OLP signs examined included localization, types, number of affected sides and clinical severity using the Thongprasom sign scoring system. There were significant associations (rs = 0.490, p &lt; 0.001) between clinical severity and the intensity of oral impacts as well as pain (rs = 0.298, p = 0.013). The intensity of oral impacts and pain increased according to the increasing OLP clinical severity, except for the white striae lesions (Thongprasom sign score 1). The erosive\/ulcerative OLP lesions (Thongprasom sign scores 4 and 5) were the most painful symptom and had the highest degree of oral impacts (p &lt; 0.001). No significant associations were found between the number of affected lesion sides and OHRQoL (p = 0.316) and pain (p = 0.284). OHRQoL was associated with OLP type and clinical severity but not with the number of affected sides.<\/jats:p>","DOI":"10.3390\/dj8040113","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T08:35:57Z","timestamp":1601886957000},"page":"113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association between Clinical Signs of Oral Lichen Planus and Oral Health-Related Quality of Life: A Preliminary Study"],"prefix":"10.3390","volume":"8","author":[{"given":"Sasirin","family":"Yiemstan","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudaduang","family":"Krisdapong","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-0256","authenticated-orcid":false,"given":"Pornpan","family":"Piboonratanakit","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.2041-1626.2010.00005.x","article-title":"A multicenter study of oral lichen planus in Thai patients","volume":"1","author":"Thongprasom","year":"2010","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tripleo.2004.06.077","article-title":"Current controversies in oral lichen planus: Report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis","volume":"100","author":"Lodi","year":"2005","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1601-0825.2005.01142.x","article-title":"Number V Oral lichen planus: Clinical features and management","volume":"11","author":"Eisen","year":"2005","journal-title":"Oral Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tripleo.2004.06.076","article-title":"Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2. Clinical management and malignant transformation","volume":"100","author":"Lodi","year":"2005","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.4317\/medoral.20524","article-title":"Disease scoring systems for oral lichen planus; a critical appraisal","volume":"20","author":"Wang","year":"2015","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1600-0714.1992.tb00974.x","article-title":"Relative efficacy of fluocinolone acetonide compared with triamcinolone acetonide in treatment of oral lichen planus","volume":"21","author":"Thongprasom","year":"1992","journal-title":"J. Oral Pathol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1365-2133.2004.05943.x","article-title":"A new delivery system of clobetasol-17-propionate (lipid-loaded microspheres 0.025%) compared with a conventional formulation (lipophilic ointment in a hydrophilic phase 0.025%) in topical treatment of atrophic\/erosive oral lichen planus. A phase IV, randomized, observer-blinded, parallel group clinical trial","volume":"150","author":"Campisi","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2133.2005.06920.x","article-title":"Ciclosporin vs. clobetasol in the topical management of atrophic and erosive oral lichen planus: A double-blind, randomized controlled trial","volume":"154","author":"Conrotto","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tripleo.2005.09.006","article-title":"A randomized controlled trial to compare steroid with cyclosporine for the topical treatment of oral lichen planus","volume":"102","author":"Yoke","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1600-0714.2008.00688.x","article-title":"Topical clobetasol in the treatment of atrophic-erosive oral lichen planus: A randomized controlled trial to compare two preparations with different concentrations","volume":"38","author":"Carbone","year":"2009","journal-title":"J. Oral Pathol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jop.12604","article-title":"Patient-reported outcome measures in oral lichen planus: A comprehensive review of the literature with focus on psychometric properties and interpretability","volume":"47","author":"Wiriyakijja","year":"2018","journal-title":"J. Oral Pathol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ajem.2018.01.008","article-title":"A systematic review of the pain scales in adults: Which to use?","volume":"36","author":"Karcioglu","year":"2018","journal-title":"Am. J. Emerg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1601-0825.2010.01734.x","article-title":"Impact of chronic oral mucosal disease on daily life: Preliminary observations from a qualitative study","volume":"17","author":"Meaney","year":"2011","journal-title":"Oral Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.oooo.2013.08.006","article-title":"Dietary alterations in patients with oral vesiculoulcerative diseases","volume":"117","author":"Czerninski","year":"2014","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Larsen, K.R., Johansen, J.D., Reibel, J., Zachariae, C., Rosing, K., and Pedersen, A.M.L. (2017). Oral symptoms and salivary findings in oral lichen planus, oral lichenoid lesions and stomatitis. BMC Oral Health, 17.","DOI":"10.1186\/s12903-017-0393-2"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1007\/s00784-017-2053-y","article-title":"Symptomatic oral lesions may be associated with contact allergy to substances in oral hygiene products","volume":"21","author":"Larsen","year":"2017","journal-title":"Clin. Oral Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/jdv.12525","article-title":"Sleep disturbances, anxiety and depression in patients with oral lichen planus: A case-control study","volume":"29","author":"Adamo","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/jclp.20816","article-title":"Pain and emotion: A biopsychosocial review of recent research","volume":"67","author":"Lumley","year":"2011","journal-title":"J. Clin. Psychol."},{"key":"ref_19","first-page":"1","article-title":"Association between psychological disorders and the presence of oral lichen planus, burning mouth syndrome and recurrent aphthous stomatitis","volume":"9","author":"Esguep","year":"2004","journal-title":"Med. Oral"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/odi.12423","article-title":"Psychological disorders and oral lichen planus: Matched case-control study and literature review","volume":"22","author":"Pippi","year":"2016","journal-title":"Oral Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1111\/ijd.13265","article-title":"Lichen planus of the lips: An intermediate disease between the skin and mucosa? Retrospective clinical study and review of the literature","volume":"55","author":"Nuzzolo","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/j.1365-4632.2011.05272.x","article-title":"Approaches to the evaluation of lip hyperpigmentation","volume":"51","author":"Vachiramon","year":"2012","journal-title":"Int. J. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/jop.12415","article-title":"Cost of illness of oral lichen planus in a U.K. population\u2014A pilot study","volume":"45","author":"Christou","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.oooo.2015.01.023","article-title":"World Workshop on Oral Medicine VI: Patient-reported outcome measures and oral mucosal disease: Current status and future direction","volume":"120","author":"Shirlaw","year":"2015","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1601-0825.2009.01647.x","article-title":"The use of quality of life measures in oral medicine: A review of the literature","volume":"16","author":"McCreary","year":"2010","journal-title":"Oral Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2105\/AJPH.70.12.1273","article-title":"The effect of inadequate language translation on Hispanics\u2019 responses to health surveys","volume":"70","author":"Berkanovic","year":"1980","journal-title":"Am. J. Public Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1054\/ijom.2002.0260","article-title":"Patient-centred outcome measures in oral medicine: Are they valid and reliable?","volume":"31","author":"Hegarty","year":"2002","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00784-019-02951-8","article-title":"Oral health-related quality of life in different clinical forms of oral lichen planus","volume":"24","author":"Parlatescu","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_29","first-page":"e20170146","article-title":"Psychopathological profile and quality of life of patients with oral lichen planus","volume":"26","author":"Zwyrtek","year":"2018","journal-title":"J. Appl. Oral Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/jop.12577","article-title":"Psychological profiles in patients with symptomatic reticular forms of oral lichen planus: A prospective cohort study","volume":"46","author":"Adamo","year":"2017","journal-title":"J. Oral Pathol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/odi.13106","article-title":"Psychological disorders and quality of life in oral lichen planus patients and a control group","volume":"25","year":"2019","journal-title":"Oral Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000196973","article-title":"Quality of life and psychological problems of patients with oral mucosal disease in dermatological practice","volume":"218","author":"Tabolli","year":"2009","journal-title":"Dermatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jcpe.12385","article-title":"The impact of structured plaque control for patients with gingival manifestations of oral lichen planus: A randomized controlled study","volume":"42","author":"Stone","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1054\/ijom.2002.0377","article-title":"Patient-centred outcome measures for oral mucosal disease are sensitive to treatment","volume":"32","author":"McGrath","year":"2003","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5005\/jp-journals-10031-1248","article-title":"Self-perceived oral health, satisfaction with overall health and quality of life comparisons between patients with oral lichen planus and their matched controls","volume":"9","author":"Rimkevicius","year":"2019","journal-title":"J. Contemp. Dent."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2753.2009.01124.x","article-title":"Quality of life in patients with oral lichen planus","volume":"16","year":"2010","journal-title":"J. Eval. Clin. Pract."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/jop.12093","article-title":"Plaque control improves the painful symptoms of oral lichen planus gingival lesions. A short-term study","volume":"42","author":"Salgado","year":"2013","journal-title":"J. Oral Pathol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/ijd.12052","article-title":"Emotional assessment of patients with oral lichen planus","volume":"54","author":"Alves","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1007\/s00784-019-02892-2","article-title":"Severity of oral lichen planus and oral lichenoid lesions is associated with anxiety","volume":"23","author":"Zucoloto","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_40","unstructured":"Slade, G.D. (1997). Oral impacts on daily performances. Measuring Oral Health and Quality of Life, University of North Carolina."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1600-0528.2009.00503.x","article-title":"Oral health-related quality of life of 12- and 15-year-old Thai children: Findings from a national survey","volume":"37","author":"Krisdapong","year":"2009","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_42","first-page":"161","article-title":"Developing and evaluating an oral health-related quality of life index for children; the child-OIDP","volume":"21","author":"Gherunpong","year":"2004","journal-title":"Community Dent. Health"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1754-4505.2003.tb00298.x","article-title":"Assessing prosthodontic dental treatment needs in older adults in Thailand: Normative vs. sociodental approaches","volume":"23","author":"Srisilapanan","year":"2003","journal-title":"Spec. Care Dentist."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/1010539519899774","article-title":"Condition-specific oral health impacts in Thai children and adolescents: Findings from the national oral health-related quality of life survey","volume":"32","author":"Prasertsom","year":"2020","journal-title":"Asia Pac. J. Public Health"},{"key":"ref_45","unstructured":"Dental Health Division, Health Division (2017). Report on the Eighth Thailand National Oral Health Survey, Ministry of Public Health. (In Thai)."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1034\/j.1600-0714.2003.00125.x","article-title":"Lack of clinicopathologic correlation in the diagnosis of oral lichen planus based on the presently available diagnostic criteria and suggestions for modifications","volume":"32","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/cdoe.12061","article-title":"Which aspects of an oral health-related quality of life measure are mainly associated with global ratings of oral health in children?","volume":"42","author":"Krisdapong","year":"2014","journal-title":"Community Dent. Oral Epidemiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.oooo.2019.12.019","article-title":"Predictors of symptomatic oral lichen planus","volume":"129","author":"Osipoff","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/odi.12803","article-title":"Outcomes of oral lichen planus and oral lichenoid lesions treated with topical corticosteroid","volume":"24","author":"Bravo","year":"2018","journal-title":"Oral Dis."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Suliman, N.M., Johannessen, A.C., Ali, R.W., Salman, H., and Astrom, A.N. (2012). Influence of oral mucosal lesions and oral symptoms on oral health related quality of life in dermatological patients: A cross sectional study in Sudan. BMC Oral Health, 12.","DOI":"10.1186\/1472-6831-12-19"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tripleo.2007.06.022","article-title":"Validation of instruments to measure the symptoms and signs of oral lichen planus","volume":"105","author":"Silverman","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.oooo.2012.02.013","article-title":"Oral lichen planus: REU scoring system correlates with pain","volume":"114","author":"Park","year":"2012","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_53","first-page":"e625","article-title":"Clinical profile of 102 patients with oral lichen planus in Thailand","volume":"11","author":"Kaomongkolgit","year":"2019","journal-title":"J. Clin. Exp. Dent."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/8\/4\/113\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:16:24Z","timestamp":1760177784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/8\/4\/113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,4]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["dj8040113"],"URL":"https:\/\/doi.org\/10.3390\/dj8040113","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,4]]}}}