{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:00:04Z","timestamp":1785276004071,"version":"3.55.0"},"reference-count":11,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Medication-related osteonecrosis of the jaw (MRONJ) frequently affects patients after treatments with bisphosphonates or denosumab, especially with high doses in patients with bone osteoporosis, neoplastic metastases, or possibly anti-angiogenic treatment for cancer. The aim of this article was to show a new treatment planning for stage 2 and stage 3 MRONJ using platelet-rich fibrin (PRF) at the surgical field to enhance healing in association with a new epi-mucosal fixation technique to prevent or treat mandibular fracture. Two cases were treated by epi-mucosa fixation and autologous PRF use for prevention of mandibular fracture risks related to necrotic bone resection or a narrow fracture reduction. Both cases were successfully treated by this new technique of epi-mucosa fixation combined with autologous PRF and achieved good results and good quality of life. Ability to wear prosthesis with good mastication in the absence of side effect such as infection, plate and screw mobilization, pain, and other disabilities or extension of necrosis was reported. After surgical removal of necrotic bone, no infection was detected without any extension of the necrosis.<\/jats:p>","DOI":"10.3390\/dj9050050","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T10:53:29Z","timestamp":1619780009000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Epi-Mucosa Fixation and Autologous Platelet-Rich Fibrin Treatment in Medication-Related Osteonecrosis of the Jaw"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0875-0725","authenticated-orcid":false,"given":"Antonio","family":"Cortese","sequence":"first","affiliation":[{"name":"Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Casarella","sequence":"additional","affiliation":[{"name":"Unit of Maxillofacial Surgery, Department of Medicine and Surgery, University of Salerno, 84084 Fisciano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace M.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-1622","authenticated-orcid":false,"given":"Pier Paolo","family":"Claudio","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Sciences, Maxillofacial Surgery, University of Mississippi, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Otto, S., Pautke, C., Van den Wyngaert, T., Niepel, D., and Schi\u00f8dt, M. (2018). Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases. Cancer Treat. Rev., 69.","DOI":"10.1016\/j.ctrv.2018.06.007"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Otto, S. (2015). Medication-Related Osteonecrosis of the Jaws, Springer. [1st ed.].","DOI":"10.1007\/978-3-662-43733-9"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijscr.2016.09.022","article-title":"Platelet-rich fibrin (PRF) in implant dentistry in combination with new bone regenerative technique in elderly patients","volume":"28","author":"Cortese","year":"2016","journal-title":"Int. J. Surg. 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Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1097\/SCS.0000000000001104","article-title":"Intraoral epimucosal fixation for reducible maxillary fractures of the jaws; surgical considerations in comparison to current techniques","volume":"25","author":"Cortese","year":"2014","journal-title":"J. Craniofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1097\/SCS.0b013e31828041a7","article-title":"A new palatal distractor device for bodily movement of maxillary bones by rigid self-locking miniplates and screws system","volume":"24","author":"Cortese","year":"2013","journal-title":"J. Craniofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1097\/SCS.0b013e31822e6417","article-title":"One-step transversal palatal distraction and maxillary repositioning: Technical considerations, advantages, and long-term stability","volume":"22","author":"Cortese","year":"2011","journal-title":"J. Craniofac. Surg."}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/9\/5\/50\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:55:53Z","timestamp":1760162153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/9\/5\/50"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,30]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["dj9050050"],"URL":"https:\/\/doi.org\/10.3390\/dj9050050","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,30]]}}}