{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:59:03Z","timestamp":1783353543975,"version":"3.54.6"},"reference-count":29,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: Due to the lack of data on bone-to-graft contact (BGC) over time in the various regions within the subantral space of the augmented sinus floor, the present study aimed to evaluate the osteoconductivity of deproteinized bovine bone mineral (DBBM) with granules of different sizes applied in maxillary sinus floor elevation. Methods: A maxillary sinus augmentation was performed bilaterally in 18 rabbits using DBBM with particle dimensions of either 0.125\u20131.0 mm or 1\u20132 mm. The antrostomy was covered using a collagen barrier. The animals were euthanized in groups of six after 2, 4, and 8 weeks of healing. MicroCT and histological analyses were performed. Results: After 2 weeks of healing, BGC was 10.9% and 11.9% for the small and large granule sites, respectively. After 8 weeks of healing, the BGC increased to 65% and 62% at the small and large granule sites, respectively. The highest values were located close to the bony walls and the bony window. New bone content developed between 2 and 8 weeks from 7.0% to 27.6% and from 6.1% to 27.6% at the small and large granule sites, respectively. Conclusions: Similar outcomes in osteoconductivity and bone formation were found at both small and large DBBM granule sites.<\/jats:p>","DOI":"10.3390\/dj9060061","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T03:45:29Z","timestamp":1622432729000},"page":"61","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Osteoconductivity of Bovine Xenograft Granules of Different Sizes in Sinus Lift: A Histomorphometric Study in Rabbits"],"prefix":"10.3390","volume":"9","author":[{"given":"Eduardo Pires","family":"Godoy","sequence":"first","affiliation":[{"name":"Department of Oral Biology, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4565-5222","authenticated-orcid":false,"given":"Karol Al\u00ed","family":"Apaza Alccayhuaman","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1632","authenticated-orcid":false,"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC Academy, 47923 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-7942","authenticated-orcid":false,"given":"Andrea","family":"Amaroli","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Dentistry, Faculty of Dentistry, First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Ferreira","family":"Balan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick Ricardo","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-5886","authenticated-orcid":false,"given":"Samuel Porfirio","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, Faculty of Dentistry of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, S\u00e3o Paulo 14040-904, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1034\/j.1600-0501.2002.130409.x","article-title":"Maxillary sinus augmentation model in rabbits: Effect of occluded nasal ostium on new bone formation","volume":"13","author":"Asai","year":"2002","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0501.2004.01003.x","article-title":"Grafting of deproteinized bone particles inhibits bone resorption after maxillary sinus floor elevation","volume":"15","author":"Xu","year":"2004","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.bjoms.2005.02.001","article-title":"Histomorphometric study of the stability of newly formed bone after elevation of the floor of the maxillary sinus","volume":"43","author":"Xu","year":"2005","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/j.1600-0501.2010.01964.x","article-title":"Early healing after elevation of the maxillary sinus floor applying a lateral access: A histological study in monkeys","volume":"21","author":"Scala","year":"2010","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1600-0501.2011.02227.x","article-title":"Lack of influence of the Schneiderian membrane in forming new bone apical to implants simultaneously installed with sinus floor elevation: An experimental study in monkeys","volume":"23","author":"Scala","year":"2012","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/clr.12702","article-title":"Histomorphometric outcomes after lateral sinus floor elevation procedure: A systematic review of the literature and meta-analysis","volume":"27","author":"Corbella","year":"2016","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/j.1600-0501.2008.01565.x","article-title":"Maxillary sinus grafting with Bio-Oss or Straumann Bone Ceramic: Histomorphometric results from a randomized controlled multicenter clinical trial","volume":"19","author":"Cordaro","year":"2008","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.11607\/prd.1423","article-title":"Effect of xenograft (ABBM) particle size on vital bone formation following maxillary sinus augmentation: A multicenter, randomized, controlled, clinical histomorphometric trial","volume":"33","author":"Testori","year":"2013","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12362","DOI":"10.1111\/jicd.12362","article-title":"Influence of the position of the antrostomy in sinus floor elevation assessed with cone-beam computed tomography: A randomized clinical trial","volume":"9","author":"Kawakami","year":"2018","journal-title":"J. Investig. Clin. Dent."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.11607\/jomi.7112","article-title":"Influence of the height of the antrostomy in sinus floor elevation assessed by cone beam computed tomography\u2014A randomized clinical trial","volume":"34","author":"Kawakami","year":"2019","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1111\/clr.12850","article-title":"Sinus mucosa elevation using Bio-Oss\u00ae or Gingistat\u00ae collagen sponge: An experimental study in rabbits","volume":"28","author":"Caneva","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1111\/clr.13027","article-title":"Influence of a collagen membrane positioned subjacent the sinus mucosa following the elevation of the maxillary sinus. A histomorphometric study in rabbits","volume":"28","author":"Iida","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/clr.13292","article-title":"Reposition of the bone plate over the antrostomy in maxillary sinus augmentation: A histomorphometric study in rabbits","volume":"29","author":"Omori","year":"2018","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.11607\/jomi.7350","article-title":"Antrostomy preparation for maxillary sinus floor augmentation using drills or a sonic instrument: A microcomputed tomography and histomorphometric study in rabbits","volume":"34","author":"Masuda","year":"2019","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/cid.12430","article-title":"Randomized Clinical Trial of Maxillary Sinus Grafting using Deproteinized Porcine and Bovine Bone Mineral","volume":"19","author":"Lee","year":"2017","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ijom.2018.09.003","article-title":"A randomized clinical trial evaluating maxillary sinus augmentation with different particle sizes of demineralized bovine bone mineral: Histological and immunohistochemical analysis","volume":"48","author":"Semedo","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/cid.12101","article-title":"Influence of particle size of deproteinized bovine bone mineral on new bone formation and implant stability after simultaneous sinus floor elevation: A histomorphometric study in minipigs","volume":"17","author":"Jensen","year":"2015","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/clr.12825","article-title":"Healing at implants installed concurrently to maxillary sinus floor elevation with Bio-Oss\u00ae or autologous bone grafts. A histo-morphometric study in rabbits","volume":"28","author":"Lang","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"739","DOI":"10.11607\/jomi.8067","article-title":"Histologic and micro-ct analyses at implants placed immediately after maxillary sinus elevation using large or small xenograft granules: An experimental study in rabbits","volume":"35","author":"Masuda","year":"2020","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1902\/jop.2011.110209","article-title":"Histologic comparison of healing after ridge preservation using human demineralized bone matrix putty with one versus two different-sized bone particles","volume":"83","author":"Hoang","year":"2012","journal-title":"J. Periodontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.ijom.2016.09.004","article-title":"Implant stability after sinus floor augmentation with deproteinized bovine bone mineral particles of different sizes: A prospective, randomized and controlled split-mouth clinical trial","volume":"45","author":"Paim","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1600-0501.2010.02032.x","article-title":"Sinus floor augmentation using large (1\u20132 mm) or small (0.25\u20131 mm) bovine bone mineral particles: A prospective, intra-individual controlled clinical, micro-computerized tomography and histomorphometric study","volume":"22","author":"Chackartchi","year":"2011","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2818.1973.tb04629.x","article-title":"Correlated morphometric and biochemical analysis of gingival tissue. Morphometric model, tissue sampling and test of stereologic procedures","volume":"99","author":"Schroeder","year":"1973","journal-title":"J. Microsc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/clr.12872","article-title":"Dynamics of osseointegration in various human and animal models\u2014A comparative analysis","volume":"28","author":"Botticelli","year":"2017","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10006-019-00813-x","article-title":"Comparison of histomorphometry and microCT after sinus augmentation using xenografts of different particle sizes in rabbits","volume":"24","author":"Iida","year":"2020","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1600-0501.2009.01733.x","article-title":"Sinus augmentation analysis revised: The gradient of graft consolidation","volume":"20","author":"Busenlechner","year":"2009","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_27","first-page":"1128","article-title":"Correlation between gingival phenotype and Schneiderian membrane thickness","volume":"23","author":"Aimetti","year":"2008","journal-title":"Int. J. Oral Maxillofac. Implant."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1111\/j.1600-0501.2010.02140.x","article-title":"Characteristics and dimensions of the Schneiderian membrane: A radiographic analysis using cone beam computed tomography in patients referred for dental implant surgery in the posterior maxilla","volume":"22","author":"Janner","year":"2011","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1288\/00005537-199506000-00002","article-title":"Pressure measurements in the normal and occluded rabbit maxillary sinus","volume":"105","author":"Scharf","year":"1995","journal-title":"Laryngoscope"}],"container-title":["Dentistry Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-6767\/9\/6\/61\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:09:13Z","timestamp":1760162953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-6767\/9\/6\/61"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["dj9060061"],"URL":"https:\/\/doi.org\/10.3390\/dj9060061","relation":{},"ISSN":["2304-6767"],"issn-type":[{"value":"2304-6767","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,31]]}}}