{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:06:19Z","timestamp":1787508379655,"version":"build-2736575974"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ARDEC Academy, Rimini, Italy","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dentistry Journal"],"abstract":"<jats:p>Background: We studied the influence on healing of a resorbable membrane covering the osteotomy site after maxillary sinus grafting, evaluated in different regions of the augmented area. Methods: Maxillary sinus augmentation was performed in 24 New Zealand rabbits. Osteotomy, 4 \u00d7 6 mm, were performed bilaterally. A collagenated cortico-cancellous porcine bone was used to fill the elevated region. A collagen membrane was randomly placed over the osteotomy site on one side (MG), and the other side was left uncovered (NMG). The animals were euthanized after 2, 4, and 8 weeks; and histomorphometric analysis was performed in eight different regions. Results: New bone percentages were similar in both groups. There were no statistically significant differences. In MG, the overall percentages were 15.6 \u00b1 7.3%, 22.9 \u00b1 6.1%, and 24.9 \u00b1 12.0% after 2, 4, and 8 weeks, respectively. In NMG, the percentages were 11.2 \u00b1 4.5%, 24.1 \u00b1 5.7%, and 24.5 \u00b1 15.7%, respectively. The proportions of new bone in the various regions after 8 weeks were 31 \u00b1 8.9% and 29.9 \u00b1 9.1% in the bone walls region, 25 \u00b1 10.1% and 32.8 \u00b1 9.1% in the submucosa region, 22.6 \u00b1 21.6% and 10.9 \u00b1 11.5 in the middle region, 17.3 \u00b1 14% and 13.4 \u00b1 9.8% in the close-to-window region, and 21.8 \u00b1 11.6%, 19.1 \u00b1 6.4% in the osteotomy region\u2014for MG and NMG, respectively. Conclusions: In both groups the greatest amounts of bone formation occurred near to the pre-existing bone walls, followed by the sub-mucosa region. The smallest amounts were found in the close-to-window region, followed by the central region. The placement of a collagen membrane to cover the osteotomy site did not influence the amount of new bone formation after sinus grafting.<\/jats:p>","DOI":"10.3390\/dj9110131","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T08:10:22Z","timestamp":1636704622000},"page":"131","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation\u2014An Experimental Study in Rabbits"],"prefix":"10.3390","volume":"9","author":[{"given":"Alessandro","family":"Perini","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Division of Dentistry, University of Padua, 35122 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4324-4550","authenticated-orcid":false,"given":"Jose","family":"Vi\u00f1a-Almunia","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Carda","sequence":"additional","affiliation":[{"name":"Department of Pathology and Health Research Institute of the Hospital Cl\u00ednico (INCLIVA), Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Ciber-BBN, Instituto de Salud Carlos III, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-9592","authenticated-orcid":false,"given":"Jos\u00e9 Javier","family":"Mart\u00edn de Llano","sequence":"additional","affiliation":[{"name":"Department of Pathology and Health Research Institute of the Hospital Cl\u00ednico (INCLIVA), Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1632","authenticated-orcid":false,"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC Academy, 47923 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Pe\u00f1arrocha-Diago","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Division of Dentistry, University of Padua, 35122 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"ref_1","unstructured":"Tatum, H. 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