{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:14:53Z","timestamp":1772572493778,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","award":["1191477"],"award-info":[{"award-number":["1191477"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Entropy"],"abstract":"<jats:p>The New Evolutionary Synthesis (NES) groups a series of theories that, departing from the gene-centric approach of Modern Synthesis evolutionary theory (MS), place the organism as the central agent of evolution. Two versions of NES, each one with advantages and disadvantages, can be distinguished in this regard; the restrictive NES and the comprehensive NES. Comparatively, the comprehensive NES is a more robust theoretical construction than the restrictive one because it comes grounded on a general, thermodynamically informed theory of living beings (something that the restrictive NES lacks). However, due to its strong teleological commitments, the comprehensive NES has serious problems fitting with modern science\u2019s methodological framework; a problem that the restrictive version, with no explicit commitment to teleology, does not face. In this paper, we propose the autopoietic approach to evolution as a way of integrating these two versions of NES, combining the theoretical robustness of the comprehensive view with the methodological appropriateness of the restrictive one. The autopoietic approach, we show, offers a non-teleological, organism-centered theory of evolution, namely the natural drift theory (NDT), and a grounding on a thermodynamic theory of living beings, namely the embodied autopoietic theory (EAT). We conclude that, from the programmatic point of view, an autopoietic (NDT plus EAT) approach to evolution offers a promising way to develop the NES project.<\/jats:p>","DOI":"10.3390\/e24070914","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T20:53:02Z","timestamp":1656622382000},"page":"914","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Autopoiesis, Thermodynamics, and the Natural Drift of Living Beings: Another Way to the New Evolutionary Synthesis"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0567-2888","authenticated-orcid":false,"given":"Mario","family":"Villalobos","sequence":"first","affiliation":[{"name":"Escuela de Psicolog\u00eda y Filosof\u00eda, Universidad de Tarapac\u00e1, Arica 1010069, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Frick","sequence":"additional","affiliation":[{"name":"Department of Philosophy, Universidad Alberto Hurtado, Santiago 6500620, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Vicencio-Jimenez","sequence":"additional","affiliation":[{"name":"The Center for Hearing and Balance, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/biolinnean\/blz064","article-title":"The Extended Evolutionary Synthesis: What is the debate about, and what might success for the extenders look like?","volume":"127","author":"Lewens","year":"2019","journal-title":"Biol. J. Linn. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10539-018-9633-3","article-title":"What\u2019s wrong with the modern evolutionary synthesis? A critical reply to Welch (2017)","volume":"33","author":"Tanghe","year":"2018","journal-title":"Biol. Philos."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10539-016-9557-8","article-title":"What\u2019s wrong with evolutionary biology?","volume":"32","author":"Welch","year":"2017","journal-title":"Biol. Philos."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Walsh, D.M. (2015). Organisms, Agency, and Evolution, Cambridge University Press.","DOI":"10.1017\/CBO9781316402719"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1086\/379296","article-title":"The New Evolutionary Synthesis: Around the corner, or impossible chimaera?","volume":"78","author":"Pigliucci","year":"2003","journal-title":"Q. Rev. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"20170015","DOI":"10.1098\/rsfs.2017.0015","article-title":"Why an extended evolutionary synthesis is necessary","volume":"7","year":"2017","journal-title":"Interface Focus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pbiomolbio.2020.02.002","article-title":"Beyond the modern synthesis: A framework for a more inclusive biological synthesis","volume":"153","author":"Corning","year":"2020","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1242\/jeb.106310","article-title":"Evolution beyond neo-Darwinism: A new conceptual framework","volume":"218","author":"Noble","year":"2015","journal-title":"J. Exp. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"20160159","DOI":"10.1098\/rsfs.2016.0159","article-title":"Evolution viewed from physics, physiology and medicine","volume":"7","author":"Noble","year":"2017","journal-title":"Interface Focus"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20151019","DOI":"10.1098\/rspb.2015.1019","article-title":"The extended evolutionary synthesis: Its structure, assumptions and predictions","volume":"282","author":"Laland","year":"2015","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pigliucci, M., and M\u00fcller, G.B. (2010). Evolution: The Extended Synthesis, MIT Press.","DOI":"10.7551\/mitpress\/9780262513678.001.0001"},{"key":"ref_12","unstructured":"Nicholson, D., and Dupr\u00e9, J. (2018). Objecty and Agency: Toward a Methodological Vitalism. Everything Flows: Towards a Process Biology, Oxford University Press."},{"key":"ref_13","unstructured":"Mossio, M. (2021). The Fourth Perspective: Evolution and Organismal Agency. OSF Preprints, 26 February. Organization in Biology, Springer."},{"key":"ref_14","unstructured":"Laland, K. (2022, February 05). Evolution Unleashed. Aeon. Available online: https:\/\/aeon.co\/essays\/science-in-flux-is-a-revolution-brewing-in-evolutionary-theory."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrg3028","article-title":"Beyond DNA: Integrating inclusive inheritance into an extended theory of evolution","volume":"12","author":"Danchin","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bonduriansky, R., and Day, T. (2018). Extended Heredity, Princeton University Press.","DOI":"10.23943\/9781400890156"},{"key":"ref_17","first-page":"463","article-title":"Epigenetic inheritance. A decade into the extended evolutionary synthesis","volume":"38","author":"Richards","year":"2020","journal-title":"Paradigmi"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104325","DOI":"10.1016\/j.biosystems.2020.104325","article-title":"Non-genetic inheritance: Evolution above the organismal level","volume":"200","author":"Sukhoverkhov","year":"2021","journal-title":"Biosystems"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1113\/jphysiol.2014.270991","article-title":"From gene action to reactive genomes","volume":"592","author":"Keller","year":"2014","journal-title":"J. Physiol."},{"key":"ref_20","unstructured":"Noble, D. (2008). The Music of Life: Biology beyond Genes, Oxford University Press."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1534\/genetics.118.300995","article-title":"Developmental bias and evolution: A regulatory network perspective","volume":"209","author":"Uller","year":"2018","journal-title":"Genetics"},{"key":"ref_22","unstructured":"Futuyma, D., and Kirkpatrick, M. (2017). Evolution, Sinauer Associates. [4th ed.]."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jablonka, E., and Lamb, M. (2020). Inheritance Systems and the Extended Synthesis, Cambridge University Press.","DOI":"10.1017\/9781108685412"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/phc3.12128","article-title":"The return of the organism as a fundamental explanatory concept in biology","volume":"9","author":"Nicholson","year":"2014","journal-title":"Philos. Compass"},{"key":"ref_25","unstructured":"Odling-Smee, F.J., Laland, K.N., and Feldman, M.W. (2003). Niche construction: The neglected process in evolution. Monographs in Population Biology, Princeton University Press."},{"key":"ref_26","first-page":"63","article-title":"The organism as the subject and object of evolution","volume":"118","author":"Lewontin","year":"1983","journal-title":"Scientia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1086\/285870","article-title":"Niche construction","volume":"147","author":"Laland","year":"1996","journal-title":"Am. Nat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/bjps\/axx050","article-title":"Niche construction and conceptual change in evolutionary biology","volume":"70","author":"Uller","year":"2019","journal-title":"Br. J. Philos. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/03080188.2020.1794383","article-title":"Creating a \u201cgestalt shift\u201d in evolutionary science: Roles for metaphor in the conceptual landscape of the extended evolutionary synthesis (EES)","volume":"45","author":"Herrington","year":"2020","journal-title":"Interdiscip. Sci. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11245-008-9042-3","article-title":"Extended life","volume":"28","year":"2009","journal-title":"Topoi"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Shapiro, L. (2014). The enactive approach. The Routledge Handbook of Embodied Cognition, Routledge Press.","DOI":"10.4324\/9781315775845"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Moreno, A., and Mossio, M. (2015). Biological Autonomy, Springer.","DOI":"10.1007\/978-94-017-9837-2"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s11229-014-0594-z","article-title":"What makes biological organisation teleological?","volume":"194","author":"Mossio","year":"2017","journal-title":"Synthese"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11245-016-9365-4","article-title":"Autonomy and enactivism: Towards a theory of sensorimotor autonomous agency","volume":"36","author":"Barandiaran","year":"2017","journal-title":"Topoi"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Uller, T., and Laland, K.N. (2019). Understanding niche-construction as an evolutionary process. Evolutinary Causation: Biological and Philosophical Reflections, The MIT Press.","DOI":"10.7551\/mitpress\/11693.003.0002"},{"key":"ref_36","unstructured":"Maturana, H., and Varela, F.J. (1987). The Tree of Knowledge: The Biological Roots of Human Understanding, New Science Library\/Shambhala Publications."},{"key":"ref_37","first-page":"261","article-title":"The origin of species by means of natural drift","volume":"732","author":"Maturana","year":"2000","journal-title":"Rev. Chil. Hist. Nat."},{"key":"ref_38","unstructured":"Zeleny, M. (1980). Autopoiesis: Reproduction, heredity and evolution. Autopoiesis, Dissipative Structures, and Spontaneous Social Orders, Westview Press. AAAS Selected Simposium 55."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0020-7373(75)80015-0","article-title":"The organization of the living: A theory of the living organization","volume":"7","author":"Maturana","year":"1975","journal-title":"Int. J. Man-Mach. Stud."},{"key":"ref_40","unstructured":"Zeleny, M. (1981). Autopoiesis. Autopoiesis: A Theory of Living Organization, North Holland."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Maturana, H., and Varela, F. (1980). Autopoiesis and Cognition: The Realization of the Living, Kluwer Academic Publishers.","DOI":"10.1007\/978-94-009-8947-4"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/1059712313482953","article-title":"Enactive cognitive science: Revisionism or revolution?","volume":"21","author":"Villalobos","year":"2013","journal-title":"Adapt. Behav."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s13347-014-0154-y","article-title":"Living systems: Autopoiesis, autonomy and enaction","volume":"28","author":"Villalobos","year":"2015","journal-title":"Philos. Technol."},{"key":"ref_44","first-page":"5","article-title":"Autopoiesis, structural coupling and cognition: A history of these and other notions in the biology of cognition","volume":"9","author":"Maturana","year":"2002","journal-title":"Cybern. Hum. Knowing"},{"key":"ref_45","first-page":"143","article-title":"Ultrastability\u2026 autopoiesis? Reflective response to Tom Froese and John Stewart","volume":"18","author":"Maturana","year":"2011","journal-title":"Cybern. Hum. Knowing"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"739","DOI":"10.4067\/S0716-078X2005000400012","article-title":"Beyond selection","volume":"78","author":"Vargas","year":"2005","journal-title":"Rev. Chil. Hist. Nat."},{"key":"ref_47","first-page":"631","article-title":"Cultural-Biology: Systemic Consequences of Our Evolutionary Natural Drift as Molecular Autopoietic Systems","volume":"21","author":"Maturana","year":"2016","journal-title":"Off. J. Assoc. Found. Sci. Lang. Cogn."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11229-019-02376-6","article-title":"Autopoietic theory, enactivism, and their incommensurable marks of the cognitive","volume":"198","author":"Villalobos","year":"2021","journal-title":"Synthese"},{"key":"ref_49","unstructured":"Razeto-Barry, P., and Ramos-Jiliberto, R. (2013). Autopoiesis y evoluci\u00f3n: Encuentros y desencuentros entre el programa autopoietico y el programa darwiniano. [Autopoiesis and evolution: Encounters and disagreements between the autopoietic program and the Darwinian program]. Autopoiesis: Un Concepto Vivo [Autopoiesis: A Living Concept], Editorial Nueva Civilizaci\u00f3n."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1177\/10597123211030694","article-title":"Autopoiesis and evolution: The role of organisms in natural drift","volume":"29","author":"Raimondi","year":"2021","journal-title":"Adapt. Behav."},{"key":"ref_51","unstructured":"Razeto-Barry, P., and Ramos-Jiliberto, R. (2013). Hace cuarenta a\u00f1os [Forty years ago]. Autopoiesis: Un Concepto Vivo [Autopoiesis: A Living Concept], Editorial Nueva Civilizaci\u00f3n."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s10539-017-9585-z","article-title":"Forces, friction and fractionation: Denis Walsh\u2019s Organisms, agency, and evolution","volume":"32","author":"Buskell","year":"2017","journal-title":"Biol. Philos."},{"key":"ref_53","unstructured":"Thompson, E. (2007). Mind in Life: Biology, Phenomenology, and the Sciences of Mind, Harvard University Press."},{"key":"ref_54","first-page":"7","article-title":"Life after Ashby: Ultrastability and the autopoietic foundations of biological autonomy","volume":"17","author":"Froese","year":"2010","journal-title":"Cybern. Hum. Knowing"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Cleland, C.E. (2019). The Quest for a Universal Theory of Life: Searching for Life as We Don\u2019t Know It, Cambridge University Press.","DOI":"10.1017\/9781139046893"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/1059712319879747","article-title":"Living beings as autopoietic bodies","volume":"28","author":"Villalobos","year":"2020","journal-title":"Adapt. Behav."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1059712318823723","article-title":"Are living beings extended autopoietic systems? An embodied reply","volume":"28","author":"Villalobos","year":"2020","journal-title":"Adapt. Behav."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/1059712319841301","article-title":"Systems or bodies? On how (not) to embody autopoiesis","volume":"28","author":"Meincke","year":"2020","journal-title":"Adapt. Behav."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/1059712319830645","article-title":"Deriving the bodily grounding of living beings with molecular autopoiesis","volume":"28","author":"Agmon","year":"2020","journal-title":"Adapt. Behav."},{"key":"ref_60","unstructured":"Razeto-Barry, P., and Ramos-Jiliberto, R. (2013). \u00bfQu\u00e9 es autopoiesis? [What is autopoiesis?]. Autopoiesis: Un Concepto Vivo [Autopoiesis: A Living Concept], Editorial Nueva Civilizaci\u00f3n."},{"key":"ref_61","unstructured":"Prigogine, I., and Stengers, I. (1984). Order out of Chaos: Man\u2019s New Dialogue with Nature, Bantam Books."},{"key":"ref_62","unstructured":"England, J. (2020). Every Life Is on Fire: How Thermodynamics Explains the Origin of Living Things, Basic Books."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Varela, F., Thompson, E., and Rosch, E. (1991). The Embodied Mind, MIT Press.","DOI":"10.7551\/mitpress\/6730.001.0001"}],"container-title":["Entropy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1099-4300\/24\/7\/914\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:41:30Z","timestamp":1760139690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1099-4300\/24\/7\/914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":63,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["e24070914"],"URL":"https:\/\/doi.org\/10.3390\/e24070914","relation":{},"ISSN":["1099-4300"],"issn-type":[{"value":"1099-4300","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]}}}