{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:08:29Z","timestamp":1777561709283,"version":"3.51.4"},"reference-count":25,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EBJ"],"abstract":"<jats:p>Background: Procedural pain in burn patients continues to be a major problem. Frequently used analgesics, such as opioids, may have various side effects, including respiratory depression, nausea, and vomiting. Inhaled methoxyflurane has been used in the pre-hospital setting for trauma-related pain. This pilot study aimed to investigate the feasibility of using methoxyflurane for pain relief during dressings changes for burns in the hospital setting. Methods: In this investigator-initiated pilot study, we included burn patients undergoing dressing changes in the burn ward. The primary outcome was the maximal pain level experienced by the patient during the procedure on a verbal rating scale of 0 to 100. Furthermore, patient satisfaction and the nurse\u2019s assessment of the patient\u2019s pain were reported. We also reported the presence of nausea, vomiting, coughing, and headache, along with changes in the pulse rate, oxygen saturation, and arterial blood pressure. Results: We included 12 patients in the period of June 2021 to July 2022. The median patient-reported maximal procedural pain was 60 (interquartile range (IQR), 37\u201380), which corresponded well with the nurse\u2019s rating of a median of 57 (IQR 28\u201367). The patients were satisfied with methoxyflurane as an analgesic, with a median score of 96 (IQR 96\u2013100). One patient reported coughing after the procedure, and another patient experienced nausea one week after the procedure. No clinically important haemodynamic changes during administration were detected. Conclusions: Methoxyflurane was found to be feasible for pain relief in burn patients undergoing dressing changes in the burn ward.<\/jats:p>","DOI":"10.3390\/ebj3040047","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T03:03:41Z","timestamp":1669863821000},"page":"780-787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Methoxyflurane for Relief of Procedural Pain in Burn Patients: A Prospective Single-Centre Evaluation Study"],"prefix":"10.3390","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-8634","authenticated-orcid":false,"given":"Andreas","family":"Creutzburg","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Center of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 6, Section 6011, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 6, Section 6011, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-6277","authenticated-orcid":false,"given":"Pernille","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 6, Section 6011, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-0529","authenticated-orcid":false,"given":"Caroline","family":"Hjelmdal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 6, Section 6011, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Rangatchew","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burn Treatment, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, Section 7035, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6579-461X","authenticated-orcid":false,"given":"Rikke","family":"Holmgaard","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Burn Treatment, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, Section 7035, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7480-3004","authenticated-orcid":false,"given":"Lars S.","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center of Head and Orthopedics, Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 6, Section 6011, DK-2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0140-6736(59)92135-X","article-title":"Analgesia for Burns Dressings","volume":"274","author":"Diamond","year":"1959","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bja\/43.2.149","article-title":"Intermittent inhalation of methoxyflurane and trichloroethylene as analgesics in burns dressings procedures","volume":"43","author":"Laird","year":"1971","journal-title":"Br. J. Anaesth."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.anplas.2019.06.007","article-title":"Utilisation du m\u00e9thoxyflurane sur la douleur aigu\u00eb lors du pansement des br\u00fbl\u00e9s [Usage of methoxyflurane for pain control for dressing change in burn patients]","volume":"65","author":"Verdier","year":"2020","journal-title":"Ann. Chir. Plast. Esthet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.burns.2009.03.003","article-title":"The management of pain in the burns unit","volume":"35","author":"Richardson","year":"2009","journal-title":"Burns"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1742-481X.2012.01067.x","article-title":"Inhaled methoxyflurane for pain and anxiety relief during burn wound care procedures: An Australian case series","volume":"11","author":"Wasiak","year":"2014","journal-title":"Int. Wound J."},{"key":"ref_6","first-page":"139","article-title":"Analgesia Protocols for Burns Dressings: Challenges with Implementation","volume":"176","author":"Wall","year":"2019","journal-title":"Burns"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.burns.2011.03.004","article-title":"Adjuvant use of intravenous lidocaine for procedural burn pain relief: A randomized double-blind, placebo-controlled, cross-over trial","volume":"37","author":"Wasiak","year":"2011","journal-title":"Burns"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cps.2017.02.026","article-title":"Sedation and Pain Management in Burn Patients","volume":"44","author":"Griggs","year":"2017","journal-title":"Clin. Plast. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/bja\/41.12.1080","article-title":"Methoxyflurane analgesia for burns dressings: Experience with the analgizer","volume":"41","author":"Packer","year":"1969","journal-title":"Br. J. Anaesth."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.bja.2018.01.011","article-title":"A review of the safety and efficacy of inhaled methoxyflurane as an analgesic for outpatient procedures","volume":"120","author":"Jephcott","year":"2018","journal-title":"Br. J. Anaesth."},{"key":"ref_11","first-page":"1291","article-title":"Methoxyflurane Anesthesia in Pediatrics: A Clinical Report","volume":"91","author":"Davenport","year":"1964","journal-title":"Can. Med. Assoc. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1742-6723.2009.01153.x","article-title":"Review article: Efficacy and safety of methoxyflurane analgesia in the emergency department and prehospital setting: Review Article","volume":"21","author":"Grindlay","year":"2009","journal-title":"EMA Emerg. Med. Australas."},{"key":"ref_13","unstructured":"(2022, August 01). Prescribing Information and Adverse Event Reporting [Internet]. Available online: https:\/\/penthrox.co.uk\/healthcare\/prescribing-information-and-adverse-event-reporting\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/adj.12346","article-title":"Methoxyflurane: A review with emphasis on its role in dental practice","volume":"61","author":"Kingon","year":"2016","journal-title":"Aust. Dent. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","article-title":"Core outcome measures for chronic pain clinical trials: IMMPACT recommendations","volume":"113","author":"Dworkin","year":"2005","journal-title":"Pain"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103208","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap Consortium: Building an International Community of Software Platform Partners","volume":"95","author":"Harris","year":"2019","journal-title":"J. Biomed. Inform."},{"key":"ref_18","unstructured":"(2022, April 10). R: Getting Help with R [Internet]. Available online: https:\/\/www.r-project.org\/help.html."},{"key":"ref_19","unstructured":"(2022, July 09). Studio\u2013RStudio [Internet]. Available online: https:\/\/www.rstudio.com\/products\/rstudio\/."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.annemergmed.2019.07.028","article-title":"Inhaled Methoxyflurane Provides Greater Analgesia and Faster Onset of Action Versus Standard Analgesia in Patients with Trauma Pain: InMEDIATE: A Randomized Controlled Trial in Emergency Departments","volume":"75","author":"Borobia","year":"2020","journal-title":"Ann. Emerg. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/anae.13377","article-title":"Self-administered methoxyflurane for procedural analgesia: Experience in a tertiary Australasian centre","volume":"71","author":"Gaskell","year":"2016","journal-title":"Anaesthesia"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/bja\/44.5.517","article-title":"Methoxyflurane analgesia for burns dressings and other painful ward procedures in children","volume":"44","author":"Firn","year":"1972","journal-title":"Br. J. Anaesth."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E487","DOI":"10.1055\/s-0034-1392366","article-title":"Portable inhaled methoxyflurane is feasible and safe for colonoscopy in subjects with morbid obesity and\/or obstructive sleep apnea","volume":"3","author":"Nguyen","year":"2015","journal-title":"Endosc. Int. Open"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ozainne, F., Cottet, P., Rial, C.L., Von D\u00fcring, S., and Fehlmann, C.A. (2021). Methoxyflurane in Non-Life-Threatening Traumatic Pain\u2014A Retrospective Observational Study. Healthcare, 9.","DOI":"10.3390\/healthcare9101360"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1742-6723.2006.00874.x","article-title":"Inhaled methoxyflurane as a prehospital analgesic in children","volume":"18","author":"Babl","year":"2006","journal-title":"EMA Emerg. Med. 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