{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:45:33Z","timestamp":1775245533268,"version":"3.50.1"},"reference-count":72,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EBJ"],"abstract":"<jats:p>As mortality relating to severe acute burn injury improves, patients are surviving longer into the critical care phase, which is commonly complicated by multisystem organ failure. Extracorporeal organ support (ECOS) represents a set of potential therapeutic technologies for managing patients with organ-specific complications. This article provides a comprehensive review of the existing literature, focusing on the use of continuous kidney replacement therapy, extracorporeal membrane oxygenation, extracorporeal carbon dioxide removal, and extracorporeal blood purification. Though promising, many of these technologies are in the early phases of implementation and are restricted to well-resourced medical systems, limiting their use in large scale casualty and austere scenarios.<\/jats:p>","DOI":"10.3390\/ebj5020006","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T14:14:12Z","timestamp":1711376052000},"page":"66-76","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Extracorporeal Organ Support for Burn-Injured Patients"],"prefix":"10.3390","volume":"5","author":[{"given":"Garrett W.","family":"Britton","sequence":"first","affiliation":[{"name":"School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda R.","family":"Keith","sequence":"additional","affiliation":[{"name":"US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barret J.","family":"Halgas","sequence":"additional","affiliation":[{"name":"US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-5811","authenticated-orcid":false,"given":"Joshua M.","family":"Boster","sequence":"additional","affiliation":[{"name":"Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas S.","family":"Niazi","sequence":"additional","affiliation":[{"name":"David Grant US Air Force Medical Center, Travis Air Force Base, CA 94535, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin K.","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo C.","family":"Cancio","sequence":"additional","affiliation":[{"name":"US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"ref_1","unstructured":"American Burn Association (2023). Annual Burn Injury Summary Report 2022 Update, Oxford University Press."},{"key":"ref_2","unstructured":"Herndon, D.N. (2018). Total Burn Care, Elsevier. [8th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s00134-010-1861-1","article-title":"Outcome of acute kidney injury in severe burns: A systematic review and meta-analysis","volume":"36","author":"Brusselaers","year":"2010","journal-title":"Intensive Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/BCR.0b013e31825aea8d","article-title":"The Acute Kidney Injury Network (AKIN) criteria applied in burns","volume":"33","author":"Chung","year":"2012","journal-title":"J. Burn Care Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2215\/CJN.04420511","article-title":"Association of AKI with adverse outcomes in burned military casualties","volume":"7","author":"Stewart","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/BCR.0b013e3181cb8c87","article-title":"Early acute kidney injury predicts progressive renal dysfunction and higher mortality in severely burned adults","volume":"31","author":"Mosier","year":"2010","journal-title":"J. Burn Care Res."},{"key":"ref_7","first-page":"277","article-title":"Comparison of clinical efficacy between continuous renal replacement therapy and intermittent haemodialysis for the treatment of sepsis-induced acute kidney injury","volume":"28","author":"Dai","year":"2016","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000512101","article-title":"Continuous Venovenous Hemofiltration is Associated with Improved Survival in Burn Patients with Shock: A Subset Analysis of a Multicenter Observational Study","volume":"50","author":"Hill","year":"2021","journal-title":"Blood Purif."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2215\/CJN.05450522","article-title":"Indications for and Timing of Initiation of KRT","volume":"18","author":"Ostermann","year":"2023","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"The STARRT-AKI Investigators (2020). Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N. Engl. J. Med., 383, 240\u2013251.","DOI":"10.1056\/NEJMoa2000741"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.burns.2023.01.002","article-title":"Optimizing the Timing of Renal Replacement Therapy in Burn Patients with Acute Kidney Injury","volume":"49","author":"Tsotsolis","year":"2023","journal-title":"Burns"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.chest.2018.09.004","article-title":"Continuous Renal Replacement Therapy: Who, When, Why, and How","volume":"155","author":"Tandukar","year":"2019","journal-title":"Chest"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1056\/NEJMoa0802639","article-title":"Intensity of renal support in critically ill patients with acute kidney injury","volume":"359","author":"Palevsky","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/jbcr\/iry036","article-title":"Renal Replacement Therapy in Severe Burns: A Multicenter Observational Study","volume":"39","author":"Chung","year":"2018","journal-title":"J. Burn Care Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.12659\/MSM.916767","article-title":"Effect of High-Volume Hemofiltration in Critically Ill Patients: A Systematic Review and Meta-Analysis","volume":"25","author":"Junhai","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1097\/00003246-199909000-00024","article-title":"Continuous venovenous hemofiltration improves cardiac performance by mechanisms other than tumor necrosis factor-alpha attenuation during endotoxic shock","volume":"27","author":"Rogiers","year":"1999","journal-title":"Crit. Care Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1164\/ajrccm.161.5.9809127","article-title":"The effect of intensive plasma water exchange by hemofiltration on hemodynamics and soluble mediators in canine endotoxemia","volume":"161","author":"Bellomo","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13054-017-1878-8","article-title":"High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: A multicenter randomized controlled trial","volume":"21","author":"Chung","year":"2017","journal-title":"Crit. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1001\/jama.2020.18618","article-title":"Effect of Regional Citrate Anticoagulation vs. Systemic Heparin Anticoagulation during Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality among Critically Ill Patients with Acute Kidney Injury: A Randomized Clinical Trial","volume":"324","author":"Zarbock","year":"2020","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1007\/s11255-018-1947-1","article-title":"Discontinuation of renal replacement therapy in critically ill patients with severe acute kidney injury: Predictive factors of renal function recovery","volume":"50","author":"Schiffl","year":"2018","journal-title":"Int. Urol. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Stads, S., Kant, K.M., de Jong, M.F.C., de Ruijter, W., Cobbaert, C.M., Betjes, M.G.H., Gommers, D., and Oudemans-van Straaten, H.M. (2019). Predictors of short-term successful discontinuation of continuous renal replacement therapy: Results from a prospective multicentre study. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1327-9"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.burns.2018.10.012","article-title":"Effectiveness of ECMO for burn-related acute respiratory distress syndrome","volume":"45","author":"Eldredge","year":"2019","journal-title":"Burns"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.burns.2016.01.031","article-title":"The Acute Respiratory Distress Syndrome (ARDS) in mechanically ventilated burn patients: An analysis of risk factors, clinical features, and outcomes using the Berlin ARDS definition","volume":"42","author":"Cartotto","year":"2016","journal-title":"Burns"},{"key":"ref_24","unstructured":"Extracorporeal Life Support Organization (2023, July 02). ECLS Registry Report. Available online: https:\/\/www.elso.org\/registry\/internationalsummaryandreports\/internationalsummary.aspx."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.burns.2018.05.008","article-title":"Revisiting extracorporeal membrane oxygenation for ARDS in burns: A case series and review of the literature","volume":"44","author":"Ainsworth","year":"2018","journal-title":"Burns"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s41038-017-0085-9","article-title":"ECMO in major burn patients: Feasibility and considerations when multiple modes of mechanical ventilation fail","volume":"5","author":"Kennedy","year":"2017","journal-title":"Burns Trauma"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/BCR.0000000000000436","article-title":"Extracorporeal Life Support Use in Adult Burn Patients","volume":"38","author":"Burke","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.burns.2012.08.006","article-title":"Extracorporeal membrane oxygenation in burn and smoke inhalation injury","volume":"39","author":"Asmussen","year":"2013","journal-title":"Burns"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1181e","DOI":"10.1097\/PRS.0000000000009149","article-title":"A Systematic Review and Meta-Analysis of Extracorporeal Membrane Oxygenation in Patients with Burns","volume":"149","author":"Chiu","year":"2022","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"tkac056","DOI":"10.1093\/burnst\/tkac056","article-title":"Efficacy and safety of extracorporeal membrane oxygenation for burn patients: A comprehensive systematic review and meta-analysis","volume":"11","author":"Heng","year":"2023","journal-title":"Burns Trauma"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/jbcr\/irab103","article-title":"The Use of Extracorporeal Membrane Oxygenation in Severely Burned Patients: A Survey of North American Burn Centers","volume":"43","author":"Hebert","year":"2022","journal-title":"J. Burn Care Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13613-017-0275-4","article-title":"Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome","volume":"7","author":"Vaquer","year":"2017","journal-title":"Ann. Intensive Care"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.burns.2019.04.023","article-title":"Infections in patients with burn injuries receiving extracorporeal membrane oxygenation","volume":"45","author":"Marcus","year":"2019","journal-title":"Burns"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/MAT.0000000000001652","article-title":"2021 ELSO Adult and Pediatric Anticoagulation Guidelines","volume":"68","author":"McMichael","year":"2022","journal-title":"ASAIO J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/MAT.0000000000001230","article-title":"Thrombosis and Bleeding in Extracorporeal Membrane Oxygenation (ECMO) without Anticoagulation: A Systematic Review","volume":"67","author":"Olson","year":"2021","journal-title":"ASAIO J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1001\/jama.2021.13374","article-title":"Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients with Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial","volume":"326","author":"McNamee","year":"2021","journal-title":"JAMA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00134-019-05567-4","article-title":"Feasibility and safety of extracorporeal CO(2) removal to enhance protective ventilation in acute respiratory distress syndrome: The SUPERNOVA study","volume":"45","author":"Combes","year":"2019","journal-title":"Intensive Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00134-012-2787-6","article-title":"Lower tidal volume strategy (\u22483 mL\/kg) combined with extracorporeal CO2 removal versus \u2018conventional\u2019 protective ventilation (6 mL\/kg) in severe ARDS: The prospective randomized Xtravent-study","volume":"39","author":"Bein","year":"2013","journal-title":"Intensive Care Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13613-019-0551-6","article-title":"Extracorporeal carbon dioxide removal for acute hypercapnic respiratory failure","volume":"9","author":"Artigas","year":"2019","journal-title":"Ann. Intensive Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.4103\/0971-9784.197791","article-title":"Cannulation strategies in adult veno-arterial and veno-venous extracorporeal membrane oxygenation: Techniques, limitations, and special considerations","volume":"20","author":"Jayaraman","year":"2017","journal-title":"Ann. Card. Anaesth."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000524973","article-title":"New Targets for Extracorporeal Blood Purification Therapies in Sepsis","volume":"52","author":"Monard","year":"2023","journal-title":"Blood Purif."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/BCR.0b013e318283d18c","article-title":"Use of therapeutic plasma exchange in the burn unit: A review of the literature","volume":"34","author":"Mosier","year":"2013","journal-title":"J. Burn Care Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/BCR.0b013e318198a30d","article-title":"The beneficial effects of plasma exchange after severe burn injury","volume":"30","author":"Klein","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archsurg.1984.01390130023004","article-title":"The effect of plasma exchange on lymphocyte suppression after burn","volume":"119","author":"Ninnemann","year":"1984","journal-title":"Arch. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00004630-198901000-00004","article-title":"A randomized trial of plasma exchange in the treatment of burn shock","volume":"10","author":"Kravitz","year":"1989","journal-title":"J. Burn Care Rehabil."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/00005373-198310000-00018","article-title":"Plasma exchange therapy in patients failing to resuscitate from burn shock","volume":"23","author":"Warden","year":"1983","journal-title":"J. Trauma"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.burns.2009.05.006","article-title":"The use of theraputic plasma exchange (TPE) in the setting of refractory burn shock","volume":"36","author":"Neff","year":"2010","journal-title":"Burns"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e0662","DOI":"10.1097\/CCE.0000000000000662","article-title":"A Multicenter Evaluation of the Seraph 100 Microbind Affinity Blood Filter for the Treatment of Severe COVID-19","volume":"4","author":"Chitty","year":"2022","journal-title":"Crit. Care Explor."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0039.2006.00649.x","article-title":"Mannose-binding lectin in innate immunity: Past, present and future","volume":"68","author":"Dommett","year":"2006","journal-title":"Tissue Antigens"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.biomaterials.2015.07.046","article-title":"Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption","volume":"67","author":"Didar","year":"2015","journal-title":"Biomaterials"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000167011","article-title":"Reduction of hepatitis C virus using lectin affinity plasmapheresis in dialysis patients","volume":"27","author":"Tullis","year":"2009","journal-title":"Blood Purif."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"586195","DOI":"10.3389\/fimmu.2021.586195","article-title":"Severe Altered Immune Status After Burn Injury Is Associated with Bacterial Infection and Septic Shock","volume":"12","author":"Cordeiro","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Ding, F., Song, J.H., Jung, J.Y., Lou, L., Wang, M., Charles, L., Westover, A., Smith, P.L., Pino, C.J., and Buffington, D.A. (2011). A Biomimetic Membrane Device That Modulates the Excessive Inflammatory Response to Sepsis. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018584"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1159\/000245645","article-title":"A Selective Cytopheretic Inhibitory Device to Treat the Immunological Dysregulation of Acute and Chronic Renal Failure","volume":"29","author":"Humes","year":"2010","journal-title":"Blood Purif."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/sdi.12032","article-title":"The Effect of the Selective Cytopheretic Device on Acute Kidney Injury Outcomes in the Intensive Care Unit: A Multicenter Pilot Study","volume":"26","author":"Tumlin","year":"2013","journal-title":"Semin. Dial."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Tumlin, J.A., Galphin, C.M., Tolwani, A.J., Chan, M.R., Vijayan, A., Finkel, K., Szamosfalvi, B., Dev, D., DaSilva, J.R., and Astor, B.C. (2015). A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132482"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ekir.2020.12.010","article-title":"Use of the Selective Cytopheretic Device in Critically Ill Children","volume":"6","author":"Goldstein","year":"2021","journal-title":"Kidney Int. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000531880","article-title":"Rationale and Design of NEUTRALIZE-AKI\u2014A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of a Selective Cytopheretic Device in Patients with Acute Kidney Injury Requiring Continuous Kidney Replacement Therapy","volume":"148","author":"Yessayan","year":"2024","journal-title":"Nephron"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000499520","article-title":"Extracorporeal Blood Purification Therapies for Sepsis","volume":"47","author":"Monard","year":"2019","journal-title":"Blood Purif."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jama.2018.14618","article-title":"Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients with Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial","volume":"320","author":"Dellinger","year":"2018","journal-title":"JAMA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.burns.2005.02.004","article-title":"Removal of inflammatory cytokines and endotoxin by veno-venous continuous renal replacement therapy for burned patients with sepsis","volume":"31","author":"Peng","year":"2005","journal-title":"Burns"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2119\/2007-00108.Nakada","article-title":"Continuous hemodiafiltration with PMMA Hemofilter in the treatment of patients with septic shock","volume":"14","author":"Nakada","year":"2008","journal-title":"Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Gruda, M.C., Ruggeberg, K.G., O\u2019Sullivan, P., Guliashvili, T., Scheirer, A.R., Golobish, T.D., Capponi, V.J., and Chan, P.P. (2018). Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb\u00ae sorbent porous polymer beads. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191676"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Sch\u00e4dler, D., Pausch, C., Heise, D., Meier-Hellmann, A., Brederlau, J., Weiler, N., Marx, G., Putensen, C., Spies, C., and J\u00f6rres, A. (2017). The effect of a novel extracorporeal cytokine hemoadsorption device on IL-6 elimination in septic patients: A randomized controlled trial. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187015"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13054-019-2588-1","article-title":"Hemoadsorption with CytoSorb shows a decreased observed versus expected 28-day all-cause mortality in ICU patients with septic shock: A propensity-score-weighted retrospective study","volume":"23","author":"Brouwer","year":"2019","journal-title":"Crit. Care"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/BCR.0b013e3182331e73","article-title":"Multiple organ failure as a cause of death in patients with severe burns","volume":"33","author":"Kallinen","year":"2012","journal-title":"J. Burn Care Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/BCR.0000000000000355","article-title":"Burns: Pathophysiology of systemic complications and current management","volume":"38","author":"Nielson","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e2055","DOI":"10.1093\/milmed\/usaa215","article-title":"Evolution of the United States Military Extracorporeal Membrane Oxygenation Transport Team","volume":"185","author":"Read","year":"2020","journal-title":"Mil. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"A167","DOI":"10.1016\/j.chest.2019.08.241","article-title":"Crossing the Pond: Transcontinental Continuous Renal Replacement Therapy in Modern Warfare","volume":"156","author":"Dittman","year":"2019","journal-title":"Chest"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1097\/TA.0b013e318299d97a","article-title":"Early implementation of continuous renal replacement therapy optimizes casualty evacuation for combat-related acute kidney injury","volume":"75","author":"Zonies","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/milmed\/usx134","article-title":"Continuous Veno-Venous Hemofiltration during Intercontinental Aeromedical Evacuation","volume":"183","author":"Driscoll","year":"2018","journal-title":"Mil. Med."}],"container-title":["European Burn Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-1991\/5\/2\/6\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:18:03Z","timestamp":1760105883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-1991\/5\/2\/6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,25]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ebj5020006"],"URL":"https:\/\/doi.org\/10.3390\/ebj5020006","relation":{},"ISSN":["2673-1991"],"issn-type":[{"value":"2673-1991","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,25]]}}}