{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:39:04Z","timestamp":1766489944564,"version":"3.48.0"},"reference-count":74,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CPUT\u2019s Research, Technology & Innovation (RTI) Project Funds: University Research Funds"},{"name":"Research Institute Niche Area"},{"name":"Faculty of Health and Wellness Sciences at CPUT"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EBJ"],"abstract":"<jats:p>(1) Background: Inhalation injury significantly worsens burn outcomes but lacks a standardized definition and diagnostic consensus, complicating prognosis. Existing diagnostic tools often show limited sensitivity and specificity, reducing clinical utility. This study aimed to identify potential clinical markers, recorded at or shortly after admission, for inhalation injury prognostication. (2) Methods: A retrospective cohort study of 59 burn patients admitted to Tygerberg Hospital\u2019s Burn Centre (South Africa) between 23 April 2016 and 15 August 2017 was conducted. Descriptive statistics were reported based on data type and distribution. Fisher\u2019s exact test, Spearman\u2019s rank correlation (rho), and partial least squares regression (VIP scores) assessed associations, correlations, and predictive value. p &lt; 0.05 (two-tailed) denoted significance. (3) Results: Severe inhalation injury accounted for 61% of admissions (mean 11.2; CI = 9.5\u201312.9), with a 38.9% mortality rate. Significant associations (p \u2264 0.008) and positive correlations (p \u2264 0.06) were noted for total body surface area (rho = 0.357), complications (rho = 0.690), and burns intensive care unit length of stay (BICU LOS, rho = 0.908). Complications and BICU LOS showed the strongest predictive contributions (VIP = 1.229 and 1.372). Lactate (rho = 0.331, p &lt; 0.011) and hoarseness (rho = \u22120.314, p &lt; 0.015) correlated significantly but lacked association. (4) Conclusions: Findings suggest elevated lactate may serve as a prognostic marker, while BICU LOS and complications may reflect disease progression. A multi-marker approach is recommended.<\/jats:p>","DOI":"10.3390\/ebj7010002","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:35:27Z","timestamp":1766392527000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential Prognostic Parameters from Patient Medical Files for Inhalation Injury Presence and\/or Degree: A Single-Center Study"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-4272","authenticated-orcid":false,"given":"Tarryn Kay","family":"Prinsloo","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology (CPUT), Cape Town 7535, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-208X","authenticated-orcid":false,"given":"Wayne George","family":"Kleintjes","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University (SU) Medical School, Francie van Zijl Avenue, Cape Town 7505, South Africa"},{"name":"Western Cape Provincial Adult Tertiary Burns Centre, Tygerberg Hospital, Tygerberg, Francie van Zijl Avenue, Cape Town 7505, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareemah","family":"Najaar","sequence":"additional","affiliation":[{"name":"Department of Wellness Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology (CPUT), District Six 8000, P.O. Box 652, Cape Town 7530, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/bjaceaccp\/mku017","article-title":"Smoke Inhalation Injury","volume":"15","author":"Gill","year":"2015","journal-title":"BJA Educ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s13054-015-1077-4","article-title":"Diagnosis and management of inhalation injury: An updated review","volume":"19","author":"Walker","year":"2015","journal-title":"Crit. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/CJ9.0000000000000042","article-title":"Airway Burn or Inhalation Injury: Should All Patients Be Intubated?","volume":"46","year":"2018","journal-title":"Colomb. J. Anesthesiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1056\/NEJMra1601128","article-title":"Fire-Related Inhalation Injury","volume":"375","author":"Sheridan","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1757-7241-21-31","article-title":"Inhalation Injury: Epidemiology, Pathology, Treatment Strategies","volume":"21","author":"Dries","year":"2013","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/CCM.0b013e3182374a67","article-title":"The Acute Pulmonary Inflammatory Response to the Graded Severity of Smoke Inhalation Injury","volume":"40","author":"Albright","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_7","first-page":"120","article-title":"Epidemiology of Ventilator-Associated Tracheobronchitis and Vantilator-Associated Pneumonia in Patients with Inhalation Injury at the Burn Centre in Brno (Czech Republic)","volume":"24","author":"Lipovy","year":"2011","journal-title":"Ann. Burns Fire Disasters"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.burns.2014.09.015","article-title":"Inhalation Injury in Burn Patients: Establishing the Link between Diagnosis and Prognosis","volume":"40","author":"You","year":"2014","journal-title":"Burns"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-0044-1782646","article-title":"Inhalation Injury","volume":"38","author":"Erickson","year":"2024","journal-title":"Semin. Plast. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.21037\/med-21-7","article-title":"Smoke inhalation injury: A narrative review","volume":"5","author":"Galeiras","year":"2021","journal-title":"Mediastinum"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s41038-017-0097-5","article-title":"Pediatric inhalation injury","volume":"5","author":"Sen","year":"2017","journal-title":"Burn. Trauma"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1097\/SAP.0000000000001377","article-title":"Inhalation Injury in the Burned Patient","volume":"80","author":"Foncerrada","year":"2018","journal-title":"Ann. Plast. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1378\/chest.107.5.1365","article-title":"Using Bronchoscopy and Biopsy to Diagnose Early Inhalation Injury: Macroscopic and Histologic Findings","volume":"107","author":"Legendre","year":"1995","journal-title":"Chest"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.burns.2014.06.016","article-title":"The impact of inhalation injury in patients with small and moderate burns","volume":"40","author":"Chen","year":"2014","journal-title":"Burns"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cps.2009.05.013","article-title":"Airway Management and Smoke Inhalation Injury in the Burn Patient","volume":"36","author":"Cancio","year":"2009","journal-title":"Clin. Plast. Surg."},{"doi-asserted-by":"crossref","unstructured":"Kim, Y., Kym, D., Hur, J., Yoon, J., Yim, H., and Cho, Y.S. (2017). Does Inhalation Injury Predict Mortality in Burns Patients or Require Redefinition?. PLoS ONE, 12.","key":"ref_16","DOI":"10.1371\/journal.pone.0185195"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cps.2017.02.009","article-title":"Inhalation Injury: Pathophysiology, Diagnosis, and Treatment","volume":"44","author":"Jones","year":"2017","journal-title":"Clin. Plast. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0140-6736(16)31458-1","article-title":"Pathophysiology, Research Challenges, and Clinical Management of Smoke Inhalation Injury","volume":"388","author":"Enkhbaatar","year":"2016","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/BCR.0b013e3181923b71","article-title":"Diagnosis and Grading of Inhalation Injury","volume":"30","author":"Woodson","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.burns.2011.07.017","article-title":"Prognostic Scoring Systems in Burns: A Review","volume":"37","author":"Sheppard","year":"2011","journal-title":"Burns"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/jbcr\/irad083","article-title":"Inhalation Injury Severity Score on Admission Predicts Overall Survival in Burn Patients","volume":"44","author":"Flinn","year":"2023","journal-title":"J. Burn Care Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1097\/BCR.0b013e318237455f","article-title":"Admission Chest CT Complements Fiberoptic Bronchoscopy in Prediction of Adverse Outcomes in Thermally Injured Patients","volume":"33","author":"Oh","year":"2012","journal-title":"J. Burn Care Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.burns.2019.03.005","article-title":"Admission Factors Associated with the In-Hospital Mortality of Burns Patients in Resource-Constrained Settings: A Two-Year Retrospective Investigation in a South African Adult Burns Centre","volume":"45","author":"Boissin","year":"2019","journal-title":"Burns"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.burns.2016.08.031","article-title":"The Impact of Patient Demographics and Comorbidities upon Burns Admitted to Tygerberg Hospital Burns Unit, Western Cape, South Africa","volume":"43","author":"Cloake","year":"2017","journal-title":"Burns"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.burns.2010.12.007","article-title":"The Aetiology of Adult Burns in the Western Cape, South Africa","volume":"38","author":"Maritz","year":"2012","journal-title":"Burns"},{"unstructured":"Department of Health and Wellness (2025, August 20). Tygerberg Hospital: Overview. Western Cape Government, Available online: https:\/\/d7.westerncape.gov.za\/your_gov\/153#:~:text=Tygerberg%20Hospital%20is%20a%20tertiary,of%20Stellenbosch\u2019s%20Health%20Science%20Faculty.&text=To%20provide%20affordable%20world%20class,excellent%20educational%20and%20research%20opportunities.&text=To%20be%20the%20best%20academic,Out%2DPatients%20Department%20Contact%20List.","key":"ref_26"},{"unstructured":"Matzopoulos, R. (2025, August 20). A Profile of Fatal Injuries in South Africa: Fifth Annual Report of the National Injury Mortality Surveillance System, 2003. Medical Research Council-University of South Africa Crime, Violence and Lead Programme, Available online: https:\/\/scholar.google.com\/scholar_lookup?&title=A%20Profile%20of%20Fatal%20Injuries%20in%20South%20Africa%3A%206th%20Annual%20Report%20of%20the%20National%20Injury%20Mortality%20Surveillance%20System%2C%202004&publication_year=2005&author=Matzopoulos%2CR#:~:text=A%20profile%20of%20fatal%20injuries%20in%20South%20Africa%3A%20Fifth%20Annual%20Report%20of%20the%20National%20Injury%20Mortality%20Surveillance%20System%2C%202003.","key":"ref_27"},{"unstructured":"Western Cape Government (2025, August 20). Tygerberg Hospital\u2019s Specialised Burn Centre a Beacon of Hope for Burns Victims, Available online: https:\/\/www.westerncape.gov.za\/health-wellness\/article\/tygerberg-hospitals-specialised-burn-centre-beacon-hope-burns-victims?utm_source=chatgpt.com.","key":"ref_28"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.36303\/SAJS.4061","article-title":"Outcomes of complex burn injury patients managed at two primary and one tertiary level burns facilities in the Western Cape province of South Africa\u2014A retrospective review","volume":"61","author":"Carolissen","year":"2023","journal-title":"S. Afr. J. Surg."},{"doi-asserted-by":"crossref","unstructured":"Parbhoo, A., Louw, Q.A., and Grimmer-Somers, K.A. (2010). Profile of hospital-admitted paediatric burns patients in South Africa. BMC Res. Notes, 3.","key":"ref_30","DOI":"10.1186\/1756-0500-3-165"},{"unstructured":"South African Government (2021, August 09). Government Gazette. No. 4 of 2013: Protection of Personal Information Act, Available online: https:\/\/www.gov.za\/sites\/default\/files\/gcis_document\/201409\/3706726-11act4of2013popi.pdf.","key":"ref_31"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0196-0644(82)80096-6","article-title":"The Abbreviated Burn Severity Index","volume":"11","author":"Tobiasen","year":"1982","journal-title":"Ann. Emerg. Med."},{"unstructured":"Dancey, C.P., and Reidy, J. (2007). Statistics Without Maths for Psychology, Pearson Education\/Prentice Hall.","key":"ref_33"},{"unstructured":"Kotz, S., and Johnson, N.L. (1985). Partial Least Squares. Encyclopedia of Statistical Sciences, Wiley.","key":"ref_34"},{"doi-asserted-by":"crossref","unstructured":"Ramabulana, A.-T., Steenkamp, P.A., Madala, N.E., and Dubery, I.A. (2020). Profiling of Altered Metabolomic States in Bidens Pilosa Leaves in Response to Treatment by Methyl Jasmonate and Methyl Salicylate. Plants, 9.","key":"ref_35","DOI":"10.3390\/plants9101275"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.12732\/ijpam.v94i3.2","article-title":"Cutoff Threshold of Variable Importance in Projection for Variable Selection","volume":"94","author":"Akarachantachote","year":"2014","journal-title":"Int. J. Pure Appl. Math."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.46747\/cfp.700295","article-title":"Approach to Burn Treatment in the Rural Emergency Department","volume":"70","author":"Tremblay","year":"2024","journal-title":"Can. Fam. Physician"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BCR.0000000000000368","article-title":"Guidelines for Burn Care Under Austere Conditions","volume":"38","author":"Cancio","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ams2.269","article-title":"Indications of Early Intubation for Patients with Inhalation Injury","volume":"4","author":"Onishi","year":"2017","journal-title":"Acute Med. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1152\/japplphysiol.00031.2004","article-title":"A Spurious Correlation","volume":"97","author":"Atkinson","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1098\/rspl.1896.0076","article-title":"Mathematical Contributions to the Theory of Evolution\u2014On a Form of Spurious Correlation Which May Arise When Indices Are Used in the Measurement of Organs","volume":"60","author":"Pearson","year":"1897","journal-title":"Proc. R. Soc. Lond."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/bmj.308.6933.896","article-title":"Statistics Notes: Correlation, Regression, and Repeated Data","volume":"308","author":"Bland","year":"1994","journal-title":"BMJ"},{"doi-asserted-by":"crossref","unstructured":"Huang, R.-Y., Chen, S.-J., Hsiao, Y.-C., Kuo, L.-W., Liao, C.-H., Hsieh, C.-H., Bajani, F., and Fu, C.-Y. (2022). Positive Signs on Physical Examination Are Not Always Indications for Endotracheal Tube Intubation in Patients with Facial Burn. BMC Emerg. Med., 22.","key":"ref_43","DOI":"10.1186\/s12873-022-00594-9"},{"key":"ref_44","first-page":"121","article-title":"Inhalation Injury in a Burn Unit: A Retrospective Review of Prognostic Factors","volume":"30","author":"Monteiro","year":"2017","journal-title":"Ann. Burn. Fire Disasters"},{"doi-asserted-by":"crossref","unstructured":"Elrod, J., Mohr, C., Wolff, R., Boettcher, M., Reinshagen, K., Bartels, P., Registry, G.B., and Koenigs, I. (2021). Using Artificial Intelligence to Obtain More Evidence? Prediction of Length of Hospitalization in Pediatric Burn Patients. Front. Pediatr., 8.","key":"ref_45","DOI":"10.3389\/fped.2020.613736"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.burns.2019.07.028","article-title":"The association between burn and trauma severity and in-hospital complications","volume":"46","author":"Lopes","year":"2020","journal-title":"Burns"},{"doi-asserted-by":"crossref","unstructured":"Stockly, O.R., Wolfe, A.E., Carrougher, G.J., Stewart, B.T., Gibran, N.S., Wolf, S.E., McMullen, K., Bamer, A.M., Kowalske, K., and Cioffi, W.G. (2020). Inhalation injury is associated with long-term employment outcomes in the burn population: Findings from a cross-sectional examination of the Burn Model System National Database. PLoS ONE, 15.","key":"ref_47","DOI":"10.1371\/journal.pone.0239556"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s41038-018-0126-z","article-title":"Quantifying the Impact of Inhalational Burns: A Prospective Study","volume":"6","author":"Chong","year":"2018","journal-title":"Burn. Trauma"},{"doi-asserted-by":"crossref","unstructured":"Jones, S.W., Zhou, H., Ortiz-Pujols, S.M., Maile, R., Herbst, M., Joyner, B.L., Zhang, H., Kesic, M., Jaspers, I., and Short, K.A. (2013). Bronchoscopy-Derived Correlates of Lung Injury Following Inhalational Injuries: A Prospective Observational Study. PLoS ONE, 8.","key":"ref_49","DOI":"10.1371\/journal.pone.0064250"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1097\/SLA.0000000000002795","article-title":"Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients with Burn Injury","volume":"270","author":"Afshar","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_51","first-page":"439","article-title":"Acute Respiratory Distress Syndrome, Mechanical Ventilation, and Inhalation Injury in Burn Patients","volume":"103","author":"Bittner","year":"2023","journal-title":"Surg. Clin."},{"key":"ref_52","first-page":"178","article-title":"Acute Respiratory Distress Syndrome in Burn Patients: Incidence and Risk Factor Analysis","volume":"29","author":"Silva","year":"2016","journal-title":"Ann. Burn. Fire Disasters"},{"key":"ref_53","first-page":"37","article-title":"ARDS among Cutaneous Burn Patients Combined with Inhalation Injury: Early Onset and Bad Outcome","volume":"32","author":"Lam","year":"2019","journal-title":"Ann. Burn. Fire Disasters"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s12967-017-1366-6","article-title":"R-100 improves pulmonary function and systemic fluid balance in sheep with combined smoke-inhalation injury and Pseudomonas aeruginosa sepsis","volume":"15","author":"Ito","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.bbrc.2009.12.124","article-title":"A murine model of sepsis following smoke inhalation injury","volume":"391","author":"Lange","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jcrc.2020.07.019","article-title":"Supervised Machine Learning for the Early Prediction of Acute Respiratory Distress Syndrome (ARDS)","volume":"60","author":"Le","year":"2020","journal-title":"J. Crit. Care"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1183\/09031936.00036810","article-title":"Acute Lung Injury Prediction Score: Derivation and Validation in a Population-Based Sample","volume":"37","author":"Kor","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/jbcr\/irz016","article-title":"Preventing Unnecessary Intubations: A 5-Year Regional Burn Center Experience Using Flexible Fiberoptic Laryngoscopy for Airway Evaluation in Patients with Suspected Inhalation or Airway Injury","volume":"40","author":"Moshrefi","year":"2019","journal-title":"J. Burn Care Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1001\/jama.2021.13084","article-title":"Mechanical Ventilation","volume":"326","author":"Walter","year":"2021","journal-title":"JAMA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and Septic Shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"20503121221136401","DOI":"10.1177\/20503121221136401","article-title":"Role of Serum Lactate as Prognostic Marker of Mortality among Emergency Department Patients with Multiple Conditions: A Systematic Review","volume":"11","author":"Alshiakh","year":"2023","journal-title":"SAGE Open Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5455\/medarh.2017.71.404-407","article-title":"Hyperlactatemia and the Importance of Repeated Lactate Measurements in Critically Ill Patients","volume":"71","author":"Godinjak","year":"2017","journal-title":"Med. Arch."},{"key":"ref_63","first-page":"293","article-title":"Blood Lactate and Lactate Clearance: Refined Biomarker and Prognostic Marker in Burn Resuscitation","volume":"33","author":"Muthukumar","year":"2020","journal-title":"Ann. Burn. Fire Disasters"},{"doi-asserted-by":"crossref","unstructured":"Park, Y.J., Kim, D.H., Kim, S.C., Kim, T.Y., Kang, C., Lee, S.H., Jeong, J.H., Lee, S.B., and Lim, D. (2018). Serum Lactate upon Emergency Department Arrival as a Predictor of 30-Day in-Hospital Mortality in an Unselected Population. PLoS ONE, 13.","key":"ref_64","DOI":"10.1371\/journal.pone.0190519"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2015.03.011","article-title":"A Lactate-Induced Response to Hypoxia","volume":"161","author":"Lee","year":"2015","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e523","DOI":"10.1097\/CCM.0000000000003075","article-title":"Determinants of Lactic Acidosis in Acute Cyanide Poisonings","volume":"46","author":"Baud","year":"2018","journal-title":"Crit. Care Med."},{"doi-asserted-by":"crossref","unstructured":"Gicheru, B., Shah, J., Wachira, B., Omuse, G., and Maina, D. (2023). The Diagnostic Accuracy of an Initial Point-of-Care Lactate at the Emergency Department as a Predictor of in-Hospital Mortality among Adult Patients with Sepsis and Septic Shock. Front. Med., 10.","key":"ref_67","DOI":"10.3389\/fmed.2023.1173286"},{"key":"ref_68","first-page":"35","article-title":"Lactate: Prognostic Biomarker in Severely Burned Patients","volume":"30","author":"Mokline","year":"2017","journal-title":"Ann. Burn. Fire Disasters"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"14","DOI":"10.21037\/jeccm.2018.01.13","article-title":"Clinical Applications of Lactate Testing in Patients with Sepsis and Septic Shock","volume":"2","author":"Ryoo","year":"2018","journal-title":"J. Emerg. Crit. Care Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell\u2013Cell and Intracellular Lactate Shuttles","volume":"587","author":"Brooks","year":"2009","journal-title":"J. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1042\/bst0300258","article-title":"Lactate Shuttles in Nature","volume":"30","author":"Brooks","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"hcad069.688","DOI":"10.1093\/qjmed\/hcad069.688","article-title":"Evaluation of Blood Lactate Concentrations as a Marker for Resuscitation and Prognosis in Patients with Major Burns","volume":"116","author":"Mohammed","year":"2023","journal-title":"QJM Int. J. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.burns.2020.06.003","article-title":"Lactate and Lactate Clearance in Critically Burned Patients: Usefulness and Limitations as a Resuscitation Guide and as a Prognostic Factor","volume":"46","year":"2020","journal-title":"Burns"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.burns.2005.06.019","article-title":"Lactate: Early predictor of morbidity and mortality in patients with severe burns","volume":"31","author":"Kamolz","year":"2005","journal-title":"Burns"}],"container-title":["European Burn Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-1991\/7\/1\/2\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T11:35:57Z","timestamp":1766489757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-1991\/7\/1\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":74,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["ebj7010002"],"URL":"https:\/\/doi.org\/10.3390\/ebj7010002","relation":{},"ISSN":["2673-1991"],"issn-type":[{"type":"electronic","value":"2673-1991"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}