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The study utilized the PRISMA methodology and included cross-sectional, retrospective studies, and randomized clinical trials from reputable databases like SCOPUS, CLARIVATE, SCIENCE DIRECT, and PUBMED. Out of the 64 selected studies, various psychotropic drug classes were analyzed, including antidepressants, anticonvulsants, and antipsychotics. Among the antidepressants, such as amitriptyline, Imipramine, and clomipramine, weight gain, constipation, and cardiovascular effects were the most commonly reported metabolic adverse effects. SSRI antidepressants like Fluoxetine, Sertraline, Citalopram, Escitalopram, and Paroxetine exhibited a high prevalence of gastrointestinal and cardiac alterations. Regarding anticonvulsants, valproic acid and Fosphenytoin were associated with adverse reactions such as weight gain and disturbances in appetite and sleep patterns. As for antipsychotics, drugs like Clozapine, Olanzapine, and Risperidone were linked to weight gain, diabetes, and deterioration of the lipid profile. The findings of this review emphasize the importance of continuous monitoring for adverse effects, particularly considering that the metabolic changes caused by psychopharmacological medications may vary depending on the age of the patients. Future research should focus on conducting field studies to further expand knowledge on the metabolic effects of other commonly prescribed psychotropic drugs. Overall, the study highlights the significance of understanding and managing metabolic alterations induced by psychopharmacological treatment to enhance patient care and well-being.<\/jats:p>","DOI":"10.3390\/ejihpe13080110","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T12:35:25Z","timestamp":1692016525000},"page":"1505-1520","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Metabolic Adverse Effects of Psychotropic Drug Therapy: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Lizeth","family":"Sep\u00falveda-Lizcano","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Jur\u00eddicas y Sociales, Universidad Sim\u00f3n Bol\u00edvar, C\u00facuta 540001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Vanessa","family":"Arenas-Villamizar","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Jur\u00eddicas y Sociales, Universidad Sim\u00f3n Bol\u00edvar, C\u00facuta 540001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enna Beatriz","family":"Jaimes-Duarte","sequence":"additional","affiliation":[{"name":"Facultad de Salud, Universidad de Pamplona, Pamplona 543050, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Garc\u00eda-Pacheco","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Departamento de Cirug\u00eda, Universidad del Zulia, Hospital General del Sur \u00abDr. Pedro Iturbe\u00bb, Maracaibo 4002, Venezuela"},{"name":"Facultad de Medicina, Escuela de Medicina, C\u00e1tedra de Fisiolog\u00eda, Universidad del Zulia, Maracaibo 4002, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Silva","family":"Paredes","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Escuela de Medicina, C\u00e1tedra de Fisiolog\u00eda, Universidad del Zulia, Maracaibo 4002, Venezuela"},{"name":"Unidad de Cirug\u00eda para Obesidad y Metabolismo (UCOM), Maracaibo 4002, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-8887","authenticated-orcid":false,"given":"Valmore","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Sim\u00f3n Bol\u00edvar, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Rivera-Porras","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Jur\u00eddicas y Sociales, Universidad Sim\u00f3n Bol\u00edvar, C\u00facuta 540001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.47307\/GMC.2020.128.4.5","article-title":"Diagnostic Criteria and Management of Metabolic Syndrome: Evolution Overtime","volume":"128","author":"Rojas","year":"2021","journal-title":"Gac. 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