{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:00:10Z","timestamp":1781161210098,"version":"3.54.1"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiologia"],"abstract":"<jats:p>Background: Hypertension remains one of the leading modifiable risk factors for cardiovascular diseases globally, yet blood pressure control remains suboptimal in many low- and middle-income countries. Understanding the prevalence of uncontrolled hypertension and its associated factors is important for improving treatment outcomes, particularly in rural primary health care settings. Methods: A cross-sectional study was conducted among 103 hypertensive patients receiving follow-up care at a rural community health centre in the Eastern Cape Province of South Africa between August and October 2024. Sociodemographic, lifestyle, and clinical information were collected using a semi-structured questionnaire and medical record review. Medication adherence was assessed using the Hill\u2013Bone Compliance to High Blood Pressure Therapy Scale. Uncontrolled hypertension was defined as systolic blood pressure \u2265 140 mmHg and\/or diastolic blood pressure \u2265 90 mmHg. Associations between explanatory variables and uncontrolled hypertension were analysed using chi-square tests and multivariable logistic regression. Results: The mean age of participants was 63 \u00b1 13 years, and 65% were female. The prevalence of uncontrolled hypertension was 63.1% (65\/103), while 36.9% (38\/103) achieved blood pressure control. The median systolic blood pressure was 149 mmHg (IQR: 135\u2013163) and the median diastolic blood pressure was 84 mmHg (IQR: 76\u201389). Low medication adherence was significantly associated with uncontrolled hypertension (OR = 4.20, 95% CI: 1.75\u201310.09, p = 0.001). Forgetfulness and non-use of reminders were common barriers to adherence. Conclusions: Uncontrolled hypertension remains highly prevalent among treated patients in this rural setting. Low medication adherence was significantly associated with uncontrolled hypertension, suggesting that adherence support strategies warrant further investigation in similar resource-limited primary health care settings.<\/jats:p>","DOI":"10.3390\/epidemiologia7030082","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:50:58Z","timestamp":1781157058000},"page":"82","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Determinants of Uncontrolled Hypertension Among Treated Adults in a Rural Primary Health Care Facility in South Africa: A Cross-Sectional Study"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6485-2059","authenticated-orcid":false,"given":"Guillermo Alfredo Pulido","family":"Estrada","sequence":"first","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5100, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4863-019X","authenticated-orcid":false,"given":"Mercedes","family":"Nico-Garcia","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Rural Health, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5100, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olufunmilayo Olukemi","family":"Akapo","sequence":"additional","affiliation":[{"name":"School of Pathology, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5100, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4749-4258","authenticated-orcid":false,"given":"Mirabel Kah-Keh","family":"Nanjoh","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Medicine and Health Sciences, Walter Sisulu University, Mthatha 5100, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"ref_1","unstructured":"(2026, January 16). Health Organisation. Hypertension. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hypertension."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2468172","DOI":"10.1080\/08037051.2025.2468172","article-title":"Temporal trends and relevant factors of hypertension in China: A cross-sectional study based on national surveys from 2002 to 2019","volume":"34","author":"Zhang","year":"2025","journal-title":"Blood Press"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0140-6736(21)01330-1","article-title":"Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants","volume":"398","author":"Zhou","year":"2021","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Masenga, S.K., and Kirabo, A. (2023). Hypertensive heart disease: Risk factors, complications and mechanisms. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1205475"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wang, B.X. (2025). Diagnosis and management of hypertensive heart disease: Incorporating 2023 European Society of Hypertension and 2024 European Society of Cardiology Guideline Updates. J. Cardiovasc. Dev. Dis., 12.","DOI":"10.3390\/jcdd12020046"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2631606","DOI":"10.1080\/10641963.2026.2631606","article-title":"Mechanisms linking hypertension to cardiovascular and cerebrovascular diseases and their clinical implications: A comprehensive review","volume":"48","author":"Li","year":"2026","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_8","first-page":"200596","article-title":"Systematic review and meta-analysis of cardiovascular disease risk among hypertensive patients in Africa","volume":"29","author":"Getahun","year":"2026","journal-title":"Int. J. Cardiol. Cardiovasc. Risk Prev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.amjcard.2025.04.028","article-title":"Incidence and risk of heart failure in patients with coronary heart disease and stroke: A population-based cohort study","volume":"250","author":"Liu","year":"2025","journal-title":"Am. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/HJH.0000000000002668","article-title":"Long-term risk of stroke and myocardial infarction in middle-aged men with a hypertensive response to exercise: A 44-year follow-up study","volume":"39","author":"Giang","year":"2021","journal-title":"J. Hypertens."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Park, J., Han, K., Lee, K., Chang, Y., and Shin, D.W. (2025). Risk of Cardiovascular Disease According to the Precedence Relationship Between Hypertension and Diabetes Mellitus. Healthcare, 13.","DOI":"10.3390\/healthcare13070796"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Apalata, T., Tsuro, U., and Akapo, O.O. (2025). Prolonged Exposure to Antiretroviral Therapy and Risk of Developing Hypertension Among HIV-Infected Clinic Attendees: A Pilot Study in Rural Eastern Cape Province, South Africa. Int. J. Environ. Res. Public Health, 22.","DOI":"10.20944\/preprints202506.0408.v1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/HYP.0000000000000203","article-title":"Medication adherence and blood pressure control: A scientific statement from the American Heart Association","volume":"79","author":"Choudhry","year":"2022","journal-title":"Hypertension"},{"key":"ref_14","first-page":"e143","article-title":"Association between population hypertension control and ischemic heart disease and stroke mortality in 36 countries of the Americas, 1990\u20132019: An ecological study","volume":"46","author":"Martinez","year":"2023","journal-title":"Rev. Panam. Salud P\u00fablica"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/cvr\/cvac130","article-title":"Addressing global disparities in blood pressure control: Perspectives of the International Society of Hypertension","volume":"119","author":"Schutte","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sorato, M.M., Davari, M., Kebriaeezadeh, A., Sarrafzadegan, N., Shibru, T., and Fatemi, B. (2021). Reasons for poor blood pressure control in eastern sub-Saharan Africa: Looking into 4P\u2019s (primary care, professional, patient, and public health policy) for improving blood pressure control: A scoping review. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-01934-6"},{"key":"ref_17","first-page":"95","article-title":"Hypertension in sub-Saharan Africa: The current profile, recent advances, gaps, and priorities","volume":"39","author":"Craig","year":"2025","journal-title":"J. Hum. Hypertens."},{"key":"ref_18","first-page":"111","article-title":"High prevalence but lack of awareness of hypertension in South Africa, particularly among men and young adults","volume":"39","author":"Woodiwiss","year":"2025","journal-title":"J. Hum. Hypertens."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e055621","DOI":"10.1136\/bmjopen-2021-055621","article-title":"Hypertension in the South African public healthcare system: A cost-of-illness and burden of disease study","volume":"12","author":"Erzse","year":"2022","journal-title":"BMJ Open"},{"key":"ref_20","first-page":"156","article-title":"National prevalence of coronary heart disease and stroke in South Africa from 1990\u20132017: A systematic review and meta-analysis","volume":"32","author":"Abdelatif","year":"2021","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.2147\/PPA.S368784","article-title":"A critical review of medication adherence in hypertension: Barriers and facilitators clinicians should consider","volume":"16","author":"Hamrahian","year":"2022","journal-title":"Patient Prefer. Adherence"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.124.323889","article-title":"Hypertension in sub-Saharan Africa: Burden, barriers and priorities for improving treatment outcomes","volume":"137","author":"Jobe","year":"2025","journal-title":"Circ. Res."},{"key":"ref_23","first-page":"e69396","article-title":"Factors Contributing to Lack of Adherence to Antihypertensive Medications Among Patients at Nishtar Hospital in Multan, Pakistan","volume":"16","author":"Khan","year":"2024","journal-title":"Cureus"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e53187","DOI":"10.2196\/53187","article-title":"Methodological challenges in randomized controlled trials of mhealth interventions: Cross-sectional survey study and consensus-based recommendations","volume":"26","author":"Wieland","year":"2024","journal-title":"J. Med. Internet Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s44401-025-00017-4","article-title":"A systematic review of strategies in digital technologies for motivating adherence to chronic illness self-care","volume":"2","author":"Lu","year":"2025","journal-title":"npj Health Syst."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5830\/CVJA-2019-025","article-title":"South African Hypertension Society commentary on the American College of Cardiology\/American Heart Association hypertension guidelines","volume":"30","author":"Rayner","year":"2019","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_27","unstructured":"(2026, February 14). National User Guide on the Prevention and Treatment of Hypertension in Adults at Primary Health Care Level|Department of Health Knowledge Hub, Available online: https:\/\/knowledgehub.health.gov.za\/elibrary\/national-user-guide-prevention-and-treatment-hypertension-adults-primary-health-care-level."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Makukule, A., Modjadji, P., Thovhogi, N., Mokgalaboni, K., and Kengne, A.P. (2023). Uncontrolled Hypertension, Treatment, and Predictors among Hypertensive Out-Patients Attending Primary Health Facilities in Johannesburg, South Africa. Healthcare, 11.","DOI":"10.3390\/healthcare11202783"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.2147\/PPA.S412198","article-title":"A Systematic Review of the Hill-Bone Compliance to Blood Pressure Therapy Scale","volume":"17","author":"Delva","year":"2023","journal-title":"Patient Prefer. Adherence"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Nakwafila, O., Mashamba-Thompson, T., Godi, A., and Sartorius, B. (2022). A Cross-Sectional Study on Hypertension Medication Adherence in a High-Burden Region in Namibia: Exploring Hypertension Interventions and Validation of the Namibia Hill-Bone Compliance Scale. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19074416"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.2147\/PPA.S548210","article-title":"Clinical Implementation of the Hill-Bone Compliance to High Blood Pressure Therapy Scale: Antihypertensive Adherence Assessment in a Romanian Cardiology Outpatient Center","volume":"19","author":"Tatar","year":"2025","journal-title":"Patient Prefer. Adherence"},{"key":"ref_32","unstructured":"IBM Corp (IBM SPSS Statistics for Windows, 2024). IBM SPSS Statistics for Windows, version 30.0."},{"key":"ref_33","unstructured":"Statistics, S.A. (2026, January 21). Non-Communicable Diseases in South Africa: Findings from Death Notifications 2008\u20132018, Available online: https:\/\/www.statssa.gov.za\/publications\/Report-03-08-01\/Report-03-08-012018.pdf#:~:text=The%20prevalence%20of%20hypertension%20was%20found%20particularly."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Rezaianzadeh, A., Johari, M.G., Baeradeh, N., Seif, M., and Hosseini, S.V. (2024). Sex differences in hypertension incidence and risk factors: A population-based cohort study in Southern Iran. BMC Public Health, 24.","DOI":"10.1186\/s12889-024-21082-8"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12265-019-09888-z","article-title":"Gender Differences in Hypertension","volume":"13","author":"Song","year":"2020","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Cheng, W., Du, Y., Zhang, Q., Wang, X., He, C., He, J., Jing, F., Ren, H., Guo, M., and Tian, J. (2022). Age-related changes in the risk of high blood pressure. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.939103"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Santosa, A., Zhang, Y., Weinehall, L., Zhao, G., Wang, N., Zhao, Q., Wang, W., and Ng, N. (2020). Gender differences and determinants of prevalence, awareness, treatment and control of hypertension among adults in China and Sweden. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-09862-4"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17553","DOI":"10.1038\/s41598-021-96175-0","article-title":"Trends and age-period-cohort effects on hypertension mortality rates from 1998 to 2018 in Mexico","volume":"11","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tasi\u0107, T., Tadi\u0107, M., and Lozi\u0107, M. (2022). Hypertension in women. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.905504"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Afshari, M., Alizadeh-Navaei, R., and Moosazadeh, M. (2021). Oral contraceptives and hypertension in women: Results of the enrolment phase of Tabari Cohort Study. BMC Women\u2019s Health, 21.","DOI":"10.1186\/s12905-021-01376-4"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0953-6205(99)00027-8","article-title":"Treatment of isolated systolic hypertension in the elderly: Evidence from three clinical trials","volume":"10","author":"Staessen","year":"1999","journal-title":"Eur. J. Intern. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.amjmed.2016.08.032","article-title":"Isolated Systolic Hypertension: An Update After SPRINT","volume":"129","author":"Bavishi","year":"2016","journal-title":"Am. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4102\/safp.v64i1.5403","article-title":"Blood pressure control in hypertensive patients attending a rural community health centre in Gauteng Province, South Africa: A cross-sectional study","volume":"64","author":"Onwukwe","year":"2022","journal-title":"S. Afr. Fam. Pract."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Mundagowa, P.T., Zambezi, P., and Muchemwa-Munasirei, P. (2024). The prevalence and determinants of blood pressure control among hypertension patients in eastern Zimbabwe: A cross-sectional study. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0293812"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Masilela, C., Pearce, B., Ongole, J.J., Adeniyi, O.V., and Benjeddou, M. (2020). Cross-sectional study of prevalence and determinants of uncontrolled hypertension among South African adult residents of Mkhondo municipality. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-09174-7"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Adeniyi, O.V., Yogeswaran, P., Longo-Mbenza, B., and Ter Goon, D. (2016). Uncontrolled Hypertension and Its Determinants in Patients with Concomitant Type 2 Diabetes Mellitus (T2DM) in Rural South Africa. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150033"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1038\/s41598-020-58685-1","article-title":"Unhealthy behaviors and risk of uncontrolled hypertension among treated individuals-The CONSTANCES population-based study","volume":"10","author":"Cherfan","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sai Sushma, K., Kumar, S., Gujjarlapudi, C., Srividya, V.B., Verma, M., Nagamani, N.G., Jothula, K.Y., Jaswal, N., and Goel, S. (2025). Unhealthy behaviours associated with uncontrolled hypertension among adults in India-Insights from a national survey. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0310099"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nguyen, P.H., Goldberg, R.J., Allison, J.J., Nguyen, D.B., Tran, H.T., Tran, O.M., Ha, D.A., Nguyen, H.L., Tran, B.A., and Wang, B. (2024). Lifestyle practices and associated factors among adults with hypertension: Conquering Hypertension in Vietnam-solutions at the grassroots level study. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0303354"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6668436","DOI":"10.1155\/2024\/6668436","article-title":"Blood Pressure Control and Associated Factors among Hypertension Comorbid Type 2 Diabetic Patients in Southeast Ethiopia","volume":"2024","author":"Desta","year":"2024","journal-title":"Int. J. Hypertens."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.4102\/safp.v67i1.6136","article-title":"Adherence to hypertension management at a rural hospital in Limpopo: A cross-sectional study","volume":"67","author":"Sikhau","year":"2025","journal-title":"S. Afr. Fam. Pract."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.amepre.2022.11.002","article-title":"Factors Associated with Blood Pressure Control Among Patients in Community Health Centers","volume":"64","author":"Huguet","year":"2023","journal-title":"Am. J. Prev. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E42","DOI":"10.5888\/pcd20.220231","article-title":"Determinants of Adherence to Antihypertension Medications Among Patients at a Tertiary Care Hospital in Islamabad, Pakistan, 2019","volume":"20","author":"Noreen","year":"2023","journal-title":"Prev. Chronic. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Horne, R., Cooper, V., Wileman, V., and Chan, A. (2019). Supporting adherence to medicines for long-term conditions. Eur. Psychol., 24.","DOI":"10.1027\/1016-9040\/a000353"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1751-7117.2000.tb00211.x","article-title":"Development and testing of the Hill-Bone Compliance to High Blood Pressure Therapy Scale","volume":"15","author":"Kim","year":"2000","journal-title":"Prog. Cardiovasc. Nurs."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"23743735241241176","DOI":"10.1177\/23743735241241176","article-title":"Barriers and Facilitators of Medication Adherence in Hypertension Patients: A Meta-Integration of Qualitative Research","volume":"11","author":"Zhou","year":"2024","journal-title":"J. Patient Exp."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40885-018-0104-6","article-title":"Adverse effects and non-adherence to antihypertensive medications in University of Gondar Comprehensive Specialized Hospital","volume":"25","author":"Gebreyohannes","year":"2019","journal-title":"Clin. Hypertens."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e5641","DOI":"10.1097\/MD.0000000000005641","article-title":"Nonadherence to antihypertensive drugs: A systematic review and meta-analysis","volume":"96","author":"Abegaz","year":"2017","journal-title":"Medicine"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4102\/HSAG.v29i0.2428","article-title":"Experiences of schizophrenia patients with treatment buddy support during the COVID-19 pandemic [compliance; antipsychotic medication; medication adherence; schizophrenia; treatment support]","volume":"29","author":"Mvunelo","year":"2024","journal-title":"Health SA Gesondheid"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e63742","DOI":"10.2196\/63742","article-title":"Digital Health Interventions to Support Chronic Disease Management: Systematic Scoping Review","volume":"14","author":"Joachim","year":"2026","journal-title":"JMIR mHealth uHealth"}],"container-title":["Epidemiologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-3986\/7\/3\/82\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:41:21Z","timestamp":1781160081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-3986\/7\/3\/82"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["epidemiologia7030082"],"URL":"https:\/\/doi.org\/10.3390\/epidemiologia7030082","relation":{},"ISSN":["2673-3986"],"issn-type":[{"value":"2673-3986","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]}}}