{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:37:59Z","timestamp":1786624679088,"version":"build-2736575974"},"reference-count":65,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiologia"],"abstract":"<jats:p>Background\/Objectives: Rhegmatogenous retinal detachment (RRD) is a vision-threatening condition characterized by the separation of the neurosensory retina from the retinal pigment epithelium due to retinal breaks, leading to subretinal fluid accumulation. This narrative review aims to provide a comprehensive overview of the epidemiology, risk factors, and historical evolution of RRD from a global perspective, highlighting trends, regional variations, and key advancements to inform clinical practice and future research. Methods: A targeted literature search was conducted using databases such as PubMed and Scopus to identify studies published from 1970 to 2025 on RRD epidemiology, risk factors, incidence rates and temporal trends. The inclusion criteria focused on population-based studies, meta-analyses, and reviews. The findings were synthesized narratively, with quantitative estimates reported where available from the included studies and meta-analyses. Results: The global annual incidence of RRD is estimated at 12.17 per 100,000 people, with significant regional variations: it is the highest in Europe (14.52 per 100,000) and lower in the Americas (8.95 per 100,000). The incidence of rhegmatogenous retinal detachment has risen by 5.4 cases per 100,000 people per decade, with projections suggesting that it could double over the next 20 years. The key risk factors include myopia (3\u201339-fold increased risk depending on severity), age (peak in 60\u201370s), male sex, cataract surgery, and trauma. Conclusions: The RRD incidence is rising globally, driven by aging populations and increasing myopia prevalence, with myopia as the strongest potentially modifiable risk factor. Historical advancements underscore the importance of early detection and surgical intervention. Future efforts should focus on applying preventive strategies in high-risk groups and addressing regional disparities in access to care.<\/jats:p>","DOI":"10.3390\/epidemiologia7040109","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:33:46Z","timestamp":1786620826000},"page":"109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology and Risk Factors of Rhegmatogenous Retinal Detachment: A Global and Historical Perspective"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6825-5283","authenticated-orcid":false,"given":"Keshav","family":"Sehgal","sequence":"first","affiliation":[{"name":"Institute of Ophthalmology, University College London, London EC1V 9EL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3459-050X","authenticated-orcid":false,"given":"Asterios","family":"Diafas","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital, London EC1V 2PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-2785","authenticated-orcid":false,"given":"Nikolaos","family":"Dervenis","sequence":"additional","affiliation":[{"name":"Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-2161","authenticated-orcid":false,"given":"Panagiotis","family":"Dervenis","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital, London EC1V 2PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.survophthal.2023.11.005","article-title":"International Incidence and Temporal Trends for Rhegmatogenous Retinal Detachment: A Systematic Review and Meta-Analysis","volume":"69","author":"Ge","year":"2024","journal-title":"Surv. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1136\/bjo.2009.157727","article-title":"The Epidemiology of Rhegmatogenous Retinal Detachment: Geographical Variation and Clinical Associations","volume":"94","author":"Mitry","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1620\/tjem.248.159","article-title":"Historical, Current and Future Approaches to Surgery for Rhegmatogenous Retinal Detachment","volume":"248","author":"Kunikata","year":"2019","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000499489","article-title":"Incidence of Rhegmatogenous Retinal Detachment in Europe\u2014A Systematic Review and Meta-Analysis","volume":"242","author":"Li","year":"2019","journal-title":"Ophthalmologica"},{"key":"ref_5","first-page":"303","article-title":"Jules Gonin. Pioneer of Retinal Detachment Surgery","volume":"51","author":"Wolfensberger","year":"2003","journal-title":"Indian J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ophtha.2012.09.001","article-title":"The Incidence of Rhegmatogenous Retinal Detachment in The Netherlands","volume":"120","author":"Hooymans","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/sj.eye.6700188","article-title":"Retinal Detachment in Developing Countries","volume":"16","author":"Yorston","year":"2002","journal-title":"Eye"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF02944107","article-title":"Remarks on the Separation of the Retina from the Chorioidea","volume":"26","author":"Hildige","year":"1858","journal-title":"Dublin Q. J. Med. Sci."},{"key":"ref_9","unstructured":"Gonin, J. (1934). Le D\u00e9collement de la R\u00e9tine: Pathog\u00e9nie, Traitement, Librairie Payot."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s10354-025-01085-9","article-title":"A Review of Rhegmatogenous Retinal Detachment: Past, Present and Future","volume":"175","author":"Xiong","year":"2025","journal-title":"Wien. Med. Wochenschr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archopht.1951.01700010004001","article-title":"Retinal Detachment and Aphakia","volume":"45","author":"Schepens","year":"1951","journal-title":"AMA Arch. Ophthalmol."},{"key":"ref_12","first-page":"476","article-title":"Treatment of retinal detachment by circumscribed diathermal coagulation and by scleral depression in the area of tear caused by imbedding of a plastic implant","volume":"129","author":"Custodis","year":"1956","journal-title":"Klin. Monatsblatter Augenheilkd. Augenarztl. Fortbild."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/archopht.1958.00940080967016","article-title":"Use of the Schepens Binocular Indirect Ophthalmoscope in Operations","volume":"60","author":"Ross","year":"1958","journal-title":"AMA Arch. Ophthalmol."},{"key":"ref_14","first-page":"813","article-title":"Vitrectomy: A Pars Plana Approach","volume":"75","author":"Machemer","year":"1971","journal-title":"Trans.\u2014Am. Acad. Ophthalmol. Otolaryngol. Am. Acad. Ophthalmol. Otolaryngol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0039-6257(98)00023-X","article-title":"Proliferative Vitreoretinopathy: An Overview","volume":"43","author":"Pastor","year":"1998","journal-title":"Surv. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.survophthal.2008.06.008","article-title":"Pneumatic Retinopexy for the Repair of Retinal Detachments: A Comprehensive Review (1986\u20132007)","volume":"53","author":"Chan","year":"2008","journal-title":"Surv. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0161-6420(02)01179-X","article-title":"A New 25-Gauge Instrument System for Transconjunctival Sutureless Vitrectomy Surgery","volume":"109","author":"Fujii","year":"2002","journal-title":"Ophthalmology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.ophtha.2010.06.014","article-title":"Small-Gauge Pars Plana Vitrectomy: A Report by the American Academy of Ophthalmology","volume":"117","author":"Recchia","year":"2010","journal-title":"Ophthalmology"},{"key":"ref_19","first-page":"328","article-title":"Outcomes of Surgery in Proliferative Vitreoretinopathy","volume":"120","author":"Danielescu","year":"2016","journal-title":"Rev. Med. Chir. Soc. Med. Nat. Iasi"},{"key":"ref_20","first-page":"90","article-title":"The Natural History of Untreated Rhegmatogenous Retinal Detachment","volume":"211","year":"2010","journal-title":"Ophthalmologica"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/aos.14876","article-title":"The History of Pneumatic Retinopexy: Have We Come Full Circle?","volume":"100","author":"Muni","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e000474","DOI":"10.1136\/bmjophth-2020-000474","article-title":"Rhegmatogenous Retinal Detachment: A Review of Current Practice in Diagnosis and Management","volume":"5","author":"Sultan","year":"2020","journal-title":"BMJ Open Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/aos.14380","article-title":"The Incidence of Rhegmatogenous Retinal Detachment Is Increasing","volume":"98","author":"Nielsen","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/aos.13113","article-title":"Epidemiologic Characteristics of Retinal Detachment Surgery at a Specialized Unit in Denmark","volume":"94","author":"Poulsen","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00417-024-06392-2","article-title":"The Rising Tide of Rhegmatogenous Retinal Detachment in Germany: A Nationwide Analysis of the Incidence, from 2005 to 2021","volume":"262","author":"Alfaar","year":"2024","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Park, S.J., Choi, N.-K., Park, K.H., and Woo, S.J. (2013). Five Year Nationwide Incidence of Rhegmatogenous Retinal Detachment Requiring Surgery in Korea. PLoS ONE, 8.","DOI":"10.1371\/annotation\/76b28079-ccd7-4f49-9cef-10498424a471"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/BF00184088","article-title":"Epidemiologic Characteristics of Rhegmatogenous Retinal Detachment in Kumamoto, Japan","volume":"233","author":"Sasaki","year":"1995","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0161-6420(99)90018-0","article-title":"Retinal Detachment in Olmsted County, Minnesota, 1976 through 1995","volume":"106","author":"Rowe","year":"1999","journal-title":"Ophthalmology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/sj.eye.6702202","article-title":"Demand Incidence of Retinal Detachment in Brazil","volume":"21","author":"Lira","year":"2007","journal-title":"Eye"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/eye.2015.43","article-title":"Ethnic Variation in Rhegmatogenous Retinal Detachments","volume":"29","author":"Chandra","year":"2015","journal-title":"Eye"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"(2025, September 21). Incidence of Retinal Detachment in Germany: Results from the Gutenberg Health Study|Ophthalmologica|Karger Publishers. Available online: https:\/\/karger.com\/oph\/article-abstract\/244\/2\/133\/256017\/Incidence-of-Retinal-Detachment-in-Germany-Results?redirectedFrom=fulltext.","DOI":"10.1159\/000513080"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1167\/iovs.10-5400","article-title":"The Epidemiology and Socioeconomic Associations of Retinal Detachment in Scotland: A Two-Year Prospective Population-Based Study","volume":"51","author":"Mitry","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","first-page":"e92028","article-title":"Seasonal Variation of Rhegmatogenous Retinal Detachment: A Systematic Literature Review","volume":"17","author":"Tooulias","year":"2025","journal-title":"Cureus"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1097\/IAE.0000000000004627","article-title":"Seasonal Variation in the Incidence of Rhegmatogenous Retinal Detachment Worldwide: A Systematic Review","volume":"45","author":"Far","year":"2025","journal-title":"Retina"},{"key":"ref_36","first-page":"167","article-title":"Risk of Retinal Detachment after Cataract Extraction, 1980\u20132004: A Population-Based Study","volume":"104","author":"Erie","year":"2006","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Park, J.Y., Byun, S.J., Woo, S.J., Park, K.H., and Park, S.J. (2021). Increasing Trend in Rhegmatogenous Retinal Detachment in Korea from 2004 to 2015. BMC Ophthalmol., 21.","DOI":"10.1186\/s12886-021-02157-1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1167\/iovs.02-0526","article-title":"Refractive Errors, Axial Ocular Dimensions, and Age-Related Cataracts: The Tanjong Pagar Survey","volume":"44","author":"Wong","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9430","DOI":"10.1038\/s41598-023-35520-x","article-title":"Epidemiology of Rhegmatogenous Retinal Detachment in Commercially Insured Myopes in the United States","volume":"13","author":"Ludwig","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"101158","DOI":"10.1016\/j.preteyeres.2022.101158","article-title":"The Genetics and Disease Mechanisms of Rhegmatogenous Retinal Detachment","volume":"97","author":"Govers","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/IAE.0000000000004641","article-title":"Clinical and Demographic Risk Factors Associated with Recurrent and Fellow Eye Rhegmatogenous Retinal Detachments","volume":"46","author":"Felfeli","year":"2022","journal-title":"Retina"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.survophthal.2025.04.006","article-title":"Prevention of Rhegmatogenous Retinal Detachment","volume":"70","author":"Chronopoulos","year":"2025","journal-title":"Surv. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40942-024-00552-6","article-title":"Management, Risk Factors and Treatment Outcomes of Rhegmatogenous Retinal Detachment Associated with Giant Retinal Tears: Scoping Review","volume":"10","author":"Babar","year":"2024","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.ophtha.2008.03.016","article-title":"Prevalence and Risk Factors for Refractive Errors in the Singapore Malay Eye Survey","volume":"115","author":"Saw","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.ophtha.2010.11.031","article-title":"The Predisposing Pathology and Clinical Characteristics in the Scottish Retinal Detachment Study","volume":"118","author":"Mitry","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ophtha.2006.01.001","article-title":"Risk Factors for Retinal Detachment after Cataract Surgery: A Case-Control Study","volume":"113","author":"Tuft","year":"2006","journal-title":"Ophthalmology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archopht.1982.01030030291012","article-title":"Epidemiology of Retinal Detachment","volume":"100","author":"Haimann","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1442-9071.2004.00003.x","article-title":"Northern New Zealand Rhegmatogenous Retinal Detachment Study: Epidemiology and Risk Factors","volume":"32","author":"Polkinghorne","year":"2004","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/archopht.123.9.1237","article-title":"Genetic Risk of Rhegmatogenous Retinal Detachment: A Familial Aggregation Study","volume":"123","author":"Go","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/sj.ejhg.5200377","article-title":"Stickler Syndrome: Further Mutations in COL11A1 and Evidence for Additional Locus Heterogeneity","volume":"7","author":"Martin","year":"1999","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0039-6257(79)90048-1","article-title":"Lattice Degeneration of the Retina","volume":"23","author":"Byer","year":"1979","journal-title":"Surv. Ophthalmol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1136\/bjophthalmol-2015-307481","article-title":"Epidemiology and Clinical Characteristics of Rhegmatogenous Retinal Detachment in Taiwan","volume":"100","author":"Chen","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archopht.117.3.379","article-title":"Racial Difference in the Incidence of Retinal Detachment in Singapore","volume":"117","author":"Wong","year":"1999","journal-title":"Arch. Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000055619","article-title":"Epidemiological Study of Nontraumatic Phakic Rhegmatogenous Retinal Detachment","volume":"32","year":"2000","journal-title":"Ophthalmic Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/09286586.2024.2434733","article-title":"Atraumatic Rhegmatogenous Retinal Detachment: Epidemiology and Association with Refractive Error in U.S. Armed Forces Service Members","volume":"32","author":"Lee","year":"2025","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/aos.17533","article-title":"Incidence and Risk Factors of Rhegmatogenous Retinal Detachment Following Paediatric Cataract Surgery: A Systematic Review and Meta-Analysis","volume":"103","author":"Serhan","year":"2025","journal-title":"Acta Ophthalmol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/s41433-024-03478-3","article-title":"Refractive Lens Exchange\u2014The Evidence behind the Practise","volume":"39","author":"Chan","year":"2025","journal-title":"Eye"},{"key":"ref_58","first-page":"12","article-title":"Rhegmatogenous Retinal Detachment\u2014An Ophthalmologic Emergency","volume":"111","author":"Feltgen","year":"2014","journal-title":"Dtsch. \u00c4rztebl. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.survophthal.2007.10.007","article-title":"Recent Trends in the Management of Rhegmatogenous Retinal Detachment","volume":"53","author":"Sodhi","year":"2008","journal-title":"Surv. Ophthalmol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Carpineto, P., Licata, A.M., and Ciancaglini, M. (2023). Proliferative Vitreoretinopathy: A Reappraisal. J. Clin. Med., 12.","DOI":"10.3390\/jcm12165287"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jamaophthalmol.2019.3103","article-title":"Current Prevalence of Myopia and Association of Myopia With Environmental Factors Among Schoolchildren in Japan","volume":"137","author":"Yotsukura","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0161-6420(99)00049-4","article-title":"Evidence-Based Analysis of Prophylactic Treatment of Asymptomatic Retinal Breaks and Lattice Degeneration","volume":"107","author":"Wilkinson","year":"2000","journal-title":"Ophthalmology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.ophtha.2007.12.019","article-title":"Outdoor Activity Reduces the Prevalence of Myopia in Children","volume":"115","author":"Rose","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ophtha.2018.05.029","article-title":"Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of 0.05%, 0.025%, and 0.01% Atropine Eye Drops in Myopia Control","volume":"126","author":"Yam","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10462-024-10736-z","article-title":"A Comprehensive Review of Artificial Intelligence Models for Screening Major Retinal Diseases","volume":"57","author":"Hassan","year":"2024","journal-title":"Artif. Intell. Rev."}],"container-title":["Epidemiologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-3986\/7\/4\/109\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:16:13Z","timestamp":1786623373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-3986\/7\/4\/109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["epidemiologia7040109"],"URL":"https:\/\/doi.org\/10.3390\/epidemiologia7040109","relation":{},"ISSN":["2673-3986"],"issn-type":[{"value":"2673-3986","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}