{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:34:05Z","timestamp":1786700045646,"version":"build-2736575974"},"reference-count":69,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004252","name":"Qatar University High Impact Grant","doi-asserted-by":"publisher","award":["QUHI-BRC-20_21-1"],"award-info":[{"award-number":["QUHI-BRC-20_21-1"]}],"id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"publisher"}]},{"award":["QUHI-BRC-20_21-1"],"award-info":[{"award-number":["QUHI-BRC-20_21-1"]}],"id":[{"id":"https:\/\/ror.org\/00yhnba62","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiologia"],"abstract":"<jats:p>Background and Objectives: Human populations show striking phenotypic disparities in traits and diseases, including responses to infectious diseases (IDs). The impact of host genetic diversity on infection susceptibility and outcomes is increasingly recognized, yet remains largely unknown in Qatar. Here, we explored the distribution of infection-related host genetic variants in Qatar. Materials and Methods: Infection-related genetic variants from the GWAS Catalog were analyzed in 6047 Qatari whole genomes from the Qatar Genome Program (QGP) and compared with populations from the 1000 Genomes Project (1000G). Results: Out of 272,610 GWAS Catalog associations, 1086 were related to ID susceptibility, resistance, severity, progression, clearance, response to treatment, or vaccination, and hence included in the subsequent analysis. A significant heterogeneity in the allelic frequencies (AFs) between Qatari (n = 6047) and the 1000G populations (n = 2504) was observed. The QGP cohort carries significantly lower AFs of most risk variants associated with susceptibility to tuberculosis, malaria, hepatitis, diarrheal disease, and shingles (up to 222-fold, p &lt; 0.0001). Contrarily, an enrichment in the AFs of variants that increase the risk of chickenpox, plantar warts, pneumonia, urinary tract infections (UTIs), and leprosy was observed among Qatari individuals, yet with much smaller-fold differences (\u22645-fold, p &lt; 0.0001). In addition, most severity\/chronicity-related variants were considerably less prevalent in the Qatari population (up to 20.5-fold). Analysis of variants associated with antibody response revealed a distinct genetic distribution, especially in Epstein\u2013Barr virus (EBV) and Chlamydia pneumoniae infections (27.8- and 3-fold, respectively). Moreover, a variable inter-population allelic distribution was observed in SNPs related to measles, mumps, and rubella (MMR), smallpox, and hepatitis B virus (HBV) vaccine response, as well as variants linked to viral clearance, viral load, virus-induced progression to cancer, and response to treatment. Conclusions: These findings reveal substantial differences in pathogen-associated host variants in a diverse Qatari cohort and highlight the need for follow-up validation and future GWAS discovery efforts.<\/jats:p>","DOI":"10.3390\/epidemiologia7040110","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:08:29Z","timestamp":1786694909000},"page":"110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Determinants of Infectious Diseases in the Qatari Population"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-0130","authenticated-orcid":false,"given":"Maria K.","family":"Smatti","sequence":"first","affiliation":[{"name":"Biomedical Research Center, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-6360","authenticated-orcid":false,"given":"Yasser A.","family":"Al-Sarraj","sequence":"additional","affiliation":[{"name":"College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Doha P.O. Box 34110, Qatar"},{"name":"Qatar Precision Health Institute (QPHI), Qatar Foundation, Ar-Rayyan P.O. Box 5825, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-5983","authenticated-orcid":false,"given":"Omar","family":"Albagha","sequence":"additional","affiliation":[{"name":"College of Health and Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Doha P.O. Box 34110, Qatar"},{"name":"Diabetes Research Center (DRC), Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Doha P.O. Box 34110, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi M.","family":"Yassine","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, QU Health, Qatar University, Doha P.O. Box 2713, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref_1","unstructured":"UNICEF (2018). C4D in Emergency Response, Emerging Infectious Disease, UNICEF."},{"key":"ref_2","unstructured":"Walsh, B. (2020, March 28). COVID-19: The History of Pandemics: BBC. Available online: https:\/\/www.bbc.com\/future\/article\/20200325-covid-19-the-history-of-pandemics."},{"key":"ref_3","unstructured":"World Health Organization (2013). Mortality and Global Health Estimates: World Health Organization, World Health Organization."},{"key":"ref_4","unstructured":"Johnson k Davies, D.M. (2025, January 13). Infectious Diseases Projected To Be No. 1 Killer Worldwide By 2050: Texax Public Radio. Available online: https:\/\/www.tpr.org\/post\/infectious-diseases-projected-be-no-1-killer-worldwide-2050."},{"key":"ref_5","unstructured":"World Health Organization Regional Office for the Eastern Mediterranean (2020). Strategic Framework for the Prevention and Control of Emerging and Epidemic-Prone Infectious Diseases in the Eastern Mediterranean Region 2019\u20132023, WHO Regional Office for the Eastern Mediterranean. Available online: https:\/\/applications.emro.who.int\/docs\/WHOEMCSR293E-eng.pdf."},{"key":"ref_6","unstructured":"(2022, March 05). Emerging Infectious Disease Outbreaks Reported in the Eastern Mediterranean Region in 2017: World Health Organization. Available online: http:\/\/www.emro.who.int\/pandemic-epidemic-diseases\/news\/emerging-infectious-disease-outbreaks-reported-in-the-eastern-mediterranean-region-in-2017.html."},{"key":"ref_7","unstructured":"(2025, January 13). Communicable Diseases: Ministry of Public Health, Available online: https:\/\/www.moph.gov.qa\/english\/strategies\/Supporting-Strategies-and-Frameworks\/QatarPublicHealthStrategy\/Pages\/Communicable-diseases.aspx."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/1469-0691.12789","article-title":"Host genetics: Deciphering the variability in susceptibility to infections","volume":"20","author":"Antonelli","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrg3114","article-title":"Human genetic susceptibility to infectious disease","volume":"13","author":"Chapman","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1875217","DOI":"10.1155\/2018\/1875217","article-title":"Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies","volume":"2018","author":"Mboowa","year":"2018","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1093\/aje\/kwz084","article-title":"Qatar Biobank Cohort Study: Study Design and First Results","volume":"188","author":"Fthenou","year":"2019","journal-title":"Am. J. Epidemiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: A tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/s41467-021-21381-3","article-title":"Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits","volume":"12","author":"Thareja","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_14","unstructured":"(2020, March 28). Diarrhoeal Disease: WHO. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diarrhoeal-disease."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1053\/j.gastro.2018.12.014","article-title":"Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus","volume":"156","author":"Vergara","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1093\/infdis\/jiaa677","article-title":"A Multiancestry Sex-Stratified Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus","volume":"223","author":"Vergara","year":"2021","journal-title":"J. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Nishida, N., Sawai, H., Matsuura, K., Sugiyama, M., Ahn, S.H., Park, J.Y., Hige, S., Kang, J.-H., Suzuki, K., and Kurosaki, M. (2012). Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0039175"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature15390","article-title":"A novel locus of resistance to severe malaria in a region of ancient balancing selection","volume":"526","author":"Band","year":"2015","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature11334","article-title":"Genome-wide association study indicates two novel resistance loci for severe malaria","volume":"489","author":"Timmann","year":"2012","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Quistrebert, J., Orlova, M., Kerner, G., Ton, L.T., Luong, N.T., Danh, N.T., Vincent, Q.B., Jabot-Hanin, F., Seeleuthner, Y., and Bustamante, J. (2021). Genome-wide association study of resistance to Mycobacterium tuberculosis infection identifies a locus at 10q26.2 in three distinct populations. PLoS Genet., 17.","DOI":"10.1371\/journal.pgen.1009392"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ajhg.2016.01.015","article-title":"A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals","volume":"98","author":"Sobota","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/jnci\/djr516","article-title":"Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups","volume":"104","author":"Urayama","year":"2012","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1158\/1078-0432.CCR-17-2537","article-title":"Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma","volume":"24","author":"Li","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1038\/s41598-018-26217-7","article-title":"Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma","volume":"8","author":"Sawai","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/ng.638","article-title":"Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers","volume":"42","author":"Zhang","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Li, S., Qian, J., Yang, Y., Zhao, W., Dai, J., Bei, J.-X., Foo, J.N., McLaren, P.J., Li, Z., and Yang, J. (2012). GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet., 8.","DOI":"10.1371\/journal.pgen.1002791"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ng.2483","article-title":"Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma","volume":"45","author":"Jiang","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng.809","article-title":"Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma","volume":"43","author":"Kumar","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jhep.2012.12.024","article-title":"A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region","volume":"58","author":"Urabe","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1053\/j.gastro.2017.01.041","article-title":"Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection","volume":"152","author":"Matsuura","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/hmg\/ddy390","article-title":"Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection","volume":"28","author":"Takeuchi","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/infdis\/jiz294","article-title":"Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial","volume":"220","author":"Ekenberg","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1038\/s41467-021-25287-y","article-title":"Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes","volume":"12","author":"Razali","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/humu.24336","article-title":"Qatar genome: Insights on genomics from the Middle East","volume":"43","author":"Mbarek","year":"2022","journal-title":"Hum. Mutat."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Garcell, H.G., Zen\u00f3n, V.E.R., Cruz, Z.G., and Serrano, R.N.A. (2016). Diagnostic Delay of Tuberculosis in Qatar: Results of an Exploratory Study. Qatar Foundation Annual Research Conference Proceedings, HBKU Press.","DOI":"10.5339\/qfarc.2016.HBPP1416"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijmyco.2014.10.052","article-title":"Tuberculosis in Qatar","volume":"4","year":"2015","journal-title":"Int. J. Mycobacteriol."},{"key":"ref_37","unstructured":"Ministry of Public Health (2018). HP&CDC Communicable Diseases\u2014BULLETIN 2018."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e2018050","DOI":"10.4084\/mjhid.2018.050","article-title":"Epidemiology of Malaria in the State of Qatar, 2008\u20132015","volume":"10","author":"Farag","year":"2018","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/2050640615580725","article-title":"Screening for hepatitis C in average and high-risk populations of Qatar using rapid point-of-care testing","volume":"3","author":"Sharma","year":"2015","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Al Romaihi, H.E., Ganesan, N., Farag, E.A., Smatti, M.K., Nasrallah, G.K., Himatt, S.M., Derbala, M.F., Alshamali, M., Mahadoon, L.K., and Khogali, H.S. (2019). Demographics and epidemiology of hepatitis B in the State of Qatar: A five-year surveillance-based incidence study. Pathogens, 8.","DOI":"10.3390\/pathogens8020068"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.3748\/wjg.v24.i27.3038","article-title":"Systematic overview of hepatitis C infection in the Middle East and North Africa","volume":"24","author":"Chaabna","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Al-Qahtani, A.A., Al-Anazi, M.R., Abdo, A.A., Sanai, F.M., Al-Hamoudi, W., Alswat, K.A., Al-Ashgar, H.I., Khalaf, N.Z., Eldali, A.M., and Viswan, N.A. (2014). Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0080445"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/jmedgenet-2013-101724","article-title":"Genome-wide association study of chronic hepatitis B virus infection reveals a novel candidate risk allele on 11q22.3","volume":"50","author":"Khalak","year":"2013","journal-title":"J. Med. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.humimm.2017.10.006","article-title":"Association of TNF-Alpha gene polymorphisms and susceptibility to hepatitis B virus infection in Egyptians","volume":"78","author":"Talaat","year":"2017","journal-title":"Hum. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Harfouche, M., Chemaitelly, H., Kouyoumjian, S.P., Mahmud, S., Chaabna, K., Al-Kanaani, Z., and Abu-Raddad, L.J. (2017). Hepatitis C virus viremic rate in the Middle East and North Africa: Systematic synthesis, meta-analyses, and meta-regressions. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187177"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107586","DOI":"10.1016\/j.isci.2023.107586","article-title":"Genome-wide association study identifies several loci for HEV seropositivity","volume":"26","author":"Smatti","year":"2023","journal-title":"iScience"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/infdis\/jit655","article-title":"A FUT2 gene common polymorphism determines resistance to rotavirus A of the P [8] genotype","volume":"209","author":"Besse","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Carlsson, B., Kindberg, E., Buesa, J., Rydell, G.E., Lid\u00f3n, M.F., Montava, R., Abu Mallouh, R., Grahn, A., Rodr\u00edguez-D\u00edaz, J., and Bellido, J. (2009). The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005593"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1093\/molbev\/msp108","article-title":"A natural history of FUT2 polymorphism in humans","volume":"26","author":"Sikora","year":"2009","journal-title":"Mol. Biol. Evol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s10096-020-04108-y","article-title":"Epidemiological, molecular, and clinical features of rotavirus infections among pediatrics in Qatar","volume":"40","author":"Mathew","year":"2021","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Cadogan, S.L., Mindell, J.S., Breuer, J., Hayward, A., and Warren-Gash, C. (2022). Prevalence of and factors associated with herpes zoster in England: A cross-sectional analysis of the Health Survey for England. BMC Infect. Dis., 22.","DOI":"10.1186\/s12879-022-07479-z"},{"key":"ref_52","first-page":"1","article-title":"Epidemiology of herpes zoster in the State of Qatar, 2012\u20132017","volume":"2020","author":"Chehab","year":"2020","journal-title":"Qatar Med. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/jrms.JRMS_979_17","article-title":"Varicella infection in the Middle East: Prevalence, complications, and vaccination","volume":"23","author":"Chehadeh","year":"2018","journal-title":"J. Res. Med. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Dimitrakopoulos, F.D., Antonacopoulou, A.G., Kottorou, A.E., Kalofonou, M., Panagopoulos, N., Dougenis, D., Makatsoris, T., Tzelepi, V., Koutras, A., and Kalofonos, H.P. (2021). Genetic Variations of CD40 and LT\u03b2R Genes Are Associated With Increased Susceptibility and Clinical Outcome of Non-Small-Cell Carcinoma Patients. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.721577"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1017\/gheg.2017.16","article-title":"Whole-genome association study of antibody response to Epstein-Barr virus in an African population: A pilot","volume":"2","author":"Sallah","year":"2017","journal-title":"Glob. Health Epidemiol. Genom."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ajhg.2015.09.008","article-title":"Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses","volume":"97","author":"Hammer","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13073-018-0568-8","article-title":"Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines","volume":"10","author":"Scepanovic","year":"2018","journal-title":"Genome Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41576-020-00297-6","article-title":"Host genetics and infectious disease: New tools, insights and translational opportunities","volume":"22","author":"Kwok","year":"2021","journal-title":"Nat. Rev. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"R265","DOI":"10.1016\/j.cub.2013.01.040","article-title":"GWAS","volume":"23","author":"Flint","year":"2013","journal-title":"Curr. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/tpj.2015.47","article-title":"Pharmacogenomic variants have larger effect sizes than genetic variants associated with other dichotomous complex traits","volume":"16","author":"Maranville","year":"2016","journal-title":"Pharmacogenom. J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"103842","DOI":"10.1016\/j.amsu.2022.103842","article-title":"HIV and AIDS-defining opportunistic illnesses in the state of Qatar: A cohort population-based retrospective study covering 17 years (2000\u20132016)","volume":"78","author":"Ali","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00439-017-1768-9","article-title":"Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine","volume":"136","author":"Haralambieva","year":"2017","journal-title":"Hum. Genet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3390\/ijerph14020166","article-title":"Possible Impact of 190G > A CCR2 and \u039432 CCR5 Mutations on Decrease of the HBV Vaccine Immunogenicity-A Preliminary Report","volume":"14","author":"Ganczak","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00251-014-0776-3","article-title":"Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients","volume":"66","author":"Kennedy","year":"2014","journal-title":"Immunogenetics"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.3129","article-title":"Common variants associated with general and MMR vaccine-related febrile seizures","volume":"46","author":"Feenstra","year":"2014","journal-title":"Nat. Genet."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e2207544120","DOI":"10.1073\/pnas.2207544120","article-title":"Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations","volume":"120","author":"Lea","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Fumagalli, M., Sironi, M., Pozzoli, U., Ferrer-Admetlla, A., Pattini, L., and Nielsen, R. (2011). Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution. PLoS Genet., 7.","DOI":"10.1371\/annotation\/ca428083-dbcb-476a-956c-d7bb6e317cf7"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrg3734","article-title":"Natural selection and infectious disease in human populations","volume":"15","author":"Karlsson","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e2217673120","DOI":"10.1073\/pnas.2217673120","article-title":"Gaucher disease protects against tuberculosis","volume":"120","author":"Fan","year":"2023","journal-title":"Proc. Natl. Acad. Sci. 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