{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:16:07Z","timestamp":1788279367241,"version":"build-2803163510"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiologia"],"abstract":"<jats:p>Background\/Objectives: The aetiology of facial clefts remains incompletely understood, and ionising radiation has been discussed as a potential exogenous factor. This review investigated the epidemiology of cleft lip and\/or palate (CL\/P) in Germany in relation to the Chernobyl NPP accident. Methods: A systematic literature search was conducted using MEDLINE, LIVIVO, and the Cochrane Library, supplemented by additional searches. OHAT risk-of-bias domains were applied to the included studies. Results: In total, 276 potentially relevant records were identified, of which six were included. Studies from Bavaria and the former German Democratic Republic reported regional associations between increased CL\/P prevalence and the Chernobyl NPP accident. None of the included studies assessed radiation exposure at the individual level; exposure assessment was regional or ecological. Conclusions: Associations were reported in some more heavily contaminated regions, whereas no statistically significant differences were found in regions affected by lower levels of fallout. One study reported an estimated additional regional exposure of 1.2 mGy in the most heavily contaminated areas. This estimate does not substitute for individual dosimetry and should be interpreted cautiously. Experimental and other sources cited in the review discuss malformation effects at doses of at least 50 mGy. Given the heterogeneous study designs, ecological exposure assessment, inadequate control of confounding, and very low certainty of evidence, the available data do not support establishing a causal relationship between Chernobyl-related exposure and CL\/P in Germany.<\/jats:p>","DOI":"10.3390\/epidemiologia7050123","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:08:43Z","timestamp":1788275323000},"page":"123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Germany\u2019s Epidemiological Data on Cleft Lip and Palate After the Chernobyl Nuclear Power Plant Accident: A Systematic Literature Review"],"prefix":"10.3390","volume":"7","author":[{"given":"Claas Willem","family":"Molsen","sequence":"first","affiliation":[{"name":"Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems an der Donau, Austria"},{"name":"Clinical Application of Artificial Intelligence in Dentistry (CAAID) Group, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstra\u00dfe 124, 3500 Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-0409","authenticated-orcid":false,"given":"Pascal","family":"Gr\u00fcn","sequence":"additional","affiliation":[{"name":"Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems an der Donau, Austria"},{"name":"Clinical Application of Artificial Intelligence in Dentistry (CAAID) Group, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstra\u00dfe 124, 3500 Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Philipp","family":"Schnell","sequence":"additional","affiliation":[{"name":"Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems an der Donau, Austria"},{"name":"Clinical Application of Artificial Intelligence in Dentistry (CAAID) Group, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstra\u00dfe 124, 3500 Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Turhani","sequence":"additional","affiliation":[{"name":"Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems an der Donau, Austria"},{"name":"Clinical Application of Artificial Intelligence in Dentistry (CAAID) Group, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstra\u00dfe 124, 3500 Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-7820","authenticated-orcid":false,"given":"Sebastian","family":"Fitzek","sequence":"additional","affiliation":[{"name":"Health Services Research Group, Medical Images Analysis and Artificial Intelligence (MIAAI), Department of Medicine, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Meier","sequence":"additional","affiliation":[{"name":"Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems an der Donau, Austria"},{"name":"Clinical Application of Artificial Intelligence in Dentistry (CAAID) Group, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstra\u00dfe 124, 3500 Krems an der Donau, Austria"},{"name":"Dental Practice, 9490 Vaduz, Liechtenstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-3191","authenticated-orcid":false,"given":"Dritan","family":"Turhani","sequence":"additional","affiliation":[{"name":"Center for Oral and Maxillofacial Surgery, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstrasse 124, 3500 Krems an der Donau, Austria"},{"name":"Clinical Application of Artificial Intelligence in Dentistry (CAAID) Group, Department of Dentistry, Faculty of Medicine and Dentistry, Danube Private University, Steiner Landstra\u00dfe 124, 3500 Krems an der Donau, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","unstructured":"Strahlenschutzkommission (2026, January 01). 20 Jahre Nach Tschernobyl\u2014Eine Bilanz aus Sicht Des Strahlenschutzes. Available online: https:\/\/ssk.de\/SharedDocs\/Beratungsergebnisse_PDF\/2006\/20JahreTschernobyl.pdf."},{"key":"ref_2","unstructured":"(2025, December 30). Gesundheitliche Folgen des Unfalls von Tschornobyl in Deutschland und Europa Au\u00dferhalb der Ehemaligen Sowjetunion Bundesamt F\u00fcr Strahlenschutz. BfS. Available online: https:\/\/www.bfs.de\/DE\/themen\/ion\/notfallschutz\/notfall\/tschornobyl\/gesundheitsfolgen-europa.html."},{"key":"ref_3","unstructured":"International Physicians for the Prevention of Nuclear War German Section (2006). Gesundheitliche Folgen von Tschernobyl: 20 Jahre nach der Reaktorkatastrophe, International Physicians for the Prevention of Nuclear War. Available online: https:\/\/www.ippnw.de\/commonFiles\/pdfs\/Atomenergie\/Gesundheitliche_Folgen_Tschernobyl.pdf."},{"key":"ref_4","unstructured":"(2025, December 30). BfS, Tschornobyl (Tschernobyl)\u2014Gesundheitliche Folgen des Unfalls von Tschornobyl in Deutschland und Europa Au\u00dferhalb der Ehemaligen Sowjetunion (2024), Web. Archive.org. Available online: https:\/\/web.archive.org\/web\/20240426192918\/https:\/www.bfs.de\/DE\/themen\/ion\/notfallschutz\/notfall\/tschornobyl\/gesundheitsfolgen-europa.html."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/1468-0009.12358","article-title":"Long-term consequences of the Chernobyl radioactive fallout: An exploration of the aggregate data","volume":"96","author":"Marino","year":"2018","journal-title":"Milbank Q."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/ije\/28.5.941","article-title":"Evaluation of the impact of Chernobyl on the prevalence of congenital anomalies in 16 regions of Europe. EUROCAT Working Group","volume":"28","author":"Dolk","year":"1999","journal-title":"Int. J. Epidemiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s004110050048","article-title":"Perinatal mortality in Germany following the Chernobyl accident","volume":"36","year":"1997","journal-title":"Radiat. Environ. Biophys."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0753-3322(91)90026-P","article-title":"Frequency of trisomy 21 in Germany before and after the Chernobyl accident","volume":"45","author":"Sperling","year":"1991","journal-title":"Biomed. Pharmacother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s004110050064","article-title":"Perinatal mortality in Bavaria, Germany, after the Chernobyl NPP accident","volume":"36","author":"Grosche","year":"1997","journal-title":"Radiat. Environ. Biophys."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-3016.1993.tb00388.x","article-title":"The Chernobyl accident, congenital anomalies and other reproductive outcomes","volume":"7","author":"Little","year":"1993","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.clon.2011.01.510","article-title":"The Chernobyl accident\u2014An epidemiological perspective","volume":"23","author":"Cardis","year":"2011","journal-title":"Clin. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_13","unstructured":"National Toxicology Program (NTP) (2025, December 30). OHAT Risk of Bias Rating Tool for Human and Animal Studies, Available online: https:\/\/ntp.niehs.nih.gov\/sites\/default\/files\/ntp\/ohat\/pubs\/riskofbiastool_508.pdf."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jclinepi.2023.05.010","article-title":"The development methods of official GRADE articles and requirements for claiming the use of GRADE\u2014A statement by the GRADE guidance group","volume":"159","author":"Brennan","year":"2023","journal-title":"J. Clin. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-0030-1267187","article-title":"Angeborene Fehlbildungen\u2014Eine systematische Kohortenstudie aus Mecklenburg-Vorpommern","volume":"214","author":"Olbertz","year":"2010","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1007\/s00784-023-05187-9","article-title":"Epidemiological and clinical evaluation of patients with a cleft in Lower Saxony Germany: A mono-center analysis","volume":"27","author":"Philipp","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0042-102345","article-title":"Pr\u00e4valenz von gastroschisis, omphalozele, spina bifida und orofazialen spaltbildungen bei neugeborenen im zeitraum Januar 2000\u2013Dezember 2010 in Leipzig, Sachsen, Sachsen-Anhalt und Deutschland","volume":"80","author":"Bremer","year":"2018","journal-title":"Gesundheitswesen"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/em.20655","article-title":"Analysis of genomic instability in the offspring of fathers exposed to low doses of ionising radiation","volume":"52","author":"Aghajanyan","year":"2011","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_19","first-page":"231","article-title":"Before and after Chernobyl accident (memoirs, researches hypotheses)","volume":"56","author":"Vorobtsova","year":"2016","journal-title":"Radiats. Biol. Radioecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00056-009-9906-1","article-title":"An evaluation of health-related quality of life (HRQoL) in a group of 4\u20137 year-old children with cleft lip and palate","volume":"70","author":"Sagheri","year":"2009","journal-title":"J. Orofac. Orthop."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1010-5182(05)80301-4","article-title":"Incidence of cleft lip, alveolus and palate forms","volume":"19","author":"Kriens","year":"1991","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijom.2005.08.007","article-title":"Influence of season on prevalence of cleft lip and palate","volume":"35","author":"Krost","year":"2006","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.33145\/2304-8336-2020-25-18-55","article-title":"Odontological effects of ionising radiation (review)","volume":"25","author":"Afanasyev","year":"2020","journal-title":"Probl. Radiat. Med. Radiobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12940-017-0273-x","article-title":"Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures","volume":"16","author":"Bazyka","year":"2017","journal-title":"Environ. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.jcms.2025.02.010","article-title":"Epidemiological analysis of the incidence of cleft lip and palate in relation to the radon concentration in the German Democratic Republic from 1980 to 1989","volume":"53","author":"Engeln","year":"2025","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_26","first-page":"5","article-title":"Incidence of facial clefts in the Magdeburg region","volume":"2","author":"Steinbicker","year":"1998","journal-title":"Mund Kiefer Gesichtschir."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s100060050129","article-title":"Spaltgeburtenrate der ehemaligen DDR vor und nach dem Reaktorunfall in Tschernobyl","volume":"3","author":"Zieglowski","year":"1999","journal-title":"Mund Kiefer Gesichtschir."},{"key":"ref_28","first-page":"106","article-title":"Cleft lip and cleft palate birth rate in Bavaria before and after the Chernobyl nuclear power plant accident","volume":"8","author":"Scherb","year":"2004","journal-title":"Mund Kiefer Gesichtschir."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/BF01720294","article-title":"Birth prevalence of congenital malformations in Bavaria, Germany, after the Chernobyl accident","volume":"11","author":"Irl","year":"1995","journal-title":"Eur. J. Epidemiol."},{"key":"ref_30","unstructured":"Petersen, S. (2002). Patienten mit Lippen-, Kiefer- und Gaumenspalten: Eine Epidemiologische Studie von 1974 bis 1998. [Doctoral Dissertation, Ruhr-University Bochum]."},{"key":"ref_31","unstructured":"Schlemme, C. (1996). Neonatalstudie \u00dcber die Frequenz von Lippen-Kiefer-Gaumenspalten im Ruhrgebiet (1984\u20131993). [Doctoral Dissertation, Ruhr-University Bochum]."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1098\/rspb.2001.1650","article-title":"Very high mutation rate in offspring of Chernobyl accident liquidators","volume":"268","author":"Weinberg","year":"2001","journal-title":"Proc. Biol. Sci."},{"key":"ref_33","unstructured":"Nriagu, J. Risk of Radiation Exposure to Children and Their Mothers. Encyclopedia of Environmental Health, Elsevier. [2nd ed.]."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1080\/09553002.2024.2306328","article-title":"A systematic review of human evidence for the intergenerational effects of exposure to ionising radiation","volume":"100","author":"Stephens","year":"2024","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00420-022-01911-2","article-title":"Low-dose ionising radiation and adverse birth outcomes: A systematic review and meta-analysis","volume":"96","author":"Frangione","year":"2023","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12982-015-0037-4","article-title":"Applying the Bradford Hill criteria in the 21st century: How data integration has changed causal inference in molecular epidemiology","volume":"12","author":"Fedak","year":"2015","journal-title":"Emerg. Themes Epidemiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"28104","DOI":"10.1038\/s41598-024-79346-7","article-title":"Maternal factors increase risk of orofacial cleft: A meta-analysis","volume":"14","author":"Cavalcante","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.3346\/jkms.2021.36.e183","article-title":"Environmental and genetic risk factors of congenital anomalies: An umbrella review of systematic reviews and meta-analyses","volume":"36","author":"Lee","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1269\/jrr.42.255","article-title":"Dependence of malformation upon gestational age and exposed dose of gamma radiation","volume":"42","author":"Kim","year":"2001","journal-title":"J. Radiat. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1667\/0033-7587(2000)154[0034:EOXIOS]2.0.CO;2","article-title":"Effect of X irradiation on secondary palate development in mice","volume":"154","author":"Hiranuma","year":"2000","journal-title":"Radiat. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/bdr2.1161","article-title":"A detailed characterization of congenital defects and mortality following moderate X-ray doses during neurulation","volume":"110","author":"Craenen","year":"2018","journal-title":"Birth Defects Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jobcr.2024.12.012","article-title":"Meta-analysis and systematic review for the genetic basis of cleft lip and palate","volume":"15","author":"Alghonemy","year":"2025","journal-title":"J. Oral Biol. Craniofacial Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11743","DOI":"10.1038\/s41598-022-15885-1","article-title":"Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip\/palate","volume":"12","author":"Awotoye","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"36","DOI":"10.31662\/jmaj.2022-0087","article-title":"Congenital anomalies in infants in Fukushima from 2011 to 2014: The Japan environment and children\u2019s study","volume":"6","author":"Nishigori","year":"2023","journal-title":"JMA J."},{"key":"ref_45","first-page":"295","article-title":"The environment and disease: Association or causation?","volume":"58","author":"Hill","year":"1965","journal-title":"Proc. R. Soc. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"15593258251367588","DOI":"10.1177\/15593258251367588","article-title":"Questioning the Linear No-Threshold Model (LNT): Lessons from Hiroshima\/Nagasaki and Fukushima","volume":"23","author":"Sutou","year":"2025","journal-title":"Dose Response"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"109979","DOI":"10.1016\/j.cbi.2022.109979","article-title":"LNTgate: How LNT benefited from editorial actions","volume":"362","author":"Calabrese","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111832","DOI":"10.1016\/j.cbi.2025.111832","article-title":"Embracing dishonesty: How LNT became king","volume":"424","author":"Calabrese","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"ref_49","first-page":"1559325820913788","article-title":"Replacing LNT: The Integrated LNT-Hormesis Model","volume":"18","author":"Kaminski","year":"2020","journal-title":"Dose-Response A Publ. Int. Hormesis Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.envpol.2018.05.051","article-title":"From Muller to mechanism: How LNT became the default model for cancer risk assessment","volume":"241","author":"Calabrese","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/cga.12388","article-title":"Chornobyl radiation-congenital anomalies: A persisting dilemma","volume":"61","author":"Wertelecki","year":"2020","journal-title":"Congenit. Anom."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/stem.5530150734","article-title":"Changes in registered congenital anomalies in the Republic of Belarus after the Chernobyl accident","volume":"15","author":"Lazjuk","year":"1997","journal-title":"Stem Cells"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sofi-Mahmudi, A., Shamsoddin, E., Khademioore, S., Khazaei, Y., Vahdati, A., and Tovani-Palone, M.R. (2025). Global, regional, and national survey on burden and Quality of Care Index (QCI) of orofacial clefts: Global burden of disease systematic analysis 1990\u20132019. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0317267"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Inchingolo, A.M., Fatone, M.C., Malcangi, G., Avantario, P., Piras, F., Patano, A., Di Pede, C., Netti, A., Ciocia, A.M., and De Ruvo, E. (2022). Modifiable risk factors of non-syndromic orofacial clefts: A systematic review. Children, 9.","DOI":"10.3390\/children9121846"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ma, Q., Wei, J., Peng, B., Liu, J., and Mo, S. (2025). Burden of orofacial clefts from 1990\u20132021 at global, regional, and national levels. Front. Pediatr., 13.","DOI":"10.3389\/fped.2025.1502877"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10006-022-01052-3","article-title":"The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility","volume":"27","author":"Askarian","year":"2023","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_57","unstructured":"Medizinische Fakult\u00e4t\/Universit\u00e4tsklinikum Magdeburg A. \u00f6. R. (2026, January 19). 8. Einsendertreffen. Available online: https:\/\/www.med.ovgu.de\/-p-2288.html."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1177\/17531934231177425","article-title":"Thalidomide upper limb embryopathy\u2013pathogenesis, past and present management and future considerations","volume":"48","author":"Vargesson","year":"2023","journal-title":"J. Hand Surg. Eur. Vol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/bdrc.21096","article-title":"Thalidomide-induced teratogenesis: History and mechanisms","volume":"105","author":"Vargesson","year":"2015","journal-title":"Birth Defects Res. C Embryo Today"}],"container-title":["Epidemiologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2673-3986\/7\/5\/123\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:21:23Z","timestamp":1788276083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2673-3986\/7\/5\/123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":59,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["epidemiologia7050123"],"URL":"https:\/\/doi.org\/10.3390\/epidemiologia7050123","relation":{},"ISSN":["2673-3986"],"issn-type":[{"value":"2673-3986","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}