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We map the precise molecular mechanisms through which these epigenetic modulators alter chromatin accessibility, drive transcriptional reprogramming, and promote phenotypic plasticity in hormone-dependent malignancies. By systematically contrasting the distinct yet overlapping epigenetic profiles of breast and ovarian tumors, we elucidate how these aberrations dictate clinical outcomes. This comprehensive synthesis offers critical insights into the dual utility of these epigenetic elements as dual-purpose diagnostic biomarkers and druggable therapeutic targets, laying the groundwork for next-generation targeted epigenetical therapies.<\/jats:p>","DOI":"10.3390\/epigenomes10030045","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:01:37Z","timestamp":1783339297000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epigenetic Mechanisms of Breast and Ovarian Cancer Development: Interplay Between DNA Methylation\/Demethylation Enzymes, MicroRNAs, and Long Non-Coding RNAs"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6246-2444","authenticated-orcid":false,"given":"Svetlana S.","family":"Lukina","sequence":"first","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-7801","authenticated-orcid":false,"given":"Irina V.","family":"Pronina","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, Federal State University of Education, 105005 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Bril","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-8075","authenticated-orcid":false,"given":"Alexey M.","family":"Burdennyy","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2668-8096","authenticated-orcid":false,"given":"Vitaly I.","family":"Loginov","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey G.","family":"Morozov","sequence":"additional","affiliation":[{"name":"Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104081","DOI":"10.1016\/j.critrevonc.2023.104081","article-title":"Risk factors for developing both primary breast and primary ovarian cancer: A systematic review","volume":"190","author":"Ferris","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lu\u010di\u0107, I., Kurtovi\u0107, M., Mlinari\u0107, M., Pite\u0161a, N., \u010cipak Ga\u0161parovi\u0107, A., Sabol, M., and Milkovi\u0107, L. (2023). Deciphering Common Traits of Breast and Ovarian Cancer Stem Cells and Possible Therapeutic Approaches. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310683"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1007\/s11033-022-07571-2","article-title":"Breast cancer in the era of precision medicine","volume":"49","author":"Sarhangi","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Longacre, M., Snyder, N.A., Housman, G., Leary, M., Lapinska, K., Heerboth, S., Willbanks, A., and Sarkar, S. (2016). A Comparative Analysis of Genetic and Epigenetic Events of Breast and Ovarian Cancer Related to Tumorigenesis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17050759"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13072-025-00636-z","article-title":"5-Hydroxymethylcytosine: A key epigenetic mark in cancer and chemotherapy response","volume":"18","author":"Kharat","year":"2025","journal-title":"Epigenet. Chromatin"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Jung, I., An, J., and Ko, M. (2023). Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy. Biomedicines, 11.","DOI":"10.3390\/biomedicines11030654"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kumar, S., Gonzalez, E.A., Rameshwar, P., and Etchegaray, J.P. (2020). Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies. Cancers, 12.","DOI":"10.3390\/cancers12123657"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(18)31268-6","article-title":"Principles of DNA methylation and their implications for biology and medicine","volume":"392","author":"Dor","year":"2018","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1007\/s12094-025-03934-w","article-title":"BRCA1\/2 methylation and expression dynamics in hereditary breast and ovarian cancer: Insights from gene, protein, and TCGA analysis","volume":"27","author":"Tarapara","year":"2025","journal-title":"Clin. Transl. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cplett.2017.10.042","article-title":"S-adenosyl-l-methionine analogs as enhanced methyl donors: Towards novel epigenetic regulators","volume":"690","author":"Jerbi","year":"2017","journal-title":"Chem. Phys. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Soda, K. (2018). Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103106"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gujar, H., Weisenberger, D.J., and Liang, G. (2019). The Roles of Human DNA Methyltransferases and Their Isoforms in Shaping the Epigenome. Genes, 10.","DOI":"10.3390\/genes10020172"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2217\/epi.14.80","article-title":"Genetic alterations of DNA methylation machinery in human diseases","volume":"7","author":"Hamidi","year":"2015","journal-title":"Epigenomics"},{"key":"ref_14","first-page":"1887","article-title":"Methylation Profiles of BRCA1, RASSF1A and GSTP1 in Vietnamese Women with Breast Cancer","volume":"19","author":"Vu","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"117313","DOI":"10.1016\/j.bcp.2025.117313","article-title":"DNA methylation as an oncogenic driver in breast cancer: Therapeutic targeting via epigenetic reprogramming of DNA methyltransferases","volume":"242","author":"Kundu","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2018.03.022","article-title":"Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer","volume":"173","author":"Hoadley","year":"2018","journal-title":"Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","article-title":"An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics","volume":"173","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Papakonstantinou, E., Pappa, I., Androutsopoulos, G., Adonakis, G., Maroulis, I., and Tzelepi, V. (2023). Comprehensive Analysis of DNA Methyltransferases Expression in Primary and Relapsed Ovarian Carcinoma. Cancers, 15.","DOI":"10.20944\/preprints202308.1193.v1"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.2174\/1874467213666200810141858","article-title":"DNA Methylation in Epithelial Ovarian Cancer: Current Data and Future Perspectives","volume":"14","author":"Papakonstantinou","year":"2021","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.3892\/or.2014.3462","article-title":"DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model","volume":"32","author":"Antunez","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1080\/15592294.2016.1241932","article-title":"Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer","volume":"11","author":"Greville","year":"2016","journal-title":"Epigenetics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"543","DOI":"10.5603\/GP.a2017.0099","article-title":"DNA methyltransferase inhibitors influence on the DIRAS3 and STAT3 expression and in vitro migration of ovarian and breast cancer cells","volume":"88","author":"Nowak","year":"2017","journal-title":"Ginekol. Pol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12640-014-9497-5","article-title":"A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants","volume":"27","author":"Kostrzewa","year":"2015","journal-title":"Neurotox. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Melamed, P., Yosefzon, Y., David, C., Tsukerman, A., and Pnueli, L. (2018). Tet Enzymes, Variants, and Differential Effects on Function. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2018.00022"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.molcel.2016.10.030","article-title":"Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development","volume":"64","author":"Zhang","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-3-031-11454-0_10","article-title":"Structure and Function of TET Enzymes","volume":"1389","author":"Yin","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"An, J., Rao, A., and Ko, M. (2017). TET family dioxygenases and DNA demethylation in stem cells and cancers. Exp. Mol. Med., 49.","DOI":"10.1038\/emm.2017.5"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/onc.2012.67","article-title":"Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation","volume":"32","author":"Yang","year":"2013","journal-title":"Oncogene"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yang, L., Yu, S.-J., Hong, Q., Yang, Y., and Shao, Z.-M. (2015). Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0133896"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.semcancer.2017.08.003","article-title":"Epigenetics in ovarian cancer","volume":"51","author":"Natanzon","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cell.2013.06.026","article-title":"MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling","volume":"154","author":"Song","year":"2013","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Collignon, E., Canale, A., Al Wardi, C., Bizet, M., Calonne, E., Dedeurwaerder, S., Garaud, S., Naveaux, C., Barham, W., and Wilson, A. (2018). Immunity drives TET1 regulation in cancer through NF-\u03baB. Sci. Adv., 4.","DOI":"10.1126\/sciadv.aap7309"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"26591","DOI":"10.1038\/srep26591","article-title":"Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/path.5266","article-title":"TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2alpha as a therapeutic target","volume":"248","author":"Chen","year":"2019","journal-title":"J. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1080\/15592294.2021.1997405","article-title":"Tumour suppressor TET2 safeguards enhancers from aberrant DNA methylation and epigenetic reprogramming in ERalpha-positive breast cancer cells","volume":"17","author":"Lyu","year":"2022","journal-title":"Epigenetics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1158\/0008-5472.CAN-17-3091","article-title":"PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent","volume":"78","author":"Song","year":"2018","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wan, F., Chen, F., Fan, Y., and Chen, D. (2022). Clinical Significance of TET2 in Female Cancers. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.790605"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00404-015-3704-3","article-title":"Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer","volume":"292","author":"Zhang","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1158\/0008-5472.CAN-14-3208","article-title":"Hypoxia Drives Breast Tumor Malignancy through a TET-TNF\u03b1-p38-MAPK Signaling Axis","volume":"75","author":"Wu","year":"2015","journal-title":"Cancer Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Salmer\u00f3n-B\u00e1rcenas, E.G., Zacapala-G\u00f3mez, A.E., Torres-Rojas, F.I., Antonio-V\u00e9jar, V., \u00c1vila-L\u00f3pez, P.A., Ba\u00f1os-Hern\u00e1ndez, C.J., N\u00fa\u00f1ez-Mart\u00ednez, H.N., Dircio-Maldonado, R., Mart\u00ednez-Carrillo, D.N., and Ortiz-Ortiz, J. (2023). TET Enzymes and 5hmC Levels in Carcinogenesis and Progression of Breast Cancer: Potential Therapeutic Targets. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010272"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13046-016-0350-y","article-title":"TET3 inhibits TGF-beta1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells","volume":"35","author":"Ye","year":"2016","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13048-019-0575-4","article-title":"Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis","volume":"12","author":"Cao","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1158\/1078-0432.CCR-17-1958","article-title":"Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer","volume":"24","author":"Tucker","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13148-024-01787-8","article-title":"BRCA1 & BRCA2 methylation as a prognostic and predictive biomarker in cancer: Implementation in liquid biopsy in the era of precision medicine","volume":"16","author":"Panagopoulou","year":"2024","journal-title":"Clin. Epigenet."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/15592294.2016.1192735","article-title":"DNA methylation and breast tumor clinicopathological features: The Western New York Exposures and Breast Cancer (WEB) study","volume":"11","author":"Callahan","year":"2016","journal-title":"Epigenetics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.31557\/APJCP.2019.20.10.3001","article-title":"Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma","volume":"20","author":"Kumar","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"188941","DOI":"10.1016\/j.bbcan.2023.188941","article-title":"Potential applications of DNA methylation testing technology in female tumors and screening methods","volume":"1878","author":"Peng","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12032-022-01679-y","article-title":"DNA methylation marker to estimate ovarian cancer cell fraction","volume":"39","author":"Ebata","year":"2022","journal-title":"Med. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.gene.2015.10.059","article-title":"Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers","volume":"576","author":"Pronina","year":"2016","journal-title":"Gene"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10517-022-05627-8","article-title":"Hypermethylation of Long Non-Coding RNA Genes Group in the Breast Cancer Development and Progression","volume":"173","author":"Selezneva","year":"2022","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10517-024-06054-7","article-title":"DNA Methylation of a Group of Long Non-Coding RNA Genes at Different Stages of Ovarian Cancer Dissemination","volume":"176","author":"Burdennyy","year":"2024","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"156232","DOI":"10.1016\/j.prp.2025.156232","article-title":"Non-coding RNA methylation modifications in ovarian cancer","volume":"275","author":"Deng","year":"2025","journal-title":"Pathol. Res. Pract."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jbiotec.2019.04.001","article-title":"Quantitative RT-PCR-based miRNA profiling of blastemal Wilms\u2019 tumors from formalin-fixed paraffin-embedded samples","volume":"298","author":"Magyar","year":"2019","journal-title":"J. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2018.03.006","article-title":"Metazoan MicroRNAs","volume":"173","author":"Bartel","year":"2018","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.cell.2015.05.010","article-title":"Functional Anatomy of the Human Microprocessor","volume":"161","author":"Nguyen","year":"2015","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Salim, U., Kumar, A., Kulshreshtha, R., and Vivekanandan, P. (2022). Biogenesis, characterization, and functions of mirtrons. Wiley Interdiscip. Rev. RNA, 13.","DOI":"10.1002\/wrna.1680"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E1881\u20131889","DOI":"10.1073\/pnas.1602532113","article-title":"Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"102782","DOI":"10.1016\/j.xpro.2023.102782","article-title":"High-throughput protocol for studying pri-miRNA processing using randomized sequences","volume":"5","author":"Le","year":"2024","journal-title":"STAR Protoc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molcel.2021.11.026","article-title":"Life of RISC: Formation, action, and degradation of RNA-induced silencing complex","volume":"82","author":"Iwakawa","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Davies, M., Davey, M.G., and Miller, N. (2022). The Potential of MicroRNAs as Clinical Biomarkers to Aid Ovarian Cancer Diagnosis and Treatment. Genes, 13.","DOI":"10.3390\/genes13112054"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1767609","article-title":"MicroRNA-125b Is a Novel Negative Regulator of P53","volume":"23","author":"Le","year":"2009","journal-title":"Genes Dev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ma, L., Li, C., Yin, H., Huang, J., Yu, S., Zhao, J., Tang, Y., Yu, M., Lin, J., and Ding, L. (2023). The Mechanism of DNA Methylation and miRNA in Breast Cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119360"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"116165","DOI":"10.1016\/j.biopha.2024.116165","article-title":"The regulatory mechanisms of oncomiRs in cancer","volume":"171","author":"Otmani","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Aghaei-Zarch, S.M., Esmaeili, A., and Bagheri-Mohammadi, S. (2025). A Comprehensive Review on LncRNAs\/miRNAs-DNMT1 Axis in Human Cancer: Mechanistic and Clinical Application. J. Cell. Mol. Med., 29.","DOI":"10.1111\/jcmm.70604"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"110936","DOI":"10.1016\/j.cellsig.2023.110936","article-title":"miR-29c-3p acts as a tumor promoter by regulating beta-catenin signaling through suppressing DNMT3A, TET1 and HBP1 in ovarian carcinoma","volume":"113","author":"Zhao","year":"2024","journal-title":"Cell. Signal."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00432-018-2689-2","article-title":"MicroRNAs in regulation of triple-negative breast cancer progression","volume":"144","author":"Piasecka","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1533033820980115","DOI":"10.1177\/1533033820980115","article-title":"Mechanism of MicroRNA-375 Promoter Methylation in Promoting Ovarian Cancer Cell Malignancy","volume":"20","author":"Shu","year":"2021","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Xing, J., Liu, H., Jiang, W., and Wang, L. (2021). LncRNA-Encoded Peptide: Functions and Predicting Methods. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.622294"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbagrm.2015.06.003","article-title":"Long noncoding RNAs: Re-writing dogmas of RNA processing and stability","volume":"1859","author":"Wilusz","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"8051717","DOI":"10.1155\/2022\/8051717","article-title":"Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction","volume":"2022","author":"Liu","year":"2022","journal-title":"Stem Cells Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"200126","DOI":"10.1098\/rsob.200126","article-title":"Long non-coding RNA-polycomb intimate rendezvous","volume":"10","author":"Cerase","year":"2020","journal-title":"Open Biol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Long, Y., Wang, X., Youmans, D.T., and Cech, T.R. (2017). How do lncRNAs regulate transcription?. Sci. Adv., 3.","DOI":"10.1126\/sciadv.aao2110"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/path.5405","article-title":"Long non-coding RNAs in development and disease: Conservation to mechanisms","volume":"250","author":"Tsagakis","year":"2020","journal-title":"J. Pathol."},{"key":"ref_75","first-page":"76125","article-title":"Roles of Non-Coding RNAs in Transcriptional Regulation","volume":"55","author":"Srijyothi","year":"2018","journal-title":"Transcr. Post-Transcr. Regul."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Wen, J., Liu, Y., Shi, Y., Huang, H., Deng, B., and Xiao, X. (2019). A classification model for lncRNA and mRNA based on k-mers and a convolutional neural network. BMC Bioinform., 20.","DOI":"10.1186\/s12859-019-3039-3"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"D190","DOI":"10.1093\/nar\/gkab998","article-title":"LncRNAWiki 2.0: A knowledgebase of human long non-coding RNAs with enhanced curation model and database system","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cca.2018.12.013","article-title":"LncRNAs in ovarian cancer","volume":"490","author":"Wang","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.omtn.2021.08.005","article-title":"lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment","volume":"25","author":"Jin","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Liu, Y., Leng, P., Liu, Y., Guo, J., and Zhou, H. (2022). Crosstalk between Methylation and ncRNAs in Breast Cancer: Therapeutic and Diagnostic Implications. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415759"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3","DOI":"10.18869\/acadpub.ibj.21.1.3","article-title":"The Role of Long Non-Coding RNAs in Ovarian Cancer","volume":"21","author":"Nikpayam","year":"2017","journal-title":"Iran. Biomed. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13048-023-01309-9","article-title":"The long non-coding RNA NEAT1 promotes the progression of human ovarian cancer through targeting miR-214-3p and regulating angiogenesis","volume":"16","author":"Liu","year":"2023","journal-title":"J. Ovarian Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"188584","DOI":"10.1016\/j.bbcan.2021.188584","article-title":"Long non-coding RNAs: A view to kill ovarian cancer","volume":"1876","author":"Zamaraev","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.7150\/thno.21389","article-title":"Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability","volume":"7","author":"Jia","year":"2017","journal-title":"Theranostics"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1111\/cas.13734","article-title":"Double-negative feedback interaction between DNA methyltransferase 3A and microRNA-145 in the Warburg effect of ovarian cancer cells","volume":"109","author":"Zhang","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3892\/ol.2021.12979","article-title":"GATA6-AS1 inhibits ovarian cancer cell proliferation and migratory and invasive abilities by sponging miR-19a-5p and upregulating TET2","volume":"22","author":"Xu","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.soncn.2019.02.001","article-title":"Ovarian Cancer: An Integrated Review","volume":"35","author":"Stewart","year":"2019","journal-title":"Semin. Oncol. Nurs."},{"key":"ref_88","first-page":"171","article-title":"Breast Cancer Treatment","volume":"104","author":"Trayes","year":"2021","journal-title":"Am. Fam. Physician"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"117299","DOI":"10.1016\/j.jep.2023.117299","article-title":"Research progress on traditional Chinese medicine-induced apoptosis signaling pathways in ovarian cancer cells","volume":"319","author":"Wang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/jmcb\/mjs049","article-title":"A regulatory circuit of miR-148a\/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1","volume":"5","author":"Xu","year":"2013","journal-title":"J. Mol. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1080\/21655979.2021.1962694","article-title":"Long non-coding RNA FOXD3 antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363\/ trefoil factor 1\/ phosphatidylinositol 3-kinase\/protein kinase B axis","volume":"12","author":"Ren","year":"2021","journal-title":"Bioengineered"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Li, H., Prever, L., Hirsch, E., and Gulluni, F. (2021). Targeting PI3K\/AKT\/mTOR signaling pathway in breast cancer. Cancers, 13.","DOI":"10.3390\/cancers13143517"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1159\/000493408","article-title":"LncRNA HOTAIR regulates CCND1 and CCND2 expression by sponging miR-206 in ovarian cancer","volume":"49","author":"Chang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/s41420-024-01906-7","article-title":"Linc00707 regulates autophagy and promotes the progression of triple negative breast cancer by activation of PI3K\/AKT\/mTOR pathway","volume":"10","author":"Li","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Wen, X., Hou, Y., Zhou, L., and Fang, X. (2023). LINC00969 inhibits proliferation with metastasis of breast cancer by regulating phosphorylation of PI3K\/AKT and ILP2 expression through HOXD8. PeerJ, 11.","DOI":"10.7717\/peerj.16679"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"121183","DOI":"10.1016\/j.lfs.2022.121183","article-title":"CCAT2 knockdown inhibits cell growth, and migration and promotes apoptosis through regulating the hsa-mir-145-5p\/AKT3\/mTOR axis in tamoxifen-resistant MCF7 cells","volume":"311","author":"Moradi","year":"2022","journal-title":"Life Sci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Tian, Y., Chen, Z.H., Wu, P., Zhang, D., Ma, Y., Liu, X.F., Wang, X., Ding, D., Cao, X.C., and Yu, Y. (2023). MIR497HG-Derived miR-195 and miR-497 Mediate Tamoxifen Resistance via PI3K\/AKT Signaling in Breast Cancer. Adv. Sci., 10.","DOI":"10.1002\/advs.202204819"},{"key":"ref_98","first-page":"2267","article-title":"LncRNA TTN-AS1 confers tamoxifen resistance in breast cancer via sponging miR-107 to modulate PI3K\/AKT signaling pathway","volume":"14","author":"Fang","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15384047.2022.2132008","article-title":"LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K\/AKT\/mTOR pathway and the EZH2-E-cadherin\/RHOB pathway","volume":"23","author":"Lei","year":"2022","journal-title":"Cancer Biol. Ther."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.2174\/1871520622666220204115151","article-title":"Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1\/PI3K\/Akt Signalling","volume":"22","author":"Nivetha","year":"2022","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/onc.2012.575","article-title":"MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: A novel epigenetic therapy independent of decitabine","volume":"33","author":"Xiang","year":"2014","journal-title":"Oncogene"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12672-025-02113-1","article-title":"ESM1 suppresses LncRNA GAS5\/miR-23a-3p\/PTEN axis to promote the cisplatin-chemotherapy resistance of ovarian cancer cells via activating the PI3K\/AKT pathway","volume":"16","author":"Li","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s13258-023-01440-3","article-title":"LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p\/VEGFA","volume":"46","author":"Dong","year":"2024","journal-title":"Genes Genom."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3892\/mmr.2021.12402","article-title":"Long non-coding RNA HAND2-AS1\/miR-106a\/PTEN axis re-sensitizes cisplatin-resistant ovarian cells to cisplatin treatment","volume":"24","author":"Li","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Standing, D., Feess, E., Kodiyalam, S., Kuehn, M., Hamel, Z., Johnson, J., Thomas, S.M., and Anant, S. (2023). The Role of STATs in Ovarian Cancer: Exploring Their Potential for Therapy. Cancers, 15.","DOI":"10.3390\/cancers15092485"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"106210","DOI":"10.1016\/j.intimp.2020.106210","article-title":"The role of JAK\/STAT signaling pathway and its inhibitors in diseases","volume":"80","author":"Xin","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/978-3-030-20301-6_14","article-title":"Targeting of JAK-STAT Signaling in Breast Cancer: Therapeutic Strategies to Overcome Drug Resistance","volume":"1152","author":"Tabassum","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_108","first-page":"1064","article-title":"STAT3\/Snail Signaling and Progression of Hypoxia Tolerance in Breast Cancer Cells","volume":"90","author":"Andreeva","year":"2025","journal-title":"Biochemistry"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Chen, J., Cheng, L., Zou, W., Wang, R., Wang, X., and Chen, Z. (2021). ADAMTS9-AS1 Constrains Breast Cancer Cell Invasion and Proliferation via Sequestering miR-301b-3p. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.719993"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13048-019-0596-z","article-title":"Wnt\/\u03b2-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis","volume":"12","author":"Nguyen","year":"2019","journal-title":"J. Ovarian Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1111\/jcmm.15140","article-title":"E-cadherin deregulation in breast cancer","volume":"24","author":"Corso","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1007\/s11010-024-05136-4","article-title":"MicroRNA-205-5p inhibits the growth and migration of breast cancer through targeting Wnt\/\u03b2-catenin co-receptor LRP6 and interacting with lncRNAs","volume":"480","author":"Mohamed","year":"2025","journal-title":"Mol. Cell. Biochem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"112287","DOI":"10.1016\/j.cellsig.2025.112287","article-title":"MIR4435-2HG promotes breast cancer evolution through miR-205-5p\/UBE2N axis and exosome-mediated macrophage M2-like polarization","volume":"139","author":"Zhang","year":"2026","journal-title":"Cell. Signal."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Yang, C., Liu, Y., Gai, L., Zhang, Z., Zhang, Y., Zhang, G., Du, K., and Gao, C. (2025). Artesunate regulates malignant progression of breast cancer cells via lncRNA TUG1\/miR-145-5p\/HOXA5 axis. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0329490"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s13258-025-01691-2","article-title":"Single-cell RNA sequencing reveals a putative lncRNA-associated ceRNA network in high-grade serous ovarian cancer","volume":"47","author":"Nam","year":"2025","journal-title":"Genes Genom."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"He, Q., Yang, S., Xin, Q., Jiang, Y., Jiang, L., and Xu, N. (2025). USP30-AS1 Dictates Breast Cancer Cell Fate and Chemoresistance via a miR-3646\/FZD7\/Wnt\/\u03b2-Catenin Circuit. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47120974"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"108304","DOI":"10.1016\/j.jbc.2025.108304","article-title":"BANCR-containing extracellular vesicles enhance breast cancer resistance","volume":"301","author":"Song","year":"2025","journal-title":"J. Biol. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Safi, A., Delgir, S., Ilkhani, K., Samei, A., Mousavi, S.R., Zeynali-Khasraghi, Z., Bastami, M., and Alivand, M.R. (2021). The expression of miRNA-152-3p and miRNA-185 in tumor tissues versus margin tissues of patients with chemo-treated breast cancer. BMC Res. Notes, 14.","DOI":"10.1186\/s13104-021-05647-z"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.yexcr.2016.07.023","article-title":"DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1\/CDH1 loop","volume":"346","author":"Sengupta","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3727\/096504019X15519249902838","article-title":"Microrna-152 inhibits cell proliferation, migration, and invasion in breast cancer","volume":"28","author":"Maimaitiming","year":"2020","journal-title":"Oncol. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.7150\/jca.46898","article-title":"EPAS1 targeting by miR-152-3p in Paclitaxel-resistant breast cancer","volume":"11","author":"Song","year":"2020","journal-title":"J. Cancer"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"15897","DOI":"10.1038\/s41598-017-15607-y","article-title":"IGF-1-mediated PKM2\/\u03b2-catenin\/miR-152 regulatory circuit in breast cancer","volume":"7","author":"Wen","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yexcr.2017.07.030","article-title":"Long non-coding RNA CCAT1 promotes metastasis and poor prognosis in epithelial ovarian cancer","volume":"359","author":"Cao","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3109\/10799893.2015.1030412","article-title":"Signaling pathway of MAPK\/ERK in cell proliferation, differentiation, migration, senescence and apoptosis","volume":"35","author":"Sun","year":"2015","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.molonc.2013.10.001","article-title":"High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth","volume":"8","author":"Leivonen","year":"2014","journal-title":"Mol. Oncol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1615\/CritRevEukaryotGeneExpr.2021040115","article-title":"Oncogenic Long Noncoding RNA Linc01287 Promotes IGF1R Expression by Sponging miR-98 in Breast Cancer","volume":"32","author":"Guo","year":"2022","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.arcmed.2021.01.007","article-title":"LncRNA PRNCR1 Promotes Breast Cancer Proliferation and Inhibits Apoptosis by Modulating microRNA-377\/CCND2\/MEK\/MAPK Axis","volume":"52","author":"Ouyang","year":"2021","journal-title":"Arch. Med. Res."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Qiao, Z.W., Jiang, Y., Wang, L., Wang, L., Jiang, J., Zhang, J.R., and Mu, P. (2021). LINC00852 promotes the proliferation and invasion of ovarian cancer cells by competitively binding with miR-140-3p to regulate AGTR1 expression. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08730-7"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.2147\/CMAR.S295097","article-title":"LNC00115 Mediates Cisplatin Resistance by Regulating the miR-7\/ERK Signalling Pathway in Ovarian Cancer","volume":"13","author":"Jiang","year":"2021","journal-title":"Cancer Manag. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"423","DOI":"10.7150\/thno.22377","article-title":"Methylation-associated silencing of miR-193a-3p promotes ovarian cancer aggressiveness by targeting GRB7 and MAPK\/ERK pathways","volume":"8","author":"Chen","year":"2018","journal-title":"Theranostics"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Ghoneum, A., and Said, N. (2019). PI3K-AKT-mTOR and NF\u03baB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics. Cancers, 11.","DOI":"10.3390\/cancers11070949"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"R369","DOI":"10.1530\/ERC-19-0087","article-title":"The NF-KB pathway and endocrine therapy resistance in breast cancer","volume":"26","author":"Khongthong","year":"2019","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1038\/onc.2015.6","article-title":"Regulatory circuit of PKM2\/NF-\u03baB\/miR-148a\/152-modulated tumor angiogenesis and cancer progression","volume":"34","author":"Xu","year":"2015","journal-title":"Oncogene"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amjms.2023.08.013","article-title":"LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2\/PPP3CC\/NF-\u03baB pathway by sponging miR-576-5p","volume":"367","author":"Li","year":"2024","journal-title":"Am. J. Med. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"156121","DOI":"10.1016\/j.phymed.2024.156121","article-title":"Berberine modulates ovarian cancer autophagy and glycolysis through the LINC01123\/P65\/MAPK10 signaling axis","volume":"135","author":"Yan","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41417-021-00306-8","article-title":"LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1","volume":"29","author":"Bai","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.omtn.2019.12.016","article-title":"Long Non-coding RNA LOXL1-AS1 Drives Breast Cancer Invasion and Metastasis by Antagonizing miR-708-5p Expression and Activity","volume":"19","author":"Dong","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.1080\/21655979.2021.1977555","article-title":"Long non-coding RNA (LncRNA) CASC9\/microRNA(miR)-590-3p\/sine oculis homeobox 1 (SIX1)\/NF-\u03baB axis promotes proliferation and migration in breast cancer","volume":"12","author":"Chang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Zhu, L., Zhang, Y.J., Wang, B., Yang, L., Zheng, Y.Q., Sun, L.D., Tian, L., Chen, T., and Wang, J.D. (2021). PCDHB17P\/miR-145-3p\/MELK\/NF-\u03baB Feedback Loop Promotes Metastasis and Angiogenesis of Breast Cancer. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.660307"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"580","DOI":"10.18632\/oncotarget.5979","article-title":"MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b","volume":"7","author":"Roscigno","year":"2016","journal-title":"Oncotarget"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3892\/etm.2023.12027","article-title":"Scoparone inhibits breast cancer cell viability through the NF-\u03baB signaling pathway","volume":"26","author":"Wu","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Dong, Y.J., Feng, W., and Li, Y. (2021). HOTTIP-miR-205-ZEB2 Axis Confers Cisplatin Resistance to Ovarian Cancer Cells. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.707424"},{"key":"ref_143","first-page":"202","article-title":"lncRNA-PRLB Confers Paclitaxel Resistance of Ovarian Cancer Cells by Regulating RSF1\/NF-\u03baB Signaling Pathway","volume":"36","author":"Zhao","year":"2021","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Tossetta, G., Fantone, S., Montanari, E., Marzioni, D., and Goteri, G. (2022). Role of NRF2 in Ovarian Cancer. Antioxidants, 11.","DOI":"10.3390\/antiox11040663"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Kumar, H., Kumar, R.M., Bhattacharjee, D., Somanna, P., and Jain, V. (2022). Role of Nrf2 Signaling Cascade in Breast Cancer: Strategies and Treatment. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.720076"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Wang, X., Du, Z.W., Xu, T.M., Wang, X.J., Li, W., Gao, J.L., Li, J., and Zhu, H. (2021). HIF-1\u03b1 Is a Rational Target for Future Ovarian Cancer Therapies. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.785111"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1002\/jcb.28337","article-title":"HIF1A-AS2 predicts poor prognosis and regulates cell migration and invasion in triple-negative breast cancer","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"13718","DOI":"10.1080\/21655979.2022.2077906","article-title":"Long noncoding RNA (lncRNA) metallothionein 1 J, pseudogene (MT1JP) is downregulated in triple-negative breast cancer and upregulates microRNA-138 (miR-138) to downregulate hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1)","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"5028","DOI":"10.1080\/21655979.2021.1960774","article-title":"Long non-coding RNA VCAN-AS1 promotes the malignant behaviors of breast cancer by regulating the miR-106a-5p-mediated STAT3\/HIF-1\u03b1 pathway","volume":"12","author":"Du","year":"2021","journal-title":"Bioengineered"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Shih, C.H., Chuang, L.L., Tsai, M.H., Chen, L.H., Chuang, E.Y., Lu, T.P., and Lai, L.C. (2021). Hypoxia-Induced MALAT1 Promotes the Proliferation and Migration of Breast Cancer Cells by Sponging MiR-3064-5p. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.658151"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Dong, L., Cao, X., Luo, Y., Zhang, G., and Zhang, D. (2020). A Positive Feedback Loop of lncRNA DSCR8\/miR-98-5p\/STAT3\/HIF-1\u03b1 Plays a Role in the Progression of Ovarian Cancer. Front. Oncol., 10.","DOI":"10.3389\/fonc.2020.01713"},{"key":"ref_152","first-page":"467","article-title":"LINC00662 promotes glycolysis and cell survival by regulating miR- 375\/HIF-1\u03b1 axis in ovarian cancer","volume":"34","author":"Tao","year":"2020","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.21037\/atm-20-4497","article-title":"NOTCH signalling in ovarian cancer angiogenesis","volume":"8","author":"Ortega","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2415489","DOI":"10.1155\/2018\/2415489","article-title":"The Notch Pathway in Breast Cancer Progression","volume":"2018","author":"Kontomanolis","year":"2018","journal-title":"Sci. World J."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/j.gendis.2022.07.006","article-title":"JAG1 enhances angiogenesis in triple-negative breast cancer through promoting the secretion of exosomal lncRNA MALAT1","volume":"10","author":"Liu","year":"2022","journal-title":"Genes Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3892\/ol.2020.12383","article-title":"lncRNA SNHG3 acts as oncogene in ovarian cancer through miR-139-5p and Notch1","volume":"21","author":"Zhang","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1210\/endrev\/bnac013","article-title":"Hippo Signaling in the ovary: Emerging Roles in Development, Fertility, and Disease","volume":"43","author":"Clark","year":"2022","journal-title":"Endocr. Rev."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.2147\/OTT.S157058","article-title":"The role of Hippo signal pathway in breast cancer metastasis","volume":"11","author":"Wei","year":"2018","journal-title":"Onco Targets Ther."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.2147\/IJGM.S278564","article-title":"Long Non-Coding RNA A2M-AS1 Promotes Breast Cancer Progression by Sponging microRNA-146b to Upregulate MUC19","volume":"13","author":"Liu","year":"2020","journal-title":"Int. J. Gen. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s13046-019-1421-7","article-title":"LINC00673 is activated by YY1 and promotes the proliferation of breast cancer cells via the miR-515-5p\/MARK4\/Hippo signaling pathway","volume":"38","author":"Qiao","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3892\/ijmm.2021.4877","article-title":"Long non-coding RNA ASAP1-IT1 suppresses ovarian cancer progression by regulating Hippo\/YAP signaling","volume":"47","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Roane, B.M., Arend, R.C., and Birrer, M.J. (2019). Review: Targeting the Transforming Growth Factor-Beta Pathway in Ovarian Cancer. Cancers, 11.","DOI":"10.3390\/cancers11050668"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Li, C.J., Chu, P.Y., Yiang, G.T., and Wu, M.Y. (2019). The Molecular Mechanism of Epithelial-Mesenchymal Transition for Breast Carcinogenesis. Biomolecules, 9.","DOI":"10.3390\/biom9090476"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Danielpour, D. (2024). Advances and Challenges in Targeting TGF-\u03b2 Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective. Pharmaceuticals, 17.","DOI":"10.3390\/ph17040533"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"112192","DOI":"10.1016\/j.cellsig.2025.112192","article-title":"The ceRNA network of LINC00536\/miR-204-5p\/TGFBR2: A novel therapeutic target for breast cancer diagnosis and treatment","volume":"137","author":"Tuersong","year":"2026","journal-title":"Cell. Signal."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10142-024-01442-8","article-title":"LncRNA XIST\/miR-455-3p\/HOXC4 axis promotes breast cancer development by activating TGF-\u03b2\/SMAD signaling pathway","volume":"24","author":"Zhao","year":"2024","journal-title":"Funct. Integr. Genom."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3892\/ol.2021.12629","article-title":"LINC00052 promotes breast cancer cell progression and metastasis by sponging miR-145-5p to modulate TGFBR2 expression","volume":"21","author":"Dong","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Li, J., Liu, H., Lin, Q., Chen, H., Liu, L., Liao, H., Cheng, Y., Zhang, X., Wang, Z., and Shen, A. (2022). Baicalin suppresses the migration and invasion of breast cancer cells via the TGF-\u03b2\/lncRNA-MALAT1\/miR-200c signaling pathway. Medicine, 101.","DOI":"10.1097\/MD.0000000000029328"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1111\/jcmm.16700","article-title":"LncRNA PVT1 promotes the progression of ovarian cancer by activating TGF-\u03b2 pathway via miR-148a-3p\/AGO1 axis","volume":"25","author":"Wu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhao, Z., Sun, D., and Li, Y. (2021). Novel long noncoding RNA LINC02323 promotes cell growth and migration of ovarian cancer via TGF-\u03b2 receptor 1 by miR-1343-3p. J. Clin. Lab. Anal., 35.","DOI":"10.1002\/jcla.23651"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1186\/s12935-021-02396-8","article-title":"p53 signaling in cancer progression and therapy","volume":"21","author":"Marei","year":"2021","journal-title":"Cancer Cell Int."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Wallis, B., Bowman, K.R., Lu, P., and Lim, C.S. (2023). The Challenges and Prospects of p53-Based Therapies in Ovarian Cancer. Biomolecules, 13.","DOI":"10.3390\/biom13010159"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00438-019-01572-w","article-title":"c-Myc induced the regulation of long non-coding RNA RHPN1-AS1 on breast cancer cell proliferation via inhibiting P53","volume":"294","author":"Zhu","year":"2019","journal-title":"Mol. Genet. Genom."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.2147\/OTT.S250850","article-title":"LEMD1-AS1 Suppresses Ovarian Cancer Progression Through Regulating miR-183-5p\/TP53 Axis","volume":"13","author":"Guo","year":"2020","journal-title":"Onco Targets Ther."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ncrna.2025.04.008","article-title":"Alternative transcription increases isoform complexity in Long Non-Coding RNAs and alters their functions in cancer","volume":"14","author":"Bone","year":"2025","journal-title":"Noncoding RNA Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s11658-023-00483-4","article-title":"CRISPR applications in cancer diagnosis and treatment","volume":"28","author":"Wang","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1172\/JCI97924","article-title":"DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine","volume":"128","author":"Yu","year":"2018","journal-title":"J. Clin. Invest."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2254976","DOI":"10.1080\/15592294.2023.2254976","article-title":"DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS\/MEK\/ERK activity in gastric cancer cells","volume":"18","author":"Chen","year":"2023","journal-title":"Epigenetics"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Penchovsky, R., Georgieva, A.V., Dyakova, V., Traykovska, M., and Pavlova, N. (2024). Antisense and Functional Nucleic Acids in Rational Drug Development. Antibiotics, 13.","DOI":"10.3390\/antibiotics13030221"},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"Zeng, J., Fang, L., Jiang, T., Liu, M., Li, W., Mao, C., Lou, S., and Zuo, H. (2023). Structural-Based Stability Enhancement of Antisense DNA Oligonucleotides. Macromol. Biosci., 23.","DOI":"10.1002\/mabi.202200453"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"De Beck, L., Awad, R.M., Basso, V., Casares, N., De Ridder, K., De Vlaeminck, Y., Gnata, A., Goyvaerts, C., Lecocq, Q., and San Jos\u00e9-En\u00e9riz, E. (2022). Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.799636"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Torsin, L.I., Petrescu, G.E.D., Sabo, A.A., Chen, B., Brehar, F.M., Dragomir, M.P., and Calin, G.A. (2021). Editing and Chemical Modifications on Non-Coding RNAs in Cancer: A New Tale with Clinical Significance. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020581"}],"container-title":["Epigenomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4655\/10\/3\/45\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:20:39Z","timestamp":1783934439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4655\/10\/3\/45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,4]]},"references-count":182,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["epigenomes10030045"],"URL":"https:\/\/doi.org\/10.3390\/epigenomes10030045","relation":{},"ISSN":["2075-4655"],"issn-type":[{"value":"2075-4655","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,4]]}}}