{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:28:26Z","timestamp":1793042906652,"version":"4.5.0"},"reference-count":198,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epigenomes"],"abstract":"<jats:p>Transgenerational inheritance can occur at telomeres in distinct contexts. Deficiency for telomerase or telomere-binding proteins in germ cells can result in shortened or lengthened chromosome termini that are transmitted to progeny. In human families, altered telomere lengths can result in stem cell dysfunction or tumor development. Genetic inheritance of altered telomeres as well as mutations that alter telomeres can result in progressive telomere length changes over multiple generations. Telomeres of yeast can modulate the epigenetic state of subtelomeric genes in a manner that is mitotically heritable, and the effects of telomeres on subtelomeric gene expression may be relevant to senescence or other human adult-onset disorders. Recently, two novel epigenetic states were shown to occur at C. elegans telomeres, where very low or high levels of telomeric protein foci can be inherited for multiple generations through a process that is regulated by histone methylation.Together, these observations illustrate that information relevant to telomere biology can be inherited via genetic and epigenetic mechanisms, although the broad impact of epigenetic inheritance to human biology remains unclear.<\/jats:p>","DOI":"10.3390\/epigenomes6010009","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T03:34:13Z","timestamp":1647401653000},"page":"9","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genetic and Epigenetic Inheritance at Telomeres"],"prefix":"10.3390","volume":"6","author":[{"given":"Evan H.","family":"Lister-Shimauchi","sequence":"first","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-3280, USA"},{"name":"Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-4730","authenticated-orcid":false,"given":"Benjamin","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-3280, USA"},{"name":"Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-1448","authenticated-orcid":false,"given":"Michael","family":"Lippincott","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-3280, USA"},{"name":"Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6365-2194","authenticated-orcid":false,"given":"Shawn","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-3280, USA"},{"name":"Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(00)80760-6","article-title":"Mammalian Telomeres End in a Large Duplex Loop","volume":"97","author":"Griffith","year":"1999","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"102901","DOI":"10.1016\/j.dnarep.2020.102901","article-title":"Twenty Years of T-Loops: A Case Study for the Importance of Collaboration in Molecular Biology","volume":"94","author":"Cesare","year":"2020","journal-title":"DNA Repair"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The Serial Cultivation of Human Diploid Cell Strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. 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