{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:31:13Z","timestamp":1775014273128,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Institutes of Health Research","award":["45600-4115"],"award-info":[{"award-number":["45600-4115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epigenomes"],"abstract":"<jats:p>Non-coding RNA fragments (ncRFs) are small RNA fragments processed from non-coding RNAs (ncRNAs). ncRFs have various functions and are commonly tissue-specific, and their processing is altered by exposure to stress. Information about ncRFs in the brain is scarce. Recently, we reported the brain region-specific and sex-specific expression of ncRNAs and their processing into ncRFs. Here, we analyzed the expression of ncRFs in the frontal cortex (FC), hippocampus (HIP), and cerebellum (CER) of male and female rats exposed to scatter radiation. We found multiple brain region- and sex-specific changes in response to scatter radiation. Specifically, we observed decreased miRNA expression and the increased expression of ra-ncRNA reads in HIP and CER, as well as an increased number of mtR-NA-associated reads in HIP. We also observed the appearance of sense-intronic ncRNAs\u2014in females, in HIP and FC, and in males, in CER. In this work, we also show that tRNA-GlyGCC and tRNA-GlyCCC are most frequently processed to tRFs, in CER in females, as compared to males. An analysis of the targeted pathways revealed that tRFs and snoRFs in scatter radiation samples mapped to genes in several pathways associated with various neuronal functions. While in HIP and CER these pathways were underrepresented, in FC, they were overrepresented. Such changes may play an important role in pathologies that develop in response to scatter radiation, the effect known as \u201cradio-brain\u201d, and may in part explain the sex-specific differences observed in animals and humans exposed to radiation and scatter radiation.<\/jats:p>","DOI":"10.3390\/epigenomes6040035","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T20:53:29Z","timestamp":1665608009000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scatter Irradiation of Rat Brain Triggers Sex- and Brain Region-Specific Changes in the Expression of Non-Coding RNA Fragments"],"prefix":"10.3390","volume":"6","author":[{"given":"Anna","family":"Fiselier","sequence":"first","affiliation":[{"name":"Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boseon","family":"Byeon","sequence":"additional","affiliation":[{"name":"Biomedical and Health Informatics, Computer Science Department, State University of New York, 2 S Clinton St, Syracuse, NY 13202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaroslav","family":"Ilnytskyy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8137-6928","authenticated-orcid":false,"given":"Igor","family":"Kovalchuk","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28400","DOI":"10.1038\/srep28400","article-title":"Identification of Tissue-Specific Protein-Coding and Noncoding Transcripts across 14 Human Tissues Using RNA-seq","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. 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