{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T06:17:24Z","timestamp":1792995444175,"version":"4.5.0"},"reference-count":63,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Florida Department of Anatomy and Cell Biology and NCI designated Cancer Center at the University of Florida start-up funds","award":["R01GM145745"],"award-info":[{"award-number":["R01GM145745"]}]},{"name":"NIH","award":["R01GM145745"],"award-info":[{"award-number":["R01GM145745"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epigenomes"],"abstract":"<jats:p>Cytosine methylation contributes to the regulation of gene expression and normal hematopoiesis in mammals. It is catalyzed by the family of DNA methyltransferases that include DNMT1, DNMT3A, and DNMT3B. Peripheral T\u2013cell lymphomas (PTCLs) represent aggressive mature T\u2013cell malignancies exhibiting a broad spectrum of clinical features with poor prognosis and inadequately understood molecular pathobiology. To better understand the molecular landscape and identify candidate genes involved in disease maintenance, we profiled DNA methylation and gene expression of PTCLs. We found that the methylation patterns in PTCLs are deregulated and heterogeneous but share 767 hypo- and 567 hypermethylated differentially methylated regions (DMRs) along with 231 genes up- and 91 genes downregulated in all samples, suggesting a potential association with tumor development. We further identified 39 hypomethylated promoters associated with increased gene expression in the majority of PTCLs. This putative oncogenic signature included the TRIP13 (thyroid hormone receptor interactor 13) gene whose genetic and pharmacologic inactivation inhibited the proliferation of T\u2013cell lines by inducing G2-M arrest and apoptosis. Our data thus show that human PTCLs have a significant number of recurrent methylation alterations that may affect the expression of genes critical for proliferation whose targeting might be beneficial in anti-lymphoma treatments.<\/jats:p>","DOI":"10.3390\/epigenomes8030032","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:26:57Z","timestamp":1724300817000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genome-Wide Methylation Profiling of Peripheral T\u2013Cell Lymphomas Identifies TRIP13 as a Critical Driver of Tumor Proliferation and Survival"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9075-6252","authenticated-orcid":false,"given":"Pawel","family":"Nowialis","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL 32610, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-6915","authenticated-orcid":false,"given":"Hiroshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon 791-0295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8823-8640","authenticated-orcid":false,"given":"Alexander","family":"Ishov","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Opavsky","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL 32610, 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