{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:24:41Z","timestamp":1783038281538,"version":"3.54.6"},"reference-count":59,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Development of Global Senior- friendly Health Functional Food Materials from Marine Resources ,Ministry of Oceans and Fisheries, Korea","award":["No. 20170297"],"award-info":[{"award-number":["No. 20170297"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Periodontitis is one of the most common chronic inflammatory diseases. The anti-inflammatory effect of the extract from brown algae Ecklonia cava was analyzed in lipopolysaccharide (LPS)-stimulated human gingival fibroblasts (HGF-1), the most abundant cells in gingival tissue. The gene expressions of cyclooxygenase-2 and interleukin-6 were decreased by 78 and 50%, respectively, at 100 \u03bcg\/mL Ecklonia cava extract (ECE) treatment. The gene expressions of matrix metalloproteases (MMP-2 and MMP-8) and chemokines (macrophage inflammatory protein 1-alpha and stromal cell-derived factor 1) were also significantly down-regulated by ECE treatment (p &lt; 0.05). The increased reactive oxygen species (ROS) production in HGF-1 cells by LPS stimulation was decreased by 30% at 100 \u03bcg\/mL ECE treatment. The mitogen-activated protein kinase pathway and the nuclear factor-kappa B (NF-\u03baB) signal activated by ROS were suppressed by ECE in a dose-dependent manner. ECE treatment (400 mg\/kg, 8 weeks) significantly improved alveolar bone resorption in the ligature-induced chronic periodontitis rat model. ECE supplementation also lowered elevated mRNA expression of the receptor activator of nuclear factor-kappa B (RANKL)\/osteoprotegerin (OPG) in the gingival tissue (p &lt; 0.05). Therefore, ECE mitigated gingival tissue destruction and bone resorption associated with chronic periodontitis condition.<\/jats:p>","DOI":"10.3390\/foods10071656","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:16:48Z","timestamp":1626643008000},"page":"1656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ecklonia cava Extract Exerts Anti-Inflammatory Effect in Human Gingival Fibroblasts and Chronic Periodontitis Animal Model by Suppression of Pro-Inflammatory Cytokines and Chemokines"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-0669","authenticated-orcid":false,"given":"Jae-In","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Foods and Nutrition, Kookmin University, Seoul 02707, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, Kookmin University, Seoul 02707, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Min","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, Kookmin University, Seoul 02707, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8362-3523","authenticated-orcid":false,"given":"Soo-Im","family":"Choi","sequence":"additional","affiliation":[{"name":"Plant Resources Research Institute, Duksung Women\u2019s University, Seoul 10326, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-7149","authenticated-orcid":false,"given":"Gun-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Plant Resources Research Institute, Duksung Women\u2019s University, Seoul 10326, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-7051","authenticated-orcid":false,"given":"Jee-Young","family":"Imm","sequence":"additional","affiliation":[{"name":"Department of Foods and Nutrition, Kookmin University, Seoul 02707, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2000","journal-title":"Periodontology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1177\/0022034513495242","article-title":"LPS-induced inflammatory response after therapy of aggressive periodontitis","volume":"92","author":"Shaddox","year":"2013","journal-title":"J. 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