{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T03:21:16Z","timestamp":1778556076009,"version":"3.51.4"},"reference-count":118,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T00:00:00Z","timestamp":1627171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004427","name":"Universidad de Valpara\u00edso","doi-asserted-by":"publisher","award":["DIUV-CIDI 4\/2016"],"award-info":[{"award-number":["DIUV-CIDI 4\/2016"]}],"id":[{"id":"10.13039\/501100004427","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID)","award":["PAI79170114"],"award-info":[{"award-number":["PAI79170114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease, with a prevalence of 25% worldwide. This pathology is a multifactorial illness, and is associated with different risks factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. Beside these predisposing features, NAFLD has been related to changes in the microbiota, which favor the disease progression. In this context, the modulation of the gut microbiota has emerged as a new therapeutic target for the prophylaxis and treatment of NAFLD. This review describes the changes in the gut microbiota associated with NAFLD and the effect of probiotics, prebiotics, and synbiotics on the gut microbiota, liver damage, anthropometric parameters, blood lipids, inflammation markers and insulin resistance in these patients.<\/jats:p>","DOI":"10.3390\/foods10081719","type":"journal-article","created":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T22:06:21Z","timestamp":1627250781000},"page":"1719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Valentina","family":"Castillo","sequence":"first","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoll","family":"Gonz\u00e1lez-Pizarro","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"},{"name":"Centro de Micro-Bioinnovaci\u00f3n, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0051-9809","authenticated-orcid":false,"given":"Paz","family":"Jopia","sequence":"additional","affiliation":[{"name":"Centro de Micro-Bioinnovaci\u00f3n, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1978-6109","authenticated-orcid":false,"given":"Claudia","family":"Ibacache-Quiroga","sequence":"additional","affiliation":[{"name":"Escuela de Nutrici\u00f3n y Diet\u00e9tica, Facultad de Farmacia, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"},{"name":"Centro de Micro-Bioinnovaci\u00f3n, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","article-title":"Global, regional, and national age-sex specific mortality for 264 causes of death, 1980\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"Naghavi","year":"2017","journal-title":"Lancet"},{"key":"ref_2","unstructured":"(2018). 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