{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:27:09Z","timestamp":1790026029835,"version":"4.0.1"},"reference-count":84,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Interdisciplinary integration to promote the high-quality development of Juncao science and Industry","award":["XKJC-712021030"],"award-info":[{"award-number":["XKJC-712021030"]}]},{"name":"Outstanding Talent of &quot;Qishan Scholar&quot; of Fuzhou University","award":["GXRC21049"],"award-info":[{"award-number":["GXRC21049"]}]},{"name":"Agricultural guiding project of Fujian science and Technology Department","award":["2020N0007"],"award-info":[{"award-number":["2020N0007"]}]},{"name":"Major Special Project of Fujian Province &quot;Research and application of key technologies for inno-vation and industrialized utilization of Juncao","award":["2021NZ0101"],"award-info":[{"award-number":["2021NZ0101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. Results showed GA supplement significantly inhibited the abnormal elevation of the liver index, serum lipid parameters, aspartate aminotransferase and alanine aminotransferase in mice exposed to alcohol intake, and also significantly protected the excessive lipid accumulation and pathological changes. Alcohol-induced oxidative stress in the liver was significantly ameliorated by GA intervention through reducing the levels of maleic dialdehyde and lactate dehydrogenase and increasing the levels of glutathione, catalase, superoxide dismutase and alcohol dehydrogenase. Intestinal microbiota profiling demonstrated GA intervention modulated the composition of intestinal microflora by increasing the levels of Lactobacillus, Faecalibaculum, Romboutsia, Bifidobacterium and decreasing the Helicobacter level. Furthermore, liver metabolomic profiling suggested GA intervention had a remarkable regulatory effect on liver metabolism with excessive alcohol consumption. Moreover, GA intervention regulated mRNA levels of alcohol metabolism, fatty lipid metabolism, oxidative stress, bile acid biosynthesis and metabolism-related genes in the liver. Conclusively, these findings demonstrate GA intervention can significantly relieve alcoholic liver injury and it is hopeful to become a new functional food ingredient for the prevention of alcoholic liver injury.<\/jats:p>","DOI":"10.3390\/foods11070949","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:31:21Z","timestamp":1648222281000},"page":"949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake"],"prefix":"10.3390","volume":"11","author":[{"given":"Ying-Jia","family":"Cao","sequence":"first","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ze","family":"You","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ling","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China"},{"name":"School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-4284","authenticated-orcid":false,"given":"Xu-Cong","family":"Lv","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-Xi","family":"Lin","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Hu","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"119328","DOI":"10.1016\/j.lfs.2021.119328","article-title":"A review on molecular mechanism of alcoholic liver disease","volume":"274","author":"Namachivayam","year":"2021","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Teschke, R. 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