{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T15:46:28Z","timestamp":1785599188481,"version":"3.56.0"},"reference-count":311,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["2020.04947.BD"],"award-info":[{"award-number":["2020.04947.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Members of the Lamiaceae family are considered chief sources of bioactive therapeutic agents. They are important ornamental, medicinal, and aromatic plants, many of which are used in traditional and modern medicine and in the food, cosmetic, and pharmaceutical industries. In North Africa, on the Mediterranean side, there is the following particularly interesting Lamiaceous species: Thymus hirtus Willd. sp. Algeriensis Boiss. Et Reut. The populations of this endemic plant are distributed from the subhumid to the lower arid zone and are mainly employed as ethnomedicinal remedies in the following Maghreb countries: Algeria, Libya, Morocco, and Tunisia. In fact, they have been applied as antimicrobial agents, antispasmodics, astringents, expectorants, and preservatives for several food products. The species is commonly consumed as a tea or infusion and is used against hypercholesterolemia, diabetes, respiratory ailments, heart disease, and food poisoning. These medicinal uses are related to constituents with many biological characteristics, including antimicrobial, antioxidant, anticancer, anti-ulcer, anti-diabetic, insecticidal, and anti-inflammatory activities. This review aims to present an overview of the botanical characteristics and geographical distribution of Thymus algeriensis Boiss. Et Reut and its traditional uses. This manuscript also examines the phytochemical profile and its correlation with biological activities revealed by in vitro and in vivo studies.<\/jats:p>","DOI":"10.3390\/foods11203195","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T20:55:11Z","timestamp":1665694511000},"page":"3195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Thymus hirtus Willd. ssp. algeriensis Boiss. and Reut: A Comprehensive Review on Phytochemistry, Bioactivities, and Health-Enhancing Effects"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-6947","authenticated-orcid":false,"given":"Radhia Aitfella","family":"Lahlou","sequence":"first","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Biology Department, Faculty of Sciences, University of M\u2019Hamed Bougara, Boumerdes 35000, Algeria"},{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nsevolo","family":"Samba","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-7020","authenticated-orcid":false,"given":"Pedro","family":"Soeiro","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4213-0714","authenticated-orcid":false,"given":"Gilberto","family":"Alves","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-795X","authenticated-orcid":false,"given":"Ana Carolina","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-3516","authenticated-orcid":false,"given":"Lu\u00eds R.","family":"Silva","sequence":"additional","affiliation":[{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"CPIRN-UDI\/IPG\u2014Centro de Potencial e Inova\u00e7\u00e3o em Recursos Naturais, Unidade de Investiga\u00e7\u00e3o Para o Desenvolvimento do Interior do Instituto Polit\u00e9cnico da Guarda, 6300-559 Guarda, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4297-5108","authenticated-orcid":false,"given":"Samuel","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"CICS-UBI\u2014Health Sciences Research Center, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"},{"name":"CNC\u2014Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-517 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-3572","authenticated-orcid":false,"given":"Jesus","family":"Rodilla","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0228-0654","authenticated-orcid":false,"given":"Maria Isabel","family":"Ismael","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tzima, K., Brunton, N.P., and Rai, D.K. 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