{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:22:01Z","timestamp":1790774521779,"version":"4.1.0"},"reference-count":168,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Cocoa and cupuassu are evergreen Amazonian trees belonging to the genus Theobroma, with morphologically distinct fruits, including pods and beans. These beans are generally used for agri-food and cosmetics and have high fat and carbohydrates contents. The beans also contain interesting bioactive compounds, among which are polyphenols and methylxanthines thought to be responsible for various health benefits such as protective abilities against cardiovascular and neurodegenerative disorders and other metabolic disorders such as obesity and diabetes. Although these pods represent 50\u201380% of the whole fruit and provide a rich source of proteins, they are regularly eliminated during the cocoa and cupuassu transformation process. The purpose of this work is to provide an overview of recent research on cocoa and cupuassu pods and beans, with emphasis on their chemical composition, bioavailability, and pharmacological properties. According to the literature, pods and beans from cocoa and cupuassu are promising ecological and healthy resources.<\/jats:p>","DOI":"10.3390\/foods11243966","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T02:17:57Z","timestamp":1670465877000},"page":"3966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Theobroma cacao and Theobroma grandiflorum: Botany, Composition and Pharmacological Activities of Pods and Seeds"],"prefix":"10.3390","volume":"11","author":[{"given":"Elodie","family":"Jean-Marie","sequence":"first","affiliation":[{"name":"Laboratoire COVAPAM, UMR Qualisud, Universit\u00e9 de Guyane, 97300 Cayenne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratoire COVAPAM, UMR Qualisud, Universit\u00e9 de Guyane, 97300 Cayenne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-3903","authenticated-orcid":false,"given":"Didier","family":"Bereau","sequence":"additional","affiliation":[{"name":"Laboratoire COVAPAM, UMR Qualisud, Universit\u00e9 de Guyane, 97300 Cayenne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Robinson","sequence":"additional","affiliation":[{"name":"Laboratoire COVAPAM, UMR Qualisud, Universit\u00e9 de Guyane, 97300 Cayenne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lim, T.K. (2012). Edible Medicinal and Non Medicinal Plants: Volume 3, Fruits, Springer.","DOI":"10.1007\/978-94-007-1764-0"},{"key":"ref_2","unstructured":"Cuatrecasas, J. (1964). Cacao and Its Allies: A Taxonomic Revision of the Genus Theobroma. Systematic Plant Studies, Contributions from the United States National Herbarium; Smithsonian Institution."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Bailey, B.A., and Meinhardt, L.W. (2016). Cacao Diseases: A History of Old Enemies and New Encounters, Springer.","DOI":"10.1007\/978-3-319-24789-2"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Fowler, M.S., and Coutel, F. (2008). Cocoa Beans: From Tree to Factory. Beckett\u2019s Industrial Chocolate Manufacture and Use, Wiley-Blackwell.","DOI":"10.1002\/9781444301588.ch2"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Toxopeus, H. (2001). Botany, Types and Populations. Cocoa, John Wiley & Sons, Ltd.","DOI":"10.1002\/9780470698983.ch2"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mart\u00edn, M.A., Goya, L., and Ramos, S. (2016). Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer. Diseases, 4.","DOI":"10.3390\/diseases4010006"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Pot\u00ec, F., Santi, D., Spaggiari, G., Zimetti, F., and Zanotti, I. (2019). Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20020351"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Jean-Marie, E., Bereau, D., and Robinson, J.-C. (2021). Benefits of Polyphenols and Methylxanthines from Cocoa Beans on Dietary Metabolic Disorders. Foods, 10.","DOI":"10.3390\/foods10092049"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1021\/np034002j","article-title":"New Bioactive Polyphenols from Theobroma grandiflorum (\u201ccupua\u00e7u\u201d)","volume":"66","author":"Yang","year":"2003","journal-title":"J. Nat. Prod."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wood, G.A.R. (2001). History and Development. Cocoa, John Wiley & Sons, Ltd.","DOI":"10.1002\/9780470698983.ch1"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Motamayor, J.C., Lachenaud, P., da Silva e Mota, J.W., Loor, R., Kuhn, D.N., Brown, J.S., and Schnell, R.J. (2008). Geographic and Genetic Population Differentiation of the Amazonian Chocolate Tree (Theobroma cacao L). PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003311"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3390\/d2010072","article-title":"Origin and Domestication of Native Amazonian Crops","volume":"2","author":"Clement","year":"2010","journal-title":"Diversity"},{"key":"ref_13","unstructured":"Morris, D. (1882). Cacao: How to Grow and How to Cure It, Government Printing Establishment."},{"key":"ref_14","unstructured":"Hart, J.H. (1892). \u201cCacao\u201d: A Treatise on the Cultivation and Curing of \u201cCacao\u201d (Theobroma cacao), Botany and Nomenclature of the Same and Hints on the Selection and Management of Estates."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/sj.hdy.6800298","article-title":"Cacao Domestication II: Progenitor Germplasm of the Trinitario Cacao Cultivar","volume":"91","author":"Motamayor","year":"2003","journal-title":"Heredity"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1017\/S1479262109990232","article-title":"The Relic Criollo Cacao in Belize\u2014Genetic Diversity and Relationship with Trinitario and Other Cacao Clones Held in the International Cocoa Genebank, Trinidad","volume":"8","author":"Motilal","year":"2010","journal-title":"Plant Genet. Resour."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1590\/S1677-04202007000400011","article-title":"Ecophysiology of the Cacao Tree","volume":"19","author":"Valle","year":"2007","journal-title":"Braz. J. Plant Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/10408398.2012.669428","article-title":"Cocoa Agronomy, Quality, Nutritional, and Health Aspects","volume":"55","author":"Badrie","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.18174\/njas.v18i2.17349","article-title":"Studies on Pod and Bean Values of Theobroma cacao L. in Nigeria. I. Environmental Effects on West African Amelonado with Particular Attention to Annual Rainfall Distribution","volume":"18","author":"Toxopeus","year":"1970","journal-title":"NJAS"},{"key":"ref_20","unstructured":"Soria, J. (1967). Notas Sobre Las Principales Variedades de Cacao Cultivadas En America Tropical. Proceedings of the Conference Internationale sur les Recherches Agronomiques Cacaoy\u00e8res, Bib. Orton IICA\/CATIE."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11295-006-0066-9","article-title":"High Levels of Genetic Divergence and Inbreeding in Populations of Cupuassu (Theobroma grandiflorum)","volume":"3","author":"Alves","year":"2007","journal-title":"Tree Genet. Genomes"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Nair, K.P.P. (2010). 5\u2014Cocoa (Theobroma cacao L.). The Agronomy and Economy of Important Tree Crops of the Developing World, Elsevier.","DOI":"10.1016\/B978-0-12-384677-8.00005-9"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Dand, R. (2011). 2\u2014Agronomics of International Cocoa Production. The International Cocoa Trade, Woodhead Publishing. [3rd ed.].","DOI":"10.1016\/B978-0-85709-125-3.50002-1"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/sj.hdy.6800156","article-title":"Cacao Domestication I: The Origin of the Cacao Cultivated by the Mayas","volume":"89","author":"Motamayor","year":"2002","journal-title":"Heredity"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.agee.2003.08.011","article-title":"Evaluation of Soil Fertility in Smallholder Agroforestry Systems and Pastures in Western Amazonia","volume":"102","author":"Alfaia","year":"2004","journal-title":"Agric. Ecosyst. Environ."},{"key":"ref_26","first-page":"74","article-title":"Growth, Yields and Mineral Nutrition of Cupua\u00e7u (Theobroma grandiflorum) in Two Multi-Strata Agroforestry Systems on a Ferralitic Amazonian Upland Soil at Four Fertilization Levels","volume":"75","author":"Schroth","year":"2001","journal-title":"J. Appl. Bot."},{"key":"ref_27","unstructured":"van Vliet, J.A., Slingerland, M.A., and Giller, K.E. (2015). Mineral Nutrition of Cocoa: A Review, Wageningen UR."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00010694-196109000-00005","article-title":"Relationships between ph values of organic soils and availabilities of 12 plant nutrients","volume":"92","author":"Lucas","year":"1961","journal-title":"Soil Sci."},{"key":"ref_29","unstructured":"Pontillon, J. (1998). Cocoa and Chocolate: Production, Utilization, Characteristics, Tec & Doc- Lavoisier."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1023\/A:1008763321959","article-title":"Use of Floral Descriptors to Study Variability in Wild Cocoa Trees (Theobroma cacao L.) in French Guiana","volume":"46","author":"Lachenaud","year":"1999","journal-title":"Genet. Resour. Crop Evol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Schwan, R.F., and Fleet, G.H. (2014). Cocoa and Coffee Fermentations, CRC Press.","DOI":"10.1201\/b17536"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/S0044-59672011000100017","article-title":"Flowering Levels, Harvest Season and Yields of Cupuassu (Theobroma grandiflorum)","volume":"41","author":"Venturieri","year":"2011","journal-title":"Acta Amaz."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/S0100-84042005000300013","article-title":"The Site of Self-Incompatibility Action in Cupuassu (Theobroma grandiflorum)","volume":"28","author":"Ramos","year":"2005","journal-title":"Braz. J. Bot."},{"key":"ref_34","unstructured":"Venturieri, G.A. (1994). Floral Biology of Cupuassu (Theobroma grandiflorum (Willdenow Ex Sprengel) Schumann). [Ph.D. Thesis, University of Reading]."},{"key":"ref_35","unstructured":"Lanaud, C. (1987). Nouvelles Donnees Sur La Biologie Du Cacaoyer (Theobroma cacao L.): Diversite Des Populations, Systeme d\u2019incompatibilite, Haploides Spontanes. Leurs Consequences Pour l\u2019amelioration Genetique de Cette Espece. [Ph.D. Thesis, Universit\u00e9 de Paris-Sud]."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/hdy.1962.14","article-title":"The Mechanism of Pollen Incompatibility in Theobroma cacao L.","volume":"17","author":"Cope","year":"1962","journal-title":"Heredity"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/hdy.1955.3","article-title":"Incompatibility in Theobroma cacao","volume":"9","author":"Knight","year":"1955","journal-title":"Heredity"},{"key":"ref_38","unstructured":"Lachenaud, P. (2019). Les cacaoyers de Guyane. Science & D\u00e9couverte, BIOTOPE. Biotope Editions."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1080\/12538078.2005.10515493","article-title":"Les Cacaoyers Spontan\u00e9s de Guyane Fran\u00e7aise: \u00c9tat Des Recherches","volume":"152","author":"Lachenaud","year":"2005","journal-title":"Acta Bot. Gall."},{"key":"ref_40","unstructured":"Calzavara, B.B.G., M\u00fcller, C.H., and de Nazar\u00e9 da Costa Kahwage, O. (2022, November 27). Fruticultura Tropical o Cupua\u00e7uzeiro; Cultivo, Beneficiamento e Utiliza\u00e7\u00e3o Do Fruto, Available online: https:\/\/www.embrapa.br\/busca-de-publicacoes\/-\/publicacao\/387253\/fruticultura-tropical-o-cupuacuzeiro-cultivo-beneficiamento-e-utilizacao-do-fruto."},{"key":"ref_41","first-page":"12","article-title":"Dynamics of Storage Materials in Cotyledon During Cocoa Seed Germination","volume":"3","author":"Sakiroh","year":"2019","journal-title":"Ilmu Pertan. (Agric. Sci.)"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"De Souza, P., Moreira, L., Sarmento, D., and Costa, F. (2018). Cacao\u2014Theobroma cacao, Academic Press. Available online: https:\/\/www.researchgate.net\/publication\/323113746_Cacao-Theobroma_cacao.","DOI":"10.1016\/B978-0-12-803138-4.00010-1"},{"key":"ref_43","unstructured":"Rodrigues, S., de Oliveira Silva, E., and de Brito, E.S. (2018). Cupuassu\u2014Theobroma grandiflorum. Exotic Fruits, Academic Press."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.5458\/jag.57.245","article-title":"Proteomic Analysis of Theobroma cacao Pod Husk","volume":"57","author":"Awang","year":"2010","journal-title":"J. Appl. Glycosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0963-9969(99)00088-5","article-title":"Protein Quality Assessment in Cocoa Husk","volume":"32","year":"1999","journal-title":"Food Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.foodres.2012.08.005","article-title":"Chemical, Technological and in Vitro Antioxidant Properties of Cocoa (Theobroma cacao L.) Co-Products","volume":"49","author":"Torres","year":"2012","journal-title":"Food Res. Int."},{"key":"ref_47","first-page":"5","article-title":"Chemical Composition of Differently Treated Forms of Cocoa POD Husk Meal (CPHM)","volume":"8","author":"Ozung","year":"2016","journal-title":"Asian J. Agric. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nguyen, V.T., and Nguyen, N.H. (2017). Proximate Composition, Extraction, and Purification of Theobromine from Cacao Pod Husk (Theobroma cacao L.). Technologies, 5.","DOI":"10.3390\/technologies5020014"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"109725","DOI":"10.1016\/j.foodres.2020.109725","article-title":"Effect of Drying Methods on the Gastrointestinal Fate and Bioactivity of Phytochemicals from Cocoa Pod Husk: In Vitro and in Silico Approaches","volume":"137","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e06799","DOI":"10.1016\/j.heliyon.2021.e06799","article-title":"Bioactive Compounds and Techno-Functional Properties of High-Fiber Co-Products of the Cacao Agro-Industrial Chain","volume":"7","author":"Martuscelli","year":"2021","journal-title":"Heliyon"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1021\/jf00011a009","article-title":"Chemical Composition of Wild Theobroma Species and Their Comparison to the Cacao Bean","volume":"39","author":"Sotelo","year":"1991","journal-title":"J. Agric. Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1021\/jf304349u","article-title":"Flavonoids, Proanthocyanidins, Vitamin C, and Antioxidant Activity of Theobroma grandiflorum (Cupuassu) Pulp and Seeds","volume":"61","author":"Pugliese","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.foodchem.2017.07.128","article-title":"Substantial Equivalence Analysis in Fruits from Three Theobroma Species through Chemical Composition and Protein Profiling","volume":"240","author":"Melgarejo","year":"2018","journal-title":"Food Chem."},{"key":"ref_54","unstructured":"Pugliese, A.G. (2010). Compostos Fen\u00f3licos do Cupua\u00e7u (Theobroma grandiflorum) e do Cupulate: Composi\u00e7\u00e3o e Poss\u00edveis Benef\u00edcios, Universidade de S\u00e3o Paulo."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.foodres.2018.02.070","article-title":"Assessment of Cocoa (Theobroma cacao L.) Butter Content and Composition throughout Fermentations","volume":"107","author":"Servent","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1590\/S0101-20612008000400035","article-title":"Proteins of Cupuacu Seeds (Theobroma grandiflorum Schum) and Changes during Fermentation and Roasting","volume":"28","author":"Carvalho","year":"2008","journal-title":"Food Sci. Technol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1590\/S0100-84042008000100013","article-title":"Localization of the Cotyledon Reserves of Theobroma grandiflorum (Willd. Ex Spreng.) K. Schum., T. Subincanum Mart., T. Bicolor Bonpl. and Their Analogies with T. Cacao L.","volume":"31","author":"Martini","year":"2008","journal-title":"Braz. J. Bot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.15446\/rcq.v49n3.84082","article-title":"Extraction, Separation, and Evaluation of Antioxidant Effect of the Different Fractions of Polyphenols from Cocoa Beans","volume":"49","year":"2020","journal-title":"Rev. Colomb. De Qu\u00edmica"},{"key":"ref_59","first-page":"1","article-title":"Characterization of cocoa (Theobroma cocoa) pod","volume":"4","author":"Adewole","year":"2013","journal-title":"Int. J. Sci. Eng. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1006\/jfca.2000.0984","article-title":"Composition of Genuine Cocoa Butter and Cocoa Butter Equivalents","volume":"14","author":"Lipp","year":"2001","journal-title":"J. Food Compos. Anal."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jfoodeng.2007.08.008","article-title":"The Effects of Particle Size, Fermentation and Roasting of Cocoa Nibs on Supercritical Fluid Extraction of Cocoa Butter","volume":"85","author":"Asep","year":"2008","journal-title":"J. Food Eng."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"111629","DOI":"10.1016\/j.lwt.2021.111629","article-title":"Colour, Fatty Acids, Bioactive Compounds, and Total Antioxidant Capacity in Commercial Cocoa Beans (Theobroma cacao L.)","volume":"147","year":"2021","journal-title":"LWT"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3989\/gya.2004.v55.i2.154","article-title":"Rheological Properties of Cupuassu and Cocoa Fats","volume":"55","author":"Lannes","year":"2004","journal-title":"Grasas Y Aceites"},{"key":"ref_64","first-page":"103","article-title":"Characterization and Lipid Extraction of Amazon Cocoa Seeds (Theobroma grandiflorum)","volume":"7","author":"Murillo","year":"2016","journal-title":"Cienc. En Desarro."},{"key":"ref_65","unstructured":"Hern\u00e1ndez, M.S., Barrera, J.A., and Carrillo, M. (2006). Oferta y Potencialidades de un Banco de Germoplasma del G\u00e9nero Theobroma en el Enriquecimiento de los Sistemas Productivos de la Regi\u00f3n Amaz\u00f3nica, SINCHI."},{"key":"ref_66","unstructured":"Castro Robayo, Z.R. (2010). Caracterizaci\u00f3n del Proceso de Fermentaci\u00f3n del Grano de COPOAZ\u00da (Theobroma grandiflorum Willd. ex Spreng). [Ph.D. Thesis, Universidad Nacional De Colombia]."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.foodchem.2018.03.026","article-title":"Profiling, Quantification and Classification of Cocoa Beans Based on Chemometric Analysis of Carbohydrates Using Hydrophilic Interaction Liquid Chromatography Coupled to Mass Spectrometry","volume":"258","author":"Grimbs","year":"2018","journal-title":"Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/chromsci\/45.5.273","article-title":"Determination of Theobromine, Theophylline, and Caffeine in by-Products of Cupuacu and Cacao Seeds by High-Performance Liquid Chromatography","volume":"45","author":"Coco","year":"2007","journal-title":"J. Chromatogr. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Abdul Karim, A., Azlan, A., Ismail, A., Hashim, P., Abd Gani, S.S., Zainudin, B.H., and Abdullah, N.A. (2014). Phenolic Composition, Antioxidant, Anti-Wrinkles and Tyrosinase Inhibitory Activities of Cocoa Pod Extract. BMC Complement. Altern. Med., 14.","DOI":"10.1186\/1472-6882-14-381"},{"key":"ref_70","first-page":"557","article-title":"Comparative Inhibitory Effects of Cocoa Bean and Cocoa Pod Husk Extracts on Enzymes Associated with Hyperuricemia and Hypertension in Vitro","volume":"26","author":"Irondi","year":"2019","journal-title":"Int. Food Res. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0963-9969(00)00068-5","article-title":"Review on Polyphenols in Theobroma cacao: Changes in Composition during the Manufacture of Chocolate and Methodology for Identification and Quantification","volume":"33","author":"Wollgast","year":"2000","journal-title":"Food Res. Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jfca.2005.02.006","article-title":"Comparative Study of Different Cocoa (Theobroma cacao L.) Clones in Terms of Their Phenolics and Anthocyanins Contents","volume":"19","author":"Niemenak","year":"2006","journal-title":"J. Food Compos. Anal."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1021\/jf8014415","article-title":"Obtention and Characterization of Phenolic Extracts from Different Cocoa Sources","volume":"56","author":"Ortega","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phrs.2009.08.008","article-title":"Theobroma cacao L., the Food of the Gods: A Scientific Approach beyond Myths and Claims","volume":"61","author":"Rusconi","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Jean-Marie, E., Bereau, D., Poucheret, P., Guzman, C., Boudard, F., and Robinson, J.-C. (2021). Antioxidative and Immunomodulatory Potential of the Endemic French Guiana Wild Cocoa \u201cGuiana\u201d. Foods, 10.","DOI":"10.3390\/foods10030522"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jff.2016.02.009","article-title":"Evaluation of the Distribution and Metabolism of Polyphenols Derived from Cupuassu (Theobroma grandiflorum) in Mice Gastrointestinal Tract by UPLC-ESI-QTOF","volume":"22","author":"Genovese","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ifset.2017.04.012","article-title":"Effects of Microwaves, Hot Air and Freeze-Drying on the Phenolic Compounds, Antioxidant Capacity, Enzyme Activity and Microstructure of Cacao Pod Husks (Theobroma cacao L.)","volume":"41","author":"Villarreal","year":"2017","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_78","first-page":"78","article-title":"Effect of Cocoa Pod Husk Extracts on Prevention of Hypercholesterolemia in Albino Rats (Rattus Novergicus)","volume":"12","author":"Natsir","year":"2008","journal-title":"Farm. Dan Farmakol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.foodres.2016.10.028","article-title":"Antioxidant Capacity of Cocoa Beans and Chocolate Assessed by FTIR","volume":"90","author":"Batista","year":"2016","journal-title":"Food Res. Int."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1007\/s13197-021-05119-z","article-title":"Cocoa Extract with High Content of Flavan 3-Ols, Procyanidins and Methylxanthines","volume":"59","year":"2022","journal-title":"J. Food Sci. Technol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00217-009-1132-y","article-title":"Differences between the Content of Phenolic Compounds in Criollo, Forastero and Trinitario Cocoa Seed (Theobroma cacao L.)","volume":"229","author":"Elwers","year":"2009","journal-title":"Eur. Food Res. Technol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1080\/10408398.2012.686934","article-title":"The Content of Polyphenolic Compounds in Cocoa Beans (Theobroma cacao L.), Depending on Variety, Growing Region, and Processing Operations: A Review","volume":"55","author":"Oracz","year":"2013","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11130-018-0700-3","article-title":"Effects of Maturity at Harvest and Fermentation Conditions on Bioactive Compounds of Cocoa Beans","volume":"74","author":"Dang","year":"2019","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Urba\u0144ska, B., Kowalska, J., and Lacerda Ramos, C. (2019). Comparison of the Total Polyphenol Content and Antioxidant Activity of Chocolate Obtained from Roasted and Unroasted Cocoa Beans from Different Regions of the World. Antioxidants, 8.","DOI":"10.3390\/antiox8080283"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.foodres.2013.02.019","article-title":"Chemical Composition of Cupuassu (Theobroma grandiflorum) and Cocoa (Theobroma cacao) Liquors and Their Effects on Streptozotocin-Induced Diabetic Rats","volume":"51","author":"Genovese","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-3-642-13443-2_2","article-title":"Distribution, Biosynthesis and Catabolism of Methylxanthines in Plants","volume":"Volume 200","author":"Ashihara","year":"2011","journal-title":"Methylxanthines"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Grases, F., Rodriguez, A., and Costa-Bauza, A. (2014). Theobromine Inhibits Uric Acid Crystallization. A Potential Application in the Treatment of Uric Acid Nephrolithiasis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0111184"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"124","DOI":"10.17584\/rcch.2015v9i1.3751","article-title":"Evaluation of Epicatechin, Theobromine and Caffeine in Cacao Husks (Theobroma cacao, L.), Determination of the Antioxidant Capacity","volume":"9","author":"Sotelo","year":"2015","journal-title":"Rev. Colomb. De Cienc. Hort\u00edcolas"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"355","DOI":"10.17268\/sci.agropecu.2016.04.01","article-title":"Methylxanthine and Catechin Content of Fresh and Fermented Cocoa Beans, Dried Cocoa Beans, and Cocoa Liquor","volume":"7","author":"Camasca","year":"2016","journal-title":"Sci. Agropecu."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.foodchem.2017.08.018","article-title":"Bioactive Compounds in Mexican Genotypes of Cocoa Cotyledon and Husk","volume":"240","year":"2018","journal-title":"Food Chem."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tifs.2018.09.022","article-title":"Cocoa (Theobroma cacao L.) Pod Husk: Renewable Source of Bioactive Compounds","volume":"81","author":"Oomah","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1080\/10942912.2015.1071840","article-title":"Antioxidant Properties of Cocoa Beans (Theobroma cacao L.): Influence of Cultivar and Roasting Conditions","volume":"19","author":"Oracz","year":"2016","journal-title":"Int. J. Food Prop."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"7292","DOI":"10.1021\/jf0344385","article-title":"Cocoa Has More Phenolic Phytochemicals and a Higher Antioxidant Capacity than Teas and Red Wine","volume":"51","author":"Lee","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"473","DOI":"10.15446\/acag.v66n4.61821","article-title":"Effect of Fermentation Time on Phenolic Content and Antioxidant Potential in Cupuassu (Theobroma grandiflorum (Willd. Ex Spreng.) K.Schum.) Beans","volume":"66","year":"2017","journal-title":"Acta Agron\u00f3mica"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.foodres.2013.06.019","article-title":"Comparison of Polyphenol, Methylxanthines and Antioxidant Activity in Theobroma cacao Beans from Different Cocoa-Growing Areas in Colombia","volume":"60","author":"Carrillo","year":"2014","journal-title":"Food Res. Int."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.lwt.2016.04.065","article-title":"Change in Stability of Procyanidins, Antioxidant Capacity and in-Vitro Bioaccessibility during Processing of Cocoa Powder from Cocoa Beans","volume":"72","year":"2016","journal-title":"LWT Food Sci. Technol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ptr.2961","article-title":"Protection of Human HepG2 Cells against Oxidative Stress by the Flavonoid Epicatechin","volume":"24","author":"Ramos","year":"2010","journal-title":"Phytother. Res. PTR"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11130-020-00807-1","article-title":"Cocoa Flavanols Protect Human Endothelial Cells from Oxidative Stress","volume":"75","author":"Martins","year":"2020","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jsfa.7079","article-title":"Antioxidant Effects of Proanthocyanidin-Rich Natural Extracts from Grape Seed and Cupuassu on Gastrointestinal Mucosa","volume":"96","author":"Pinent","year":"2016","journal-title":"J. Sci. Food Agric."},{"key":"ref_100","first-page":"478","article-title":"New Products from Theobroma cacao: Seed Pulp and Pod Gum","volume":"475","author":"Figueira","year":"1993","journal-title":"New Crops"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"106599","DOI":"10.1016\/j.smallrumres.2021.106599","article-title":"Cocoa Husks Fed to Lactating Dairy Ewes Affect Milk Fatty Acid Profile and Oxidative Status of Blood and Milk","volume":"207","author":"Carta","year":"2022","journal-title":"Small Rumin. Res."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Yerena, A., Perez, M., Vallverd\u00fa-Queralt, A., and Escribano-Ferrer, E. (2020). Insights into the Binding of Dietary Phenolic Compounds to Human Serum Albumin and Food-Drug Interactions. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12111123"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"231","DOI":"10.17660\/ActaHortic.2014.1047.28","article-title":"Comparison between Chocolate and an Analog Product Made from Copoaz\u00fa (Theobroma grandiflorum)","volume":"1047","author":"Cucaita","year":"2014","journal-title":"Acta Hortic."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1002\/jsfa.3349","article-title":"Fermentation of Cocoa Beans: Influence of Microbial Activities and Polyphenol Concentrations on the Flavour of Chocolate","volume":"88","author":"Camu","year":"2008","journal-title":"J. Sci. Food Agric."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1080\/10408398.2019.1581726","article-title":"An Overview of the Physical and Biochemical Transformation of Cocoa Seeds to Beans and to Chocolate: Flavor Formation","volume":"60","author":"Vaillant","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jfq.12070","article-title":"Effect of Fermentation and Roasting on the Phenolic Concentration and Antioxidant Activity of Cocoa from Nicaragua","volume":"37","author":"Suazo","year":"2014","journal-title":"J. Food Qual."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/ijfs.12760","article-title":"Evaluation of the Effect of Processing on Cocoa Polyphenols: Antiradical Activity, Anthocyanins and Procyanidins Profiling from Raw Beans to Chocolate","volume":"50","author":"Bordiga","year":"2015","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1590\/S0101-20612009000400017","article-title":"da S. Comparison of Total Phenolic Content and Antiradical Capacity of Powders and \u201cChocolates\u201d from Cocoa and Cupuassu","volume":"29","author":"Genovese","year":"2009","journal-title":"Food Sci. Technol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jfca.2015.01.018","article-title":"Polyphenols, Methylxanthines, and Antioxidant Capacity of Chocolates Produced in Serbia","volume":"41","author":"Todorovic","year":"2015","journal-title":"J. Food Compos. Anal."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fct.2008.09.058","article-title":"Antidiabetic Effect of Punica Granatum Flowers: Effect on Hyperlipidemia, Pancreatic Cells Lipid Peroxidation and Antioxidant Enzymes in Experimental Diabetes","volume":"47","author":"Bagri","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.phanu.2015.01.002","article-title":"Poliphenolic-Rich Extracts from Cocoa (Theobroma cacao L.) and Cupuassu (Theobroma grandiflorum Willd. Ex Spreng. K. Shum) Liquors: A Comparison of Metabolic Effects in High-Fat Fed Rats","volume":"3","author":"Rogero","year":"2015","journal-title":"PharmaNutrition"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic Fatty Liver Disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_113","unstructured":"Abbas, A.K., and Lichtman, A.H. (2008). Les Bases de L\u2019immunologie Fondamentale et Clinique, Elsevier Masson."},{"key":"ref_114","unstructured":"Clos, J. (2012). Immunit\u00e9 Chez les Animaux et les V\u00e9g\u00e9taux, Lavoisier."},{"key":"ref_115","first-page":"87","article-title":"Stress oxydatif et inflammation","volume":"1995","author":"Pasquier","year":"1995","journal-title":"Rev. Fran\u00e7aise Des Lab."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12937-016-0186-5","article-title":"The Importance of Antioxidants Which Play the Role in Cellular Response against Oxidative\/Nitrosative Stress: Current State","volume":"15","author":"Kurutas","year":"2016","journal-title":"Nutr. J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fimmu.2014.00614","article-title":"Molecular Mechanisms That Influence the Macrophage M1-M2 Polarization Balance","volume":"5","author":"Wang","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of Reactive Oxygen Species and NF-\u039aB Signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0602325","article-title":"The Many Faces of Macrophage Activation","volume":"73","author":"Mosser","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"6293740","DOI":"10.1155\/2017\/6293740","article-title":"Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti-Inflammatory M2 State","volume":"2017","author":"Dugo","year":"2017","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.clnu.2017.12.016","article-title":"Cupua\u00e7u Extract Reduces Nitrosative Stress and Modulates Inflammatory Mediators in the Kidneys of Experimental Diabetes","volume":"38","author":"Punaro","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"100599","DOI":"10.1016\/j.fbio.2020.100599","article-title":"Prebiotic, Antioxidant and Anti-Inflammatory Properties of Edible Amazon Fruits","volume":"36","author":"Curimbaba","year":"2020","journal-title":"Food Biosci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.1021\/jf0511042","article-title":"Flavonoids from Theobroma cacao Down-Regulate Inflammatory Mediators","volume":"53","author":"Ramiro","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/1044667031000137601","article-title":"Modulation of TNF-\u03b1 Secretion in Peripheral Blood Mononuclear Cells by Cocoa Flavanols and Procyanidins","volume":"9","author":"Mao","year":"2002","journal-title":"J. Immunol. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/mnfr.200700396","article-title":"Influence of a Cocoa-Enriched Diet on Specific Immune Response in Ovalbumin-Sensitized Rats","volume":"53","author":"Castellote","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jnutbio.2015.09.022","article-title":"Effect of a Cocoa-Enriched Diet on Immune Response and Anaphylaxis in a Food Allergy Model in Brown Norway Rats","volume":"27","author":"Franch","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Rossin, D., Barbosa-Pereira, L., Iaia, N., Sottero, B., Danzero, A.C., Poli, G., Zeppa, G., and Biasi, F. (2021). Protective Effect of Cocoa Bean Shell against Intestinal Damage: An Example of Byproduct Valorization. Antioxidants, 10.","DOI":"10.3390\/antiox10020280"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"109058","DOI":"10.1016\/j.foodres.2020.109058","article-title":"Cocoa Diet Modulates Gut Microbiota Composition and Improves Intestinal Health in Zucker Diabetic Rats","volume":"132","author":"Ramos","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"131494","DOI":"10.1016\/j.foodchem.2021.131494","article-title":"\u03b1-Amylase Inhibition, Cytotoxicity and Influence of the in Vitro Gastrointestinal Digestion on the Bioaccessibility of Phenolic Compounds in the Peel and Seed of Theobroma grandiflorum","volume":"373","author":"Andrade","year":"2022","journal-title":"Food Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"e549287","DOI":"10.1155\/2014\/549287","article-title":"In Vitro Studies on the Antioxidant Property and Inhibition of \u03b1-Amylase, \u03b1-Glucosidase, and Angiotensin I-Converting Enzyme by Polyphenol-Rich Extracts from Cocoa (Theobroma cacao) Bean","volume":"2014","author":"Oboh","year":"2014","journal-title":"Pathol. Res. Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1021\/acs.jafc.6b01725","article-title":"Loss of Native Flavanols during Fermentation and Roasting Does Not Necessarily Reduce Digestive Enzyme-Inhibiting Bioactivities of Cocoa","volume":"64","author":"Ryan","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Cantele, C., Rojo-Poveda, O., Bertolino, M., Ghirardello, D., Cardenia, V., Barbosa-Pereira, L., and Zeppa, G. (2020). In Vitro Bioaccessibility and Functional Properties of Phenolic Compounds from Enriched Beverages Based on Cocoa Bean Shell. Foods, 9.","DOI":"10.3390\/foods9060715"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1021\/acs.jafc.1c07547","article-title":"Chronic Consumption of Cocoa Rich in Procyanidins Has a Marginal Impact on Gut Microbiota and on Serum and Fecal Metabolomes in Male Endurance Athletes","volume":"70","author":"Tabone","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"108854","DOI":"10.1016\/j.jnutbio.2021.108854","article-title":"Consumption of 85% Cocoa Dark Chocolate Improves Mood in Association with Gut Microbial Changes in Healthy Adults: A Randomized Controlled Trial","volume":"99","author":"Shin","year":"2022","journal-title":"J. Nutr. Biochem."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Lagunas, M.J., Vicente, F., Pereira, P., Castell, M., and P\u00e9rez-Cano, F.J. (2019). Relationship between Cocoa Intake and Healthy Status: A Pilot Study in University Students. Molecules, 24.","DOI":"10.3390\/molecules24040812"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1017\/S0007114509993473","article-title":"Distribution of Epicatechin Metabolites in Lymphoid Tissues and Testes of Young Rats with a Cocoa-Enriched Diet","volume":"103","author":"Khan","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1021\/jf070487w","article-title":"Cocoa-Enriched Diet Enhances Antioxidant Enzyme Activity and Modulates Lymphocyte Composition in Thymus from Young Rats","volume":"55","author":"Franch","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s00394-018-1736-8","article-title":"Gene Expression Changes by High-Polyphenols Cocoa Powder Intake: A Randomized Crossover Clinical Study","volume":"58","author":"Poquet","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1093\/gerona\/glz107","article-title":"High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and Inflammation Levels While Improving Mobility and Quality of Life in Older Subjects: A Double-Blind Randomized Clinical Trial","volume":"74","author":"Munguia","year":"2019","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.foodchem.2006.02.006","article-title":"Intake and Bioaccessibility of Total Polyphenols in a Whole Diet","volume":"101","author":"Serrano","year":"2007","journal-title":"Food Chem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tifs.2020.10.030","article-title":"Effect of Food Matrix on the Content and Bioavailability of Flavonoids","volume":"117","author":"Kamiloglu","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-food-022510-133725","article-title":"Influence of Formulation and Processing on Absorption and Metabolism of Flavan-3-Ols from Tea and Cocoa","volume":"2","author":"Neilson","year":"2011","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2125.2012.04425.x","article-title":"Bioavailability of Bioactive Food Compounds: A Challenging Journey to Bioefficacy","volume":"75","author":"Rein","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Sorrenti, V., Fortinguerra, S., Caudullo, G., and Buriani, A. (2020). Deciphering the Role of Polyphenols in Sports Performance: From Nutritional Genomics to the Gut Microbiota toward Phytonutritional Epigenomics. Nutrients, 12.","DOI":"10.3390\/nu12051265"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Sorrenti, V., Ali, S., Mancin, L., Davinelli, S., Paoli, A., and Scapagnini, G. (2020). Cocoa Polyphenols and Gut Microbiota Interplay: Bioavailability, Prebiotic Effect, and Impact on Human Health. Nutrients, 12.","DOI":"10.3390\/nu12071908"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/10715760000301151","article-title":"Bioavailability of (\u2013)-Epicatechin upon Intake of Chocolate and Cocoa in Human Volunteers","volume":"33","author":"Baba","year":"2000","journal-title":"Free. Radic. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1006\/bbrc.2000.3701","article-title":"Epicatechin and Catechin Are O-Methylated and Glucuronidated in the Small Intestine","volume":"277","author":"Kuhnle","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"6190","DOI":"10.1021\/jf050377u","article-title":"Rapid Liquid Chromatography Tandem Mass Spectrometry Assay to Quantify Plasma (\u2013)-Epicatechin Metabolites after Ingestion of a Standard Portion of Cocoa Beverage in Humans","volume":"53","author":"Roura","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_149","first-page":"348","article-title":"Polyphenols, Dietary Sources and Bioavailability","volume":"43","author":"Filesi","year":"2007","journal-title":"Ann. Dell\u2019istituto Super. Di Sanita"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e13432","DOI":"10.1097\/MD.0000000000013432","article-title":"Dark Chocolate Modulates Platelet Function with a Mechanism Mediated by Flavan-3-Ol Metabolites","volume":"97","author":"Montagnana","year":"2018","journal-title":"Medicine"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and Bioefficacy of Polyphenols in Humans. I. Review of 97 Bioavailability Studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1079\/BJN20051480","article-title":"The Absorption, Metabolism and Excretion of Flavan-3-Ols and Procyanidins Following the Ingestion of a Grape Seed Extract by Rats","volume":"94","author":"Tsang","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1017\/S0007114509992741","article-title":"Bioavailability of Procyanidin Dimers and Trimers and Matrix Food Effects in in Vitro and in Vivo Models","volume":"103","author":"Serra","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/jn\/130.11.2733","article-title":"Polymeric Proanthocyanidins Are Catabolized by Human Colonic Microflora into Low-Molecular-Weight Phenolic Acids","volume":"130","author":"Brezillon","year":"2000","journal-title":"J. Nutr."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1208\/s12248-015-9732-x","article-title":"Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids","volume":"17","author":"Dai","year":"2015","journal-title":"AAPS J."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.foodchem.2018.08.099","article-title":"Bioaccessibility of Phenolic Compounds in Native and Exotic Frozen Pulps Explored in Brazil Using a Digestion Model Coupled with a Simulated Intestinal Barrier","volume":"274","author":"Dantas","year":"2019","journal-title":"Food Chem."},{"key":"ref_157","unstructured":"Food and Agriculture Organization of the United Nations (1997). FAOSTAT Statistical Database, FAO."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"20220421039","DOI":"10.31220\/agriRxiv.2022.00156","article-title":"Transparency, Traceability and Deforestation in the Ivorian Cocoa Supply Chain","volume":"2022","author":"Renier","year":"2022","journal-title":"agriRxiv"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.scitotenv.2016.03.024","article-title":"Vulnerability to Climate Change of Cocoa in West Africa: Patterns, Opportunities and Limits to Adaptation","volume":"556","author":"Schroth","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"6","DOI":"10.29244\/jtcs.5.1.6-17","article-title":"Cocoa Production Stability in Relation to Changing Rainfall and Temperature in East Java, Indonesia","volume":"5","author":"Santosa","year":"2018","journal-title":"JTCS"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/0100-29452018061","article-title":"Spondias Mombin and Theobroma grandiflorum in Agroforestry System: Productivity Implications","volume":"40","author":"Alves","year":"2018","journal-title":"Rev. Bras. De Frutic."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.foodres.2017.07.055","article-title":"Impact of Fermentation Conditions on the Quality and Sensory Properties of a Probiotic Cupuassu (Theobroma grandiflorum) Beverage","volume":"100","author":"Pereira","year":"2017","journal-title":"Food Res. Int."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.3168\/jds.2015-9738","article-title":"Cupuassu (Theobroma grandiflorum) Pulp, Probiotic, and Prebiotic: Influence on Color, Apparent Viscosity, and Texture of Goat Milk Yogurts","volume":"98","author":"Costa","year":"2015","journal-title":"J. Dairy Sci."},{"key":"ref_164","unstructured":"(1999). International trade centre (ITC), Trade Statistics for International Business Development, International Trade Centre."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Santana, N.B., Dias, J.C.T., Rezende, R.P., Franco, M., Oliveira, L.K.S., and Souza, L.O. (2018). Production of Xylitol and Bio-Detoxification of Cocoa Pod Husk Hemicellulose Hydrolysate by Candida Boidinii XM02G. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0195206"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40097-016-0191-4","article-title":"Cocoa Pod Husk Extract-Mediated Biosynthesis of Silver Nanoparticles: Its Antimicrobial, Antioxidant and Larvicidal Activities","volume":"6","author":"Lateef","year":"2016","journal-title":"J. Nanostructure Chem."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"13163","DOI":"10.1038\/s41598-020-69763-9","article-title":"Nutritional Value and Safety of Animal Feed Supplemented with Talaromyces Verruculosus-Treated Cocoa Pod Husks","volume":"10","author":"Ocloo","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"119250","DOI":"10.1016\/j.fuel.2020.119250","article-title":"Characterization of Rice, Coffee and Cocoa Crops Residues as Fuel of Thermal Power Plant in C\u00f4te d\u2019Ivoire","volume":"283","author":"Zinla","year":"2021","journal-title":"Fuel"}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/11\/24\/3966\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:36:06Z","timestamp":1760146566000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/11\/24\/3966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,8]]},"references-count":168,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["foods11243966"],"URL":"https:\/\/doi.org\/10.3390\/foods11243966","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,8]]}}}