{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:12:31Z","timestamp":1787951551780,"version":"build-2784847793"},"reference-count":87,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["AGL2017-83599-R"],"award-info":[{"award-number":["AGL2017-83599-R"]}]},{"name":"Centro de Excelencia Severo Ochoa","award":["AGL2017-83599-R"],"award-info":[{"award-number":["AGL2017-83599-R"]}]},{"name":"CERCA Programme\/Generalitat de Catalunya","award":["AGL2017-83599-R"],"award-info":[{"award-number":["AGL2017-83599-R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar\u2013Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After 10 weeks, the HF + Inulin diet promoted high dominance of a few bacterial genera including Blautia and Olsenella in feces while reducing richness, diversity, and rarity compared to the HF diet. These changes in fecal microbiota were accompanied by an increased amount of propionic acid in feces. The HF + Inulin diet decreased cardiometabolic risk factors, decreased the amount of the eicosanoids 11(12)-EET and 15-HETrE in the liver, and decreased oxidative stress in blood compared to the HF diet. In conclusion, increasing consumption of inulin may be a useful nutritional strategy to protect against the onset of obesity and its associated metabolic abnormalities by means of modulation of gut microbiota.<\/jats:p>","DOI":"10.3390\/foods11244072","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T07:27:30Z","timestamp":1671434850000},"page":"4072","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1294-7069","authenticated-orcid":false,"given":"Bernat","family":"Miralles-P\u00e9rez","sequence":"first","affiliation":[{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-SALUT), Pharmacology Unit, Department of Basic Medical Sciences, Universitat Rovira i Virgili, C\/ Sant Lloren\u00e7 21, E-43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4626-5672","authenticated-orcid":false,"given":"Maria Rosa","family":"Nogu\u00e9s","sequence":"additional","affiliation":[{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-SALUT), Pharmacology Unit, Department of Basic Medical Sciences, Universitat Rovira i Virgili, C\/ Sant Lloren\u00e7 21, E-43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"S\u00e1nchez-Martos","sequence":"additional","affiliation":[{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-SALUT), Pharmacology Unit, Department of Basic Medical Sciences, Universitat Rovira i Virgili, C\/ Sant Lloren\u00e7 21, E-43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0ngels","family":"Fortu\u00f1o-Mar","sequence":"additional","affiliation":[{"name":"Eldine Patolog\u00eda, C\/ Plom 32, E-43006 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9293-4454","authenticated-orcid":false,"given":"Sara","family":"Ramos-Romero","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C\/ Jordi Girona 18\u201326, E-08034 Barcelona, Spain"},{"name":"Department of Cell Biology, Physiology & Immunology, Faculty of Biology, University of Barcelona, Avd\/ Diagonal 643, E-08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep L.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C\/ Jordi Girona 18\u201326, E-08034 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ponomarenko","sequence":"additional","affiliation":[{"name":"Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Universitat Pompeu Fabra (UPF), E-08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-467X","authenticated-orcid":false,"given":"Susana","family":"Am\u00e9zqueta","sequence":"additional","affiliation":[{"name":"Departament d\u2019Enginyeria Qu\u00edmica i Qu\u00edmica Anal\u00edtica and Institut de Biomedicina (IBUB), Universitat de Barcelona, E-08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-6313","authenticated-orcid":false,"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Louisville, 2210 S. Brook Street, Louisville, KY E-40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1858","authenticated-orcid":false,"given":"Marta","family":"Romeu","sequence":"additional","affiliation":[{"name":"Functional Nutrition, Oxidation and Cardiovascular Diseases Research Group (NFOC-SALUT), Pharmacology Unit, Department of Basic Medical Sciences, Universitat Rovira i Virgili, C\/ Sant Lloren\u00e7 21, E-43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fabiani, R., Naldini, G., and Chiavarini, M. (2019). Dietary patterns and metabolic syndrome in adult subjects: A systematic review and meta-analysis. Nutrients, 11.","DOI":"10.3390\/nu11092056"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Imamura, F., Micha, R., Wu, J.H.Y., de Oliveira Otto, M.C., Otite, F.O., Abioye, A.I., and Mozaffarian, D. (2016). Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials. PLoS Med., 13.","DOI":"10.1371\/journal.pmed.1002087"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05488","article-title":"Abdominal obesity and metabolic syndrome","volume":"444","author":"Lemieu","year":"2006","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chom.2017.11.003","article-title":"Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health","volume":"23","author":"Zou","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_5","first-page":"E552","article-title":"Mechanistically different effects of fat and sugar on insulin resistance, hypertension and gut microbiota in rats","volume":"314","author":"Hereu","year":"2018","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1600252","DOI":"10.1002\/mnfr.201600252","article-title":"Gut microbiota, diet, and obesity-related disorders\u2014The good, the bad, and the future challenges","volume":"61","author":"Portune","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"G528","DOI":"10.1152\/ajpgi.00172.2015","article-title":"Lack of soluble fiber drives diet-induced adiposity in mice","volume":"309","author":"Chassaing","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic Endotoxemia Initiates Obesity and Insulin Resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.clnu.2014.07.013","article-title":"Changes of hepatic lipid mediators associated with intake of high-fat diet for 12 weeks in endotoxemic rats using LC-ESI-MS\/MS","volume":"34","author":"Nishiokada","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","article-title":"Omega-6 fatty acids and inflammation","volume":"132","author":"Innes","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0006-2952(95)00195-6","article-title":"Evidence for the activation of the signal-responsive phospholipase A2 by exogenous hydrogen peroxide","volume":"50","author":"Boyer","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0891-5849(96)00178-5","article-title":"Activation of NF kappa B by the respiratory burst of macrophages","volume":"21","author":"Kaul","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI21625","article-title":"Increased oxidative stress in obesity and its impact on metabolic syndrome","volume":"114","author":"Furukawa","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Jakubiak, G.K., Osadnik, K., Lejawa, M., Osadnik, T., Go\u0142awski, M., Lewandowski, P., and Pawlas, N. (2022). \u201cObesity and insulin resistance\u201d is the component of the metabolic syndrome most strongly associated with oxidative stress. Antioxidants, 11.","DOI":"10.3390\/antiox11010079"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1172\/JCI37048","article-title":"Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans","volume":"119","author":"Anderson","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/CIRCULATIONAHA.115.018585","article-title":"Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.3389\/fmicb.2017.01749","article-title":"How to feed the Mammalian gut microbiota: Bacterial and metabolic modulation by dietary fibers","volume":"8","author":"Ferrario","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1079\/BJN20041350","article-title":"Introducing inulin-type fructans","volume":"93","author":"Roberfroid","year":"2005","journal-title":"Br. J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408398.2017.1355775","article-title":"Functional and therapeutic potential of inulin: A comprehensive review","volume":"59","author":"Ahmed","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1436S","DOI":"10.1093\/jn\/129.7.1436S","article-title":"Caloric Value of Inulin and Oligofructose","volume":"129","author":"Roberfroid","year":"1999","journal-title":"J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.metabol.2018.06.009","article-title":"The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men","volume":"87","author":"Canfora","year":"2018","journal-title":"Metabolism"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1038\/s41598-017-06447-x","article-title":"Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice","volume":"7","author":"Weitkunat","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism","volume":"54","author":"Groen","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/db14-1213","article-title":"Short-chain fatty acids protect against high-fat diet-induced obesity via a pparg-dependent switch from lipogenesis to fat oxidation","volume":"64","author":"Bleeker","year":"2015","journal-title":"Diabetes"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.jnutbio.2015.03.010","article-title":"Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice","volume":"26","author":"Weitkunat","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102165","DOI":"10.1016\/j.redox.2021.102165","article-title":"Short-chain fatty acids as modulators of redox signaling in health and disease","volume":"47","author":"Boorman","year":"2021","journal-title":"Redox Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0021-9258(18)74965-X","article-title":"Spectrophotometric studies: II. Preparations from washed blood cells; nitric oxide hemoglobin and sulfhemoglobin","volume":"112","author":"Drabkin","year":"1935","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1161\/ATVBAHA.114.303374","article-title":"Olive oil polyphenols enhance high-density lipoprotein function in humans: A randomized controlled trial","volume":"34","author":"Subirana","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Pasquali, P. (2015). Cryobiopsy, Cryoanesthesia, and Cryoanalgesia. Cryosurgery. A Practica Manual, Springer.","DOI":"10.1007\/978-3-662-43939-5"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: Open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"Schloss","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1093\/nar\/gkm864","article-title":"SILVA: A comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB","volume":"35","author":"Pruesse","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"McMurdie, P.J., and Holmes, S. (2013). Phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061217"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"ref_36","unstructured":"Lahti, L., and Shetty, S. (2021, September 17). Tools for Microbiome Analysis in R. Available online: http:\/\/microbiome.github.io\/microbiome."},{"key":"ref_37","unstructured":"Oksanen, J., Simpson, G.L., Blanchet, F.G., Kindt, R., Legendre, P., Minchin, P.R., O\u2019Hara, R.B., Solymos, P., Stevens, M.H.H., and Szoecs, E. (2021, September 17). Vegan: Community Ecology Package. Available online: https:\/\/cran.r-project.org\/package=vegan."},{"key":"ref_38","first-page":"20","article-title":"Targeted Lipidomics of Oxylipins (Oxygenated Fatty Acids)","volume":"147","author":"Strassburg","year":"2015","journal-title":"Waters Appl. Note"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1021\/jf010586o","article-title":"Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe","volume":"49","author":"Ou","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The Ferric Reducing Ability of Plasma (FRAP) as a Measure of \u201cAntioxidant Power\u201d: The FRAP Assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0003-2697(70)90083-7","article-title":"Measurement of catalase activity in tissue extracts","volume":"34","author":"Cohen","year":"1970","journal-title":"Anal. Biochem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0003-2697(90)90668-Y","article-title":"Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity","volume":"184","author":"Wheeler","year":"1990","journal-title":"Anal. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzym."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/clinchem\/38.5.704","article-title":"Malondialdehyde kit evaluated for determining plasma and lipoprotein fractions that react with thiobarbituric acid","volume":"38","author":"Richard","year":"1992","journal-title":"Clin. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1021\/tx970180z","article-title":"Reactions of 1-methyl-2-phenylindole with malondialdehyde and 4-hydroxyalkenals. Analytical applications to a colorimetric assay of lipid peroxidation","volume":"11","author":"Erdelmeier","year":"1998","journal-title":"Chem. Res. Toxicol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1039\/C8FO02578A","article-title":"Ameliorative effect of fermentable fibres on adiposity and insulin resistance in C57BL\/6 mice fed a high-fat and sucrose diet","volume":"10","author":"Jangra","year":"2019","journal-title":"Food Funct."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Albouery, M., Bretin, A., Buteau, B., Gr\u00e9goire, S., Martine, L., Gambert, S., Bron, A.M., Acar, N., Chassaing, B., and Bringer, M.A. (2021). Soluble fiber inulin consumption limits alterations of the gut microbiota and hepatic fatty acid metabolism caused by high-fat diet. Nutrients, 13.","DOI":"10.3390\/nu13031037"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10100","DOI":"10.1038\/s41598-018-28521-8","article-title":"Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet","volume":"8","author":"Tan","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jnutbio.2018.05.017","article-title":"Inulin fiber dose-dependently modulates energy balance, glucose tolerance, gut microbiota, hormones and diet preference in high-fat-fed male rats","volume":"59","author":"Singh","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s13679-012-0016-9","article-title":"Is There a Place for Dietary Fiber Supplements in Weight Management?","volume":"1","author":"Lyon","year":"2012","journal-title":"Curr. Obes. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Hoffman, J.D., Yanckello, L.M., Chlipala, G., Hammond, T.C., McCulloch, S.D., Parikh, I., Sun, S., Morganti, J.M., Green, S.J., and Lin, A.L. (2019). Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221828"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/jn\/137.11.2399","article-title":"Cecum is the major degradation site of ingested inulin in young pigs","volume":"137","author":"Yasuda","year":"2007","journal-title":"J. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3945\/jn.115.227504","article-title":"Nondigestible fructans alter gastrointestinal barrier function, gene expression, histomorphology, and themicrobiota profiles of diet-induced obese C57BL\/6J Mice","volume":"146","author":"Liu","year":"2016","journal-title":"J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1021\/acs.jafc.9b06571","article-title":"Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice","volume":"68","author":"Du","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1021\/jf505156h","article-title":"Metagenomic insights into the effects of fructo-oligosaccharides (FOS) on the composition of fecal microbiota in mice","volume":"63","author":"Mao","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Neyrinck, A.M., Pachikian, B., Taminiau, B., Daube, G., Fr\u00e9d\u00e9rick, R., Cani, P.D., Bindels, L.B., and Delzenne, N.M. (2016). Intestinal sucrase as a novel target contributing to the regulation of glycemia by prebiotics. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160488"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41522-019-0101-x","article-title":"Blautia genus associated with visceral fat accumulation in adults 20\u201376 years of age","volume":"5","author":"Ozato","year":"2019","journal-title":"NPJ Biofilm. Microbiomes"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1016\/j.clnu.2020.04.005","article-title":"Link between gut microbiota and health outcomes in inulin-treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial","volume":"39","author":"Hiel","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Den Besten, G., Havinga, R., Bleeker, A., Rao, S., Gerding, A., Van Eunen, K., Groen, A.K., Reijngoud, D.J., and Bakker, B.M. (2014). The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107392"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.molmet.2016.10.011","article-title":"Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety","volume":"6","author":"Brooks","year":"2017","journal-title":"Mol. Metab."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1039\/C5FO00591D","article-title":"D-Fagomine attenuates metabolic alterations induced by a high-energy-dense diet in rats","volume":"6","author":"Taltavull","year":"2015","journal-title":"Food Funct."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.freeradbiomed.2008.11.020","article-title":"Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems","volume":"46","author":"Sutra","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00125-013-2846-8","article-title":"Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding","volume":"56","author":"Montgomery","year":"2013","journal-title":"Diabetologia"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"15430","DOI":"10.1073\/pnas.0904944106","article-title":"Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity","volume":"106","author":"Fabbrini","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"608875","DOI":"10.3389\/fimmu.2021.608875","article-title":"Fish Oil Improves Pathway-Oriented Profiling of Lipid Mediators for Maintaining Metabolic Homeostasis in Adipose Tissue of Prediabetic Rats","volume":"12","author":"Dasilva","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz, S., M\u00e9ndez, L., Dasilva, G., Torres, J.L., Ramos-Romero, S., Romeu, M., Nogu\u00e9s, M.R., and Medina, I. (2018). Targeting hepatic protein carbonylation and oxidative stress occurring on diet-induced metabolic diseases through the supplementation with fish oils. Mar. Drugs, 16.","DOI":"10.3390\/md16100353"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1800373","DOI":"10.1002\/mnfr.201800373","article-title":"Functional Effects of the Buckwheat Iminosugar d-Fagomine on Rats with Diet-Induced Prediabetes","volume":"62","author":"Hereu","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1194\/jlr.M047357","article-title":"Dietary omega-3 fatty acids modulate the eicosanoid profi le in man primarily via the CYP-epoxygenase pathway","volume":"55","author":"Fischer","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/oby.23282","article-title":"Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults","volume":"30","author":"Di","year":"2022","journal-title":"Obesity"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.metabol.2017.01.034","article-title":"Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE)","volume":"70","author":"Pickens","year":"2017","journal-title":"Metabolism"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9772","DOI":"10.1073\/pnas.0503279102","article-title":"Soluble epoxide hydrolase is a therapeutic target for acute inflammation","volume":"102","author":"Schmelzer","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1177\/15353702-0322807-03","article-title":"11,12-Epoxyeicosatrienoic acid attenuates synthesis of prostaglandin E2 in rat monocytes stimulated with lipopolysaccharide","volume":"228","author":"Kozak","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.metabol.2008.03.010","article-title":"Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity","volume":"57","author":"Takamura","year":"2008","journal-title":"Metabolism"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1074\/jbc.M112.412890","article-title":"High dietary fat selectively increases catalase expression within cardiac mitochondria","volume":"288","author":"Rindler","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Taltavull, N., Miralles-P\u00e9rez, B., Nogu\u00e9s, M.R., Ramos-Romero, S., M\u00e9ndez, L., Medina, I., Torres, J.L., and Romeu, M. (2020). Effects of fish oil and grape seed extract combination on hepatic endogenous antioxidants and bioactive lipids in diet-induced early stages of insulin resistance in rats. Mar. Drugs, 18.","DOI":"10.3390\/md18060318"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Renaud, H.J., Cui, J.Y., Lu, H., and Klaassen, C.D. (2014). Effect of diet on expression of genes involved in lipid metabolism, oxidative stress, and inflammation in mouse liver-insights into mechanisms of hepatic steatosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088584"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1152\/ajpgi.00322.2010","article-title":"Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism","volume":"299","author":"Huang","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.gene.2004.06.015","article-title":"Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model","volume":"340","author":"Kim","year":"2004","journal-title":"Gene"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jnutbio.2014.06.014","article-title":"Protein carbonylation associated to high-fat, high-sucrose diet and its metabolic effects","volume":"25","author":"Pazos","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jnutbio.2018.03.022","article-title":"Beneficial psychological effects of novel psychobiotics in diabetic rats: The interaction among the gut, blood, and amygdala","volume":"57","author":"Morshedi","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9987352","DOI":"10.1155\/2021\/9987352","article-title":"Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults","volume":"2021","author":"Jakubiak","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"6940515","DOI":"10.1155\/2018\/6940515","article-title":"Redox balance, antioxidant defense, and oxidative damage in the hypothalamus and cerebral cortex of rats with high fat diet-induced insulin resistance","volume":"2018","author":"Maciejczyk","year":"2018","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/clinchem\/44.6.1309","article-title":"Comparison of different analytical methods for assessing total antioxidant capacity of human serum","volume":"44","author":"Cao","year":"1998","journal-title":"Clin. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"110994","DOI":"10.1016\/j.biopha.2020.110994","article-title":"Sodium butyrate arrests pancreato-hepatic synchronous uric acid and lipid dysmetabolism in high fat diet fed Wistar rats","volume":"133","author":"Adeyanju","year":"2021","journal-title":"Biomed. Pharmacother."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/11\/24\/4072\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:42:47Z","timestamp":1760146967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/11\/24\/4072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":87,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["foods11244072"],"URL":"https:\/\/doi.org\/10.3390\/foods11244072","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]}}}