{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:33:08Z","timestamp":1793089988751,"version":"4.5.0"},"reference-count":57,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The anticholinesterase and antioxidant activities with chemical composition and molecular docking of essential oil and nonpolar extracts of Mentha piperita were evaluated using enzymatic and chemical methods. Molecular docking tools were used to explain the interaction of the major chemical constituents with the enzymes. GC\/MS analyses revealed that the main compounds in M. piperita essential oil were l-menthone (43.601%) followed by pulegone (21.610%), linolenic acid (25.628%), and l-menthone (10.957%), representing the major compounds of the petroleum ether extract. Imidazoquinoline (7.767%) and 17-N-acetyl-oroidine (5.363%) were the major constituents of the chloroform extract. Linolenic acid (19.397%) and l-menthone (6.336%) were the most abundant compounds in the hexane extract. The M. piperita essential oil and nonpolar extracts showed moderate antioxidant activity. The essential oil showed the most promising anticholinesterase activity with IC50 = 10.66 \u00b1 0.12 \u00b5g\/mL and IC50 = 16.33 \u00b1 0.03 \u00b5g\/mL against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively, close to galantamine in AChE and more active in BChE, followed by the interesting activity in the petroleum ether extract with IC50 = 23.42 \u00b1 3.06 \u00b5g\/mL in AChE and IC50 = 62.00 \u00b1 3.22 \u00b5g\/mL in BChE. The docking experiments showed that among the seven major identified compounds, N-acetyl-17-oroidine showed the highest binding score (63.01 in AChE and 63.68 in BChE). This compound was found to bind the catalytic and peripheral sites, resulting in more potent inhibitory activity than galantamine, which only binds to the catalytic site. These findings suggested the possible use of M. piperita essential oil and nonpolar extracts as a potential source of alternative natural anti-Alzheimer compounds.<\/jats:p>","DOI":"10.3390\/foods12010190","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T02:44:03Z","timestamp":1672627443000},"page":"190","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of In Vitro and In Silico Anti-Alzheimer Potential of Nonpolar Extracts and Essential Oil from Mentha piperita"],"prefix":"10.3390","volume":"12","author":[{"given":"Manel","family":"Srief","sequence":"first","affiliation":[{"name":"Biotechnology Laboratory, National Higher School of Biotechnology, Constantine 25000, Algeria"},{"name":"Biotechnology Research Center, Ali Mendjli New City UV 03, BP E73, Constantine 25016, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa","family":"Bani","sequence":"additional","affiliation":[{"name":"Biotechnology Laboratory, National Higher School of Biotechnology, Constantine 25000, Algeria"},{"name":"Biotechnology Research Center, Ali Mendjli New City UV 03, BP E73, Constantine 25016, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El Hassen","family":"Mokrani","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry, Department of Biochemistry and Cellular and Molecular Biology, Faculty of Natural and Life Sciences, University Mentouri Brothers Constantine 1, Constantine 25017, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-5878","authenticated-orcid":false,"given":"Imad","family":"Mennai","sequence":"additional","affiliation":[{"name":"Research Unit Valorisation of Natural Resources, Bioactive Molecules and Physicochemical and Biological Analysis, University Mentouri Brothers Constantine 1, Route d\u2019Ain El Bey, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Hamdi","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Ali Mendjli New City UV 03, BP E73, Constantine 25016, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdenour","family":"Boumechhour","sequence":"additional","affiliation":[{"name":"Centre for Scientific and Technical Research in AnalysisPhysico-Chemicals (C.R.A.P.C), BP384, Bou-Ismail, Tipaza, Algiers 42004, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abou Mustapha","sequence":"additional","affiliation":[{"name":"Centre for Scientific and Technical Research in AnalysisPhysico-Chemicals (C.R.A.P.C), BP384, Bou-Ismail, Tipaza, Algiers 42004, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Derdour","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Ali Mendjli New City UV 03, BP E73, Constantine 25016, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messouad","family":"Kerkatou","sequence":"additional","affiliation":[{"name":"Research Unit Valorisation of Natural Resources, Bioactive Molecules and Physicochemical and Biological Analysis, University Mentouri Brothers Constantine 1, Route d\u2019Ain El Bey, Constantine 25000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Shazly","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt"},{"name":"Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, The German University in Cairo, Cairo 11432, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawki","family":"Bensouici","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Ali Mendjli New City UV 03, BP E73, Constantine 25016, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2349-2899","authenticated-orcid":false,"given":"Gema","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, University of Murcia, 30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4999-5673","authenticated-orcid":false,"given":"Salah","family":"Akkal","sequence":"additional","affiliation":[{"name":"Unit of Recherche Valorisation of Natural Resources, Bioactive Molecules and Analyses Physicochemical and Biological 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