{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:11:05Z","timestamp":1779207065546,"version":"3.51.4"},"reference-count":86,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Intelligent &amp; Sustainable aquaculturE system for Fish\u2014fish RISE (MIUR)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Rice bran is a rather underutilized by-product of the rice industry that nowadays is far from being valorized. In this study, the lipidomic profile of bran of the Italian rice variety, Roma, has been evaluated through ultra performance liquid chromatography\u2014tandem mass spectrometry. Crude lipid extracts were obtained from rice bran treated with different green solvents (1-butanol, ethanol and methyl tert-butyl ether\/methanol mixture) in combination with an ultrasonic pre-treatment, and then compared with extracts obtained with standard solvents (chloroform\/methanol mixture). Lipid yield, number and type of lipids and composition of prevalent lipid classes extracted were evaluated in order to provide an exhaustive lipid profile of the rice bran and to identify the most efficient green solvent for solid\u2013liquid extractions. Twelve different lipid classes and a maximum of 276 lipids were identified. Ethanol and methyl tert-butyl ether\/methanol solvents provided higher lipid extraction yields, the former being the most effective solvent for the extraction of triglycerides and N-acylethanolamines and the latter the most effective for the extraction of diglycerides, phospholipids and ceramides at 4 \u00b0C. Moreover, extraction with ethanol at 20 \u00b0C gave similar results as at 4 \u00b0C in terms of lipid yield and for most of the classes of lipids extracted. Taken together, our results indicate ethanol and methyl tert-butyl ether\/methanol as excellent solvents for lipid extraction from rice bran, with the aim to further valorize this food by-product in the perspective of a circular economy.<\/jats:p>","DOI":"10.3390\/foods12020384","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T03:28:10Z","timestamp":1673580490000},"page":"384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lipidomic Profiling of Rice Bran after Green Solid\u2013Liquid Extractions for the Development of Circular Economy Approaches"],"prefix":"10.3390","volume":"12","author":[{"given":"Silvia","family":"Guazzotti","sequence":"first","affiliation":[{"name":"Biological Mass Spectrometry Lab, Department of Translational Medicine (DiMeT), University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy"},{"name":"Center for Translational Research on Autoimmune & Allergic Diseases\u2014CAAD, University of Piemonte Orientale, Corso Trieste 15\/A, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pagliano","sequence":"additional","affiliation":[{"name":"Department of Sciences and Technological Innovation, University of Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-3712","authenticated-orcid":false,"given":"Francesco","family":"Dondero","sequence":"additional","affiliation":[{"name":"Department of Sciences and Technological Innovation, University of Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Biological Mass Spectrometry Lab, Department of Translational Medicine (DiMeT), University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy"},{"name":"Center for Translational Research on Autoimmune & Allergic Diseases\u2014CAAD, University of Piemonte Orientale, Corso Trieste 15\/A, 28100 Novara, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","unstructured":"(2022, September 30). FAO Cereal Supply and Demand Brief|World Food Situation|Food and Agriculture Organization of the United Nations. Available online: https:\/\/www.fao.org\/worldfoodsituation\/csdb\/en\/."},{"key":"ref_2","unstructured":"(2021). 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