{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:13:15Z","timestamp":1782907995395,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Technology Research and Development Program of Hebei Province (CN)","award":["19227527D"],"award-info":[{"award-number":["19227527D"]}]},{"name":"Key Technology Research and Development Program of Hebei Province (CN)","award":["32172221"],"award-info":[{"award-number":["32172221"]}]},{"name":"Key Technology Research and Development Program of Hebei Province (CN)","award":["31922008"],"award-info":[{"award-number":["31922008"]}]},{"name":"Key Technology Research and Development Program of Hebei Province (CN)","award":["SL2020ZD103"],"award-info":[{"award-number":["SL2020ZD103"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["19227527D"],"award-info":[{"award-number":["19227527D"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172221"],"award-info":[{"award-number":["32172221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31922008"],"award-info":[{"award-number":["31922008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SL2020ZD103"],"award-info":[{"award-number":["SL2020ZD103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oceanic Interdisciplinary Program of Shanghai Jiao Tong University","award":["19227527D"],"award-info":[{"award-number":["19227527D"]}]},{"name":"Oceanic Interdisciplinary Program of Shanghai Jiao Tong University","award":["32172221"],"award-info":[{"award-number":["32172221"]}]},{"name":"Oceanic Interdisciplinary Program of Shanghai Jiao Tong University","award":["31922008"],"award-info":[{"award-number":["31922008"]}]},{"name":"Oceanic Interdisciplinary Program of Shanghai Jiao Tong University","award":["SL2020ZD103"],"award-info":[{"award-number":["SL2020ZD103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>A long-term high-fat diet causes hepatic steatosis, which further leads to oxidative stress and inflammation. In this study, we firstly investigated the regulation effects of different amounts of quinoa on hepatic steatosis, oxidative stress, and inflammation of rats fed a high-fat diet, then the gut microbiota was dynamically determined. Sprague\u2013Dawley (SD, male) rats were randomized into four groups: normal controls (NC, fed standard chow), model groups (HF, fed a high-fat diet), low quinoa intake (HF + LQ), and high quinoa intake (HF + HQ) groups, which were supplemented with 9% and 27% quinoa in the high-fat feed (equivalent to 100 g\/day and 300 g\/day human intake, respectively). The results showed that quinoa intake significantly inhibited the hepatomegaly and splenomegaly, ameliorated hepatic steatosis pathologically; effectively rescued the decrease in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) and the increase in malondialdehyde (MDA). The levels of tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-10 (IL-10), transforming growth factor-\u03b2 (TGF-\u03b2), and leptin in rats of two quinoa groups were close to those of the NC group. Besides, high quinoa intake significantly increased the relative abundance of Akkermansia, and low quinoa intake significantly increased the relative abundance of Blautia at the genus level. The relative abundances of Blautia and Dorea in rats in the HF + HQ group were lower than those in rats in the HF + LQ group. In addition, the relative abundances of Clostridium and Turicibacter of rats in the two quinoa intervention groups were lower than those of rats in the HF group after 12 weeks of intervention. In summary, quinoa exhibits a series of beneficial effects in the prevention of nonalcoholic fatty liver disease (NAFLD) and is suggested to be a component of a daily diet for the prevention of NAFLD.<\/jats:p>","DOI":"10.3390\/foods12091780","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T04:27:02Z","timestamp":1682396822000},"page":"1780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Quinoa Ameliorates Hepatic Steatosis, Oxidative Stress, Inflammation and Regulates the Gut Microbiota in Nonalcoholic Fatty Liver Disease Rats"],"prefix":"10.3390","volume":"12","author":[{"given":"Lingyue","family":"Zhong","sequence":"first","affiliation":[{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lyu","sequence":"additional","affiliation":[{"name":"National Semi-Arid Agriculture Engineering Technology Research Center, Shijiazhuang 050051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlou","family":"Geng","sequence":"additional","affiliation":[{"name":"National Semi-Arid Agriculture Engineering Technology Research Center, Shijiazhuang 050051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-4712","authenticated-orcid":false,"given":"Lihua","family":"Song","sequence":"additional","affiliation":[{"name":"School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1541-3890","authenticated-orcid":false,"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 201602, China"},{"name":"School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/liv.13643","article-title":"Global epidemiology of non-alcoholic fatty liver disease\/non-alcoholic steatohepatitis: What we need in the future","volume":"38","author":"Araujo","year":"2018","journal-title":"Liver Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-981-10-8684-7_9","article-title":"Microbiota, Obesity and NAFLD","volume":"1061","author":"Lau","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.21037\/hbsn.2018.12.03","article-title":"Nonalcoholic fatty liver disease in obese adolescents: The role of genetic polymorphisms","volume":"8","author":"Abenavoli","year":"2019","journal-title":"HepatoBiliary Surg. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.3748\/wjg.v23.i23.4146","article-title":"Antioxidant dietary approach in treatment of fatty liver: New insights and updates","volume":"23","author":"Ferramosca","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1600767","DOI":"10.1002\/mnfr.201600767","article-title":"Phytochemicals in quinoa and amaranth grains and their antioxidant, anti-inflammatory, and potential health beneficial effects: A review","volume":"61","author":"Tang","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1080\/10408398.2014.1001811","article-title":"Quinoa: Nutritional, functional, and antinutritional aspects","volume":"57","author":"Filho","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1111\/1541-4337.12730","article-title":"Specialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review","volume":"20","author":"Alasalvar","year":"2021","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11130-010-0164-6","article-title":"Effect of diet supplemented with quinoa seeds on oxidative status in plasma and selected tissues of high fructose-fed rats","volume":"65","author":"Pasko","year":"2010","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"H1018","DOI":"10.1111\/1750-3841.12425","article-title":"Anti-inflammatory activity of saponins from quinoa (Chenopodium quinoa Willd.) seeds in lipopolysaccharide-stimulated RAW 264.7 macrophages cells","volume":"79","author":"Yao","year":"2014","journal-title":"J. Food Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.foodchem.2019.02.061","article-title":"Quinoa intake reduces plasma and liver cholesterol, lessens obesity-associated inflammation, and helps to prevent hepatic steatosis in obese db\/db mouse","volume":"287","author":"Noratto","year":"2019","journal-title":"Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1053\/j.gastro.2020.01.049","article-title":"Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?","volume":"158","author":"Warmbrunn","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1002\/fsn3.2540","article-title":"In vitro study of the effect of quinoa and quinoa polysaccharides on human gut microbiota","volume":"9","author":"Zeyneb","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijbiomac.2020.06.241","article-title":"Dietary quinoa (Chenopodium quinoa Willd.) polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota","volume":"163","author":"Cao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Guo, H., Hao, Y., Fan, X., Richel, A., Everaert, N., Yang, X., and Ren, G. (2021). Administration with Quinoa Protein Reduces the Blood Pressure in Spontaneously Hypertensive Rats and Modifies the Fecal Microbiota. Nutrients, 13.","DOI":"10.3390\/nu13072446"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14916","DOI":"10.1038\/s41598-018-33092-9","article-title":"Quinoa whole grain diet compromises the changes of gut microbiota and colonic colitis induced by dextran Sulfate sodium in C57BL\/6 mice","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"131655","DOI":"10.1016\/j.foodchem.2021.131655","article-title":"Safety assessment of crude saponins from Chenopodium quinoa willd. husks: 90-day oral toxicity and gut microbiota & metabonomics study in rats","volume":"375","author":"Zhang","year":"2022","journal-title":"Food Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Maciejewska, D., \u0141ukomska, A., Dec, K., Skonieczna-\u017bydecka, K., Gutowska, I., Sk\u00f3rka-Majewicz, M., Styburski, D., Misiakiewicz-Has, K., Pilutin, A., and Palma, J. (2019). Diet-Induced Rat Model of Gradual Development of Non-Alcoholic Fatty Liver Disease (NAFLD) with Lipopolysaccharides (LPS) Secretion. Diagnostics, 9.","DOI":"10.3390\/diagnostics9040205"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"108894","DOI":"10.1016\/j.abb.2021.108894","article-title":"Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats","volume":"705","author":"Zhang","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2264737","DOI":"10.1155\/2021\/2264737","article-title":"Probiotics Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats via Gut Microbiota\/FXR\/FGF15 Signaling Pathway","volume":"2021","author":"Luo","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12986-021-00631-7","article-title":"Alleviating the effect of quinoa and the underlying mechanism on hepatic steatosis in high-fat diet-fed rats","volume":"18","author":"Song","year":"2021","journal-title":"Nutr. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fan, N., Yu, Y., Li, L., Xia, H., Dong, X., Li, Y., Chen, H., and Duan, W. (2021). Uricase deficiency causes mild and multiple organ injuries in rats. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0256594"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110467","DOI":"10.1016\/j.foodres.2021.110467","article-title":"Regulatory effects of Lactobacillus fermented black barley on intestinal microbiota of NAFLD rats","volume":"147","author":"Zhu","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s11739-017-1746-1","article-title":"Spleen dimensions are inversely associated with lysosomal acid lipase activity in patients with non-alcoholic fatty liver disease","volume":"12","author":"Polimeni","year":"2017","journal-title":"Intern. Emerg. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1023\/A:1005446418589","article-title":"Spleen enlargement in patients with nonalcoholic fatty liver: Correlation between degree of fatty infiltration in liver and size of spleen","volume":"45","author":"Tsushima","year":"2000","journal-title":"Dig. Dis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.2147\/JIR.S330499","article-title":"Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota","volume":"14","author":"Zhang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MPG.0b013e31822578db","article-title":"Mechanisms of lipotoxicity in NAFLD and clinical implications","volume":"53","author":"Ibrahim","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11892-006-0031-x","article-title":"Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver","volume":"6","author":"Boden","year":"2006","journal-title":"Curr. Diab. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"E758","DOI":"10.1152\/ajpendo.00172.2018","article-title":"Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply","volume":"315","author":"Harmon","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Santana, L.F., Inada, A.C., Santo, B.L.S.D.E., Fili\u00fa, W.F.O., Pott, A., Alves, F.M., Guimar\u00e3es, R.D.C.A., Freitas, K.D.C., and Hiane, P.A. (2019). Nutraceutical Potential of Carica papaya in Metabolic Syndrome. Nutrients, 11.","DOI":"10.3390\/nu11071608"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"118868","DOI":"10.1016\/j.lfs.2020.118868","article-title":"Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-alpha signaling in obese mice","volume":"266","author":"Diniz","year":"2021","journal-title":"Life Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.biopha.2017.03.099","article-title":"Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats","volume":"90","author":"Kobyliak","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"29965","DOI":"10.1074\/jbc.M110.128694","article-title":"The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways","volume":"285","author":"Gao","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11154-016-9339-2","article-title":"The role of immune cells in metabolism-related liver inflammation and development of non-alcoholic steatohepatitis (NASH)","volume":"17","author":"Nati","year":"2016","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.2337\/db08-1475","article-title":"Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice","volume":"58","author":"Fujisaka","year":"2009","journal-title":"Diabetes"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Srdi\u0107, M., Ov\u010dina, I., Fotschki, B., Haros, C.M., and Llopis, J.M.L. (2020). C. quinoa and S. hispanica L. Seeds Provide Immunonutritional Agonists to Selectively Polarize Macrophages. Cells, 9.","DOI":"10.3390\/cells9030593"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Machado, M.V., and Cortez-Pinto, H. (2016). Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17040481"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1021\/acs.jafc.7b00489","article-title":"Effects of alpha-Galactooligosaccharides from Chickpeas on High-Fat-Diet-Induced Metabolic Syndrome in Mice","volume":"65","author":"Dai","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e0032922","DOI":"10.1128\/spectrum.00329-22","article-title":"Quinoa Reduces High-Fat Diet-Induced Obesity in Mice via Potential Microbiota-Gut-Brain-Liver Interaction Mechanisms","volume":"10","author":"Wang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Stojanov, S., Berlec, A., and \u0160trukelj, B. (2020). The Influence of Probiotics on the Firmicutes\/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111715"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/1751-7915.13410","article-title":"Akkermansia muciniphila is a promising probiotic","volume":"12","author":"Zhang","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1080\/10408398.2018.1517725","article-title":"A next generation probiotic, Akkermansia muciniphila","volume":"59","author":"Zhai","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"001435","DOI":"10.1099\/jmm.0.001435","article-title":"The role of Akkermansia muciniphila in obesity, diabetes and atherosclerosis","volume":"70","author":"Hasani","year":"2021","journal-title":"J. Med. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e03004-19","DOI":"10.1128\/AEM.03004-19","article-title":"Akkermansia muciniphila Prevents Fatty Liver Disease, Decreases Serum Triglycerides, and Maintains Gut Homeostasis","volume":"86","author":"Kim","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3748\/wjg.v23.i1.60","article-title":"Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier","volume":"23","author":"Zhou","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/hep.28572","article-title":"Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach","volume":"65","author":"Nobili","year":"2017","journal-title":"Hepatology"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Pircalabioru, G.G., Ilie, I., Oprea, L., Picu, A., Petcu, L.M., Burlibasa, L., Chifiriuc, M.-C., and Musat, M. (2022). Microbiome, Mycobiome and Related Metabolites Alterations in Patients with Metabolic Syndrome-A Pilot Study. Metabolites, 12.","DOI":"10.3390\/metabo12030218"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1017\/S0007114510001030","article-title":"Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy human subjects","volume":"104","author":"Benus","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.phrs.2012.09.002","article-title":"Gut microbiota, immune development and function","volume":"69","author":"Bengmark","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41579-019-0256-8","article-title":"Diet-microbiota interactions and personalized nutrition","volume":"17","author":"Kolodziejczyk","year":"2019","journal-title":"Nat. Rev. Microbiol."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/12\/9\/1780\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:23:00Z","timestamp":1760124180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/12\/9\/1780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["foods12091780"],"URL":"https:\/\/doi.org\/10.3390\/foods12091780","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]}}}