{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:00:37Z","timestamp":1793404837454,"version":"4.5.0"},"reference-count":47,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003654","name":"Korea Ministry of Environment (MOE)","doi-asserted-by":"publisher","award":["RE202201850"],"award-info":[{"award-number":["RE202201850"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003654","name":"Korea Ministry of Environment (MOE)","doi-asserted-by":"publisher","award":["6-2019-0172"],"award-info":[{"award-number":["6-2019-0172"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003654","name":"Korea Ministry of Environment (MOE)","doi-asserted-by":"publisher","award":["GCU-202008490007"],"award-info":[{"award-number":["GCU-202008490007"]}],"id":[{"id":"10.13039\/501100003654","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yonsei University College of Medicine","award":["RE202201850"],"award-info":[{"award-number":["RE202201850"]}],"id":[{"id":"https:\/\/ror.org\/01wjejq96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Yonsei University College of Medicine","award":["6-2019-0172"],"award-info":[{"award-number":["6-2019-0172"]}],"id":[{"id":"https:\/\/ror.org\/01wjejq96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Yonsei University College of Medicine","award":["GCU-202008490007"],"award-info":[{"award-number":["GCU-202008490007"]}],"id":[{"id":"https:\/\/ror.org\/01wjejq96","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Gachon University research funds","award":["RE202201850"],"award-info":[{"award-number":["RE202201850"]}],"id":[{"id":"https:\/\/ror.org\/03ryywt80","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Gachon University research funds","award":["6-2019-0172"],"award-info":[{"award-number":["6-2019-0172"]}],"id":[{"id":"https:\/\/ror.org\/03ryywt80","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Gachon University research funds","award":["GCU-202008490007"],"award-info":[{"award-number":["GCU-202008490007"]}],"id":[{"id":"https:\/\/ror.org\/03ryywt80","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Common prostate diseases such as prostatitis and benign prostatic hyperplasia (BPH) have a high incidence at any age. Cellular stresses, such as reactive oxygen species (ROS) and chronic inflammation, are implicated in prostate enlargement and cancer progression and development. Kaempferol is a flavonoid found in abundance in various plants, including broccoli and spinach, and has been reported to exhibit positive biological activities, such as antioxidant and anti-inflammatory properties. In the present study, we introduced prostate organoids to investigate the protective effects of kaempferol against various cellular stresses. The levels of COX-2, iNOS, p-I\u03baB, a pro-inflammatory cytokine, and ROS were increased by LPS treatment but reversed by kaempferol treatment. Kaempferol activated the nuclear factor erythroid 2-related factor 2(Nrf2)-related pathway and enhanced the mitochondrial quality control proteins PGC-1\u03b1, PINK1, Parkin, and Beclin. The increase in mitochondrial ROS and oxygen consumption induced by LPS was stabilized by kaempferol treatment. First, our study used prostate organoids as a novel evaluation platform. Secondly, it was demonstrated that kaempferol could alleviate the mitochondrial damage in LPS-induced induced prostate organoids by reducing the production of mitochondrial ROS.<\/jats:p>","DOI":"10.3390\/foods12203836","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:39:37Z","timestamp":1697762377000},"page":"3836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Kaempferol Alleviates Mitochondrial Damage by Reducing Mitochondrial Reactive Oxygen Species Production in Lipopolysaccharide-Induced Prostate Organoids"],"prefix":"10.3390","volume":"12","author":[{"given":"Myeong Joon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonoh","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngheun","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Urology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Gu","family":"Kim","sequence":"additional","affiliation":[{"name":"Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"},{"name":"Department of Bioprocess Engineering, KRIBB School of Biotechnology, Korea University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Urology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-7595","authenticated-orcid":false,"given":"Jong Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0022-5347(01)63564-X","article-title":"How common is prostatitis? 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