{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:45:40Z","timestamp":1792647940401,"version":"4.5.0"},"reference-count":76,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Medical University of Lublin","doi-asserted-by":"publisher","award":["DS 680"],"award-info":[{"award-number":["DS 680"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Ginger (Zingiber officinale Rosc.) is a plant known all over the world that is used as a spice and as an ingredient in drinks, dietary supplements, and cosmetics. The growing availability of its fresh rhizomes makes it even more likely to be used in the diet, mainly due to its beneficial health properties and high content of polyphenols (gingerols and shogaols). The main goal and motivation of the authors was to assess the bioavailability of active substances contained in the extract from ginger rhizomes in the presence of various types of diets using the in vitro digestion method, enabling simulation of the processes occurring during the digestion and absorption of metabolites in the small intestine. For the qualitative and quantitative analyses, the HPLC-MS (High Performance Liquid Chromatography\u2013Mass Spectrometry) and HPLC (High Performance Liquid Chromatography) techniques were used, respectively. Based on the obtained results, it was found that the best bioavailability of the selected ginger polyphenols (6-gingerol, 8-gingerdione, 8-shogaol, and 10-gingerdione) was estimated for a high-fiber diet, while the weakest results were obtained for standard and basic diets. In the case of the high-fiber diet, the bioavailability of the mentioned compounds was estimated as 33.3, 21.4, 6.73, and 21.0%, while for the basic diet, it was only 21.3, 5.3, 2.0, and 1.0%, respectively.<\/jats:p>","DOI":"10.3390\/foods12213897","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:34:47Z","timestamp":1698147287000},"page":"3897","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Influence of Diet on the Bioavailability of Active Components from Zingiber officinale Using an In Vitro Digestion Model"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-2882","authenticated-orcid":false,"given":"Justyna","family":"Zag\u00f3rska","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-1832","authenticated-orcid":false,"given":"Karolina","family":"Pietrzak","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7076-600X","authenticated-orcid":false,"given":"Wirginia","family":"Kukula-Koch","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy with Medical Plants Garden, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8113-5841","authenticated-orcid":false,"given":"Marcin","family":"Czop","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, 11 Radziwi\u0142\u0142owska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Laszuk","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-9657","authenticated-orcid":false,"given":"Wojciech","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Medical University of Lublin, 4a Chodzki Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"ref_1","first-page":"546","article-title":"Clinical Aspects and Health Benefits of Ginger Zingiber officinale in Both Traditional Chinese Medicine and Modern Industry","volume":"69","author":"Shahrajabian","year":"2019","journal-title":"Acta Agric. Scand. Sect. B\u2014Soil Plant Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/87559129.2019.1573829","article-title":"Antimicrobial Activity of Ginger (Zingiber officinale) and Its Application in Food Products","volume":"35","year":"2019","journal-title":"Food Rev. Int."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zag\u00f3rska, J., Czernicka-Bo\u015b, L., Kukula-Koch, W., Szalak, R., and Koch, W. (2022). Impact of Thermal Processing on the Composition of Secondary Metabolites of Ginger Rhizome\u2014A Review. Foods, 11.","DOI":"10.3390\/foods11213484"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10408391003624848","article-title":"Ginger and Its Health Claims: Molecular Aspects","volume":"51","author":"Butt","year":"2011","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1080\/10942912.2023.2194576","article-title":"Food Flavor Enhancement, Preservation, and Bio-Functionality of Ginger (Zingiber officinale): A Review","volume":"26","author":"Teka","year":"2023","journal-title":"Int. J. Food Prop."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mao, Q.-Q., Xu, X.-Y., Cao, S.-Y., Gan, R.-Y., Corke, H., Beta, T., and Li, H.-B. (2019). Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods, 8.","DOI":"10.3390\/foods8060185"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad, M., Varoni, E.M., Salehi, B., Sharifi-Rad, J., Matthews, K.R., Ayatollahi, S.A., Kobarfard, F., Ibrahim, S.A., Mnayer, D., and Zakaria, Z.A. (2017). Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy. Molecules, 22.","DOI":"10.20944\/preprints201711.0102.v1"},{"key":"ref_8","first-page":"171","article-title":"Effect of Nitrogen on Growth, Nutrient Assimilation, Essential Oil Content, Yield and Quality Attributes in Zingiber officinale Rosc","volume":"15","author":"Singh","year":"2016","journal-title":"J. Saudi Soc. Agric. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Koch, W., Kukula-Koch, W., Marzec, Z., Kasperek, E., Wyszogrodzka-Koma, L., Szwerc, W., and Asakawa, Y. (2017). Application of Chromatographic and Spectroscopic Methods towards the Quality Assessment of Ginger (Zingiber officinale) Rhizomes from Ecological Plantations. IJMS, 18.","DOI":"10.3390\/ijms18020452"},{"key":"ref_10","first-page":"83","article-title":"Medicinal Uses of Ginger (Zingiber officinale Roscoe) Improves Growth and Enhances Immunity in Aquaculture","volume":"3","author":"Shakya","year":"2015","journal-title":"Int. J. Chem. Stud."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Peng, W., Li, P., Ling, R., Wang, Z., Feng, X., Liu, J., Yang, Q., and Yan, J. (2022). Diversity of Volatile Compounds in Ten Varieties of Zingiberaceae. Molecules, 27.","DOI":"10.3390\/molecules27020565"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"136036","DOI":"10.1016\/j.foodchem.2023.136036","article-title":"Influence of Peeling on Volatile and Non-Volatile Compounds Responsible for Aroma, Sensory, and Nutrition in Ginger (Zingiber officinale)","volume":"419","author":"Liang","year":"2023","journal-title":"Food Chem."},{"key":"ref_13","first-page":"1","article-title":"Research Progress on Chemical Constituents of Zingiber officinale Roscoe","volume":"2019","author":"Liu","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gawel, K., Kukula-Koch, W., Banono, N.S., Nieoczym, D., Targowska-Duda, K.M., Czernicka, L., Parada-Turska, J., and Esguerra, C.V. (2021). 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147745"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00210-022-02372-7","article-title":"Revisiting the Therapeutic Potential of Gingerols against Different Pharmacological Activities","volume":"396","author":"Sharma","year":"2023","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.foodchem.2006.06.023","article-title":"Antioxidant Activity of a Ginger Extract (Zingiber officinale)","volume":"102","author":"Stoilova","year":"2007","journal-title":"Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1021\/tx500211x","article-title":"Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells In Vitro and In Vivo","volume":"27","author":"Chen","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000479789","article-title":"Protective Effect of Ginger Zingiber officinale Roscoe) Extract against Oxidative Stress and Mitochondrial Apoptosis Induced by Interleukin-1\u03b2 in Cultured Chondrocytes","volume":"204","author":"Hosseinzadeh","year":"2017","journal-title":"Cells Tissues Organs"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.biopha.2017.04.107","article-title":"Protective Effects of Phenolics Rich Extract of Ginger against Aflatoxin B1-Induced Oxidative Stress and Hepatotoxicity","volume":"91","author":"Vipin","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.foodchem.2017.07.055","article-title":"Antioxidant Activities of Ginger Extract and Its Constituents toward Lipids","volume":"239","author":"Si","year":"2018","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.sjbs.2017.02.004","article-title":"Antimicrobial Activity of Some Plant Extracts against Bacterial Strains Causing Food Poisoning Diseases","volume":"25","author":"Mostafa","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1016\/j.arabjc.2020.09.031","article-title":"Phytochemical Profiling and Antimicrobial Activity of Ginger (Zingiber officinale) Essential Oils against Important Phytopathogens","volume":"13","author":"Abdullahi","year":"2020","journal-title":"Arab. J. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"882","DOI":"10.21475\/ajcs.21.15.06.p3034","article-title":"Composition and Antimicrobial Activity of Ginger (Zingiber officinale Roscoe)","volume":"15","author":"Lara","year":"2021","journal-title":"Aust. J. Crop Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"012005","DOI":"10.1088\/1757-899X\/633\/1\/012005","article-title":"Antimicrobial Effect of Zingiber officinale Var. Officinale Essential Oil and Nisin against Pathogenic and Spoilage Microorganisms","volume":"633","author":"Ashari","year":"2019","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ajodo.2019.10.025","article-title":"Anti-Inflammatory and Antimicrobial Effects of Zingiber officinale Mouthwash on Patients with Fixed Orthodontic Appliances","volume":"159","author":"Franzini","year":"2021","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mohammadi, M., Zaki, L., KarimiPourSaryazdi, A., Tavakoli, P., Tavajjohi, A., Poursalehi, R., Delavari, H., and Ghaffarifar, F. (2021). Efficacy of Green Synthesized Silver Nanoparticles via Ginger Rhizome Extract against Leishmania Major In Vitro. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0255571"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.vetpar.2018.11.011","article-title":"Efficacy and Antiparasitic Mechanism of 10-Gingerol Isolated from Ginger Zingiber officinale against Ichthyophthirius Multifiliis in Grass Carp","volume":"265","author":"Fu","year":"2019","journal-title":"Vet. Parasitol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Sharma, P., Verma, P.K., Sood, S., Yousuf, R., Kumar, A., Raina, R., Shabbir, M.A., and Bhat, Z.F. (2023). Protective Effect of Quercetin and Ginger (Zingiber officinale) Extract against Dimethoate Potentiated Fluoride-Induced Nephrotoxicity in Rats. Foods, 12.","DOI":"10.3390\/foods12091899"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.phanu.2016.02.004","article-title":"Anti-Inflammatory Effects of the Essential Oils of Ginger (Zingiber officinale Roscoe) in Experimental Rheumatoid Arthritis","volume":"4","author":"Funk","year":"2016","journal-title":"PharmaNutrition"},{"key":"ref_30","first-page":"420","article-title":"Elucidation of Antidiabetic Mechanism of Centella Asiatica and Zingiber officinale\u2014An In-Vitro and In-Vivo Approach","volume":"27","author":"M","year":"2023","journal-title":"J. Res. Pharm."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Noipha, K., and Ninla-Aesong, P. (2018). Antidiabetic Activity of Zingiber officinale Roscoe Rhizome Extract: An In Vitro Study. HAYATI J. Biosci., 25.","DOI":"10.4308\/hjb.25.4.160"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3109\/1061186X.2011.561855","article-title":"Development and Evaluation of a Gastro-Retentive Delivery System for Improved Antiulcer Activity of Ginger Extract (Zingiber officinale)","volume":"19","year":"2011","journal-title":"J. Drug Target."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"IMI.S36273","DOI":"10.4137\/IMI.S36273","article-title":"The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy","volume":"11","author":"Lete","year":"2016","journal-title":"Integr. Med. Insights"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jtcme.2017.06.008","article-title":"Effects of Preoperative Administration of Ginger (Zingiber officinale Roscoe) on Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy","volume":"8","author":"Soltani","year":"2018","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.phymed.2018.09.007","article-title":"Ginger (Zingiber officinale): An Alternative for the Prevention of Postoperative Nausea and Vomiting. A Meta-Analysis","volume":"50","author":"Lantos","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/ptr.6377","article-title":"The Effect of Ginger (Zingiber officinale) on Chemotherapy-Induced Nausea and Vomiting in Breast Cancer Patients: A Systematic Literature Review of Randomized Controlled Trials","volume":"33","author":"Emamat","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.0004-8666.2003.00039.x","article-title":"Effect of a Ginger Extract on Pregnancy-Induced Nausea: A Randomised Controlled Trial","volume":"43","author":"Willetts","year":"2003","journal-title":"Aust. N. Z. J. Obs. Gynaecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-8741(90)90037-T","article-title":"Ginger (Zingiber officinale) in Migraine Headache","volume":"29","author":"Mustafa","year":"1990","journal-title":"J. Ethnopharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0306-9877(92)90059-L","article-title":"Ginger (Zingiber officinale) in Rheumatism and Musculoskeletal Disorders","volume":"39","author":"Srivastava","year":"1992","journal-title":"Med. Hypotheses"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1002\/1529-0131(200111)44:11<2531::AID-ART433>3.0.CO;2-J","article-title":"Effects of a Ginger Extract on Knee Pain in Patients with Osteoarthritis","volume":"44","author":"Altman","year":"2001","journal-title":"Arthritis Rheum."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/ptr.2142","article-title":"Evidence of Effectiveness of Herbal Antiinflammatory Drugs in the Treatment of Painful Osteoarthritis and Chronic Low Back Pain","volume":"21","author":"Chrubasik","year":"2007","journal-title":"Phytother. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.jpain.2009.12.013","article-title":"Ginger (Zingiber officinale) Reduces Muscle Pain Caused by Eccentric Exercise","volume":"11","author":"Black","year":"2010","journal-title":"J. Pain"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9809","DOI":"10.1021\/jf902315e","article-title":"6-Shogaol, an Active Constituent of Dietary Ginger, Induces Autophagy by Inhibiting the AKT\/MTOR Pathway in Human Non-Small Cell Lung Cancer A549 Cells","volume":"57","author":"Hung","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1158\/1940-6207.CAPR-13-0420","article-title":"6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-\u039aB Signaling","volume":"7","author":"Saha","year":"2014","journal-title":"Cancer Prev. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Akimoto, M., Iizuka, M., Kanematsu, R., Yoshida, M., and Takenaga, K. (2015). Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126605"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.foodchem.2011.06.026","article-title":"Steamed Ginger (Zingiber officinale): Changed Chemical Profile and Increased Anticancer Potential","volume":"129","author":"Cheng","year":"2011","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15586\/ijfs.v34i3.2212","article-title":"A Review of Nutritional Implications of Bioactive Compounds of Ginger (Zingiber officinale Roscoe), Their Biological Activities and Nano-Formulations","volume":"34","author":"Ishfaq","year":"2022","journal-title":"Ital. J. Food Sci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Matacchione, G., Borgonetti, V., Ramini, D., Silvestrini, A., Ojetti, M., Galeotti, N., and Olivieri, F. (2023). Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells. Biology, 12.","DOI":"10.3390\/biology12030438"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Ballester, P., Cerd\u00e1, B., Arcusa, R., Garc\u00eda-Mu\u00f1oz, A.M., Marhuenda, J., and Zafrilla, P. (2023). Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger. Molecules, 28.","DOI":"10.3390\/molecules28104024"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zag\u00f3rska, J., Czernicka-Bo\u015b, L., Kukula-Koch, W., I\u0142owiecka, K., and Koch, W. (2023). Impact of Thermal Processing on the Selected Biological Activities of Ginger Rhizome\u2014A Review. Molecules, 28.","DOI":"10.3390\/molecules28010412"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.foodchem.2015.11.033","article-title":"Comparison of Different Drying Methods on Chinese Ginger (Zingiber officinale Roscoe): Changes in Volatiles, Chemical Profile, Antioxidant Properties, and Microstructure","volume":"197","author":"An","year":"2016","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jchromb.2016.01.009","article-title":"Chemical Characterization and Antioxidant Activities Comparison in Fresh, Dried, Stir-Frying and Carbonized Ginger","volume":"1011","author":"Li","year":"2016","journal-title":"J. Chromatogr. B"},{"key":"ref_53","first-page":"1934578X1601100","article-title":"Influence of Thermal Processing and In Vitro Digestion on the Antioxidant Potential of Ginger and Ginger Containing Products","volume":"11","author":"Koch","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/ejlt.200600127","article-title":"Natural Antioxidants from Herbs and Spices","volume":"108","author":"Yanishlieva","year":"2006","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/1541-4337.12081","article-title":"In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility: In Vitro Models for Bioaccessibility and Digestion Studies\u2026","volume":"13","author":"Alminger","year":"2014","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1111\/j.1750-3841.2007.00274.x","article-title":"Food Microstructure Affects the Bioavailability of Several Nutrients","volume":"72","author":"Parada","year":"2007","journal-title":"J. Food Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.foodchem.2012.02.165","article-title":"Trace Metals in Marine Foodstuff: Bioavailability Estimation and Effect of Major Food Constituents","volume":"134","year":"2012","journal-title":"Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.foodchem.2013.01.116","article-title":"In Vitro Bioavailability of Total Selenium and Selenium Species from Seafood","volume":"139","year":"2013","journal-title":"Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.foodchem.2016.03.006","article-title":"Bioavailability Assessment of Essential and Toxic Metals in Edible Nuts and Seeds","volume":"205","year":"2016","journal-title":"Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/10408398.2014.934437","article-title":"In Vivo and in Vitro Testing for Selenium and Selenium Compounds Bioavailability Assessment in Foodstuff","volume":"57","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Bawiec, P., Sawicki, J., \u0141asi\u0144ska-Pracuta, P., Czop, M., Sowa, I., I\u0142owiecka, K., and Koch, W. (2023). In Vitro Evaluation of Bioavailability of Se from Daily Food Rations and Dietary Supplements. Nutrients, 15.","DOI":"10.3390\/nu15061511"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Russo, R., Costa, M.A., Lampiasi, N., Chiaramonte, M., Provenzano, A., Mangione, M.R., Passantino, R., and Zito, F. (2023). A New Ginger Extract Characterization: Immunomodulatory, Antioxidant Effects and Differential Gene Expression. Food Biosci., 53.","DOI":"10.1016\/j.fbio.2023.102746"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1039\/C3FO60702J","article-title":"A Standardised Static in Vitro Digestion Method Suitable for Food\u2014An International Consensus","volume":"5","author":"Minekus","year":"2014","journal-title":"Food Funct."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foodchem.2011.02.052","article-title":"Total Phenolics, Flavonoids, Anthocyanins and Antioxidant Activity Following Simulated Gastro-Intestinal Digestion and Dialysis of Apple Varieties: Bioaccessibility and Potential Uptake","volume":"128","author":"Bouayed","year":"2011","journal-title":"Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jfca.2010.03.029","article-title":"Influence of Storage and In Vitro Gastrointestinal Digestion on Total Antioxidant Capacity of Fruit Beverages","volume":"24","author":"Cilla","year":"2011","journal-title":"J. Food Compos. Anal."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1745-4514.2011.00569.x","article-title":"The First Tract of Alimentary Canal as an Extractor. Release of Phytochemicals from Solid Food Matrices During Simulated Digestion","volume":"36","author":"Tagliazucchi","year":"2012","journal-title":"J. Food Biochem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"497","DOI":"10.26656\/fr.2017.5(1).361","article-title":"Ginger Rhizomes (Zingiber officinale) Functionality in Food and Health Perspective: A Review","volume":"5","author":"Indiarto","year":"2021","journal-title":"Food Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.foodchem.2014.12.013","article-title":"Interactions of Polyphenols with Carbohydrates, Lipids and Proteins","volume":"175","author":"Jakobek","year":"2015","journal-title":"Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Wang, J., Chen, Y., Hu, X., Feng, F., Cai, L., and Chen, F. (2020). Assessing the Effects of Ginger Extract on Polyphenol Profiles and the Subsequent Impact on the Fecal Microbiota by Simulating Digestion and Fermentation In Vitro. Nutrients, 12.","DOI":"10.3390\/nu12103194"},{"key":"ref_70","first-page":"1934578X1801300","article-title":"In Vitro Digestion of Zingiber officinale Extract and Evaluation of Stability as a First Step to Determine Its Bioaccesibility","volume":"13","author":"Annunziato","year":"2018","journal-title":"Nat. Prod. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"128581","DOI":"10.1016\/j.foodchem.2020.128581","article-title":"The Effect of in Vitro Digestion, Food Matrix, and Hydrothermal Treatment on the Potential Bioaccessibility of Selected Phenolic Compounds","volume":"344","author":"Sugier","year":"2021","journal-title":"Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/09637486.2013.825699","article-title":"The Matrix Effect of Blueberry, Oat Meal and Milk on Polyphenols, Antioxidant Activity and Potential Bioavailability","volume":"65","author":"Cebeci","year":"2014","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.foodchem.2019.01.107","article-title":"In Vitro Digestion of Meat- and Cereal-Based Food Matrix Enriched with Grape Extracts: How Are Polyphenol Composition, Bioaccessibility and Antioxidant Activity Affected?","volume":"284","year":"2019","journal-title":"Food Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.foodchem.2017.07.104","article-title":"The Matrix of Fruit & Vegetables Modulates the Gastrointestinal Bioaccessibility of Polyphenols and Their Impact on Dietary Protein Digestibility","volume":"240","author":"Dufour","year":"2018","journal-title":"Food Chem."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Wojtunik-Kulesza, K., Oniszczuk, A., Oniszczuk, T., Combrzy\u0144ski, M., Nowakowska, D., and Matwijczuk, A. (2020). Influence of In Vitro Digestion on Composition, Bioaccessibility and Antioxidant Activity of Food Polyphenols\u2014A Non-Systematic Review. Nutrients, 12.","DOI":"10.3390\/nu12051401"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1021\/jf050131p","article-title":"Assessing Potential Bioavailability of Raspberry Anthocyanins Using an in Vitro Digestion System","volume":"53","author":"McDougall","year":"2005","journal-title":"J. Agric. Food Chem."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/12\/21\/3897\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:11:01Z","timestamp":1760130661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/12\/21\/3897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":76,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["foods12213897"],"URL":"https:\/\/doi.org\/10.3390\/foods12213897","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]}}}