{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:40:51Z","timestamp":1782412851849,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2021YFC2101500"],"award-info":[{"award-number":["2021YFC2101500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2023k-27"],"award-info":[{"award-number":["2023k-27"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2021001"],"award-info":[{"award-number":["2021001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific and Technologic Research Program of Shaanxi Academy of Sciences","award":["2021YFC2101500"],"award-info":[{"award-number":["2021YFC2101500"]}]},{"name":"Scientific and Technologic Research Program of Shaanxi Academy of Sciences","award":["2023k-27"],"award-info":[{"award-number":["2023k-27"]}]},{"name":"Scientific and Technologic Research Program of Shaanxi Academy of Sciences","award":["2021001"],"award-info":[{"award-number":["2021001"]}]},{"name":"Shaanxi Advanced Program of Scientific and Technological activities for Returned Overseas Scholars","award":["2021YFC2101500"],"award-info":[{"award-number":["2021YFC2101500"]}]},{"name":"Shaanxi Advanced Program of Scientific and Technological activities for Returned Overseas Scholars","award":["2023k-27"],"award-info":[{"award-number":["2023k-27"]}]},{"name":"Shaanxi Advanced Program of Scientific and Technological activities for Returned Overseas Scholars","award":["2021001"],"award-info":[{"award-number":["2021001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Ginsenoside CK, a kind of rare ginsenoside transformed from protopanaxadiol saponins extracted from the genus Panax, has been proven to possess favorable bioactivities such as anti-inflammatory, anti-cancer, anti-diabetes, and hepatoprotective effects. The current study is targeted to determine the effect of ginsenoside CK on hepatitis induced by concanavalin A (Con A). Mice were treated with different dosages of ginsenoside CK for 7 days, and Con A (15 mg\/kg) was intravenously injected to induce autoimmune hepatitis (AIH) after the last administration. The results demonstrated that pretreatment with ginsenoside CK (40 mg\/kg) could obviously ameliorate the increase in serum indicators related to liver function such as AST, ALT, and ALP, and hepatic lesions induced by Con A. Meanwhile, ginsenoside CK suppressed hepatocyte apoptosis, which was observed in pathological data, and immunoblotting results showed that the expression of Bax, Bcl-2, and other proteins was regulated by CK. Furthermore, the release of inflammatory cytokines such as tumor necrosis factor-\u03b1 (TNF-\u03b1) and IL-6 in mice with AIH were lowered by the administration of 40 mg\/kg of ginsenoside CK. Furthermore, ginsenoside CK elevated the gene expression of Nrf2 and Sirt1 and augmented downstream target genes such as HO-1. In addition, a significant inhibition effect of the TLR4\/NF-\u03baB signal was observed in 40 mg\/kg CK-pretreated mice compared with the model group. To sum up, the results indicated that ginsenoside CK has a notable hepatoprotective effect against AIH by activating Sirt1\/Nrf2 and suppressing the TLR4\/NF-\u03baB signaling pathway.<\/jats:p>","DOI":"10.3390\/foods12244379","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T08:09:17Z","timestamp":1701763757000},"page":"4379","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A"],"prefix":"10.3390","volume":"12","author":[{"given":"Jingjing","family":"Zhang","sequence":"first","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"An","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saijian","family":"Ma","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Shao","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjiao","family":"Xue","sequence":"additional","affiliation":[{"name":"Shaanxi Institute of Microbiology, Shaanxi Key Laboratory of Qinling Ecological Security, Xiying Road 76, Xi\u2019an 710043, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0002-9343(70)80129-2","article-title":"The role of the liver in drug metabolism","volume":"49","author":"Remmer","year":"1970","journal-title":"Am. 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