{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:15:44Z","timestamp":1793834144945,"version":"4.6.1"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2014NextGenerationEU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem","award":["ECS00000041\u2014VITALITY"],"award-info":[{"award-number":["ECS00000041\u2014VITALITY"]}]},{"name":"European Union\u2014NextGenerationEU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem","award":["1550\/2022"],"award-info":[{"award-number":["1550\/2022"]}]},{"name":"European Union\u2014NextGenerationEU under the Italian Ministry of University and Research (MUR) National Innovation Ecosystem","award":["CUP D93C22000890001"],"award-info":[{"award-number":["CUP D93C22000890001"]}]},{"name":"Italian Ministry of University","award":["ECS00000041\u2014VITALITY"],"award-info":[{"award-number":["ECS00000041\u2014VITALITY"]}]},{"name":"Italian Ministry of University","award":["1550\/2022"],"award-info":[{"award-number":["1550\/2022"]}]},{"name":"Italian Ministry of University","award":["CUP D93C22000890001"],"award-info":[{"award-number":["CUP D93C22000890001"]}]},{"name":"European Union\u2014NextGenerationEU for the project \u201cON Foods\u2014Research and innovation network on food and nutrition Sustainability, Safety and Security\u2014Working ON Foods\u201d","award":["ECS00000041\u2014VITALITY"],"award-info":[{"award-number":["ECS00000041\u2014VITALITY"]}]},{"name":"European Union\u2014NextGenerationEU for the project \u201cON Foods\u2014Research and innovation network on food and nutrition Sustainability, Safety and Security\u2014Working ON Foods\u201d","award":["1550\/2022"],"award-info":[{"award-number":["1550\/2022"]}]},{"name":"European Union\u2014NextGenerationEU for the project \u201cON Foods\u2014Research and innovation network on food and nutrition Sustainability, Safety and Security\u2014Working ON Foods\u201d","award":["CUP D93C22000890001"],"award-info":[{"award-number":["CUP D93C22000890001"]}]},{"name":"Agritech National Research Center","award":["ECS00000041\u2014VITALITY"],"award-info":[{"award-number":["ECS00000041\u2014VITALITY"]}]},{"name":"Agritech National Research Center","award":["1550\/2022"],"award-info":[{"award-number":["1550\/2022"]}]},{"name":"Agritech National Research Center","award":["CUP D93C22000890001"],"award-info":[{"award-number":["CUP D93C22000890001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Edible plant and fruit-derived nanovesicles (NVs) are membrane-enclosed particles with round-shape morphology and signaling functions, which resemble mammalian cell-derived extracellular vesicles. These NVs can transmit cross-kingdom signals as they contain bioactive molecules and exert biological effects on mammalian cells. Their properties and stability in the gastrointestinal tract suggest NVs as a promising nutraceutical tool. In this study, we have demonstrated for the first time the presence of NVs in olive vegetation water (OVW), a waste by-product generated during olive oil production. Biophysical characterization by scanning electron microscopy, cryo-transmission electron microscopy, and nanoparticle tracking analysis revealed the presence in OVW of NVs having size and morphology similar to that of vesicles isolated from edible plants. Integrated lipidomic, metabolomic, and proteomic analyses showed that OVW-NVs carry a set of lipids, metabolites and proteins which have recognized antioxidant and anti-inflammatory activities. The nature of biomolecules identified in OVW-NVs suggests that these vesicles could exert beneficial effects on mammalian cells and could be used in the nutraceutical and food industries. The successful isolation of OVW-NVs and the characterization of their features strengthen the idea that agricultural waste might represent a source of NVs having features similar to NVs isolated from edible plants\/fruits.<\/jats:p>","DOI":"10.3390\/foods13060835","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T10:10:52Z","timestamp":1709892652000},"page":"835","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Characterization of Nanovesicles Isolated from Olive Vegetation Water"],"prefix":"10.3390","volume":"13","author":[{"given":"Sandra","family":"Buratta","sequence":"first","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Latella","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0958-9187","authenticated-orcid":false,"given":"Elisabetta","family":"Chiaradia","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7192-8760","authenticated-orcid":false,"given":"Anna Maria","family":"Salzano","sequence":"additional","affiliation":[{"name":"Proteomics, Metabolomics and Mass Spectrometry Laboratory, Institute for the Animal Production System in the Mediterranean Environment (ISPAAM), National Research Council, 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunella","family":"Tancini","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-383X","authenticated-orcid":false,"given":"Roberto Maria","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0621-8476","authenticated-orcid":false,"given":"Lorena","family":"Urbanelli","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Cerrotti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-952X","authenticated-orcid":false,"given":"Eleonora","family":"Calzoni","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, University of Perugia, 06100 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9229-088X","authenticated-orcid":false,"given":"Husam B. 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Plant Phys."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bokka, R., Ramos, A.P., Fiume, I., Manno, M., Raccosta, S., Turi\u00e1k, L., Sug\u00e1r, S., Adamo, G., Csizmadia, T., and Pocsfalvi, G. (2020). Biomanufacturing of Tomato-Derived Nanovesicles. Foods, 9.","DOI":"10.3390\/foods9121852"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Stanly, C., Moubarak, M., Fiume, I., Turi\u00e1k, L., and Pocsfalvi, G. (2019). Membrane Transporters in Citrus clementina Fruit Juice-Derived Nanovesicles. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246205"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Stanly, C., Alfieri, M.E., Ambrosone, A., Leone, A., Fiume, I., and Pocsfalvi, G. (2020). Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line. Cells, 9.","DOI":"10.3390\/cells9122722"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/mnfr.201300729","article-title":"Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles","volume":"58","author":"Mu","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ito, Y., Taniguchi, K., Kuranaga, Y., Eid, N., Inomata, Y., Lee, S.W., and Uchiyama, K. (2021). Uptake of MicroRNAs from Exosome-Like Nanovesicles of Edible Plant Juice by Rat Enterocytes. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073749"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/mt.2013.190","article-title":"Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit","volume":"22","author":"Wang","year":"2014","journal-title":"Mol. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"19514","DOI":"10.18632\/oncotarget.4004","article-title":"Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death","volume":"6","author":"Raimondo","year":"2015","journal-title":"Oncotarget"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"28713","DOI":"10.3402\/jev.v4.28713","article-title":"Ginger-derived nanoparticles protect against alcohol-induced liver damage","volume":"4","author":"Zhuang","year":"2015","journal-title":"J. Extr. Ves."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1021\/acs.jafc.1c03020","article-title":"Utilization of Nanotechnology to Improve the Application and Bioavailability of Phytochemicals Derived from Waste Streams","volume":"70","author":"McClements","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.procbio.2013.07.010","article-title":"Olive mill wastes: Biochemical characterizations and valorization strategies","volume":"48","author":"Dermeche","year":"2013","journal-title":"Process Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Adamo, G., Fierli, D., Romancino, D.P., Picciotto, S., Barone, M.E., Aranyos, A., Bo\u017ei\u010d, D., Morsbach, S., Raccosta, S., and Stanly, C. (2021). Nanoalgosomes: Introducing extracellular vesicles produced by microalgae. J. Extr. Ves.","DOI":"10.1002\/jev2.12081"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1038\/s41598-021-84268-9","article-title":"Lipotoxic stress alters the membrane lipid profile of extracellular vesicles released by Huh-7 hepatocarcinoma cells","volume":"11","author":"Buratta","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chiaradia, E., Sansone, A., Ferreri, C., Tancini, B., Latella, R., Tognoloni, A., Gambelunghe, A., dell\u2019Omo, M., Urbanelli, L., and Giovagnoli, S. (2023). Phospholipid fatty acid remodeling and carbonylated protein increase in extracellular vesicles released by airway epithelial cells exposed to cigarette smoke extract. Eur. J. Cell Biol., 102.","DOI":"10.1016\/j.ejcb.2022.151285"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.1007\/s00216-014-8255-0","article-title":"LC\/MS lipid profiling from human serum: A new method for global lipid extraction","volume":"406","author":"Pellegrino","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: Data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Meth."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1194\/jlr.S120001025","article-title":"Update on LIPID MAPS Classification, Nomenclature, and Shorthand Notation for MS-Derived Lipid Structures","volume":"61","author":"Liebisch","year":"2020","journal-title":"J. Lip. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Cajka, T., Hricko, J., Kulhava, R.L., Paucova, M., Novakova, M., and Kuda, O. (2023). Optimization of Mobile Phase Modifiers for Fast LC-MS-Based Untargeted Metabolomics and Lipidomics. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24031987"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13742-016-0134-5","article-title":"Genome sequence of the olive tree, Olea europaea","volume":"5","author":"Cruz","year":"2016","journal-title":"Gigascience"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/pce.12231","article-title":"Mercator: A fast and simple web server for genome scale functional annotation of plant sequence data","volume":"37","author":"Lohse","year":"2014","journal-title":"Plant Cell Environ."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9311","DOI":"10.7150\/thno.60265","article-title":"Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases","volume":"11","author":"Liu","year":"2021","journal-title":"Theranostics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e2200013","DOI":"10.1002\/mnfr.202200013","article-title":"Watermelon-Derived Extracellular Vesicles Influence Human Ex Vivo Placental Cell Behavior by Altering Intestinal Secretions","volume":"66","author":"Timms","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/mt.2013.64","article-title":"Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis","volume":"21","author":"Ju","year":"2013","journal-title":"Mol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biochi.2011.03.012","article-title":"Role of phosphatidic acid in plant galactolipid synthesis","volume":"94","author":"Dubots","year":"2021","journal-title":"Biochimie"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1039\/C8FO02295J","article-title":"Biological properties of plant-derived extracellular vesicles","volume":"10","author":"Rome","year":"2019","journal-title":"Food Funct."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.chom.2018.10.001","article-title":"Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota","volume":"24","author":"Teng","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1021\/acs.molpharmaceut.9b00246","article-title":"Exosome-like Nanoparticles from Ginger Rhizomes Inhibited NLRP3 Inflammasome Activation","volume":"16","author":"Chen","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/tpj.15390","article-title":"Caffeoylquinic acids: Chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity","volume":"107","author":"Kamimura","year":"2021","journal-title":"Plant J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ejmech.2014.06.007","article-title":"Design, synthesis and structure-activity relationship of novel semi-synthetic flavonoids as antiproliferative agents","volume":"82","author":"Ragab","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1124\/dmd.106.011122","article-title":"Methylated flavonoids have greatly improved intestinal absorption and metabolic stability","volume":"34","author":"Wen","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.intimp.2016.07.016","article-title":"Shikimic acid inhibits LPS-induced cellular pro-inflammatory cytokines and attenuates mechanical hyperalgesia in mice","volume":"39","author":"Rabelo","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s12031-015-0559-9","article-title":"In Vitro Neuroprotective Effect of Shikimic Acid against Hydrogen Peroxide-Induced Oxidative Stress","volume":"56","author":"Rabelo","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"De Palma, M., Ambrosone, A., Leone, A., Del Gaudio, P., Ruocco, M., Turi\u00e1k, L., Bokka, R., Fiume, I., Tucci, M., and Pocsfalvi, G. (2020). Plant Roots Release Small Extracellular Vesicles with Antifungal Activity. Plants, 9.","DOI":"10.3390\/plants9121777"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1038\/s41598-021-85833-y","article-title":"Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro","volume":"11","author":"Garaeva","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kilasoniya, A., Garaeva, L., Shtam, T., Spitsyna, A., Putevich, E., Moreno-Chamba, B., Salazar-Bermeo, J., Komarova, E., Malek, A., and Valero, M. (2023). Potential of Plant Exosome Vesicles from Grapefruit (Citrus \u00d7 paradisi) and Tomato (Solanum lycopersicum) Juices as Functional Ingredients and Targeted Drug Delivery Vehicles. Antioxidants, 12.","DOI":"10.3390\/antiox12040943"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1002\/1873-3468.13236","article-title":"Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4","volume":"592","author":"Ochieng","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.semcancer.2019.02.004","article-title":"Ras and exosome signaling","volume":"54","author":"Sexton","year":"2019","journal-title":"Sem. Cancer Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1038\/s41598-023-31335-y","article-title":"Radical cation scavenging activity of berberine bridge enzyme-like oligosaccharide oxidases acting on short cell wall fragments","volume":"13","author":"Scortica","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/1389203715666140828100351","article-title":"The trans-membrane cytochrome b561 proteins: Structural information and biological function","volume":"15","author":"Berczi","year":"2014","journal-title":"Curr. Prot. Pept. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"dos Santos, C., and Franco, O.L. (2023). Pathogenesis-Related Proteins (PRs) with Enzyme Activity Activating Plant Defense Responses. Plants, 12.","DOI":"10.3390\/plants12112226"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Anil, S. (2022). Potential Medical Applications of Chitooligosaccharides. Polymers, 14.","DOI":"10.3390\/polym14173558"},{"key":"ref_42","first-page":"100099","article-title":"Identification of seed storage proteins as the major constituents of the extra virgin olive oil proteome","volume":"7","author":"Castro","year":"2020","journal-title":"Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1104\/pp.17.01672","article-title":"Plastid translation elongation factor Tu is prone to heat- induced aggregation despite its critical role in plant heat tolerance","volume":"176","author":"Li","year":"2018","journal-title":"Plant Physiol."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/13\/6\/835\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:11:06Z","timestamp":1760105466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/13\/6\/835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,8]]},"references-count":43,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["foods13060835"],"URL":"https:\/\/doi.org\/10.3390\/foods13060835","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,8]]}}}