{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:10:22Z","timestamp":1788581422740,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BK21 plus program, Ministry of Education of Korea","award":["5120200313836"],"award-info":[{"award-number":["5120200313836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Excessive sugar consumption provides energy but has little nutritional value, contributing to the prevalence of obesity. Hence, \u201csugar-free\u201d products using artificial or natural sweeteners, including sugar alcohols, have become popular. Accordingly, safety concerns and curiosity have arisen. Therefore, this study used a double-blind, crossover design to compare the effects of commercial sugar-free and sugar jellies (control) on the glycemic response in 16 adults without diabetes. Blood samples were collected to measure blood glucose, insulin, glucagon, ghrelin, C-peptide, glycated hemoglobin, and glycated albumin levels, and an oral glucose tolerance test was performed. Questionnaires on satiety and intestinal health were also administered. Sugar-free jellies resulted in significantly lower glucose and insulin levels and a reduced area under the curve while showing higher glucagon levels than the controls. Moreover, the sugar-free jelly initially resulted in the greater secretion of ghrelin; however, after 2 h, the control jelly resulted in higher ghrelin. No significant differences were observed in gut quotient, C-peptide, glycated hemoglobin, and glycated albumin levels. In conclusion, substituting sugar jelly with sugar-free jelly may induce lower blood glucose and insulin levels and higher glucagon levels, indicating a better ability to control glucose metabolism. Appetite was not stimulated by sugar-free jelly consumption.<\/jats:p>","DOI":"10.3390\/foods13060920","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T08:17:29Z","timestamp":1710749849000},"page":"920","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Sugar-Free Jelly on Glycemic Metabolism and Its Potential Health Benefits in Non-Diabetic Adults"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1859-6218","authenticated-orcid":false,"given":"Heejin","family":"Han","sequence":"first","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-537X","authenticated-orcid":false,"given":"Minchul","family":"Gim","sequence":"additional","affiliation":[{"name":"Lotte R&D Center, Seoul 07594, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7485-5438","authenticated-orcid":false,"given":"Hoyeon","family":"Shin","sequence":"additional","affiliation":[{"name":"Lotte R&D Center, Seoul 07594, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsook","family":"Jang","sequence":"additional","affiliation":[{"name":"Lotte R&D Center, Seoul 07594, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Joo","family":"Yoon","sequence":"additional","affiliation":[{"name":"Lotte R&D Center, Seoul 07594, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong-Hweon","family":"Lee","sequence":"additional","affiliation":[{"name":"Lotte R&D Center, Seoul 07594, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8536-0835","authenticated-orcid":false,"given":"Yoo Kyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"},{"name":"Department of Medical Nutrition, AgeTech-Service Convergence Major, Graduate School of East-West Medical Science, Kyung Hee University, Yongin 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"ref_1","unstructured":"Olivia Lawe Davies, C.L. 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