{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:58:54Z","timestamp":1790017134190,"version":"4.0.1"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FEDER funds","award":["MAC2\/1.1a\/265"],"award-info":[{"award-number":["MAC2\/1.1a\/265"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The surging global demand for fish has increased aquaculture practices, where antibiotics have become indispensable to prevent diseases. However, the passive incorporation of these compounds into the diet may have adverse effects on human health. In this work, the QuEChERS method combined with ultra-high-performance liquid chromatography tandem mass spectrometry was applied for the determination of 10 multiclass antibiotics (5 quinolones, 2 sulfonamides, 2 diaminopyrimidines, and 1 macrolide) in muscle tissue of farmed fish (European sea bass and gilt-head sea bream). The applied method demonstrated acceptable recovery values, mostly between 70 and 120%, with limits of quantification of the method meeting the established EU maximum residue limits. The analysis of twenty fish samples in duplicate revealed that most antibiotics were not present, with the only exception of oxolinic acid and tilmicosin in European sea bass, which were below the limit of quantification of the method.<\/jats:p>","DOI":"10.3390\/foods13071081","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T05:42:43Z","timestamp":1711950163000},"page":"1081","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Determination of Multiclass Antibiotics in Fish Muscle Using a QuEChERS-UHPLC-MS\/MS Method"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0143-6573","authenticated-orcid":false,"given":"Yousra","family":"Aissaoui","sequence":"first","affiliation":[{"name":"Useful Materials Laboratory (LMU), National Institute for Physical and Chemical Research and Analysis (INRAP), Ariana 2020, Tunisia"},{"name":"Departamento de Qu\u00edmica, Unidad Departamental de Qu\u00edmica Anal\u00edtica, Facultad de Ciencias, Universidad de La Laguna (ULL), Avda. Astrof\u00edsico Fco. S\u00e1nchez, s\/n, 38206 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Jim\u00e9nez-Skrzypek","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Unidad Departamental de Qu\u00edmica Anal\u00edtica, Facultad de Ciencias, Universidad de La Laguna (ULL), Avda. Astrof\u00edsico Fco. S\u00e1nchez, s\/n, 38206 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna (ULL), Avda. Astrof\u00edsico Fco. S\u00e1nchez, s\/n, 38206 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1522-8302","authenticated-orcid":false,"given":"Javier","family":"Gonz\u00e1lez-S\u00e1lamo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Unidad Departamental de Qu\u00edmica Anal\u00edtica, Facultad de Ciencias, Universidad de La Laguna (ULL), Avda. Astrof\u00edsico Fco. S\u00e1nchez, s\/n, 38206 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna (ULL), Avda. Astrof\u00edsico Fco. S\u00e1nchez, s\/n, 38206 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malika","family":"Trabelsi-Ayadi","sequence":"additional","affiliation":[{"name":"Laboratory of Application Chemistry to the Resources and Natural Substances and the Environment (LACReSNE), Faculty of Science of Bizerte, University of Carthage, Zarzouna, Bizerte 7021, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9367-8704","authenticated-orcid":false,"given":"Ibtissem","family":"Ghorbel-Abid","sequence":"additional","affiliation":[{"name":"Useful Materials Laboratory (LMU), National Institute for Physical and Chemical Research and Analysis (INRAP), Ariana 2020, Tunisia"},{"name":"Laboratory of Application Chemistry to the Resources and Natural Substances and the Environment (LACReSNE), Faculty of Science of Bizerte, University of Carthage, Zarzouna, Bizerte 7021, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-5554","authenticated-orcid":false,"given":"Javier","family":"Hern\u00e1ndez-Borges","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Unidad Departamental de Qu\u00edmica Anal\u00edtica, Facultad de Ciencias, Universidad de La Laguna (ULL), Avda. Astrof\u00edsico Fco. S\u00e1nchez, s\/n, 38206 San Crist\u00f3bal de La Laguna, Spain"},{"name":"Instituto Universitario de Enfermedades Tropicales y Salud P\u00fablica de Canarias, Universidad de La Laguna (ULL), Avda. Astrof\u00edsico Fco. S\u00e1nchez, s\/n, 38206 San Crist\u00f3bal de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tian, H., Liu, T., Mu, G., Chen, F., He, M., You, S., Yang, M., Li, Y., and Zhang, F. (2020). Rapid and Sensitive Determination of Trace Fluoroquinolone Antibiotics in Milk by Molecularly Imprinted Polymer-Coated Stainless Steel Sheet Electrospray Ionization Mass Spectrometry. Talanta, 219.","DOI":"10.1016\/j.talanta.2020.121282"},{"key":"ref_2","unstructured":"Food and Agriculture Organization of the United Nations (FAO) (2024). FAOLEX Database, FAO. 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