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Hovenia dulcis fruit peduncle polysaccharides (HDPs) have the potential to alleviate alcoholic liver injury and play essential roles in treating alcohol-exposed liver disease; however, the hepatoprotective effects and mechanisms remain elusive. In this study, we investigated the hepatoprotective effects of HDPs and their potential mechanisms in alcohol-exposed mice through liver metabolomics and gut microbiome. The results found that HDPs reduced medium-dose alcohol-caused dyslipidemia (significantly elevated T-CHO, TG, LDL-C), elevated liver glycogen levels, and inhibited intestinal-hepatic inflammation (significantly decreased IL-4, IFN-\u03b3 and TNF-\u03b1), consequently reversing hepatic pathological changes. When applying gut microbiome analysis, HDPs showed significant decreases in Proteobacteria, significant increases in Firmicutes at the phylum level, increased Lactobacillus abundance, and decreased Enterobacteria abundance, maintaining the composition of gut microbiota. Further hepatic metabolomics analysis revealed that HDPs had a regulatory effect on hepatic fatty acid metabolism, by increasing the major metabolic pathways including arachidonic acid and glycerophospholipid metabolism, and identified two important metabolites\u2014C00157 (phosphatidylcholine, a glycerophospholipid plays a central role in energy production) and C04230 (1-Acyl-sn-glycero-3-phosphocholine, a lysophospholipid involved in the breakdown of phospholipids)\u2014involved in the above metabolism. Overall, HDPs reduced intestinal dysbiosis and hepatic fatty acid metabolism disorders in alcohol-exposed mice, suggesting that HDPs have a beneficial effect on alleviating alcohol-induced hepatic metabolic disorders.<\/jats:p>","DOI":"10.3390\/foods13081145","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T10:08:50Z","timestamp":1712657330000},"page":"1145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hovenia dulcis Fruit Peduncle Polysaccharides Reduce Intestinal Dysbiosis and Hepatic Fatty Acid Metabolism Disorders in Alcohol-Exposed Mice"],"prefix":"10.3390","volume":"13","author":[{"given":"Liangyu","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China"},{"name":"Department of Food Science and Engineering, Moutai Institute, Renhuai 564507, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Moutai Institute, Renhuai 564507, China"},{"name":"College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300222, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Brewing Engineering, Moutai Institute, Renhuai 564507, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-5240","authenticated-orcid":false,"given":"Zhenyuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300222, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Moutai Institute, Renhuai 564507, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2018). 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