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L.) originating from the high-altitude vineyards of Argentina\u2019s Calchaqu\u00ed Valleys were characterized. Total phenolics, hydroxycinnamic acids, orthodiphenols, anthocyanins, non-flavonoid phenolics, total flavonoids, flavones\/flavonols, flavanones\/dihydroflavonols, and tannins were quantified through spectrophotometric methods, with the Malbec extract exhibiting higher concentrations in most of phytochemical groups when compared to Torront\u00e9s. HPLC-DAD identified more than 30 phenolic compounds in both extracts. Malbec displayed superior antiradical activity (ABTS cation, nitric oxide, and superoxide anion radicals), reduction power (iron, copper, and phosphomolybdenum), hypochlorite scavenging, and iron chelating ability compared to Torront\u00e9s. The cytotoxicity assessments revealed that Torront\u00e9s affected the viability of HT29-MTX and Caco-2 colon cancer cells by 70% and 50%, respectively, at the highest tested concentration (1 mg\/mL). At the same time, both extracts did not demonstrate acute toxicity in Artemia salina or in red blood cell assays at 500 \u00b5g\/mL. Both extracts inhibited the lipoxygenase enzyme (IC50: 154.7 and 784.7 \u00b5g\/mL for Malbec and Torront\u00e9s), with Malbec also reducing the tyrosinase activity (IC50: 89.9 \u00b5g\/mL), and neither inhibited the xanthine oxidase. The substantial phenolic content and diverse biological activities in the Calchaqu\u00ed Valleys\u2019 pomaces underline their potentialities to be valorized for pharmaceutical, cosmetic, and food industries.<\/jats:p>","DOI":"10.3390\/foods13121795","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T08:05:17Z","timestamp":1717747517000},"page":"1795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Phytochemical Composition and the Bioactive Properties of Malbec and Torront\u00e9s Wine Pomaces from the Calchaqu\u00edes Valleys (Argentina) for Their Sustainable Exploitation"],"prefix":"10.3390","volume":"13","author":[{"given":"Pablo Ezequiel","family":"Tapia","sequence":"first","affiliation":[{"name":"Instituto de Biotecnolog\u00eda Farmac\u00e9utica y Alimentaria (INBIOFAL) CONICET\u2013UNT, Avenida N Kirchner 1900, San Miguel de Tucum\u00e1n CP 4000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-9816","authenticated-orcid":false,"given":"Ana Margarida","family":"Silva","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ISEP, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-776X","authenticated-orcid":false,"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ISEP, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-9211","authenticated-orcid":false,"given":"Manuela","family":"Moreira","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ISEP, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-0041","authenticated-orcid":false,"given":"Francisca","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"REQUIMTE\/LAQV, ISEP, Polytechnic of Porto, Rua Dr. Ant\u00f3nio Bernardino de Almeida 431, 4249-015 Porto, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Torres Carro","sequence":"additional","affiliation":[{"name":"Instituto de Biotecnolog\u00eda Farmac\u00e9utica y Alimentaria (INBIOFAL) CONICET\u2013UNT, Avenida N Kirchner 1900, San Miguel de Tucum\u00e1n CP 4000, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-1424","authenticated-orcid":false,"given":"Mar\u00eda Daniela","family":"Santi","sequence":"additional","affiliation":[{"name":"Farmacognosia, Instituto Multidisciplinario de Biolog\u00eda Vegetal (IMBIV), CONICET and Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Gabriela","family":"Ortega","sequence":"additional","affiliation":[{"name":"Farmacognosia, Instituto Multidisciplinario de Biolog\u00eda Vegetal (IMBIV), CONICET and Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Ciudad Universitaria, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-9328","authenticated-orcid":false,"given":"Mar\u00eda Amparo","family":"Bl\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departament de Farmacologia, Facultat de Farm\u00e0cia i Ci\u00e8ncies de l\u2019Alimentaci\u00f3, Universitat de Val\u00e8ncia, Avd. 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