{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:01:45Z","timestamp":1793160105459,"version":"4.5.0"},"reference-count":97,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Grant of Inner Mongolia Agricultural University","award":["NDKY2021-04"],"award-info":[{"award-number":["NDKY2021-04"]}]},{"name":"Research Grant of Inner Mongolia Agricultural University","award":["QT202215"],"award-info":[{"award-number":["QT202215"]}]},{"name":"Research Grant of Inner Mongolia Agricultural University","award":["2022PT0004"],"award-info":[{"award-number":["2022PT0004"]}]},{"name":"High-level Achievement Cultivation Project of College of Animal Science, Inner Mongolia Agricultural University","award":["NDKY2021-04"],"award-info":[{"award-number":["NDKY2021-04"]}]},{"name":"High-level Achievement Cultivation Project of College of Animal Science, Inner Mongolia Agricultural University","award":["QT202215"],"award-info":[{"award-number":["QT202215"]}]},{"name":"High-level Achievement Cultivation Project of College of Animal Science, Inner Mongolia Agricultural University","award":["2022PT0004"],"award-info":[{"award-number":["2022PT0004"]}]},{"name":"Inner Mongolia Autonomous Region Science and Technology Plan Project","award":["NDKY2021-04"],"award-info":[{"award-number":["NDKY2021-04"]}]},{"name":"Inner Mongolia Autonomous Region Science and Technology Plan Project","award":["QT202215"],"award-info":[{"award-number":["QT202215"]}]},{"name":"Inner Mongolia Autonomous Region Science and Technology Plan Project","award":["2022PT0004"],"award-info":[{"award-number":["2022PT0004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Fermented mare\u2019s milk (koumiss), a traditional Central Asian dairy product derived from fermented mare\u2019s milk, is renowned for its unique sour taste and texture. It has long been consumed by nomadic tribes for its nutritional and medicinal benefits. This study aimed to comprehensively analyze the protective effects of koumiss against alcohol-induced harm across behavioral, hematological, gastrointestinal, hepatic, and reproductive dimensions using a mouse model. Optimal intoxicating doses of alcohol and koumiss doses were determined, and their effects were explored through sleep tests and blood indicator measurements. Pretreatment with koumiss delayed inebriation, accelerated sobering, and reduced mortality in mice, mitigating alcohol\u2019s impact on blood ethanol levels and various physiological parameters. Histopathological and molecular analyses further confirmed koumiss\u2019s protective role against alcohol-induced damage in the liver, stomach, small intestine, and reproductive system. Transcriptomic studies on reproductive damage indicated that koumiss exerts its benefits by influencing mitochondrial and ribosomal functions and also shows promise in mitigating alcohol\u2019s effects on the reproductive system. In summary, koumiss emerges as a potential natural agent for protection against alcohol-induced harm, opening avenues for future research in this field.<\/jats:p>","DOI":"10.3390\/foods13152344","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T13:10:28Z","timestamp":1721913028000},"page":"2344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Food from Equids\u2014Commercial Fermented Mare\u2019s Milk (Koumiss) Products: Protective Effects against Alcohol Intoxication"],"prefix":"10.3390","volume":"13","author":[{"given":"Ming","family":"Du","sequence":"first","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1999-4120","authenticated-orcid":false,"given":"Yuanyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7084-1749","authenticated-orcid":false,"given":"Jialong","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilig","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China"},{"name":"Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manglai","family":"Dugarjaviin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China"},{"name":"Inner Mongolia Key Laboratory 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Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/03602532.2019.1679169","article-title":"Ethanol and its metabolites: Update on toxicity, benefits, and focus on immunomodulatory effects","volume":"51","author":"Lagente","year":"2019","journal-title":"Drug Metab. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.18433\/jpps30572","article-title":"Therapeutic Applications of Ethanol: A Review","volume":"22","author":"Gicquel","year":"2019","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/(SICI)1098-1063(2000)10:1<88::AID-HIPO10>3.0.CO;2-L","article-title":"Ethanol, memory, and hippocampal function: A review of recent findings","volume":"10","author":"White","year":"2000","journal-title":"Hippocampus"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Butts, M., Sundaram, V.L., Murughiyan, U., Borthakur, A., and Singh, S. (2023). The Influence of Alcohol Consumption on Intestinal Nutrient Absorption: A Comprehensive Review. Nutrients, 15.","DOI":"10.3390\/nu15071571"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.alcohol.2009.10.015","article-title":"Effects of ethanol on hippocampal function during adolescence: A look at the past and thoughts on the future","volume":"44","author":"Chin","year":"2010","journal-title":"Alcohol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0091-3057(96)00255-9","article-title":"Teratogenic actions of ethanol in the mouse: A minireview","volume":"55","author":"Becker","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.pneurobio.2005.03.003","article-title":"The role of acetaldehyde in the neurobehavioral effects of ethanol: A comprehensive review of animal studies","volume":"75","author":"Quertemont","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.alcohol.2020.06.004","article-title":"Learning experiences comprising central ethanol exposure in rat neonates: Impact upon respiratory plasticity and the activity of brain catalase","volume":"88","author":"Trujillo","year":"2020","journal-title":"Alcohol"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Giannoni-Guzm\u00e1n, M.A., Giray, T., Agosto-Rivera, J.L., Stevison, B.K., Freeman, B., Ricci, P., Brown, E.A., and Abramson, C.I. (2014). Ethanol-induced effects on sting extension response and punishment learning in the western honey bee (Apis mellifera). PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100894"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Ganzorig, K., Urashima, T., and Fukuda, K. (2020). Exploring Potential Bioactive Peptides in Fermented Bactrian Camel\u2019s Milk and Mare\u2019s Milk Made by Mongolian Nomads. Foods, 9.","DOI":"10.3390\/foods9121817"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Akishev, Z., Aktayeva, S., Kiribayeva, A., Abdullayeva, A., Baltin, K., Mussakhmetov, A., Tursunbekova, A., Ramankulov, Y., and Khassenov, B. (2022). Obtaining of Recombinant Camel Chymosin and Testing Its Milk-Clotting Activity on Cow\u2019s, Goat\u2019s, Ewes\u2019, Camel\u2019s and Mare\u2019s Milk. Biology, 11.","DOI":"10.3390\/biology11111545"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Teichert, J., Cais-Sokoli\u0144ska, D., Dank\u00f3w, R., Pikul, J., Chudy, S., Bierzu\u0144ska, P., and Kaczy\u0144ski, \u0141.K. (2020). Color Stability of Fermented Mare\u2019s Milk and a Fermented Beverage from Cow\u2019s Milk Adapted to Mare\u2019s Milk Composition. Foods, 9.","DOI":"10.3390\/foods9020217"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhang, M., Dang, N., Ren, D., Zhao, F., Lv, R., Ma, T., Bao, Q., Menghe, B., and Liu, W. (2020). Comparison of Bacterial Microbiota in Raw Mare\u2019s Milk and Koumiss Using PacBio Single Molecule Real-Time Sequencing Technology. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.581610"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/asj.12668","article-title":"In vitro safety assessments and antimicrobial activities of Lactobacillus rhamnosus strains isolated from a fermented mare\u2019s milk","volume":"88","author":"Aryantini","year":"2017","journal-title":"Anim. Sci. J."},{"key":"ref_16","unstructured":"(2024, July 20). China Inner Mongolia Autonomous Region Health Commission Announcement No. 12, Available online: http:\/\/wjw.nmg.gov.cn\/zfxxgk\/fdzzgknr\/wjzt\/202106\/t20210615_1620013.html."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/acer.12437","article-title":"Protective effect of Flos puerariae extract following acute alcohol intoxication in mice","volume":"38","author":"Chen","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"114593","DOI":"10.1016\/j.jep.2021.114593","article-title":"The protective effects and mechanisms of modified Lvdou Gancao decoction on acute alcohol intoxication in mice","volume":"282","author":"Xie","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2018.01.030","article-title":"Behavioral effects of the combined use of alcohol and energy drinks on alcohol hangover in an experimental mice model","volume":"670","author":"Asorey","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Roederer, M. (2015). Parsimonious Determination of the Optimal Infectious Dose of a Pathogen for Nonhuman Primate Models. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1005100"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s002130050543","article-title":"Acute tolerance to the ataxic effects of ethanol in short-sleep (SS) and long-sleep (LS) mice","volume":"136","author":"Gill","year":"1998","journal-title":"Psychopharmacology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/SLA.0b013e31825d5d47","article-title":"Physiological and biochemical basis of clinical liver function tests: A review","volume":"257","author":"Hoekstra","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Liu, Y., Du, M., Zhang, L., Wang, N., He, Q., Cao, J., Zhao, B., Li, X., Li, B., and Bou, G. (2024). Comparative Analysis of mRNA and lncRNA Expression Profiles in Testicular Tissue of Sexually Immature and Sexually Mature Mongolian Horses. Animals, 14.","DOI":"10.3390\/ani14121717"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Liu, Y., Du, M., Li, X., Zhang, L., Zhao, B., Wang, N., and Dugarjaviin, M. (2024). Single-Cell Transcriptome Sequencing Reveals Molecular Expression Differences and Marker Genes in Testes during the Sexual Maturation of Mongolian Horses. Animals, 14.","DOI":"10.3390\/ani14091258"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1684\/epd.2022.1434","article-title":"Cu-Zn SOD suppresses epilepsy in pilocarpine-treated rats and alters SCN2A\/Nrf2\/HO-1 expression","volume":"24","author":"Wen","year":"2022","journal-title":"Epileptic Disord."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Georgiou-Siafis, S.K., and Tsiftsoglou, A.S. (2023). The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates. Antioxidants, 12.","DOI":"10.3390\/antiox12111953"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ccell.2020.06.007","article-title":"IL6\/STAT3 Signaling Hijacks Estrogen Receptor \u03b1 Enhancers to Drive Breast Cancer Metastasis","volume":"38","author":"Scabia","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41598-020-79732-x","article-title":"Assessing coral sperm motility","volume":"11","author":"Zuchowicz","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhao, L., Zhang, X., Qiu, Z., and Huang, Y. (2018). De Novo Assembly and Characterization of the Xenocatantops brachycerus Transcriptome. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020520"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ygeno.2019.02.004","article-title":"Muscle transcriptome signature and gene regulatory network analysis in two divergent lines of a hilly bovine species Mithun (Bos frontalis)","volume":"112","author":"Mukherjee","year":"2020","journal-title":"Genomics"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.molcel.2022.05.027","article-title":"Integrated lncRNA function upon genomic and epigenomic regulation","volume":"82","author":"Herman","year":"2022","journal-title":"Mol. Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1111\/jcmm.13866","article-title":"The novel regulatory role of lncRNA-miRNA-mRNA axis in cardiovascular diseases","volume":"22","author":"Huang","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jaci.2023.06.025","article-title":"Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy","volume":"152","author":"Altman","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1071\/RD19133","article-title":"Analysis of the miRNA transcriptome during testicular development and spermatogenesis of the Mongolian horse","volume":"32","author":"Li","year":"2020","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bao, T., Han, H., Li, B., Zhao, Y., Bou, G., Zhang, X., Du, M., Zhao, R., Mongke, T., and Ding, W. (2020). The distinct transcriptomes of fast-twitch and slow-twitch muscles in Mongolian horses. Comp. Biochem. Physiol. Part. D Genom. Proteom., 33.","DOI":"10.1016\/j.cbd.2019.100649"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"103458","DOI":"10.1016\/j.jevs.2021.103458","article-title":"A Fast PCR Test for the Simultaneous Identification of Species and Gender in Horses, Donkeys, Mules and Hinnies","volume":"102","author":"Wang","year":"2021","journal-title":"J. Equine Vet. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Han, H., McGivney, B.A., Allen, L., Bai, D., Corduff, L.R., Davaakhuu, G., Davaasambuu, J., Dorjgotov, D., Hall, T.J., and Hemmings, A.J. (2022). Common protein-coding variants influence the racing phenotype in galloping racehorse breeds. Commun. Biol., 5.","DOI":"10.1038\/s42003-022-04206-x"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Ren, X., Liu, Y., Zhao, Y., Li, B., Bai, D., Bou, G., Zhang, X., Du, M., Wang, X., and Bou, T. (2022). Analysis of the Whole-Genome Sequences from an Equus Parent-Offspring Trio Provides Insight into the Genomic Incompatibilities in the Hybrid Mule. Genes, 13.","DOI":"10.3390\/genes13122188"},{"key":"ref_39","first-page":"108","article-title":"Bioactivation of titanium dioxide scaffolds by ALP-functionalization","volume":"2","author":"Sengottuvelan","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jcmgh.2023.09.001","article-title":"Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four Ancestries","volume":"17","author":"Rosoff","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"139455","DOI":"10.1016\/j.chemosphere.2023.139455","article-title":"Independent and combined associations of urinary metals exposure with markers of liver injury: Results from the NHANES 2013\u20132016","volume":"338","author":"Tang","year":"2023","journal-title":"Chemosphere"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1182\/blood-2011-04-325225","article-title":"Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey","volume":"119","author":"Aggarwal","year":"2012","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.molcel.2023.05.011","article-title":"IL-1\u03b2-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance","volume":"83","author":"Han","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Tanaka, T., Narazaki, M., and Kishimoto, T. (2014). IL-6 in inflammation, immunity, and disease. Cold Spring Harb. Perspect. Biol., 6.","DOI":"10.1101\/cshperspect.a016295"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1360-0443.2011.03404.x","article-title":"Alcohol harm\u2014The urgent need for a global response","volume":"106","author":"Casswell","year":"2011","journal-title":"Addiction"},{"key":"ref_46","first-page":"129","article-title":"A Review of Alcohol-Related Harms: A Recent Update","volume":"11","author":"Iranpour","year":"2019","journal-title":"Addict. Health"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1016\/S2468-2667(20)30119-5","article-title":"Understanding the alcohol-harm paradox: What next?","volume":"5","author":"Bloomfield","year":"2020","journal-title":"Lancet Public Health"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Loche, A., Simonetti, F., Lobina, C., Carai, M.A., Colombo, G., Castelli, M.P., Barone, D., and Cacciaglia, R. (2012). Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front. Psychiatry, 3.","DOI":"10.3389\/fpsyt.2012.00008"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/nutrit\/nuy059","article-title":"The role of yogurt in food-based dietary guidelines","volume":"76","author":"Gueimonde","year":"2018","journal-title":"Nutr. Rev."},{"key":"ref_50","first-page":"214","article-title":"Biological roles of milk osteopontin","volume":"19","author":"Jiang","year":"2016","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13556210071306","article-title":"Osmotic effects of ethanol on lymphocytes","volume":"5","author":"Greig","year":"2000","journal-title":"Addict. Biol."},{"key":"ref_52","unstructured":"Zhao, J.L. (2017). The Effect of Yogurt on Immune Regulation in Wistar Rats. [Master\u2019s Thesis, Inner Mongolia Agricultural University]."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Domon, H., and Terao, Y. (2021). The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.615959"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-0039-1677875","article-title":"Role of Platelet Size Revisited-Function and Protein Composition of Large and Small Platelets","volume":"119","author":"Handtke","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/alcalc\/agv048","article-title":"Beer Is Less Harmful for the Liver than Plain Ethanol: Studies in Male Mice Using a Binge-Drinking Model","volume":"50","author":"Landmann","year":"2015","journal-title":"Alcohol Alcohol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/1091581810395630","article-title":"Oxidative damage in the liver of rats treated with glycolaldehyde","volume":"30","author":"Lorenzi","year":"2011","journal-title":"Int. J. Toxicol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s10620-017-4492-3","article-title":"Increasing Burden of Chronic Liver Disease among Adolescents and Young Adults in the USA: A Silent Epidemic","volume":"62","author":"Doycheva","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12291-013-0408-y","article-title":"Alkaline phosphatase: An overview","volume":"29","author":"Sharma","year":"2014","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.clinbiochem.2012.01.018","article-title":"Total and bone-specific alkaline phosphatases in haemodialysis patients with chronic liver disease","volume":"45","author":"Jean","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1002\/hep4.1570","article-title":"Elevated Aspartate Aminotransferase to Alanine Aminotransferase Ratio Predicts Poor Outcome in Hepatocellular Carcinoma","volume":"4","author":"Wege","year":"2020","journal-title":"Hepatol. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cld.2012.08.004","article-title":"Histologic findings in alcoholic liver disease","volume":"16","author":"Crawford","year":"2012","journal-title":"Clin. Liver Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hep.510230121","article-title":"Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol","volume":"23","author":"Albano","year":"1996","journal-title":"Hepatology"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Massey, V.L., and Arteel, G.E. (2012). Acute alcohol-induced liver injury. Front. Physiol., 3.","DOI":"10.3389\/fphys.2012.00193"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1016\/S0021-9258(18)34356-4","article-title":"Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits","volume":"257","author":"Koop","year":"1982","journal-title":"J. Biol. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Borgstahl, G.E.O., and Oberley-Deegan, R.E. (2018). Superoxide Dismutases (SODs) and SOD Mimetics. Antioxidants, 7.","DOI":"10.3390\/antiox7110156"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Sykiotis, G.P. (2021). Keap1\/Nrf2 Signaling Pathway. Antioxidants, 10.","DOI":"10.3390\/antiox10060828"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MOG.0000000000000502","article-title":"Alcohol and gastrointestinal cancers","volume":"35","author":"Vanella","year":"2019","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.3390\/ijms13055740","article-title":"Gastroprotective effect of selenium on ethanol-induced gastric damage in rats","volume":"13","author":"Kim","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbrc.2020.11.028","article-title":"Alcohol stimulates the proliferation of mouse small intestinal epithelial cells via Wnt signaling","volume":"534","author":"Park","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biopha.2016.01.015","article-title":"Protective effect of vitamin E against ethanol-induced small intestine damage in rats","volume":"78","author":"Shirpoor","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/apt.16642","article-title":"Review article: Drug-induced small bowel injury","volume":"54","author":"Hamdeh","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1111\/acer.12483","article-title":"Micro-RNA-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice","volume":"38","author":"Lippai","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-012414-040431","article-title":"The inflammasomes and autoinflammatory syndromes","volume":"10","author":"Broderick","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.dci.2011.03.031","article-title":"Origin and evolution of TNF and TNF receptor superfamilies","volume":"35","author":"Wiens","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"ref_75","first-page":"cm1","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cmet.2014.05.009","article-title":"IL-6 strikes a balance in metabolic inflammation","volume":"19","author":"Covarrubias","year":"2014","journal-title":"Cell Metab."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1186\/1742-2094-10-140","article-title":"Activation of the inflammatory transcription factor nuclear factor interleukin-6 during inflammatory and psychological stress in the brain","volume":"10","author":"Fuchs","year":"2013","journal-title":"J. Neuroinflamm."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/rda.14089","article-title":"Key aspects of domestic cat spermatogenesis","volume":"57","author":"Gobello","year":"2022","journal-title":"Reprod. Domest. Anim."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41588-022-01040-z","article-title":"DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis","volume":"54","author":"Dura","year":"2022","journal-title":"Nat. Genet."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11427-010-0091-7","article-title":"Animal reproduction and physiology: From basis to application","volume":"53","author":"Gui","year":"2010","journal-title":"Sci. China Life Sci."},{"key":"ref_81","first-page":"637","article-title":"Post-treatment with Telfairia occidentalis seed oil attenuates alcohol-induced testicular damage in Sprague-Dawley rats","volume":"11","year":"2013","journal-title":"Iran. J. Reprod. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2015.01.016","article-title":"Spermatic and testicular damages in rats exposed to ethanol: Influence of lipid peroxidation but not testosterone","volume":"330","author":"Siervo","year":"2015","journal-title":"Toxicology"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Wang, G., Li, Y., Yang, Q., Xu, S., Ma, S., Yan, R., Zhang, R., Jia, G., Ai, D., and Yang, Q. (2019). Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak. J. Anim. Sci. Biotechnol., 10.","DOI":"10.1186\/s40104-019-0360-7"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Bo, D., Jiang, X., Liu, G., Hu, R., and Chong, Y. (2021). RNA-Seq Implies Divergent Regulation Patterns of LincRNA on Spermatogenesis and Testis Growth in Goats. Animals, 11.","DOI":"10.3390\/ani11030625"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jare.2022.12.007","article-title":"A single-cell transcriptomic landscape of mouse testicular aging","volume":"53","author":"Zhang","year":"2023","journal-title":"J. Adv. Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Taruno, A. (2018). ATP Release Channels. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030808"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ebiom.2017.07.024","article-title":"ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson\u2019s Disease","volume":"22","author":"Nakano","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1073\/pnas.1917968117","article-title":"Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes","volume":"117","author":"Toth","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.molcel.2023.04.022","article-title":"The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy","volume":"83","author":"Fukuda","year":"2023","journal-title":"Mol. Cell"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1445-5781.2002.00007.x","article-title":"Spermatozoon and mitochondrial DNA","volume":"1","author":"Hirata","year":"2002","journal-title":"Reprod. Med. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"R163","DOI":"10.1530\/REP-13-0178","article-title":"Mitochondria functionality and sperm quality","volume":"146","author":"Amaral","year":"2013","journal-title":"Reproduction"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1016\/j.bbagen.2014.09.005","article-title":"Mitochondrial PKA mediates sperm motility","volume":"1840","author":"Mizrahi","year":"2014","journal-title":"Biochim. Biophys. Acta."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Barbagallo, F., La Vignera, S., Cannarella, R., Aversa, A., Calogero, A.E., and Condorelli, R.A. (2020). Evaluation of Sperm Mitochondrial Function: A Key Organelle for Sperm Motility. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020363"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: Functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J. Mol. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1126\/science.aaa1193","article-title":"Ribosome. The structure of the human mitochondrial ribosome","volume":"348","author":"Amunts","year":"2015","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4103\/1008-682X.133318","article-title":"Ultrastructural changes and asthenozoospermia in murine spermatozoa lacking the ribosomal protein L29\/HIP gene","volume":"16","author":"Aravindan","year":"2014","journal-title":"Asian. J. Androl."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41586-022-05508-0","article-title":"A male germ-cell-specific ribosome controls male fertility","volume":"612","author":"Li","year":"2022","journal-title":"Nature"}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/13\/15\/2344\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:23:24Z","timestamp":1760109804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/13\/15\/2344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":97,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["foods13152344"],"URL":"https:\/\/doi.org\/10.3390\/foods13152344","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]}}}