{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:44:18Z","timestamp":1791233058330,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Funds","award":["32072223"],"award-info":[{"award-number":["32072223"]}]},{"name":"National Natural Science Funds","award":["2022A1515011344"],"award-info":[{"award-number":["2022A1515011344"]}]},{"name":"National Natural Science Funds","award":["2023A1515030213"],"award-info":[{"award-number":["2023A1515030213"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["32072223"],"award-info":[{"award-number":["32072223"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2022A1515011344"],"award-info":[{"award-number":["2022A1515011344"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2023A1515030213"],"award-info":[{"award-number":["2023A1515030213"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Osteoporosis (OP) represents a global health challenge. Certain functional food has the potential to mitigate OP. Honeysuckle (Lonicera japonica) solution has medicinal effects, such as anti-inflammatory and immune enhancement, and can be used in functional foods such as health drinks and functional snacks. The composition of honeysuckle changed significantly after fermentation, and 376 metabolites were enriched. In this study, we used dexamethasone to induce OP in the rat model. Research has confirmed the ability of FS (fermented Lonicera japonica solution) to enhance bone mineral density (BMD), repair bone microarchitectural damage, and increase blood calcium levels. Markers such as tartrate-resistant acid phosphatase-5b (TRACP-5b) and pro-inflammatory cytokines (TNF-\u03b1 and IL-6) were notably decreased, whereas osteocalcin (OCN) levels increased after FS treatment. FS intervention in OP rats restored the abundance of 6 bacterial genera and the contents of 17 serum metabolites. The results of the Spearman correlation analysis showed that FS may alleviate OP by restoring the abundance of 6 bacterial genera and the contents of 17 serum metabolites, reducing osteoclast differentiation, promoting osteoblast differentiation, and reducing the inflammatory response. This study revealed that Lactobacillus plantarum-fermented honeysuckle alleviated OP through intestinal bacteria and serum metabolites and provided a theoretical basis for the development of related functional foods.<\/jats:p>","DOI":"10.3390\/foods13172649","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:38:43Z","timestamp":1724416723000},"page":"2649","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lonicera japonica Fermented by Lactobacillus plantarum Improve Multiple Patterns Driven Osteoporosis"],"prefix":"10.3390","volume":"13","author":[{"given":"Zimin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiye","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e64872","DOI":"10.7554\/eLife.64872","article-title":"7,8-Dihydroxyflavone Modulates Bone Formation and Resorption and Ameliorates Ovariectomy-Induced Osteoporosis","volume":"10","author":"Xue","year":"2021","journal-title":"eLife"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5312\/wjo.v7.i3.171","article-title":"Major Osteoporotic Fragility Fractures: Risk Factor Updates and Societal Impact","volume":"7","author":"Pisani","year":"2016","journal-title":"World J. 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