{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:43:49Z","timestamp":1760114629811,"version":"build-2065373602"},"reference-count":74,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)\u2014Finance Code 001","award":["1816645","23038.000795\/2018-61","400411\/2016-4","403328\/2016-0","301496\/2019-6","306891\/2021-2","2015\/50333-1"],"award-info":[{"award-number":["1816645","23038.000795\/2018-61","400411\/2016-4","403328\/2016-0","301496\/2019-6","306891\/2021-2","2015\/50333-1"]}]},{"name":"the National Council for Scientific and Technological Development (CNPq)","award":["1816645","23038.000795\/2018-61","400411\/2016-4","403328\/2016-0","301496\/2019-6","306891\/2021-2","2015\/50333-1"],"award-info":[{"award-number":["1816645","23038.000795\/2018-61","400411\/2016-4","403328\/2016-0","301496\/2019-6","306891\/2021-2","2015\/50333-1"]}]},{"name":"FAPESP","award":["1816645","23038.000795\/2018-61","400411\/2016-4","403328\/2016-0","301496\/2019-6","306891\/2021-2","2015\/50333-1"],"award-info":[{"award-number":["1816645","23038.000795\/2018-61","400411\/2016-4","403328\/2016-0","301496\/2019-6","306891\/2021-2","2015\/50333-1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Solanum lycocarpum St. Hil. is considered a natural anti-inflammatory. In traditional medicine, it is used to reduce cholesterol levels in the treatment of obesity. Foods capable of conferring a protective and nutritious effect have been used to prevent or attenuate the clinical symptoms of inflammatory bowel diseases. Ulcerative colitis is a multifactorial inflammatory bowel disease. This study investigated the impact of the consumption of the fibrous fraction (FF) and resistant starch (RS) of fruta-do-lobo in an experimental model of colitis induced with the use 2,4,6-trinitrobenzene sulphonic acid (TNBS) in rats. The different colitis groups all experienced decreased weight gain, which could be linked to the inflammatory process (p = 0.603). Additionally, the experimental model led to increased oxidative stress, higher levels of pro-inflammatory cytokines, and the elevated gene expression of these cytokines. Despite this, consuming the fibrous fraction of fruta-do-lobo (RS and FF) did not appear to protect the animals against the inflammatory process. Regarding the expression of TNF-\u03b1, only the group treated with the drug mesalamine had a reduced serum level of this inflammatory marker (p = 0.03). Our results showed that the diet containing RS and FF did not protect the intestinal mucosa against TNBS inflammation. New studies on the variation in the time of consumption or the supplemented dose of fruta-do-lobo fibers could help to elucidate their effects in protecting the mucosa.<\/jats:p>","DOI":"10.3390\/foods13182949","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T09:43:13Z","timestamp":1726652593000},"page":"2949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Consumption of the Fibrous Fraction of Solanum lycocarpum St. Hil. Does Not Preserve the Intestinal Mucosa in TNBS-Induced Rats"],"prefix":"10.3390","volume":"13","author":[{"given":"Amanda Maria Tomazini Munhoz","family":"Moya","sequence":"first","affiliation":[{"name":"School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-5808","authenticated-orcid":false,"given":"Tha\u00eds Dolfini","family":"Alexandrino","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseane","family":"Morari","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universidade Estadual de Campinas, Rua Tess\u00e1lia Vieira de Camargo, 126, Campinas 13083-887, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia Mateus","family":"Reguengo","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licio Augusto","family":"Velloso","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universidade Estadual de Campinas, Rua Tess\u00e1lia Vieira de Camargo, 126, Campinas 13083-887, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-4402","authenticated-orcid":false,"given":"Raquel Franco","family":"Leal","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universidade Estadual de Campinas, Rua Tess\u00e1lia Vieira de Camargo, 126, Campinas 13083-887, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4382-5745","authenticated-orcid":false,"given":"Stanislau Bogusz","family":"Junior","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Chemistry (IQSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-9707","authenticated-orcid":false,"given":"Ana Paula Aparecida","family":"Pereira","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, S\u00e3o Paulo, Brazil"},{"name":"Faculty of Nutrition, Federal University of Mato Grosso, Avenida Fernando Correa da Costa, 2367, Boa Esperan\u00e7a, Cuiab\u00e1 78068-600, Mato Grosso, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glaucia Maria","family":"Pastore","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5252-4004","authenticated-orcid":false,"given":"Juliano Lemos","family":"Bicas","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9849-2546","authenticated-orcid":false,"given":"Cinthia Ba\u00fa Betim","family":"Cazarin","sequence":"additional","affiliation":[{"name":"School of Food Engineering, Universidade Estadual de Campinas, Rua Monteiro Lobato, 80, Campinas 13083-862, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1590\/s0004-2803.202100000-87","article-title":"Epidemiological profile and clinical characteristics of inflammatory bowel diseases in a brazilian referral center","volume":"58","author":"Fucilini","year":"2021","journal-title":"Arq. 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