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This compound is a known cognitive enhancer that works by increasing the release of acetylcholine, a neurotransmitter essential for learning and memory. In this study, select root and tuber crops, as well as fruits, were subjected to Saccharomyces cerevisiae fermentation to observe the co-production of ethanol and \u03b1-GPC. The ethanol yields from these substrates were comparable to those from wheat (var. AC Andrew), ranging from 30.44 g\/L (beet) to 70.04 g\/L (lotus root). Aside from ethanol, \u03b1-GPC was also produced, with purple top turnip yielding 0.91 g\/L, the second highest concentration after wheat (used as a reference), which produced 1.25 g\/L. Although \u03b1-GPC yields in the tested substrates were lower than those from cereal grains (e.g., wheat and barley), a noteworthy observation was the production of methanol in many of these substrates. Methanol was detected in all feedstocks except wheat, with concentrations ranging from 0.10 g\/L (cassava) to 1.69 g\/L (purple top turnip). A linear regression analysis revealed a strong correlation between methanol and \u03b1-GPC content (R2 = 0.876; slope = 0.52), suggesting a potential link in their biosynthetic pathways. These feedstocks not only proved effective as substrates for bioethanol production, but also showed potential for generating value-added compounds such as \u03b1-GPC. This dual-purpose potential presents new market opportunities for producers by leveraging both biofuel and nootropic compound production. Furthermore, the observed relationship between methanol and \u03b1-GPC production warrants further investigation to elucidate the metabolic pathways involved.<\/jats:p>","DOI":"10.3390\/foods13193085","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T06:10:27Z","timestamp":1727417427000},"page":"3085","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Production of \u03b1-Glycerylphosphorylcholine in Fermented Roots, Tubers, and Fruits"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-0736","authenticated-orcid":false,"given":"Timothy J.","family":"Tse","sequence":"first","affiliation":[{"name":"Department of Food and Bioproduct Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farley","family":"Chicilo","sequence":"additional","affiliation":[{"name":"Department of Food and Bioproduct Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5988-315X","authenticated-orcid":false,"given":"Daniel J.","family":"Wiens","sequence":"additional","affiliation":[{"name":"Department of Food and Bioproduct Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianheng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Food and Bioproduct Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Anleu Alegria","sequence":"additional","affiliation":[{"name":"Department of Food and Bioproduct Sciences, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK S7N 5A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Biotechnology, Korea University, 2511 Sejong-ro, Sejong 30019, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5379-7875","authenticated-orcid":false,"given":"Ji Youn","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Food Regulatory Science, Korea University, 2511 Sejong-ro, Sejong 30019, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kyeom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Biotechnology, Korea University, 2511 Sejong-ro, Sejong 30019, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui-Cheol","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food Science, Gyeongsang National University, 501 Jinju-daero, Jinju 52828, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J. 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