{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:25:08Z","timestamp":1788953108084,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NMPA Key Laboratory for Quality Research and Evaluation of Traditional Marine Chinese Medicine","award":["HYZY-KF-2022006"],"award-info":[{"award-number":["HYZY-KF-2022006"]}]},{"name":"NMPA Key Laboratory for Quality Research and Evaluation of Traditional Marine Chinese Medicine","award":["2023SKLDRS0105"],"award-info":[{"award-number":["2023SKLDRS0105"]}]},{"name":"NMPA Key Laboratory for Quality Research and Evaluation of Traditional Marine Chinese Medicine","award":["2023Z07"],"award-info":[{"award-number":["2023Z07"]}]},{"name":"NMPA Key Laboratory for Quality Research and Evaluation of Traditional Marine Chinese Medicine","award":["2023YFC3504100"],"award-info":[{"award-number":["2023YFC3504100"]}]},{"name":"NMPA Key Laboratory for Quality Research and Evaluation of Traditional Marine Chinese Medicine","award":["2022YFC3501500"],"award-info":[{"award-number":["2022YFC3501500"]}]},{"name":"National Key Laboratory of Medicine Regulatory Science","award":["HYZY-KF-2022006"],"award-info":[{"award-number":["HYZY-KF-2022006"]}]},{"name":"National Key Laboratory of Medicine Regulatory Science","award":["2023SKLDRS0105"],"award-info":[{"award-number":["2023SKLDRS0105"]}]},{"name":"National Key Laboratory of Medicine Regulatory Science","award":["2023Z07"],"award-info":[{"award-number":["2023Z07"]}]},{"name":"National Key Laboratory of Medicine Regulatory Science","award":["2023YFC3504100"],"award-info":[{"award-number":["2023YFC3504100"]}]},{"name":"National Key Laboratory of Medicine Regulatory Science","award":["2022YFC3501500"],"award-info":[{"award-number":["2022YFC3501500"]}]},{"name":"Research Project on the Improvement of National Medicine Standards","award":["HYZY-KF-2022006"],"award-info":[{"award-number":["HYZY-KF-2022006"]}]},{"name":"Research Project on the Improvement of National Medicine Standards","award":["2023SKLDRS0105"],"award-info":[{"award-number":["2023SKLDRS0105"]}]},{"name":"Research Project on the Improvement of National Medicine Standards","award":["2023Z07"],"award-info":[{"award-number":["2023Z07"]}]},{"name":"Research Project on the Improvement of National Medicine Standards","award":["2023YFC3504100"],"award-info":[{"award-number":["2023YFC3504100"]}]},{"name":"Research Project on the Improvement of National Medicine Standards","award":["2022YFC3501500"],"award-info":[{"award-number":["2022YFC3501500"]}]},{"name":"the National Key R&amp;D Program","award":["HYZY-KF-2022006"],"award-info":[{"award-number":["HYZY-KF-2022006"]}]},{"name":"the National Key R&amp;D Program","award":["2023SKLDRS0105"],"award-info":[{"award-number":["2023SKLDRS0105"]}]},{"name":"the National Key R&amp;D Program","award":["2023Z07"],"award-info":[{"award-number":["2023Z07"]}]},{"name":"the National Key R&amp;D Program","award":["2023YFC3504100"],"award-info":[{"award-number":["2023YFC3504100"]}]},{"name":"the National Key R&amp;D Program","award":["2022YFC3501500"],"award-info":[{"award-number":["2022YFC3501500"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Arsenic is a common toxic heavy metal contaminant that is widely present in the ocean, and seaweeds have a strong ability to concentrate arsenic, posing a potential risk to human health. This study first analyzed the arsenic content in two different seaweeds and then used an innovative method to categorize the seaweeds into low-arsenic and high-arsenic groups based on their arsenic exposure levels. Finally, a non-targeted metabolomic analysis based on mass spectrometry was conducted on seaweed from different arsenic exposure groups. The results indicated that as the arsenic concentration increased in the seaweeds, linolenic acid, tyrosine, pheophorbide a, riboflavin, and phenylalanine were upregulated, while arachidonic acid, eicosapentaenoic acid (EPA), betaine, and oleamide were downregulated. The following four key metabolic pathways involving unsaturated fatty acids and amino acids were identified: isoquinoline alkaloid biosynthesis, tyrosine metabolism, phenylalanine metabolism, and riboflavin metabolism. The identification of biomarkers and the characterization of key metabolic pathways will aid in the selection and breeding of low-arsenic-accumulating seaweed varieties, providing insights into the metabolic and detoxification mechanisms of arsenic in seaweeds.<\/jats:p>","DOI":"10.3390\/foods13244055","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T10:08:53Z","timestamp":1734343733000},"page":"4055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mass Spectrometry-Based Metabolomics Investigation on Two Different Seaweeds Under Arsenic Exposure"],"prefix":"10.3390","volume":"13","author":[{"given":"Yuan-sheng","family":"Guo","sequence":"first","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"},{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Integrative Medicine, Anhui University of Chinese Medicine, Hefei 230012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-min","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangzhou Institute for Drug Control, Key Laboratory for Quality Evaluation of Chinese Patent Medicine, National Medical Products Administration, Guangzhou 510160, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Qingdao Institute for Food and Drug Control, NMPA Key Laboratory for Quality Research and Evaluation of Traditional Marine Chinese Medicine, Qingdao 266073, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-yu","family":"Jin","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Kang","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7598-0723","authenticated-orcid":false,"given":"Feng","family":"Wei","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-tian","family":"Zuo","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-cheng","family":"Ma","sequence":"additional","affiliation":[{"name":"National Institutes for Food and Drug Control, State Key Laboratory of Drug Regulatory Science, Beijing 100050, China"},{"name":"Chinese Pharmacopoeia Commission, Beijing 100061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pharmtox-030220-013418","article-title":"Arsenic: A Global Environmental Challenge","volume":"61","author":"Chen","year":"2021","journal-title":"Annu. 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