{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T21:33:37Z","timestamp":1794346417855,"version":"4.9.0"},"reference-count":89,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014Brazil (CNPq)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>(1) Background: Inflammatory bowel diseases (IBDs) are characterized by chronic and complex inflammatory processes of the digestive tract that evolve with frequent relapses and manifest at any age; they predominantly affect young individuals. Diet plays a direct role in maintaining the gut mucosal integrity and immune function. Regarding the diet, the administration of probiotics stands out. The use of probiotics for IBD treatment has shown promising effects on consumers\u2019 quality of life. (2) Methods: This study aimed to conduct a literature review on the effects of probiotic and smart probiotic ingestion on IBD and analyze the available literature based on the searched keywords using boxplot diagrams to search for scientific data in the online literature published up to October 2024. (3) Results: Google Scholar (containing ~6 \u00d7 106 articles) and Science Direct (containing ~5 \u00d7 106 articles) were the databases with the highest number of articles for the keywords used in the study. When analyzing the content of the articles, although probiotic microorganisms are currently not part of the standard treatment protocol for IBD, these live biotherapeutics have proven to be an effective treatment option, considering the adverse effects of conventional therapies. Furthermore, the development of genetically engineered probiotics or smart probiotics is a promising treatment for IBD. (4) Conclusions: Probiotics and smart probiotics could represent the future of nutritional medicine in IBD care, allowing patients to be treated in a more natural, safe, effective, and nutritious way. However, although many studies have demonstrated the potential of this biotherapy, clinical trials standardizing dosage and strains are still necessary.<\/jats:p>","DOI":"10.3390\/foods13244097","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T08:56:32Z","timestamp":1734512192000},"page":"4097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food"],"prefix":"10.3390","volume":"13","author":[{"given":"Emanuelle Natalee","family":"Santos","sequence":"first","affiliation":[{"name":"Post-Graduate Program in Food Science, Federal University of Vale of Jequitinhonha and Mucuri (UFVJM), Street MGT 367\u2014Km 583, No. 5000, Alto da Jacuba, Diamantina 39100-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-9331","authenticated-orcid":false,"given":"Karina Teixeira","family":"Magalh\u00e3es-Guedes","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Arist\u00eddes Novis, 02, Federa\u00e7\u00e3o, Salvador 40210-630, BA, Brazil"},{"name":"Post-Graduate Program in Food Science, Federal University of Bahia (UFBA), Bar\u00e3o of Geremoabo Street, s\/n, Ondina, Salvador 40171-970, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1972-0740","authenticated-orcid":false,"given":"Fernando Elias de Melo","family":"Borges","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Systems Engineering and Automation, Department of Automatic, Federal University of Lavras (UFLA), University Campus, Lavras 37000-200, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4504-7721","authenticated-orcid":false,"given":"Danton Diego","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Systems Engineering and Automation, Department of Automatic, Federal University of Lavras (UFLA), University Campus, Lavras 37000-200, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Ferreira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Food Science, Federal University of Vale of Jequitinhonha and Mucuri (UFVJM), Street MGT 367\u2014Km 583, No. 5000, Alto da Jacuba, Diamantina 39100-000, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Carlos Gon\u00e7alves","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Arist\u00eddes Novis, 02, Federa\u00e7\u00e3o, Salvador 40210-630, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Katerine de Carvalho","family":"Lima","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Arist\u00eddes Novis, 02, Federa\u00e7\u00e3o, Salvador 40210-630, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Guimar\u00e3es","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Arist\u00eddes Novis, 02, Federa\u00e7\u00e3o, Salvador 40210-630, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3145-6935","authenticated-orcid":false,"given":"Marcelo Andr\u00e9s","family":"Umsza-Guez","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Food Science, Federal University of Bahia (UFBA), Bar\u00e3o of Geremoabo Street, s\/n, Ondina, Salvador 40171-970, BA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-2300","authenticated-orcid":false,"given":"C\u00edntia Lacerda","family":"Ramos","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Food Science, Federal University of Vale of Jequitinhonha and Mucuri (UFVJM), Street MGT 367\u2014Km 583, No. 5000, Alto da Jacuba, Diamantina 39100-000, MG, 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