{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:21:23Z","timestamp":1784164883622,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31801514"],"award-info":[{"award-number":["31801514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["246Z2807G"],"award-info":[{"award-number":["246Z2807G"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"2024 Central Guiding Local Scientific Development Funding Projects in Hebei Province","award":["31801514"],"award-info":[{"award-number":["31801514"]}]},{"name":"2024 Central Guiding Local Scientific Development Funding Projects in Hebei Province","award":["246Z2807G"],"award-info":[{"award-number":["246Z2807G"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Previous studies have shown that supplementation with specific probiotics can be used to alleviate allergy symptoms. The purpose of this study was to evaluate the anti-allergic effects of Lactobacillus kefiranofaciens ZW3 (ZW3) in ovalbumin (OVA)-induced allergic mice. The mice were divided into six groups: the food allergy group, positive group (Lactobacillus rhamnosus GG), low-dose ZW3 group, middle-dose ZW3 group, high-dose ZW3 group, and the control group involving healthy mice. BALB\/c mice were intraperitoneally injected with OVA\/complete Freund\u2019s adjuvant (CFA) for allergy sensitization. Probiotics were administered orally once every two days in the probiotic-treated groups. The allergic score, serum OVA-sIgE, body mass, thymus, and spleen indexes were detected on day 22, and the relative mRNA expression of inflammatory cytokines was detected via RT-qPCR. The results suggest that the body weight and thymus index returned to normal levels; allergy scores, serum OVA-sIgE, IL-4, IL-5, and IL-10 expression decreased; and IFN-\u03b3 and IL-2 increased significantly in the ZW3 group compared with the allergy group. Furthermore, ZW3 decreased Muribaculaceae and Ruminococcaceae abundance and increased Lachnospiraceae abundance in the intestinal flora. In summary, ZW3 induced anti-allergic effects by increasing Th1 cytokines and decreasing Th2 cytokines, which can remarkably ameliorate the symptoms of an ovalbumin-induced food allergy.<\/jats:p>","DOI":"10.3390\/foods14010016","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:19:32Z","timestamp":1735154372000},"page":"16","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Amelioration Effect of Lactobacillus kefiranofaciens ZW3 on Ovalbumin-Induced Allergic Symptoms in BALB\/c Mice"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-670X","authenticated-orcid":false,"given":"Hanxue","family":"Xu","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6283-820X","authenticated-orcid":false,"given":"Xiaowei","family":"Duan","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3619-6642","authenticated-orcid":false,"given":"Weitao","family":"Geng","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.cca.2018.08.004","article-title":"Component-resolved diagnosis in allergic disease: Utility and limitations","volume":"489","author":"Armentia","year":"2019","journal-title":"Clin. 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