{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:11:50Z","timestamp":1791562310622,"version":"4.3.4"},"reference-count":114,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2024\/15778-1"],"award-info":[{"award-number":["2024\/15778-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["306020\/2022-0"],"award-info":[{"award-number":["306020\/2022-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2024\/15778-1"],"award-info":[{"award-number":["2024\/15778-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306020\/2022-0"],"award-info":[{"award-number":["306020\/2022-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["2024\/15778-1"],"award-info":[{"award-number":["2024\/15778-1"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["306020\/2022-0"],"award-info":[{"award-number":["306020\/2022-0"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Coffee and cocoa agribusinesses generate large volumes of byproducts, including coffee husk, coffee pulp, parchment skin, silver skin, and cocoa bean shell. Despite the rich composition of these materials, studies on biomolecule extraction with green solvents are still scarce, and further research is needed. Extraction methods using alternative solvents to obtain biomolecules must be developed to enhance the byproducts\u2019 value and align with biorefinery concepts. This article reviews the compositions of coffee and cocoa byproducts, their potential applications, and biomolecule extraction methods, focusing on alternative solvents. The extraction methods currently studied include microwave-assisted, ultrasound-assisted, pulsed electric field-assisted, supercritical fluid, and pressurized liquid extraction. At the same time, the alternative solvents encompass the biobased ones, supercritical fluids, supramolecular, ionic liquids, and eutectic solvents. Considering the biomolecule caffeine, using alternative solvents such as pressurized ethanol, supercritical carbon dioxide, ionic liquids, and supramolecular solvents resulted in extraction yields of 2.5 to 3.3, 4.7, 5.1, and 1.1 times higher than conventional solvents. Similarly, natural deep eutectic solvents led to a chlorogenic acid extraction yield 84 times higher than water. The results of this research provide a basis for the development of environmentally friendly and efficient biomolecule extraction methods, improving the utilization of agricultural waste.<\/jats:p>","DOI":"10.3390\/foods14030342","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:47:42Z","timestamp":1737438462000},"page":"342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Extraction of Biomolecules from Coffee and Cocoa Agroindustry Byproducts Using Alternative Solvents"],"prefix":"10.3390","volume":"14","author":[{"given":"Jos\u00e9 Pedro Zanetti","family":"Prado","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Engenharia de Separa\u00e7\u00f5es (LES), Departamento de Engenharia de Alimentos (ZEA), Faculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de S\u00e3o Paulo (USP), Pirassununga 13635-900, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1714-8322","authenticated-orcid":false,"given":"Rodrigo Corr\u00eaa","family":"Basso","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancia e Tecnologia, Universidade Federal de Alfenas (UNIFAL), Po\u00e7os de Caldas 37715-400, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-9708","authenticated-orcid":false,"given":"Christianne Elisabete da Costa","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Engenharia de Separa\u00e7\u00f5es (LES), Departamento de Engenharia de Alimentos (ZEA), Faculdade de Zootecnia e Engenharia de Alimentos (FZEA), Universidade de S\u00e3o Paulo (USP), Pirassununga 13635-900, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ref_1","unstructured":"(2024, December 04). International Cocoa Organization (ICCO). ICCO Quarterly Bulletin of Cocoa Statistics, Volume L, n\u00b0 3, Cocoa Year 2023\/24. Published on 30 August 2024. Available online: https:\/\/www.icco.org\/november-2024-quarterly-bulletin-of-cocoa-statistics\/."},{"key":"ref_2","unstructured":"(2024, December 04). United States Department of Agriculture, Foreign Agricultural Service. Coffee: World Markets and Trade. Global Market Analysis, June 2024, Available online: https:\/\/www.fas.usda.gov\/commodities\/coffee."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Botella-Mart\u00ednez, C., Lucas-Gonzalez, R., Ballester-Costa, C., P\u00e9rez-\u00c1lvarez, J.\u00c1., Fern\u00e1ndez-L\u00f3pez, J., Delgado-Ospina, J., Chaves-L\u00f3pez, C., and Viuda-Martos, M. (2021). Ghanaian Cocoa (Theobroma cacao L.) Bean Shells Coproducts: Effect of Particle Size on Chemical Composition, Bioactive Compound Content and Antioxidant Activity. Agronomy, 11.","DOI":"10.3390\/agronomy11020401"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"109361","DOI":"10.1016\/j.lwt.2020.109361","article-title":"Optimization of Microwave-Assisted Extraction of Cocoa Bean Shell Waste and Evaluation of Its Antioxidant, Physicochemical and Functional Properties","volume":"127","author":"Mellinas","year":"2020","journal-title":"LWT"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.resconrec.2012.06.005","article-title":"Sustainable Management of Coffee Industry By-Products and Value Addition\u2014A Review","volume":"66","author":"Murthy","year":"2012","journal-title":"Resour. Conserv. Recycl."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.indcrop.2018.12.063","article-title":"Effect of the Temperature on the Kinetics of Cocoa Bean Shell Fat Extraction Using Pressurized Ethanol and Evaluation of the Lipid Fraction and Defatted Meal","volume":"130","author":"Okiyama","year":"2019","journal-title":"Ind. Crops Prod."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Prandi, B., Ferri, M., Monari, S., Zurlini, C., Cigognini, I., Verstringe, S., Schaller, D., Walter, M., Navarini, L., and Tassoni, A. (2021). Extraction and Chemical Characterization of Functional Phenols and Proteins from Coffee (Coffea arabica) by-Products. Biomolecules, 11.","DOI":"10.3390\/biom11111571"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tifs.2020.08.005","article-title":"Embracing Nutritional Qualities, Biological Activities and Technological Properties of Coffee Byproducts in Functional Food Formulation","volume":"104","author":"Gemechu","year":"2020","journal-title":"Trends Food Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Klingel, T., Kremer, J.I., Gottstein, V., Rajcic de Rezende, T., Schwarz, S., and Lachenmeier, D.W. (2020). A Review of Coffee By-Products Including Leaf, Flower, Cherry, Husk, Silver Skin, and Spent Grounds as Novel Foods Within the European Union. Foods, 9.","DOI":"10.3390\/foods9050665"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Dur\u00e1n-Aranguren, D., Robledo, S., Gomez-Restrepo, E., Arboleda Valencia, J., and Tarazona, N. (2021). Scientometric Overview of Coffee By-Products and Their Applications. Molecules, 26.","DOI":"10.3390\/molecules26247605"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tifs.2022.03.013","article-title":"Phenolic Compounds from Coffee By-Products: Extraction and Application in the Food and Pharmaceutical Industries","volume":"123","author":"Bondam","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115759","DOI":"10.1016\/j.seppur.2019.115759","article-title":"Valorization of Spent Coffee Grounds by Supramolecular Solvent Extraction","volume":"228","author":"Sanin","year":"2019","journal-title":"Sep. Purif. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1007\/s13399-020-00712-2","article-title":"Optimisation and Characterisation of Protein Extraction from Coffee Silverskin Assisted by Ultrasound or Microwave Techniques","volume":"11","author":"Wen","year":"2021","journal-title":"Biomass Convers. Biorefinery"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tifs.2017.03.007","article-title":"Cocoa Shell and Its Compounds: Applications in the Food Industry","volume":"63","author":"Okiyama","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Belwal, T., Cravotto, C., Ramola, S., Thakur, M., Chemat, F., and Cravotto, G. (2022). Bioactive Compounds from Cocoa Husk: Extraction, Analysis and Applications in Food Production Chain. Foods, 11.","DOI":"10.3390\/foods11060798"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Rojo-Poveda, O., Barbosa-Pereira, L., Zeppa, G., and St\u00e9vigny, C. (2020). Cocoa Bean Shell\u2014A By-Product with Nutritional Properties and Biofunctional Potential. Nutrients, 12.","DOI":"10.3390\/nu12041123"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/jsfa.9996","article-title":"Biomolecules Extraction from Coffee and Cocoa By- and Co-products Using Deep Eutectic Solvents","volume":"100","author":"Cazals","year":"2020","journal-title":"J. Sci. Food Agric."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.indcrop.2018.04.008","article-title":"Influence of Solvent Selection and Extraction Temperature on Yield and Composition of Lipids Extracted from Spent Coffee Grounds","volume":"119","author":"Efthymiopoulos","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s10098-018-1515-5","article-title":"Design of Alternate Solvent for Recovery of Residual Palm Oil: Simultaneous Optimization of Process Performance with Environmental, Health and Safety Aspects","volume":"20","author":"Chang","year":"2018","journal-title":"Clean. Technol. Environ. Policy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.psep.2017.01.006","article-title":"Computer Aided Molecular Design for Alternative Sustainable Solvent to Extract Oil from Palm Pressed Fibre","volume":"106","author":"Khor","year":"2017","journal-title":"Process Saf. Environ. Prot."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/arclin\/10.1.1","article-title":"Longitudinal Neuropsychological Effects of N-Hexane Exposure: Neurotoxic Effects versus Depression","volume":"10","author":"Armstrong","year":"1995","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Cravotto, C., Fabiano-Tixier, A.-S., Claux, O., Abert-Vian, M., Tabasso, S., Cravotto, G., and Chemat, F. (2022). Towards Substitution of Hexane as Extraction Solvent of Food Products and Ingredients with No Regrets. Foods, 11.","DOI":"10.20944\/preprints202209.0183.v1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1007\/s13197-020-04433-2","article-title":"Recent Advances and Comparisons of Conventional and Alternative Extraction Techniques of Phenolic Compounds","volume":"57","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10083","DOI":"10.1021\/acssuschemeng.1c01848","article-title":"Molecular Property-Tailored Soy Protein Extraction Process Using a Deep Eutectic Solvent","volume":"9","author":"Chen","year":"2021","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10337-018-3614-1","article-title":"Hyphenating Supramolecular Solvents and Liquid Chromatography: Tips for Efficient Extraction and Reliable Determination of Organics","volume":"82","author":"Lunar","year":"2019","journal-title":"Chromatographia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.trac.2019.05.037","article-title":"Green Extraction of Natural Products. Origins, Current Status, and Future Challenges","volume":"118","author":"Chemat","year":"2019","journal-title":"Trends Anal. Chem."},{"key":"ref_27","unstructured":"(2024, November 30). United Nations Development Programme Sustainable Development Goals. Available online: https:\/\/www.undp.org\/sustainable-development-goals."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"109622","DOI":"10.1016\/j.foodres.2020.109622","article-title":"da C. Simultaneous Green Extraction of Fat and Bioactive Compounds of Cocoa Shell and Protein Fraction Functionalities Evaluation","volume":"137","author":"Soares","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Silva, M.d.O., Honfoga, J.N.B., de Medeiros, L.L., Madruga, M.S., and Bezerra, T.K.A. (2020). Obtaining Bioactive Compounds from the Coffee Husk (Coffea arabica L.) Using Different Extraction Methods. Molecules, 26.","DOI":"10.3390\/molecules26010046"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Amran, M.A., Palaniveloo, K., Fauzi, R., Satar, N.M., Mohidin, T.B.M., Mohan, G., Razak, S.A., Arunasalam, M., Nagappan, T., and Sathiya Seelan, J.S. (2021). Value-Added Metabolites from Agricultural Waste and Application of Green Extraction Techniques. Sustainability, 13.","DOI":"10.3390\/su132011432"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.wasman.2020.11.052","article-title":"Natural Deep Eutectic Solvent as a Unique Solvent for Valorisation of Orange Peel Waste by the Integrated Biorefinery Approach","volume":"120","author":"Andlar","year":"2021","journal-title":"Waste Manag."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"102601","DOI":"10.1016\/j.ifset.2021.102601","article-title":"Process Intensification Technologies for the Recovery of Valuable Compounds from Cocoa By-Products","volume":"68","author":"Mariatti","year":"2021","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_33","first-page":"13","article-title":"Agro-Industrial Waste Revalorization: The Growing Biorefinery. In Biomass for Bioenergy\u2014Recent Trends and Future Challenges","volume":"11","year":"2019","journal-title":"IntechOpen"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.wasman.2020.12.018","article-title":"Potential Applications of By-Products from the Coffee Industry in Polymer Technology\u2014Current State and Perspectives","volume":"121","author":"Hejna","year":"2021","journal-title":"Waste Manag."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.scitotenv.2018.07.201","article-title":"Coffea canephora Silverskin from Different Geographical Origins: A Comparative Study","volume":"645","author":"Bessada","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Clarke, R.J., and Macrae, R.C. (1987). Coffee, Springer.","DOI":"10.1007\/978-94-009-3417-7"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0032-9592(99)00144-2","article-title":"Fruity Flavour Production by Ceratocystis Fimbriata Grown on Coffee Husk in Solid-State Fermentation","volume":"35","author":"Soares","year":"2000","journal-title":"Process Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.15376\/biores.18.3.5703-5723","article-title":"Evaluation of Colombian Coffee Waste to Produce Antioxidant Extracts","volume":"18","author":"Santa","year":"2023","journal-title":"Bioresources"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.foodres.2011.05.028","article-title":"Functional Properties of Coffee and Coffee By-Products","volume":"46","author":"Esquivel","year":"2012","journal-title":"Food Res. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tifs.2021.02.064","article-title":"Coffee By-Products in Topical Formulations: A Review","volume":"111","author":"Santos","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_41","first-page":"2","article-title":"Coffee Berry Processing By-Product Valorization: Coffee Parchment as a Potential Fiber Source to Enrich Bakery Goods","volume":"1","author":"Elba","year":"2017","journal-title":"J. Food Nutr. Popul. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.lwt.2018.11.013","article-title":"Valorization of Coffee Parchment Waste (Coffea arabica) as a Source of Caffeine and Phenolic Compounds in Antifungal Gellan Gum Films","volume":"101","year":"2019","journal-title":"LWT"},{"key":"ref_43","first-page":"91","article-title":"Review: Utilization of Waste From Coffee Production","volume":"25","author":"Sirotiak","year":"2017","journal-title":"Res. Pap. Fac. Mater. Sci. Technol. Slovak. Univ. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lachenmeier, D.W., Schwarz, S., Rieke-Zapp, J., Cantergiani, E., Rawel, H., Mart\u00edn-Cabrejas, M.A., Martuscelli, M., Gottstein, V., and Angeloni, S. (2021). Coffee By-Products as Sustainable Novel Foods: Report of the 2nd International Electronic Conference on Foods\u2014\u201cFuture Foods and Food Technologies for a Sustainable World\u201d. Foods, 11.","DOI":"10.3390\/foods11010003"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/tqem.21903","article-title":"Coffee Pulp as a Source for Polyphenols Extraction Using Ultrasound, Microwave, and Green Solvents","volume":"32","author":"Zakaria","year":"2022","journal-title":"Environ. Qual. Manag."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1002\/jsfa.9659","article-title":"Coffee Silverskin as Nutraceutical Ingredient in Yogurt: Its Effect on Functional Properties and Its Bioaccessibility","volume":"99","author":"Bertolino","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1111\/ijfs.15127","article-title":"Application of Chemometric Tools in the Development of Food Bars Based on Cocoa Shell, Soy Flour and Green Banana Flour","volume":"56","author":"Natarelli","year":"2021","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Soares, I.D., Cirilo, M.E.M., Junqueira, I.G., Vanin, F.M., and Rodrigues, C.E. (2023). da C. Production of Cookies Enriched with Bioactive Compounds through the Partial Replacement of Wheat Flour by Cocoa Bean Shells. Foods, 12.","DOI":"10.3390\/foods12030436"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"461770","DOI":"10.1016\/j.chroma.2020.461770","article-title":"Selective Extraction of Bioactive Compounds from Plants Using Recent Extraction Techniques: A Review","volume":"1635","author":"Lefebvre","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12393-019-09206-y","article-title":"Green Solvents for the Extraction of High Added-Value Compounds from Agri-Food Waste","volume":"12","author":"Rubio","year":"2020","journal-title":"Food Eng. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"124147","DOI":"10.1016\/j.seppur.2023.124147","article-title":"What Is next? The Greener Future of Solid Liquid Extraction of Biobased Compounds: Novel Techniques and Solvents Overpower Traditional Ones","volume":"320","author":"Su","year":"2023","journal-title":"Sep. Purif. Technol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Silva, J.M., Peyronel, F., Huang, Y., Boschetti, C.E., and Corradini, M.G. (2024). Extraction, Identification, and Quantification of Polyphenols from the Theobroma cacao L. Fruit: Yield vs. Environmental Friendliness. Foods, 13.","DOI":"10.3390\/foods13152397"},{"key":"ref_53","unstructured":"Wypych, G. (2014). Handbook of Solvents, ChemTec Pu."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jfoodeng.2013.01.014","article-title":"Techniques for Extraction of Bioactive Compounds from Plant Materials: A Review","volume":"117","author":"Azmir","year":"2013","journal-title":"J. Food Eng."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Coscarella, M., Nardi, M., Alipieva, K., Bonacci, S., Popova, M., Procopio, A., Scarpelli, R., and Simeonov, S. (2023). Alternative Assisted Extraction Methods of Phenolic Compounds Using NaDESs. Antioxidants, 13.","DOI":"10.3390\/antiox13010062"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"131918","DOI":"10.1016\/j.foodchem.2021.131918","article-title":"Influence of the Extraction Method on the Recovery of Bioactive Phenolic Compounds from Food Industry By-Products","volume":"378","author":"Romero","year":"2022","journal-title":"Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s11947-017-2045-6","article-title":"Pulsed Electric Field Assisted Extraction of Bioactive Compounds from Cocoa Bean Shell and Coffee Silverskin","volume":"11","author":"Guglielmetti","year":"2018","journal-title":"Food Bioprocess Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.aca.2011.07.018","article-title":"Pressurized Liquid Extraction as a Green Approach in Food and Herbal Plants Extraction: A Review","volume":"703","author":"Mustafa","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"101815","DOI":"10.1016\/j.pmpp.2022.101815","article-title":"Intensification of Supercritical Fluid in the Extraction of Flavonoids: A Comprehensive Review","volume":"118","author":"Vinitha","year":"2022","journal-title":"Physiol. Mol. Plant Pathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"202","DOI":"10.22271\/phyto.2023.v12.i3c.14682","article-title":"A Comprehensive Review of Conventional and Non-Conventional Solvent Extraction Techniques","volume":"12","author":"Goti","year":"2023","journal-title":"J. Pharmacogn. Phytochem."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Patra, A., Abdullah, S., and Pradhan, R.C. (2022). Review on the Extraction of Bioactive Compounds and Characterization of Fruit Industry By-Products. Bioresour. Bioprocess, 9.","DOI":"10.1186\/s40643-022-00498-3"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Rebollo-Hernanz, M., Ca\u00f1as, S., Taladrid, D., Ben\u00edtez, V., Bartolom\u00e9, B., Aguilera, Y., and Mart\u00edn-Cabrejas, M.A. (2021). Revalorization of Coffee Husk: Modeling and Optimizing the Green Sustainable Extraction of Phenolic Compounds. Foods, 10.","DOI":"10.3390\/foods10030653"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Mac\u00edas-Garbett, R., Sosa-Hern\u00e1ndez, J.E., Iqbal, H.M.N., Contreras-Esquivel, J.C., Chen, W.N., Melchor-Mart\u00ednez, E.M., and Parra-Sald\u00edvar, R. (2022). Combined Pulsed Electric Field and Microwave-Assisted Extraction as a Green Method for the Recovery of Antioxidant Compounds with Electroactive Potential from Coffee Agro-Waste. Plants, 11.","DOI":"10.3390\/plants11182362"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1039\/C9FO00544G","article-title":"Response Surface Methodology to Optimise the Heat-Assisted Aqueous Extraction of Phenolic Compounds from Coffee Parchment and Their Comprehensive Analysis","volume":"10","author":"Aguilera","year":"2019","journal-title":"Food Funct."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e13191","DOI":"10.1111\/jfpe.13191","article-title":"Ultrasound-assisted Extraction (UAE) of Bioactive Compounds from Coffee Silverskin: Impact on Phenolic Content, Antioxidant Activity, and Morphological Characteristics","volume":"42","author":"Wen","year":"2019","journal-title":"J. Food Process Eng."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.supflu.2011.07.018","article-title":"Extraction of Caffeine from Robusta Coffee (Coffea canephora Var. Robusta) Husks Using Supercritical Carbon Dioxide","volume":"59","author":"Tello","year":"2011","journal-title":"J. Supercrit. Fluids"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.wasman.2018.10.017","article-title":"Solid Coffee Waste as Alternative to Produce Carotenoids with Antioxidant and Antimicrobial Activities","volume":"82","author":"Moreira","year":"2018","journal-title":"Waste Manag."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"124286","DOI":"10.1016\/j.molliq.2024.124286","article-title":"Extraction of Caffeine from Coffee Husk Employing Choline-Based Ionic Liquids: Optimization of the Process and Theoretical Study on Solute-Salts Interactions","volume":"398","author":"Matus","year":"2024","journal-title":"J. Mol. Liq."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"10866","DOI":"10.1021\/acsomega.8b01447","article-title":"Treatment of Coffee Husk with Ammonium-Based Ionic Liquids: Lignin Extraction, Degradation, and Characterization","volume":"3","author":"Tolesa","year":"2018","journal-title":"ACS Omega"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.talanta.2011.11.031","article-title":"Supercritical Fluid Extraction from Spent Coffee Grounds and Coffee Husks: Antioxidant Activity and Effect of Operational Variables on Extract Composition","volume":"88","author":"Andrade","year":"2012","journal-title":"Talanta"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2306\/scienceasia1513-1874.2020.S002","article-title":"Conventional and Microwave-Assisted Extraction for Bioactive Compounds from Dried Coffee Cherry Peel by-Products and Antioxidant Activity of the Aqueous Extracts","volume":"46S","author":"Thaiphanit","year":"2020","journal-title":"ScienceAsia"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"139842","DOI":"10.1016\/j.foodchem.2024.139842","article-title":"da Method Optimization for the Extraction of Chlorogenic Acids from Coffee Parchment: An Ecofriendly Alternative","volume":"458","author":"Antonio","year":"2024","journal-title":"Food Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"103365","DOI":"10.1016\/j.ifset.2023.103365","article-title":"Green Solvents for the Selective Extraction of Bioactive Compounds from By-Products of the Coffee Production Chain","volume":"86","author":"Jelley","year":"2023","journal-title":"Innov. Food Sci. Emerg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1007\/s13197-020-04738-2","article-title":"Ultrasound Processing of Coffee Silver Skin, Brewer\u2019s Spent Grain and Potato Peel Wastes for Phenolic Compounds and Amino Acids: A Comparative Study","volume":"58","author":"Zhang","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1007\/s12649-021-01435-9","article-title":"Valorisation of Coffee Roasting By-Products: Recovery of Silverskin Fat By Supercritical CO2 Extraction","volume":"12","author":"Nasti","year":"2021","journal-title":"Waste Biomass Valorization"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Brzezi\u0144ska, R., Wirkowska-Wojdy\u0142a, M., Piasecka, I., and G\u00f3rska, A. (2023). Application of Response Surface Methodology to Optimize the Extraction Process of Bioactive Compounds Obtained from Coffee Silverskin. Appl. Sci., 13.","DOI":"10.3390\/app13095388"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e22209","DOI":"10.1002\/tqem.22209","article-title":"Valorization of Waste Coffee Silverskin as a Source of Antioxidant by Extraction with Agitation","volume":"34","author":"Kulkarni","year":"2024","journal-title":"Environ. Qual. Manag."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Peixoto, J.A.B., Andrade, N., Machado, S., Costa, A.S.G., Puga, H., Oliveira, M.B.P.P., Martel, F., and Alves, R.C. (2022). Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale. Foods, 11.","DOI":"10.3390\/foods11121671"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1002\/fsn3.3541","article-title":"Physiochemical Properties of Sarawak\u2019s Adapted Liberica Coffee Silverskin Utilizing Varying Solvents","volume":"11","author":"Buyong","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"109933","DOI":"10.1016\/j.jfoodeng.2020.109933","article-title":"Supramolecular Solvent Extraction of Bioactives from Coffee Cherry Pulp","volume":"278","author":"Rubio","year":"2020","journal-title":"J. Food Eng."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Tran, T.M.K., Akanbi, T.O., Kirkman, T., Nguyen, M.H., and Vuong, Q. (2022). Van Recovery of Phenolic Compounds and Antioxidants from Coffee Pulp (Coffea canephora) Waste Using Ultrasound and Microwave-Assisted Extraction. Processes, 10.","DOI":"10.3390\/pr10051011"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Rojo-Poveda, O., Zeppa, G., Ferrocino, I., St\u00e9vigny, C., and Barbosa-Pereira, L. (2021). Chemometric Classification of Cocoa Bean Shells Based on Their Polyphenolic Profile Determined by RP-HPLC-PDA Analysis and Spectrophotometric Assays. Antioxidants, 10.","DOI":"10.3390\/antiox10101533"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Joki\u0107, S., Nasti\u0107, N., Vidovi\u0107, S., Flanjak, I., Aladi\u0107, K., and Vladi\u0107, J. (2020). An Approach to Value Cocoa Bean By-Product Based on Subcritical Water Extraction and Spray Drying Using Different Carriers. Sustainability, 12.","DOI":"10.3390\/su12062174"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Jensch, C., Schmidt, A., and Strube, J. (2022). Versatile Green Processing for Recovery of Phenolic Compounds from Natural Product Extracts towards Bioeconomy and Cascade Utilization for Waste Valorization on the Example of Cocoa Bean Shell (CBS). Sustainability, 14.","DOI":"10.3390\/su14053126"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.supflu.2017.12.039","article-title":"Integrated Green-Based Processes Using Supercritical CO2 and Pressurized Ethanol Applied to Recover Antioxidant Compouds from Cocoa (Theobroma cacao) Bean Hulls","volume":"135","author":"Mazzutti","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.foodres.2018.07.055","article-title":"Pressurized Liquid Extraction of Flavanols and Alkaloids from Cocoa Bean Shell Using Ethanol as Solvent","volume":"114","author":"Okiyama","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"100614","DOI":"10.1016\/j.crfs.2023.100614","article-title":"Effect of Choline Chloride-Based Deep Eutectic Solvents on Polyphenols Extraction from Cocoa (Theobroma cacao L.) Bean Shells and Antioxidant Activity of Extracts","volume":"7","year":"2023","journal-title":"Curr. Res. Food Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.fbp.2024.05.003","article-title":"Circular Bioeconomy for Cocoa By-Product Industry: Development of Whey Protein-Cocoa Bean Shell Concentrate Particles Obtained by Spray-Drying and Freeze-Drying for Commercial Applications","volume":"146","author":"Valencia","year":"2024","journal-title":"Food Bioprod. Process."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"106887","DOI":"10.1016\/j.ultsonch.2024.106887","article-title":"High Potential Extracts from Cocoa Byproducts through Sonotrode Optimal Extraction and a Comprehensive Characterization","volume":"106","year":"2024","journal-title":"Ultrason. Sonochem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"100908","DOI":"10.1016\/j.scp.2022.100908","article-title":"ESG Approach in the Valorization of Cocoa (Theobroma Cacao) by-Products by Subcritical Water: Application in the Cosmetic Industry","volume":"31","author":"Dzedik","year":"2023","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Llerena, W., Samaniego, I., Vallejo, C., Arreaga, A., Zhunio, B., Coronel, Z., Quiroz, J., Ang\u00f3s, I., and Carrillo, W. (2023). Profile of Bioactive Components of Cocoa (Theobroma cacao L.) By-Products from Ecuador and Evaluation of Their Antioxidant Activity. Foods, 12.","DOI":"10.3390\/foods12132583"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"114115","DOI":"10.1016\/j.lwt.2022.114115","article-title":"Extraction of Methylxanthines by Pressurized Hot Water Extraction from Cocoa Shell By-Product as Natural Source of Functional Ingredient","volume":"170","author":"Pagliari","year":"2022","journal-title":"LWT"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Pavlovi\u0107, N., Joki\u0107, S., Jakovljevi\u0107, M., Bla\u017ei\u0107, M., and Molnar, M. (2020). Green Extraction Methods for Active Compounds from Food Waste\u2014Cocoa Bean Shell. Foods, 9.","DOI":"10.3390\/foods9020140"},{"key":"ref_94","first-page":"77","article-title":"Ultrasound-Assisted Extraction of Active Compounds from Cocoa Bean Shell","volume":"10","author":"Molnar","year":"2021","journal-title":"Sci. Prof. J. Nutr. Diet."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Disca, V., Travaglia, F., Carini, C., Co\u00efsson, J.D., Cravotto, G., Arlorio, M., and Locatelli, M. (2024). Improving the Extraction of Polyphenols from Cocoa Bean Shells by Ultrasound and Microwaves: A Comparative Study. Antioxidants, 13.","DOI":"10.3390\/antiox13091097"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1007\/s11694-023-01986-6","article-title":"Effects of Enzymatic and Ultrasonic-Assisted Extraction of Bioactive Compounds from Cocoa Bean Shells","volume":"17","author":"Huynh","year":"2023","journal-title":"J. Food Meas. Charact."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1021\/ac400432p","article-title":"Natural Deep Eutectic Solvents as a New Extraction Media for Phenolic Metabolites in Carthamus tinctorius L","volume":"85","author":"Dai","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"130181","DOI":"10.1016\/j.jclepro.2021.130181","article-title":"An Integrated Approach for Sustainable Valorization of Winery Wastewater Using Bio-Based Solvents for Recovery of Natural Antioxidants","volume":"334","year":"2022","journal-title":"J. Clean. Prod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.chemosphere.2019.02.089","article-title":"Multifunctional Vesicular Coacervates as Engineered Supramolecular Solvents for Wastewater Treatment","volume":"223","author":"Lunar","year":"2019","journal-title":"Chemosphere"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"121515","DOI":"10.1016\/j.talanta.2020.121515","article-title":"Supramolecular Solvent-Based Micro-Extraction of Pesticides in Food and Environmental Samples","volume":"223","author":"Musarurwa","year":"2021","journal-title":"Talanta"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"129731","DOI":"10.1016\/j.jclepro.2021.129731","article-title":"Green Efficient Octanoic Acid Based Supramolecular Solvents for Extracting Active Ingredients from Zanthoxylum Bungeanum Maxim","volume":"331","author":"Cai","year":"2022","journal-title":"Peels. J. Clean. Prod."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"761","DOI":"10.31635\/ccschem.022.202201936","article-title":"In Situ Supramolecular Polymerization via Organometallic-Catalyzed Macromolecular Metamorphosis","volume":"5","author":"Yang","year":"2023","journal-title":"CCS Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"462483","DOI":"10.1016\/j.chroma.2021.462483","article-title":"Improving Identification of Low Abundance and Hydrophobic Proteins Using Fluoroalcohol Mediated Supramolecular Biphasic Systems with Quaternary Ammonium Salts","volume":"1655","author":"Azizi","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1021\/jf3040594","article-title":"Evaluation of Spent Coffee Obtained from the Most Common Coffeemakers as a Source of Hydrophilic Bioactive Compounds","volume":"60","author":"Bravo","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Bouhzam, I., Cantero, R., Balcells, M., Margallo, M., Aldaco, R., Bala, A., Fullana-i-Palmer, P., and Puig, R. (2023). Environmental and Yield Comparison of Quick Extraction Methods for Caffeine and Chlorogenic Acid from Spent Coffee Grounds. Foods, 12.","DOI":"10.3390\/foods12040779"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/ac2026207","article-title":"Environment-Responsive Alkanol-Based Supramolecular Solvents: Characterization and Potential as Restricted Access Property and Mixed-Mode Extractants","volume":"84","author":"Rubio","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1039\/b210714g","article-title":"Novel Solvent Properties of Choline Chloride\/Urea Mixtures","volume":"1","author":"Abbott","year":"2003","journal-title":"Chem. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Cannavacciuolo, C., Pagliari, S., Frigerio, J., Giustra, C.M., Labra, M., and Campone, L. (2022). Natural Deep Eutectic Solvents (NADESs) Combined with Sustainable Extraction Techniques: A Review of the Green Chemistry Approach in Food Analysis. Foods, 12.","DOI":"10.3390\/foods12010056"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"126965","DOI":"10.1016\/j.foodchem.2020.126965","article-title":"Green and Simple Extraction of Free Seleno-Amino Acids from Powdered and Lyophilized Milk Samples with Natural Deep Eutectic Solvents","volume":"326","author":"Regni","year":"2020","journal-title":"Food Chem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/sc500096j","article-title":"Natural Deep Eutectic Solvents\u2014Solvents for the 21st Century","volume":"2","author":"Paiva","year":"2014","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"R\u00e1mon, J.D., and Guillena, G. (2019). Toxicity and Biodegradability of Deep Eutectic Solvents. Deep Eutectic Solvents, Wiley.","DOI":"10.1002\/9783527818488"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chemosphere.2013.02.047","article-title":"Toxicological Evaluation of Magnetic Ionic Liquids in Human Cell Lines","volume":"92","author":"Frade","year":"2013","journal-title":"Chemosphere"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.chemosphere.2012.11.004","article-title":"Are Deep Eutectic Solvents Benign or Toxic?","volume":"90","author":"Hayyan","year":"2013","journal-title":"Chemosphere"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.indcrop.2018.02.029","article-title":"Enhanced Extraction of Phenolic Compounds Using Choline Chloride Based Deep Eutectic Solvents from Juglans regia L","volume":"115","author":"Vieira","year":"2018","journal-title":"Ind. Crops Prod."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/3\/342\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:32:44Z","timestamp":1759919564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/3\/342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":114,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["foods14030342"],"URL":"https:\/\/doi.org\/10.3390\/foods14030342","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]}}}