{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:19:33Z","timestamp":1789514373442,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Venture &amp; Innovation Support Program for Chongqing Overseas","award":["cx2018031"],"award-info":[{"award-number":["cx2018031"]}]},{"name":"Venture &amp; Innovation Support Program for Chongqing Overseas","award":["SW-KQ22073"],"award-info":[{"award-number":["SW-KQ22073"]}]},{"name":"Venture &amp; Innovation Support Program for Chongqing Overseas","award":["COMAITS202311"],"award-info":[{"award-number":["COMAITS202311"]}]},{"name":"Venture &amp; Innovation Support Program for Chongqing Overseas","award":["CARS-18-zj0505"],"award-info":[{"award-number":["CARS-18-zj0505"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["cx2018031"],"award-info":[{"award-number":["cx2018031"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["SW-KQ22073"],"award-info":[{"award-number":["SW-KQ22073"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["COMAITS202311"],"award-info":[{"award-number":["COMAITS202311"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["CARS-18-zj0505"],"award-info":[{"award-number":["CARS-18-zj0505"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Chongqing Modern Agricultural Industry Technology System","award":["cx2018031"],"award-info":[{"award-number":["cx2018031"]}]},{"name":"The Chongqing Modern Agricultural Industry Technology System","award":["SW-KQ22073"],"award-info":[{"award-number":["SW-KQ22073"]}]},{"name":"The Chongqing Modern Agricultural Industry Technology System","award":["COMAITS202311"],"award-info":[{"award-number":["COMAITS202311"]}]},{"name":"The Chongqing Modern Agricultural Industry Technology System","award":["CARS-18-zj0505"],"award-info":[{"award-number":["CARS-18-zj0505"]}]},{"name":"CARS","award":["cx2018031"],"award-info":[{"award-number":["cx2018031"]}]},{"name":"CARS","award":["SW-KQ22073"],"award-info":[{"award-number":["SW-KQ22073"]}]},{"name":"CARS","award":["COMAITS202311"],"award-info":[{"award-number":["COMAITS202311"]}]},{"name":"CARS","award":["CARS-18-zj0505"],"award-info":[{"award-number":["CARS-18-zj0505"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Monascus is a fungus widely used in food fermentation. This study employed microbial technology, combined with microscopic morphological observations and ITS sequence analysis, to isolate, purify, and identify 10 strains of red yeast mold from various Monascus products. After the HPLC detection of metabolic products, the M8 strain containing the toxic substance citrinin was excluded. Using the EWM-TOPSIS model, the remaining nine safe Monascus strains were evaluated for their inhibitory activities against pancreatic lipase, \u03b1-glucosidase, \u03b1-amylase, and the angiotensin-converting enzyme. The M2 strain with the highest comprehensive scores for lowering blood sugar, blood lipids, and blood pressure was selected. Its fermentation product at a concentration of 3 mg\/mL had inhibition rates of 96.938%, 81.903%, and 72.215%, respectively. The contents of the blood lipid-lowering active substance Monacolin K and the blood sugar and blood pressure-lowering active substance GABA were 18.078 mg\/g and 5.137 mg\/g, respectively. This strain can be utilized for the biosynthesis of important active substances such as Monacolin K and GABA, as well as for the fermentation production of safe and effective functional foods to address health issues like high blood lipids, high blood sugar, and high blood pressure in people. This study also provides insights into the use of natural fungi to produce healthy foods for combating chronic diseases in humans.<\/jats:p>","DOI":"10.3390\/foods14050835","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T10:12:33Z","timestamp":1740737553000},"page":"835","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Screening for Safe and Efficient Monascus Strains with Functions of Lowering Blood Lipids, Blood Glucose, and Blood Pressure"],"prefix":"10.3390","volume":"14","author":[{"given":"Chuling","family":"Liu","sequence":"first","affiliation":[{"name":"College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingtian","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengli","family":"He","sequence":"additional","affiliation":[{"name":"College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.ridd.2013.06.044","article-title":"An exploratory study of health behaviors and the risks for triple H (hypertension, hyperlipidemia, and hyperglycemia) in young adults with disabilities between 20 and 39 years of age","volume":"34","author":"Lin","year":"2013","journal-title":"Res. 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