{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:42:43Z","timestamp":1793396563325,"version":"4.5.0"},"reference-count":299,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lodz","award":["No. 503\/1-002-01\/503-11-001"],"award-info":[{"award-number":["No. 503\/1-002-01\/503-11-001"]}]},{"name":"Polish Society for Digestive Tract Neoplasms Prevention","award":["No. 503\/1-002-01\/503-11-001"],"award-info":[{"award-number":["No. 503\/1-002-01\/503-11-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>Celiac disease is defined as a systemic immunological disorder caused by gluten (gliadin and other prolamin) in genetically predisposed individuals, who present with a variety of gluten-dependent symptoms, specific antibodies, the presence of the HLA DQ2 and DQ8 histocompatibility antigen, and enteropathy. Its prevalence, depending on the studied population and methodology, is estimated at 0.75\u20131.6% of the general population. During the complex immune reaction it induces, most cells involved in inflammatory processes are activated, which leads to the gradual atrophy of intestinal villi and the proliferation of enterocytes within intestinal crypts. The pathogenesis of celiac disease is extremely complicated and is still the subject of research. According to the current diagnostic guidelines, the following criteria should be taken into account: clinical symptoms (intestinal and extraintestinal), the presence of antibodies against tissue transglutaminase in the IgA class, the level of total IgA, and the presence of typical histological changes in duodenal biopsies. Diet-resistant celiac disease is one of the most important clinical challenges, causing serious complications. Currently, the basic method for treating celiac disease is an elimination diet (i.e., the exclusion of products that may contain gluten from the diet), however, new therapeutic strategies are still being sought, mainly based on supplementation with exogenous endopeptidases, modification of the immune response, and the use of zonulin inhibitors and transglutaminase 2 inhibitors. Clinical trials of new drugs are ongoing. The gradually expanding knowledge about the pathogenesis of celiac disease may allow for the development of new therapeutic strategies for both patients with a mild disease course, as well as those that are diet-resistant.<\/jats:p>","DOI":"10.3390\/foods14060959","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:39:03Z","timestamp":1741711143000},"page":"959","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Celiac Disease\u2014Narrative Review on Progress in Celiac Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Marek K.","family":"Kowalski","sequence":"first","affiliation":[{"name":"Department of Digestive Tract Diseases, Norbert Barlicki University Hospital, 90-153 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-0944","authenticated-orcid":false,"given":"Danuta","family":"Dom\u017ca\u0142-Magrowska","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Diseases, Norbert Barlicki University Hospital, 90-153 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1825-1807","authenticated-orcid":false,"given":"Ewa","family":"Ma\u0142ecka-Wojciesko","sequence":"additional","affiliation":[{"name":"Department of Digestive Tract Diseases, Norbert Barlicki University Hospital, 90-153 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.14309\/ajg.0000000000002075","article-title":"American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease","volume":"118","author":"Hill","year":"2023","journal-title":"Am. J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MPG.0000000000002497","article-title":"European Society Paediatric Gastroenterology, Hepatology and Nutrition Guidelines for Diagnosing Coeliac Disease 2020","volume":"70","author":"Husby","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/MPG.0b013e31814c3d79","article-title":"Clinical pattern of celiac disease is still changing","volume":"45","author":"Garampazzi","year":"2007","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s12519-009-0053-y","article-title":"Celiac disease in 87 children with typical and atypical symptoms in Black Sea region of Turkey","volume":"5","author":"Dinler","year":"2009","journal-title":"World J. Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1651-2227.1993.tb12755.x","article-title":"Changes in coeliac disease behaviour over the years","volume":"82","author":"Bottaro","year":"1993","journal-title":"Acta Paediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1080\/003655299750025714","article-title":"Dietary analysis in symptomatic patients with coeliac disease on a gluten-free diet: The role of trace amounts of gluten and non-gluten food intolerances","volume":"34","author":"Selby","year":"1999","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_7","first-page":"140","article-title":"Czy choroba trzewna predysponuje do rozwoju chor\u00f3b nowotworowych?","volume":"2","author":"Marek","year":"2015","journal-title":"Onkol. Prakt. Klin."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3109\/00365521.2015.1092576","article-title":"Symptoms and findings in adult-onset celiac disease in a historical Danish patient cohort","volume":"51","author":"Schosler","year":"2016","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1053\/j.gastro.2024.02.044","article-title":"Celiac Disease-Related Conditions: Who to Test?","volume":"167","author":"Zingone","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/acps.13554","article-title":"Celiac disease and risk of neuropsychiatric disorders: A nationwide cohort study","volume":"148","author":"Hansen","year":"2023","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/gut.31.1.111","article-title":"Grains of truth: Evolutionary changes in small intestinal mucosa in response to environmental antigen challenge","volume":"31","author":"Marsh","year":"1990","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0016-5085(80)90373-X","article-title":"Studies of intestinal lymphoid tissue. III. Quantitative analyses of epithelial lymphocytes in the small intestine of human control subjects and of patients with celiac sprue","volume":"79","author":"Marsh","year":"1980","journal-title":"Gastroenterology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","article-title":"The histopathology of coeliac disease: Time for a standardized report scheme for pathologists","volume":"11","author":"Oberhuber","year":"1999","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-2001-11147","article-title":"Study Group of Gastroenterological Pathology of the German Society of Pathology. Recommendations for celiac disease\/sprue diagnosis","volume":"39","author":"Oberhuber","year":"2001","journal-title":"Z. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0753-3322(01)80003-2","article-title":"Histopathology of celiac disease","volume":"54","author":"Oberhuber","year":"2000","journal-title":"Biomed. Pharmacother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/bmj.328.7435.322","article-title":"Undiagnosed coeliac disease at age seven: Population based prospective birth cohort study","volume":"328","author":"Bingley","year":"2004","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"ref_18","first-page":"41","article-title":"Liver disorders and celiac disease","volume":"116","year":"2024","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kalayci, A.G., Kansu, A., Girgin, N., Kucuk, O., and Aras, G. (2001). Bone mineral density and importance of a gluten-free diet in patients with celiac disease in childhood. Pediatrics, 108.","DOI":"10.1542\/peds.108.5.e89"},{"key":"ref_20","first-page":"313","article-title":"Effect of treatment on bone mass, mineral metabolism, and body composition in untreated celiac disease patients","volume":"92","author":"Mautalen","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2036.1997.112283000.x","article-title":"Long-term effect of gluten restriction on bone mineral density of patients with coeliac disease","volume":"11","author":"Bai","year":"1997","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_22","first-page":"992","article-title":"Effects of dietary treatment on bone mineral density in adults with celiac disease: Factors predicting response","volume":"92","author":"Ciacci","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jbmr.2922","article-title":"Impaired Bone Microarchitecture Improves After One Year On Gluten-Free Diet: A Prospective Longitudinal HRpQCT Study in Women with Celiac Disease","volume":"32","author":"Zanchetta","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Santonicola, A., Wieser, H., Gizzi, C., Soldaini, C., and Ciacci, C. (2024). Associations between Celiac Disease, Extra-Gastrointestinal Manifestations, and Gluten-Free Diet: A Narrative Overview. Nutrients, 16.","DOI":"10.3390\/nu16121814"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Sun, Y., Zhou, Q., Tian, D., Zhou, J., and Dong, S. (2024). Relationship between vitamin D levels and pediatric celiac disease: A systematic review and meta-analysis. BMC Pediatr., 24.","DOI":"10.1186\/s12887-024-04688-0"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/cen.15184","article-title":"Prevalence of Vitamin D Deficiency With Biochemical Abnormalities in Children Undergoing Vitamin D Testing","volume":"102","author":"Bolland","year":"2024","journal-title":"Clin. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.2147\/IJGM.S503293","article-title":"Serum Vitamin D Profiles of Children with Asthma in Southwest Saudi: A Comparative Cross-Sectional Study","volume":"17","author":"Asseri","year":"2024","journal-title":"Int. J. Gen. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cgh.2017.09.054","article-title":"Improved Bone Microarchitecture in Patients With Celiac Disease After 3 Years on a Gluten-Free Diet","volume":"16","author":"Zanchetta","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Galli, G., Carabotti, M., Conti, L., Scalamonti, S., Annibale, B., and Lahner, E. (2023). Comparison of Clinical, Biochemical and Histological Features between Adult Celiac Patients with High and Low Anti-Transglutaminase IgA Titer at Diagnosis and Follow-Up. Nutrients, 15.","DOI":"10.3390\/nu15092151"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12937-019-0434-6","article-title":"Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: A systematic review","volume":"18","author":"Ganji","year":"2019","journal-title":"Nutr. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.34172\/mejdd.2022.262","article-title":"Bone Loss Correlated with Parathyroid Hormone Levels in Adult Celiac Patients","volume":"14","author":"Ganji","year":"2022","journal-title":"Middle East J. Dig. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cgh.2019.03.049","article-title":"Measurement of Forearm Bone Density by Dual Energy X-Ray Absorptiometry Increases the Prevalence of Osteoporosis in Men With Celiac Disease","volume":"18","author":"Walker","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"600","DOI":"10.5152\/tjg.2021.20313","article-title":"Bone Mineral Density Screening and the Frequency of Osteopenia\/Osteoporosis in Turkish Adult Patients With Celiac Disease","volume":"32","author":"Sayar","year":"2021","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.5114\/pg.2024.145481","article-title":"The other side of celiac disease\u2014Assessment of bone mineral density and body composition in patients with celiac disease","volume":"19","author":"Kinga","year":"2024","journal-title":"Gastroenterol. Rev. Przegl\u0105d Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s10620-009-0943-9","article-title":"Celiac disease is associated with restless legs syndrome","volume":"55","author":"Weinstock","year":"2010","journal-title":"Dig. Dis. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.sleep.2008.07.014","article-title":"Celiac disease as a possible cause for low serum ferritin in patients with restless legs syndrome","volume":"10","author":"Manchanda","year":"2009","journal-title":"Sleep. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s12026-015-8750-1","article-title":"Gluten ataxia is better classified as non-celiac gluten sensitivity than as celiac disease: A comparative clinical study","volume":"64","author":"Rodrigo","year":"2016","journal-title":"Immunol. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1590\/S0004-28032015000400005","article-title":"Increased tissue transglutaminase levels are associated with increased epileptiform activity in electroencephalography among patients with celiac disease","volume":"52","author":"Isikay","year":"2015","journal-title":"Arq. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1600-0447.2011.01795.x","article-title":"Meta-analysis on anxiety and depression in adult celiac disease","volume":"125","author":"Smith","year":"2012","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1192\/bjp.bp.111.092098","article-title":"Prevalence of autoimmune diseases in in-patients with schizophrenia: Nationwide population-based study","volume":"200","author":"Chen","year":"2012","journal-title":"Br. J. Psychiatry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/00365520600863472","article-title":"Coeliac disease and risk of schizophrenia and other psychosis: A general population cohort study","volume":"42","author":"Ludvigsson","year":"2007","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1365-2036.2009.03942.x","article-title":"Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States","volume":"29","author":"Garud","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s13317-014-0064-0","article-title":"Celiac and non-celiac gluten sensitivity: A review on the association with schizophrenia and mood disorders","volume":"5","author":"Porcelli","year":"2014","journal-title":"Auto. Immun. Highlights"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s13052-021-01183-5","article-title":"Is the clinical pattern of pediatric celiac disease changing? A thirty-years real-life experience of an Italian center","volume":"47","author":"Pedretti","year":"2021","journal-title":"Ital. J. Pediatr."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Popp, A., and M\u00e4ki, M. (2019). Changing Pattern of Childhood Celiac Disease Epidemiology: Contributing Factors. Front. Pediatr., 7.","DOI":"10.3389\/fped.2019.00357"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bianchi, P.I., Lenti, M.V., Petrucci, C., Gambini, G., Aronico, N., Varallo, M., Rossi, C.M., Pozzi, E., Groppali, E., and Siccardo, F. (2024). Diagnostic Delay of Celiac Disease in Childhood. JAMA Netw. Open, 7.","DOI":"10.1001\/jamanetworkopen.2024.5671"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Smith, L.B., Lynch, K.F., Kurppa, K., Koletzko, S., Krischer, J., Liu, E., Johnson, S.B., and Agardh, D. (2017). Psychological Manifestations of Celiac Disease Autoimmunity in Young Children. Pediatrics, 139.","DOI":"10.1542\/peds.2016-2848"},{"key":"ref_48","first-page":"185","article-title":"New guidelines for diagnosis and treatment of coeliac disease in children and adolescents","volume":"7","year":"2012","journal-title":"Gastroenterol. Rev. Przegl\u0105d Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders","volume":"7","author":"Volta","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_50","first-page":"28","article-title":"Histopathology of Celiac Disease. Position Statements of the Italian Group of Gastrointestinal Pathologists (GIPAD-SIAPEC)","volume":"23","author":"Villanacci","year":"2020","journal-title":"Transl. Med. UniSa"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1053\/j.gastro.2022.07.086","article-title":"AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review","volume":"163","author":"Green","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s11899-016-0357-7","article-title":"Enteropathy-Associated T-Cell Lymphoma","volume":"11","author":"Ondrejka","year":"2016","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1542-3565(05)00295-8","article-title":"Effect of elemental diet on mucosal immunopathology and clinical symptoms in type 1 refractory celiac disease","volume":"3","author":"Olaussen","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5306\/wjco.v13.i3.200","article-title":"Possible relationship between refractory celiac disease and malignancies","volume":"13","author":"Demiroren","year":"2022","journal-title":"World J. Clin. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bpg.2005.02.001","article-title":"Refractory coeliac disease","volume":"19","author":"Daum","year":"2005","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1038\/ctg.2016.70","article-title":"Outcome of Referrals for Non-Responsive Celiac Disease in a Tertiary Center: Low Incidence of Refractory Celiac Disease in the Netherlands","volume":"8","author":"Bouma","year":"2017","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1097\/MCG.0000000000000919","article-title":"World Gastroenterology Organisation Global Guidelines: Celiac Disease February 2017","volume":"51","author":"Bai","year":"2017","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_58","first-page":"94","article-title":"All-Russian Consensus on Diagnosis and Treatment of Celiac Disease in Children and Adults","volume":"89","author":"Parfenov","year":"2017","journal-title":"Ter. Arkh."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"h4513","DOI":"10.1136\/bmj.h4513","article-title":"Recognition, assessment, and management of coeliac disease: Summary of updated NICE guidance","volume":"351","author":"Downey","year":"2015","journal-title":"BMJ"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"ACG clinical guidelines: Diagnosis and management of celiac disease","volume":"108","author":"Hill","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_62","first-page":"434","article-title":"Clinical guidelines on the diagnosis and treatment of celiac disease in Mexico","volume":"83","year":"2018","journal-title":"Rev. Gastroenterol. M\u00e9xico"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3748\/wjg.v28.i1.154","article-title":"Current guidelines for the management of celiac disease: A systematic review with comparative analysis","volume":"28","author":"Raiteri","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1056\/NEJMoa021687","article-title":"Prevalence of Celiac disease among children in Finland","volume":"348","author":"Maki","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_65","first-page":"553","article-title":"The prevalence of celiac disease in children and adolescents in Germany","volume":"112","author":"Laass","year":"2015","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/jgh.13270","article-title":"Prevalence of Celiac disease in Asia: A systematic review and meta-analysis","volume":"31","author":"Singh","year":"2015","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ajg.2015.8","article-title":"Trends and racial\/ethnic disparities in gluten-sensitive problems in the United States: Findings from the National Health and Nutrition Examination Surveys from 1988 to 2012","volume":"110","author":"Choung","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1001\/archinte.163.3.286","article-title":"Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: A large multicenter study","volume":"163","author":"Fasano","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/ajg.2015.296","article-title":"Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients with Celiac Disease: A Systematic Review and Meta-Analysis","volume":"110","author":"Singh","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5409\/wjcp.v11.i4.351","article-title":"Frequency of celiac disease and distribution of HLA-DQ2\/DQ8 haplotypes among siblings of children with celiac disease","volume":"11","author":"Sahin","year":"2022","journal-title":"World J. Clin. Pediatr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3109\/07853890.2010.505931","article-title":"The prevalence of celiac disease in Europe: Results of a centralized, international mass screening project","volume":"42","author":"Mustalahti","year":"2010","journal-title":"Ann. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bpg.2015.05.004","article-title":"Celiac disease from a global perspective","volume":"29","author":"Lionetti","year":"2015","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"El-Metwally, A., Toivola, P., AlAhmary, K., Bahkali, S., AlKhathaami, A., AlSaqabi, M.K., Al Ammar, S.A., Jawed, M., and Alosaimi, S.M. (2020). The Epidemiology of Celiac Disease in the General Population and High-Risk Groups in Arab Countries: A Systematic Review. Biomed. Res. Int., 2020.","DOI":"10.1155\/2020\/6865917"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Tamai, T., and Ihara, K. (2023). Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032075"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.3748\/wjg.v27.i19.2251","article-title":"Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers","volume":"27","author":"Poddighe","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ashtari, S., Najafimehr, H., Pourhoseingholi, M.A., Rostami, K., Asadzadeh-Aghdaei, H., Rostami-Nejad, M., Tavirani, M.R., Olfatifar, M., Makharia, G.K., and Zali, M.R. (2021). Prevalence of celiac disease in low and high risk population in Asia-Pacific region: A systematic review and meta-analysis. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-82023-8"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1177\/2050640614561668","article-title":"Screening for celiac disease in the general population and in high-risk groups","volume":"3","author":"Ludvigsson","year":"2015","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Parra-Medina, R., Molano-Gonzalez, N., Rojas-Villarraga, A., Agmon-Levin, N., Arango, M.T., Shoenfeld, Y., and Anaya, J.M. (2015). Prevalence of celiac disease in latin america: A systematic review and meta-regression. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124040"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Savvateeva, L.V., Erdes, S.I., Antishin, A.S., and Zamyatnin, A.A. (2017). Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence. J. Immunol. Res., 2017.","DOI":"10.1155\/2017\/2314813"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/1751-2980.13049","article-title":"Prevalence of celiac disease in China: Meta-analysis and serological survey in high-risk populations","volume":"22","author":"Zhou","year":"2021","journal-title":"J. Dig. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1440-1746.2010.06606.x","article-title":"Prevalence of celiac disease in the northern part of India: A community based study","volume":"26","author":"Makharia","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5694\/j.1326-5377.2009.tb02491.x","article-title":"Screening for coeliac disease using anti-tissue transglutaminase antibody assays, and prevalence of the disease in an Australian community","volume":"190","author":"Chin","year":"2009","journal-title":"Med. J. Aust."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5144\/0256-4947.2013.159","article-title":"Prevalence of celiac disease in healthy Iranian school children","volume":"33","author":"Dehghani","year":"2013","journal-title":"Ann. Saudi Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.sjbs.2015.04.015","article-title":"Screening of coeliac disease in undetected adults and patients diagnosed with irritable bowel syndrome in Riyadh, Saudi Arabia","volume":"23","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/apt.16282","article-title":"Increased incidence of coeliac disease autoimmunity rate in Israel: A 9-year analysis of population-based data","volume":"53","author":"Lechtman","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.patbio.2005.02.005","article-title":"Celiac disease in Tunisia: Serological screening in healthy blood donors","volume":"54","author":"Landolsi","year":"2006","journal-title":"Pathol. Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31815ce5d1","article-title":"Prevalence of celiac disease in Egyptian children disputes the east-west agriculture-dependent spread of the disease","volume":"47","author":"Kryszak","year":"2008","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/MPG.0b013e3181bab30c","article-title":"Celiac disease seropositivity in Saharawi children: A follow-up and family study","volume":"50","author":"Teresi","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Aboulaghras, S., Piancatelli, D., Taghzouti, K., Balahbib, A., Alshahrani, M.M., Al Awadh, A.A., Goh, K.W., Ming, L.C., Bouyahya, A., and Oumhani, K. (2023). Meta-Analysis and Systematic Review of HLA DQ2\/DQ8 in Adults with Celiac Disease. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021188"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"11825","DOI":"10.3748\/wjg.v21.i41.11825","article-title":"Role of oats in celiac disease","volume":"21","author":"Comino","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1043-4526(09)57006-4","article-title":"Introduction of oats in the diet of individuals with celiac disease: A systematic review","volume":"57","author":"Pulido","year":"2009","journal-title":"Adv. Food Nutr. Res."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"La Vieille, S., Pulido, O.M., Abbott, M., Koerner, T.B., and Godefroy, S. (2016). Celiac Disease and Gluten-Free Oats: A Canadian Position Based on a Literature Review. Can. J. Gastroenterol. Hepatol., 2016.","DOI":"10.1155\/2016\/1870305"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/j.gastro.2017.04.009","article-title":"Safety of Adding Oats to a Gluten-Free Diet for Patients with Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies","volume":"153","author":"Aboulaghras","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jpeds.2017.10.062","article-title":"Safety of Oats in Children with Celiac Disease: A Double-Blind, Randomized, Placebo-Controlled Trial","volume":"194","author":"Lionetti","year":"2018","journal-title":"J. Pediatr."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Tanner, G., Juh\u00e1sz, A., Florides, C.G., Nye-Wood, M., B\u00e9k\u00e9s, F., Colgrave, M.L., Russell, A.K., Hardy, M.Y., and Tye-Din, J.A. (2019). Preparation and Characterization of Avenin-Enriched Oat Protein by Chill Precipitation for Feeding Trials in Celiac Disease. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00162"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Palova-Jelinkova, L., Danova, K., Drasarova, H., Dvorak, M., Funda, D.P., Fundova, P., Kotrbova-Kozak, A., Cerna, M., Kamanova, J., and Martin, S.F. (2013). Pepsin digest of wheat gliadin fraction increases production of IL-1beta via TLR4\/MyD88\/TRIF\/MAPK\/NF-kappaB signaling pathway and an NLRP3 inflammasome activation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062426"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/00365520601019819","article-title":"Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease","volume":"42","author":"Venalainen","year":"2007","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1053\/j.gastro.2005.06.016","article-title":"Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease","volume":"129","author":"Candalh","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Wei, G., Helmerhorst, E.J., Darwish, G., Blumenkranz, G., and Schuppan, D. (2020). Gluten Degrading Enzymes for Treatment of Celiac Disease. Nutrients, 12.","DOI":"10.3390\/nu12072095"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Dunaevsky, Y.E., Tereshchenkova, V.F., Belozersky, M.A., Filippova, I.Y., Oppert, B., and Elpidina, E.N. (2021). Effective Degradation of Gluten and Its Fragments by Gluten-Specific Peptidases: A Review on Application for the Treatment of Patients with Gluten Sensitivity. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13101603"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.biochi.2012.03.025","article-title":"Differences in faecal bacteria populations and faecal bacteria metabolism in healthy adults and celiac disease patients","volume":"94","author":"Nistal","year":"2012","journal-title":"Biochimie"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/gmic.1.3.11868","article-title":"Effects of a gluten-free diet on gut microbiota and immune function in healthy adult humans","volume":"1","author":"Sanz","year":"2010","journal-title":"Gut Microbes"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1017\/S0007114509371767","article-title":"Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects","volume":"102","author":"Nadal","year":"2009","journal-title":"Br. J. Nutr."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1128\/AEM.02793-08","article-title":"Different fecal microbiotas and volatile organic compounds in treated and untreated children with celiac disease","volume":"75","author":"Rizzello","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13073-016-0295-y","article-title":"The influence of a short-term gluten-free diet on the human gut microbiome","volume":"8","author":"Bonder","year":"2016","journal-title":"Genome Med."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Szczuci\u0144ski, W., Salamon, D., Sopel, A., and Gosiewski, T. (2024). Celiac disease and human gut microbiota\u2014How can we study the composition of microorganisms?. Gastroenterol. Rev. Przegl\u0105d Gastroenterol., 19.","DOI":"10.5114\/pg.2024.139574"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1017\/S0007114515002767","article-title":"Differences in gluten metabolism among healthy volunteers, coeliac disease patients and first-degree relatives","volume":"114","author":"Caminero","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Zamakhchari, M., Wei, G., Dewhirst, F., Lee, J., Schuppan, D., Oppenheim, F.G., and Helmerhorst, E.J. (2011). Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024455"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Helmerhorst, E.J., Zamakhchari, M., Schuppan, D., and Oppenheim, F.G. (2010). Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0013264"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"G621","DOI":"10.1152\/ajpgi.00034.2006","article-title":"Highly efficient gluten degradation with a newly identified prolyl endoprotease: Implications for celiac disease","volume":"291","author":"Stepniak","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/BJ20040907","article-title":"Comparative biochemical analysis of three bacterial prolyl endopeptidases: Implications for coeliac sprue","volume":"383","author":"Shan","year":"2004","journal-title":"Biochem. J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1016\/S0021-9258(19)85566-7","article-title":"Proline-specific endopeptidase from Flavobacterium. Purification and properties","volume":"255","author":"Yoshimoto","year":"1980","journal-title":"J. Biol. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2004.06.020","article-title":"Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease","volume":"21","author":"Meresse","year":"2004","journal-title":"Immunity"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.molimm.2004.12.005","article-title":"Gliadin as a stimulator of innate responses in celiac disease","volume":"42","author":"Londei","year":"2005","journal-title":"Mol. Immunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0140-6736(03)13803-2","article-title":"Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease","volume":"362","author":"Maiuri","year":"2003","journal-title":"Lancet"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/eji.200324705","article-title":"Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors","volume":"34","author":"Andre","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2004.06.018","article-title":"A direct role for NKG2D\/MICA interaction in villous atrophy during celiac disease","volume":"21","author":"Hue","year":"2004","journal-title":"Immunity"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jmr.987","article-title":"Interaction of \u2018toxic\u2019 and \u2018immunogenic\u2019 A-gliadin peptides with a membrane-mimetic environment","volume":"23","author":"Vilasi","year":"2010","journal-title":"J. Mol. Recognit."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Nanayakkara, M., Kosova, R., Lania, G., Sarno, M., Gaito, A., Galatola, M., Greco, L., Cuomo, M., Troncone, R., and Auricchio, S. (2013). A celiac cellular phenotype, with altered LPP sub-cellular distribution, is inducible in controls by the toxic gliadin peptide P31-43. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079763"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/gut.2005.086637","article-title":"Growth factor-like activity of gliadin, an alimentary protein: Implications for coeliac disease","volume":"56","author":"Barone","year":"2007","journal-title":"Gut"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0014-5793(03)00236-9","article-title":"Wheat gliadin induces apoptosis of intestinal cells via an autocrine mechanism involving Fas-Fas ligand pathway","volume":"540","author":"Giovannini","year":"2003","journal-title":"FEBS Lett."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ajpath.2011.10.019","article-title":"Paracellular versus transcellular intestinal permeability to gliadin peptides in active celiac disease","volume":"180","author":"Menard","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2008.03.023","article-title":"Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3","volume":"135","author":"Lammers","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1136\/gut.52.2.218","article-title":"Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function","volume":"52","author":"Clemente","year":"2003","journal-title":"Gut"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/00365520500235334","article-title":"Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines","volume":"41","author":"Drago","year":"2006","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/S0140-6736(00)02169-3","article-title":"Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease","volume":"355","author":"Fasano","year":"2000","journal-title":"Lancet"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"16799","DOI":"10.1073\/pnas.0906773106","article-title":"Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2","volume":"106","author":"Tripathi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2337\/db05-1593","article-title":"Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives","volume":"55","author":"Sapone","year":"2006","journal-title":"Diabetes"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1053\/gast.2002.36578","article-title":"Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure","volume":"123","author":"Panigrahi","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/jcs.113.24.4435","article-title":"Human zonulin, a potential modulator of intestinal tight junctions","volume":"113","author":"Wang","year":"2000","journal-title":"J. Cell Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2249.2008.03635.x","article-title":"Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture","volume":"152","author":"Lindfors","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.191.4.603","article-title":"The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase","volume":"191","author":"Korner","year":"2000","journal-title":"J. Exp. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/1521-4141(200105)31:5<1317::AID-IMMU1317>3.0.CO;2-I","article-title":"T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase","volume":"31","author":"Molberg","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2506::AID-IMMU2506>3.0.CO;2-9","article-title":"HLA binding and T cell recognition of a tissue transglutaminase-modified gliadin epitope","volume":"29","author":"Quarsten","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.4049\/jimmunol.0803181","article-title":"Intestinal T cell responses to gluten peptides are largely heterogeneous: Implications for a peptide-based therapy in celiac disease","volume":"182","author":"Camarca","year":"2009","journal-title":"J. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1136\/gut.2004.059998","article-title":"T cells in peripheral blood after gluten challenge in coeliac disease","volume":"54","author":"Anderson","year":"2005","journal-title":"Gut"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","volume":"161","author":"Kooy","year":"1998","journal-title":"J. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1021\/pr800960n","article-title":"A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: Implications for the T-cell response in celiac disease","volume":"8","author":"Dorum","year":"2009","journal-title":"J. Proteome Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4049\/jimmunol.175.1.254","article-title":"Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: Importance of proline spacing and glutamine deamidation","volume":"175","author":"Qiao","year":"2005","journal-title":"J. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1172\/JCI27620","article-title":"HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease","volume":"116","author":"Tollefsen","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"12390","DOI":"10.1073\/pnas.2135229100","article-title":"The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses","volume":"100","author":"Vader","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1107\/S1744309107051408","article-title":"The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease","volume":"63","author":"Henderson","year":"2007","journal-title":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/MPG.0b013e31815ee555","article-title":"Deamidated gliadin peptides form epitopes that transglutaminase antibodies recognize","volume":"46","author":"Vecsei","year":"2008","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_145","first-page":"571","article-title":"Antibodies to gliadin, endomysium, and tissue transglutaminase for the diagnosis of celiac disease","volume":"29","author":"Vitoria","year":"1999","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/clinchem\/47.11.2023","article-title":"Celiac disease: Antibody recognition against native and selectively deamidated gliadin peptides","volume":"47","author":"Aleanzi","year":"2001","journal-title":"Clin. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/01.mpg.0000174845.90668.fa","article-title":"Autoantibodies against soluble and immobilized human recombinant tissue transglutaminase in children with celiac disease","volume":"41","author":"Agardh","year":"2005","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/S0016-5085(98)70008-3","article-title":"Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease","volume":"115","author":"Sulkanen","year":"1998","journal-title":"Gastroenterology"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/mi.2010.36","article-title":"HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22","volume":"3","author":"Bodd","year":"2010","journal-title":"Mucosal Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.clim.2010.01.003","article-title":"Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: Implications for celiac disease","volume":"135","author":"Harris","year":"2010","journal-title":"Clin. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/gut.50.2.186","article-title":"Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease","volume":"50","author":"Salvati","year":"2002","journal-title":"Gut"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/gut.2007.129882","article-title":"Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease","volume":"57","author":"Fina","year":"2008","journal-title":"Gut"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1053\/j.gastro.2007.08.018","article-title":"Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease","volume":"133","author":"Pickard","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.humimm.2005.02.005","article-title":"Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with celiac disease in male subjects","volume":"66","author":"Mora","year":"2005","journal-title":"Hum. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/labinvest.3700225","article-title":"Matrix metalloproteinase pattern in celiac duodenal mucosa","volume":"85","author":"Ciccocioppo","year":"2005","journal-title":"Lab. Investig."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/00365520510023918","article-title":"Metalloelastase (MMP-12) is upregulated in the gut of pediatric patients with potential celiac disease and in type 1 diabetes","volume":"40","author":"Bister","year":"2005","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2567.2010.03378.x","article-title":"Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease","volume":"132","author":"Lammers","year":"2011","journal-title":"Immunology"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3945\/ajcn.112.054544","article-title":"An undigested gliadin peptide activates innate immunity and proliferative signaling in enterocytes: The role in celiac disease","volume":"98","author":"Nanayakkara","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.3390\/ijms151120518","article-title":"Gliadin peptides as triggers of the proliferative and stress\/innate immune response of the celiac small intestinal mucosa","volume":"15","author":"Barone","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1007\/s10620-007-0058-0","article-title":"Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-up","volume":"53","author":"Volta","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Majsiak, E., Cukrowska, B., Choina, M., Bielawski, K., Cielecka-Kuszyk, J., Konopka, E., Wysoki\u0144ski, M., and Bier\u0142a, J.B. (2022). Evaluation of the Usefulness of a Serological Test for Diagnosis of Celiac Disease Simultaneously Detecting Specific Antibodies and Total IgA. Nutrients, 15.","DOI":"10.3390\/nu15010202"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1053\/j.gastro.2005.02.028","article-title":"The diagnostic accuracy of serologic tests for celiac disease: A systematic review","volume":"128","author":"Rostom","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"Husby","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4292\/wjgpt.v7.i2.254","article-title":"Clinical utility of quantitative multi-antibody Polycheck immunoassays in the diagnosis of coeliac disease","volume":"7","author":"Konopka","year":"2016","journal-title":"World J. Gastrointest. Pharmacol. Ther."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cgh.2007.05.024","article-title":"Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease","volume":"5","author":"Agardh","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/MPG.0b013e318216f2e5","article-title":"Accuracy of diagnostic antibody tests for coeliac disease in children: Summary of an evidence report","volume":"54","author":"Giersiepen","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cca.2012.10.051","article-title":"Neo-epitope tissue transglutaminase autoantibodies as a biomarker of the gluten sensitive skin disease\u2014Dermatitis herpetiformis","volume":"415","author":"Lytton","year":"2013","journal-title":"Clin. Chim. Acta"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jim.2015.12.006","article-title":"Antibodies against neo-epitope tTg complexed to gliadin are different and more reliable then anti-tTg for the diagnosis of pediatric celiac disease","volume":"429","author":"Lerner","year":"2016","journal-title":"J. Immunol. Methods"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/eji.201343382","article-title":"Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease","volume":"43","author":"Bodd","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.3390\/nu7125515","article-title":"Gliadin-Specific T-Cells Mobilized in the Peripheral Blood of Coeliac Patients by Short Oral Gluten Challenge: Clinical Applications","volume":"7","author":"Picascia","year":"2015","journal-title":"Nutrients"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1073\/pnas.0608610104","article-title":"Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients","volume":"104","author":"Raki","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/ajg.2011.23","article-title":"Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test","volume":"106","author":"Brottveit","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/2050640614540154","article-title":"Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge","volume":"2","author":"Christophersen","year":"2014","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.4049\/jimmunol.1501152","article-title":"Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease","volume":"196","author":"Christophersen","year":"2016","journal-title":"J. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5152\/tjg.2019.18255","article-title":"HLA-DQ2\/DQ8 frequency in adult patients with celiac disease, their first-degree relatives, and normal population in Turkey","volume":"30","author":"Temel","year":"2019","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S0102-67202015000300009","article-title":"The prevalence of HLA DQ2 and DQ8 in patients with celiac disease, in family and in general population","volume":"28","author":"Cecilio","year":"2015","journal-title":"Arq. Bras. Cir. Dig."},{"key":"ref_177","first-page":"36","article-title":"The frequency of HLA-DQ2\/DQ8 haplotypes and celiac disease among the first-degree relatives of patients with celiac disease","volume":"14","author":"Mansouri","year":"2021","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Paziewska, A., Cukrowska, B., Dabrowska, M., Goryca, K., Piatkowska, M., Kluska, A., Mikula, M., Karczmarski, J., Oralewska, B., and Rybak, A. (2015). Combination Testing Using a Single MSH5 Variant alongside HLA Haplotypes Improves the Sensitivity of Predicting Coeliac Disease Risk in the Polish Population. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139197"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/gutjnl-2012-304110","article-title":"Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants","volume":"63","author":"Romanos","year":"2014","journal-title":"Gut"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00251-009-0361-3","article-title":"Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations","volume":"61","author":"Koskinen","year":"2009","journal-title":"Immunogenetics"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Monsuur, A.J., de Bakker, P.I., Zhernakova, A., Pinto, D., Verduijn, W., Romanos, J., Auricchio, R., Lopez, A., van Heel, D.A., and Crusius, J.B. (2008). Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002270"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Huang, S.Q., Zhang, N., Zhou, Z.X., Huang, C.C., Zeng, C.L., Xiao, D., Guo, C.C., Han, Y.J., Ye, X.H., and Ye, X.G. (2017). Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis. Int. J. Environ. Res. Public. Health, 14.","DOI":"10.3390\/ijerph14020171"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/cei.13578","article-title":"Whole blood interleukin-2 release test to detect and characterize rare circulating gluten-specific T cell responses in coeliac disease","volume":"204","author":"Anderson","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Goel, G., Tye-Din, J.A., Qiao, S.W., Russell, A.K., Mayassi, T., Ciszewski, C., Sarna, V.K., Wang, S., Goldstein, K.E., and Dzuris, J.L. (2019). Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. Sci. Adv., 5.","DOI":"10.1126\/sciadv.aaw7756"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Tye-Din, J.A., Daveson, A.J.M., Goldstein, K.E., Hand, H.L., Neff, K.M., Goel, G., Williams, L.J., Truitt, K.E., and Anderson, R.P. (2020). Patient factors influencing acute gluten reactions and cytokine release in treated coeliac disease. BMC Med., 18.","DOI":"10.1186\/s12916-020-01828-y"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1399-0039.1998.tb03066.x","article-title":"HLA restriction patterns of gliadin- and astrovirus-specific CD4+ T cells isolated in parallel from the small intestine of celiac disease patients","volume":"52","author":"Molberg","year":"1998","journal-title":"Tissue Antigens"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/73200","article-title":"In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope","volume":"6","author":"Anderson","year":"2000","journal-title":"Nat. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-3083.1994.tb03414.x","article-title":"T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules","volume":"39","author":"Gjertsen","year":"1994","journal-title":"Scand. J. Immunol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1177\/2050640619874183","article-title":"CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease","volume":"7","author":"Risnes","year":"2019","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.nutres.2018.09.003","article-title":"Oat safety for celiac disease patients: Theoretical analysis correlates adverse symptoms in clinical studies to contaminated study oats","volume":"60","author":"Fritz","year":"2018","journal-title":"Nutr. Res."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Thompson, T., and Keller, A. (2023). Gluten cross contact in oats: Retrospective database analysis 2011 to 2023. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1284636"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.foodres.2017.11.031","article-title":"Oats in healthy gluten-free and regular diets: A perspective","volume":"110","author":"Smulders","year":"2018","journal-title":"Food Res. Int."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Lahdeaho, M.L., Maki, M., Laurila, K., Huhtala, H., and Kaukinen, K. (2011). Small- bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease. BMC Gastroenterol., 11.","DOI":"10.1186\/1471-230X-11-129"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/ajcn\/85.1.160","article-title":"A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease","volume":"85","author":"Catassi","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.3390\/nu5114614","article-title":"The clinical response to gluten challenge: A review of the literature","volume":"5","author":"Bruins","year":"2013","journal-title":"Nutrients"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1365-2036.2008.03669.x","article-title":"Systematic review: Tolerable amount of gluten for people with coeliac disease","volume":"27","author":"Akobeng","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1097\/01.meg.0000236884.21343.e4","article-title":"Consumption of gluten-free products: Should the threshold value for trace amounts of gluten be at 20, 100 or 200 p.p.m.?","volume":"18","author":"Gibert","year":"2006","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_198","unstructured":"Food and Drug Administration (2013). Food labeling: Gluten-free labeling of foods. Final rule. Fed. Regist., 78, 47154\u201347179."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/ajg.2012.220","article-title":"Persistent duodenal intraepithelial lymphocytosis despite a long-term strict gluten-free diet in celiac disease","volume":"107","author":"Tuire","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Hollon, J.R., Cureton, P.A., Martin, M.L., Puppa, E.L., and Fasano, A. (2013). Trace gluten contamination may play a role in mucosal and clinical recovery in a subgroup of diet-adherent non-responsive celiac disease patients. BMC Gastroenterol., 13.","DOI":"10.1186\/1471-230X-13-40"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00394-016-1238-5","article-title":"Celiac disease: Understanding the gluten-free diet","volume":"56","author":"Bascunan","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_202","first-page":"139","article-title":"Gluten-free diet and quality of life in celiac disease","volume":"7","author":"Samasca","year":"2014","journal-title":"Gastroenterol. Hepatol. Bed Bench"},{"key":"ref_203","first-page":"374","article-title":"Is compliance with gluten-free diet sufficient? Diet composition of celiac patients","volume":"57","author":"Balamtekin","year":"2015","journal-title":"Turk. J. Pediatr."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.3390\/nu7075234","article-title":"Analysis of Body Composition and Food Habits of Spanish Celiac Women","volume":"7","author":"Churruca","year":"2015","journal-title":"Nutrients"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/jhn.12125","article-title":"Nutrient intake in adolescent girls and boys diagnosed with coeliac disease at an early age is mostly comparable to their non-coeliac contemporaries","volume":"27","author":"Kautto","year":"2014","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1017\/S0007114515002056","article-title":"Are gluten-free foods healthier than non-gluten-free foods? An evaluation of supermarket products in Australia","volume":"114","author":"Wu","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/jhn.12018","article-title":"Nutritional inadequacies of the gluten-free diet in both recently-diagnosed and long-term patients with coeliac disease","volume":"26","author":"Shepherd","year":"2013","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s11130-014-0410-4","article-title":"Nutritional differences between a gluten-free diet and a diet containing equivalent products with gluten","volume":"69","author":"Miranda","year":"2014","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.clnu.2016.05.002","article-title":"Gluten free diet and nutrient deficiencies: A review","volume":"35","author":"Vici","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000348850","article-title":"Inadequate nutrient intake in patients with celiac disease: Results from a German dietary survey","volume":"87","author":"Martin","year":"2013","journal-title":"Digestion"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/pch\/19.6.305","article-title":"Factors affecting adherence to a gluten-free diet in children with celiac disease","volume":"19","author":"MacCulloch","year":"2014","journal-title":"Paediatr. Child. Health"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/postgradmedj-2015-133395","article-title":"Cost and availability of gluten-free food in the UK: In store and online","volume":"91","author":"Burden","year":"2015","journal-title":"Postgrad. Med. J."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Missbach, B., Schwingshackl, L., Billmann, A., Mystek, A., Hickelsberger, M., Bauer, G., and Konig, J. (2015). Gluten-free food database: The nutritional quality and cost of packaged gluten-free foods. PeerJ, 3.","DOI":"10.7717\/peerj.1337"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Zanini, B., Marullo, M., Villanacci, V., Salemme, M., Lanzarotto, F., Ricci, C., and Lanzini, A. (2016). Persistent Intraepithelial Lymphocytosis in Celiac Patients Adhering to Gluten-Free Diet Is Not Abolished Despite a Gluten Contamination Elimination Diet. Nutrients, 8.","DOI":"10.3390\/nu8090525"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1365-2036.2009.03992.x","article-title":"Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet","volume":"29","author":"Lanzini","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1055\/s-2006-925178","article-title":"Endoscopic and histological findings in the duodenum of adults with celiac disease before and after changing to a gluten-free diet: A 2-year prospective study","volume":"38","author":"Tursi","year":"2006","journal-title":"Endoscopy"},{"key":"ref_217","first-page":"51","article-title":"Gluten content in special dietary use gluten-free products and other food products","volume":"61","author":"Daniewski","year":"2010","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_218","unstructured":"Cicha\u0144ska, B.A. (2025, March 08). Problemy z Rozr\u00f3\u017cnianiem \u017bywno\u015bci Bezglutenowej. Pediatria Wsp\u00f3\u0142czesna. Gastroenterologia, Hepatologia i \u017bywienie Dziecka. Available online: https:\/\/katalogi.bn.org.pl\/discovery\/fulldisplay?docid=alma9910307223805606&vid=48OMNIS_NLOP:48OMNIS_NLOP."},{"key":"ref_219","first-page":"362","article-title":"Zawarto\u015b\u0107 glutenu (gliadyny) w wybranych produktach spo\u017cywczych","volume":"XLIII","author":"Wojtasik","year":"2010","journal-title":"Bromat. Chem. Toksykol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1080\/19440049.2013.840744","article-title":"Gluten contamination of naturally gluten-free flours and starches used by Canadians with celiac disease","volume":"30","author":"Koerner","year":"2013","journal-title":"Food Addit. Contam. Part. A Chem. Anal. Control Expo. Risk Assess."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jada.2010.03.014","article-title":"Gluten contamination of grains, seeds, and flours in the United States: A pilot study","volume":"110","author":"Thompson","year":"2010","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4315\/0362-028X.JFP-15-213","article-title":"Catering Gluten-Free When Simultaneously Using Wheat Flour","volume":"79","author":"Miller","year":"2016","journal-title":"J. Food Prot."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1021\/acs.jproteome.5b00187","article-title":"Proteomic profiling of 16 cereal grains and the application of targeted proteomics to detect wheat contamination","volume":"14","author":"Colgrave","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3945\/ajcn.112.047985","article-title":"Might gluten traces in wheat substitutes pose a risk in patients with celiac disease? A population-based probabilistic approach to risk estimation","volume":"97","author":"Gibert","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3390\/nu6020881","article-title":"Estimated levels of gluten incidentally present in a Canadian gluten-free diet","volume":"6","author":"Dubois","year":"2014","journal-title":"Nutrients"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.4315\/0362-028X.JFP-14-149","article-title":"Gluten contamination in foods labeled as \u201cgluten free\u201d in the United States","volume":"77","author":"Lee","year":"2014","journal-title":"J. Food Prot."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/apt.13725","article-title":"Symptomatic suspected gluten exposure is common among patients with coeliac disease on a gluten-free diet","volume":"44","author":"Silvester","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-277X.2009.01036.x","article-title":"Dietary compliance and life style of children with coeliac disease","volume":"23","author":"Roma","year":"2010","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1365-277X.2011.01170.x","article-title":"Impact of coeliac disease on dietary habits and quality of life","volume":"24","author":"Black","year":"2011","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1099\/00221287-142-4-799","article-title":"A new, broad-substrate-specificity aminopeptidase from the dairy organism Lactobacillus helveticus SBT 2171","volume":"142","author":"Sasaki","year":"1996","journal-title":"Microbiology"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1128\/aem.57.12.3593-3599.1991","article-title":"Purification and characterization of an endopeptidase from Lactococcus lactis subsp. cremoris Wg2","volume":"57","author":"Tan","year":"1991","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/BF00164419","article-title":"Cell-wall-associated proteinase of Lactobacillus delbrueckii subsp. bulgaricus CNRZ 397: Differential extraction, purification and properties of the enzyme","volume":"36","author":"Laloi","year":"1991","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1128\/AEM.68.2.623-633.2002","article-title":"Proteolysis by sourdough lactic acid bacteria: Effects on wheat flour protein fractions and gliadin peptides involved in human cereal intolerance","volume":"68","author":"Lavermicocca","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1128\/AEM.70.2.1088-1096.2004","article-title":"Sourdough bread made from wheat and nontoxic flours and started with selected lactobacilli is tolerated in celiac sprue patients","volume":"70","author":"Auricchio","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1021\/jf048341+","article-title":"Pasta made from durum wheat semolina fermented with selected lactobacilli as a tool for a potential decrease of the gluten intolerance","volume":"53","author":"Alfonsi","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1472-765X.2008.02448.x","article-title":"Functionality of lactic acid bacteria peptidase activities in the hydrolysis of gliadin-like fragments","volume":"47","author":"Gerez","year":"2008","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1365-2672.2005.02730.x","article-title":"Proteolytic activity and reduction of gliadin-like fractions by sourdough lactobacilli","volume":"99","author":"Rollan","year":"2005","journal-title":"J. Appl. Microbiol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.foodchem.2014.11.053","article-title":"Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation","volume":"174","author":"Montserrat","year":"2015","journal-title":"Food Chem."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.3748\/wjg.v19.i35.5837","article-title":"Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study","volume":"19","author":"Tack","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.clim.2009.11.001","article-title":"The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo","volume":"134","author":"Anderson","year":"2010","journal-title":"Clin. Immunol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s10620-011-1906-5","article-title":"Safety, tolerability, and activity of ALV003: Results from two phase 1 single, escalating-dose clinical trials","volume":"57","author":"Siegel","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/j.gastro.2014.02.031","article-title":"Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease","volume":"146","author":"Lahdeaho","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1053\/j.gastro.2022.07.071","article-title":"Latiglutenase Protects the Mucosa and Attenuates Symptom Severity in Patients with Celiac Disease Exposed to a Gluten Challenge","volume":"163","author":"Murray","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1021\/jacs.5b08325","article-title":"Engineering of Kuma030: A Gliadin Peptidase That Rapidly Degrades Immunogenic Gliadin Peptides in Gastric Conditions","volume":"137","author":"Wolf","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.gastro.2021.03.019","article-title":"Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease","volume":"161","author":"Pultz","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1007\/s10620-015-3769-7","article-title":"Administration of Bifidobacterium breve Decreases the Production of TNF-alpha in Children with Celiac Disease","volume":"60","author":"Klemenak","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.1021\/jf201212m","article-title":"Influence of Bifidobacterium longum CECT 7347 and gliadin peptides on intestinal epithelial cell proteome","volume":"59","author":"Olivares","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1017\/S0007114514000609","article-title":"Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease","volume":"112","author":"Olivares","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MCG.0b013e31827759ac","article-title":"Exploratory, randomized, double-blind, placebo-controlled study on the effects of Bifidobacterium infantis natren life start strain super strain in active celiac disease","volume":"47","author":"Smecuol","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0022-3476(72)80234-8","article-title":"The use of corticosteroids in celiac crisis","volume":"81","author":"Grand","year":"1972","journal-title":"J. Pediatr."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Abbas, A., Shahab, T., Sherwani, R.K., and Alam, S. (2018). Addition of a Short Course of Prednisolone to a Gluten-Free Diet vs. Gluten-Free Diet Alone in Recovery of Celiac Disease: A Pilot Randomized Controlled Trial. Cureus, 10.","DOI":"10.7759\/cureus.2118"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/MPG.0000000000003596","article-title":"Budesonide and the Gluten Containing Elimination Diet as Treatments for Non-responsive Celiac Disease in Children","volume":"75","author":"Kenyon","year":"2022","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/gut.2009.195131","article-title":"Classification and management of refractory coeliac disease","volume":"59","author":"Murray","year":"2010","journal-title":"Gut"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/ajg.2017.71","article-title":"Open-Capsule Budesonide for Refractory Celiac Disease","volume":"112","author":"Mukewar","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s10620-020-06454-5","article-title":"Enteric-Release Budesonide May Be Useful in the Management of Non-Responsive Celiac Disease","volume":"66","author":"Therrien","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/S0002-9270(02)04387-3","article-title":"Azathioprine in refractory sprue: Results from a prospective, open-label study","volume":"97","author":"Niveloni","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2036.2003.01687.x","article-title":"Azathioprine and prednisone combination therapy in refractory coeliac disease","volume":"18","author":"Goerres","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"199","DOI":"10.14740\/gr819w","article-title":"Refractory Celiac Disease Successfully Treated with Azathioprine","volume":"10","author":"Iqbal","year":"2017","journal-title":"Gastroenterol. Res."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"121","DOI":"10.14309\/crj.2015.25","article-title":"Remission of Refractory Celiac Disease With Infliximab in a Pediatric Patient","volume":"2","author":"Rawal","year":"2015","journal-title":"ACG Case Rep. J."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/MCG.0b013e31829e460e","article-title":"Autoimmune enteropathy in a 13-year-old celiac girl successfully treated with infliximab","volume":"48","author":"Valitutti","year":"2014","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.dld.2006.10.017","article-title":"Treatment of life-threatening type I refractory coeliac disease with long-term infliximab","volume":"40","author":"Costantino","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.autrev.2009.03.010","article-title":"Prospective new biological therapies for rheumatoid arthritis","volume":"9","author":"Senolt","year":"2009","journal-title":"Autoimmun. Rev."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1182\/blood-2012-08-450585","article-title":"Phase 1 trial of IL-15 trans presentation blockade using humanized Mikbeta1 mAb in patients with T-cell large granular lymphocytic leukemia","volume":"121","author":"Waldmann","year":"2013","journal-title":"Blood"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1073\/pnas.0509575103","article-title":"Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia","volume":"103","author":"Morris","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S2468-1253(19)30264-X","article-title":"Safety and efficacy of AMG 714 in adults with coeliac disease exposed to gluten challenge: A phase 2a, randomised, double-blind, placebo-controlled study","volume":"4","author":"Scheinin","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S2468-1253(19)30265-1","article-title":"Safety and efficacy of AMG 714 in patients with type 2 refractory coeliac disease: A phase 2a, randomised, double-blind, placebo-controlled, parallel-group study","volume":"4","author":"Cellier","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.cgh.2024.05.022","article-title":"Enduring Clinical Remission in Refractory Celiac Disease Type II with Tofacitinib: An Open-Label Clinical Study","volume":"22","author":"Dieckman","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jaci.2014.07.022","article-title":"Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease","volume":"135","author":"Croese","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_269","doi-asserted-by":"crossref","unstructured":"McSorley, H.J., Gaze, S., Daveson, J., Jones, D., Anderson, R.P., Clouston, A., Ruyssers, N.E., Speare, R., McCarthy, J.S., and Engwerda, C.R. (2011). Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024092"},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Daveson, A.J., Jones, D.M., Gaze, S., McSorley, H., Clouston, A., Pascoe, A., Cooke, S., Speare, R., Macdonald, G.A., and Anderson, R. (2011). Effect of hookworm infection on wheat challenge in celiac disease--a randomised double-blinded placebo controlled trial. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0017366"},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Giacomin, P., Zakrzewski, M., Croese, J., Su, X., Sotillo, J., McCann, L., Navarro, S., Mitreva, M., Krause, L., and Loukas, A. (2015). Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects. Sci. Rep., 5.","DOI":"10.1038\/srep13797"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/infdis\/jiu256","article-title":"Impact of experimental hookworm infection on the human gut microbiota","volume":"210","author":"Cantacessi","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Croese, J., Miller, G.C., Marquart, L., Llewellyn, S., Gupta, R., Becker, L., Clouston, A.D., Welch, C., Sidorenko, J., and Wallace, L. (2020). Randomized, Placebo Controlled Trial of Experimental Hookworm Infection for Improving Gluten Tolerance in Celiac Disease. Clin. Transl. Gastroenterol., 11.","DOI":"10.14309\/ctg.0000000000000274"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S2468-1253(23)00107-3","article-title":"Safety and tolerability of KAN-101, a liver-targeted immune tolerance therapy, in patients with coeliac disease (ACeD): A phase 1 trial","volume":"8","author":"Murray","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1053\/j.gastro.2021.03.014","article-title":"TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study","volume":"161","author":"Kelly","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.4161\/hv.22753","article-title":"Human vaccines: News","volume":"8","author":"Riedmann","year":"2012","journal-title":"Hum. Vaccin. Immunother."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ebiom.2017.11.018","article-title":"Epitope-Specific Immunotherapy Targeting CD4-Positive T Cells in Celiac Disease: Safety, Pharmacokinetics, and Effects on Intestinal Histology and Plasma Cytokines with Escalating Dose Regimens of Nexvax2 in a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study","volume":"26","author":"Daveson","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/apt.15435","article-title":"Randomised clinical trial: A placebo-controlled study of subcutaneous or intradermal NEXVAX2, an investigational immunomodulatory peptide therapy for coeliac disease","volume":"50","author":"Truitt","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Hardy, M.Y., Goel, G., Russell, A.K., Chen Yi Mei, S.L.G., Brown, G.J.E., Wang, S., Szymczak, E., Zhang, R., Goldstein, K.E., and Neff, K.M. (2021). A Sensitive Whole Blood Assay Detects Antigen-Stimulated Cytokine Release From CD4+ T Cells and Facilitates Immunomonitoring in a Phase 2 Clinical Trial of Nexvax2 in Coeliac Disease. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.661622"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S2468-1253(22)00428-9","article-title":"Efficacy and safety of gluten peptide-based antigen-specific immunotherapy (Nexvax2) in adults with coeliac disease after bolus exposure to gluten (RESET CeD): An interim analysis of a terminated randomised, double-blind, placebo-controlled phase 2 study","volume":"8","author":"Daveson","year":"2023","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1152\/physrev.00003.2008","article-title":"Zonulin and its regulation of intestinal barrier function: The biological door to inflammation, autoimmunity, and cancer","volume":"91","author":"Fasano","year":"2011","journal-title":"Physiol. Rev."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.cgh.2012.08.012","article-title":"Intestinal permeability and its regulation by zonulin: Diagnostic and therapeutic implications","volume":"10","author":"Fasano","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.2012.06538.x","article-title":"Zonulin, regulation of tight junctions, and autoimmune diseases","volume":"1258","author":"Fasano","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/ajg.2012.211","article-title":"A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge","volume":"107","author":"Leffler","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/apt.12147","article-title":"Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: A randomised placebo-controlled study","volume":"37","author":"Kelly","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/j.gastro.2015.02.008","article-title":"Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: A randomized controlled trial","volume":"148","author":"Leffler","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2036.2007.03413.x","article-title":"The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: A proof of concept study","volume":"26","author":"Paterson","year":"2007","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.peptides.2012.02.015","article-title":"Larazotide acetate regulates epithelial tight junctions in vitro and in vivo","volume":"35","author":"Gopalakrishnan","year":"2012","journal-title":"Peptides"},{"key":"ref_289","unstructured":"Biopharma (2025, March 08). 9 Meters Biopharma Announces Interim Analysis of Phase 3 Study of Larazotide for Celiac Disease Does Not Support Trial Continuation (Press Release 21 June 2022). Available online: https:\/\/www.biospace.com\/poor-results-end-9-meters-phase-iii-trial-for-larazotide."},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Hoilat, G.J., Altowairqi, A.K., Ayas, M.F., Alhaddab, N.T., Alnujaidi, R.A., Alharbi, H.A., Alyahyawi, N., Kamal, A., Alhabeeb, H., and Albazee, E. (2022). Larazotide acetate for treatment of celiac disease: A systematic review and meta-analysis of randomized controlled trials. Clin. Res. Hepatol. Gastroenterol., 46.","DOI":"10.1016\/j.clinre.2021.101782"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"5766","DOI":"10.1021\/jo8004843","article-title":"Cinnamoyl inhibitors of tissue transglutaminase","volume":"73","author":"Pardin","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1016\/j.bmcl.2010.12.037","article-title":"Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2","volume":"21","author":"Klock","year":"2011","journal-title":"Bioorg Med. Chem. Lett."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1074-5521(03)00045-0","article-title":"Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase","volume":"10","author":"Hausch","year":"2003","journal-title":"Chem. Biol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.4049\/jimmunol.0803444","article-title":"Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells","volume":"182","author":"Toth","year":"2009","journal-title":"J. Immunol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1073\/pnas.0832466100","article-title":"Transglutaminase 2-\/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells","volume":"100","author":"Szondy","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s10875-012-9745-5","article-title":"Are transglutaminase 2 inhibitors able to reduce gliadin-induced toxicity related to celiac disease? A proof-of-concept study","volume":"33","author":"Rauhavirta","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1517\/14728222.2014.985207","article-title":"Transglutaminase as a therapeutic target for celiac disease","volume":"19","author":"Sulic","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa2032441","article-title":"A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease","volume":"385","author":"Schuppan","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/s41590-024-01867-0","article-title":"Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease","volume":"25","author":"Dotsenko","year":"2024","journal-title":"Nat. Immunol."}],"container-title":["Foods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/6\/959\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:50:49Z","timestamp":1760028649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2304-8158\/14\/6\/959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,11]]},"references-count":299,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["foods14060959"],"URL":"https:\/\/doi.org\/10.3390\/foods14060959","relation":{},"ISSN":["2304-8158"],"issn-type":[{"value":"2304-8158","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,11]]}}}