{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:06:48Z","timestamp":1791562008681,"version":"4.3.4"},"reference-count":95,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Foods"],"abstract":"<jats:p>The aim of this study was to evaluate bioactive properties of Basidiomycota fungi, mainly Suillus sp. Wide spectrum of activities were revealed for S.\u00a0variegatus, S.\u00a0luteus, S.\u00a0bovinus and S.\u00a0granulatus; and obtained results were compared with other common fungi. Total Phenolic Content (TPC) varied from 245.32 \u00b1 5.45 to 580.77 \u00b1 13.10 (mg (GAE) per 100 g of dry weight) in methanolic extracts of S.\u00a0bovinus and S.\u00a0granulatus fruiting bodies, respectively. In ethyl acetate extracts, the highest TPC were obtained for S.\u00a0variegatus (310 \u00b1 9.68, mg (GAE)\/100 g, dry matter), and the lowest means for S.\u00a0luteus (105 \u00b1 3.55, mg (GAE)\/100 g dry weight). The ethyl acetate extracts of the tested Suillus species exhibited a stronger antioxidant activity (AA) to scavenge DPPH\u25cf and ABTS\u2022+ than the methanolic ones, and the highest effects were determined for S.\u00a0luteus (EC50, 0.15 \u00b1 0.05 and 0.23 \u00b1 0.05%, respectively). In the case of methanolic extracts, the highest AA were evaluated for S.\u00a0granulatus. (EC50 for DPPH\u25cf and ABTS\u2022+, 0.81 \u00b1 0.30 and 0.95 \u00b1 0.22%, respectively). The ABTS\u2022+ scavenging potential varied from 0.25 \u00b1 0.05 to 0.74 \u00b1 0.10 (mmol\/L, TROLOX equivalent, for S. granulatus and S. variegatus fruiting body extracts, respectively) in the ethyl acetate extracts. S.\u00a0granulatus extracts demonstrated the widest range of antimicrobial effects against both gram-positive and gram-negative bacteria (from 11.7 \u00b1 1.3 to 28.5 \u00b1 3.3 mm against Pseudomonas\u00a0aeruginosa and Bacillus\u00a0mycoides, respectively); and against two fungal strains (up to 13.6 \u00b1 0.4 mm on Meyerozyma\u00a0guilliermondii) in agar disc diffusion tests. Our study revealed that methanolic extracts of the most tested Suillus sp. were not active enough against the tested parasites: Trypanosoma\u00a0cruzi, Trypanosoma\u00a0brucei, Leishmania\u00a0infantum and Plasmodium\u00a0falciparum. Only S.\u00a0variegatus extracts showed good antiprotozoal effects against P.\u00a0falciparum\u00a0(12.70 \u00b5g\/mL). Cytotoxic activity was observed on human diploid lung cells MRC-5 SV2 by S.\u00a0granulatus extracts (64.45 \u00b5g\/mL). For comparative purposes, extracts of other common Lithuanian fungi, such as Xerocomus sp. (X.\u00a0badius, X.\u00a0chrysenteron and X. subtomentosus), Tylopilus\u00a0felleus, Phallus\u00a0impudicus and Pycnoporus\u00a0cinnabarinus were investigated for their activity. The P.\u00a0cinnabarinus extracts demonstrated the highest and broadest overall effects: 1.32 \u00b5g\/mL against T.\u00a0brucei, 1.46 \u00b5g\/mL against P.\u00a0falciparum, 3.93 \u00b5g\/mL against T.\u00a0cruzi and 21.53 \u00b5g\/mL against L.\u00a0infantum. Additionally, this extract exhibited strong cytotoxicity on MRC-5 cells (13.05 \u00b5g\/mL). The investigation of bioactive fungal metabolites is important for the development of a new generation of antioxidants, antimicrobials, antiparasitic and anticancer agents.<\/jats:p>","DOI":"10.3390\/foods14071130","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T10:48:58Z","timestamp":1742899738000},"page":"1130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative Research of Antioxidant, Antimicrobial, Antiprotozoal and Cytotoxic Activities of Edible Suillus sp. Fruiting Body Extracts"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3575-2475","authenticated-orcid":false,"given":"Asta","family":"Jud\u017eentien\u0117","sequence":"first","affiliation":[{"name":"Institute of Biosciences, Life Sciences Center, Vilnius University, Saul\u0117tekio Avenue 7, LT-10257 Vilnius, Lithuania"},{"name":"Department of Organic Chemistry, Center for Physical Sciences and Technology, Saul\u0117tekio Avenue 3, LT-10257 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-1716","authenticated-orcid":false,"given":"Jonas","family":"\u0160arlauskas","sequence":"additional","affiliation":[{"name":"Department of Xenobiotics Biochemistry, Institute of Biochemistry, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13225-022-00501-4","article-title":"The numbers of fungi: Are the most speciose genera truly diverse?","volume":"114","author":"Bhunjun","year":"2022","journal-title":"Fungal Divers."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R1312","DOI":"10.1016\/j.cub.2021.06.083","article-title":"Fungal biodiversity and conservation mycology in light of new technology, big data, and changing attitudes","volume":"31","author":"Lofgren","year":"2021","journal-title":"Curr. 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